1-methyl-3-isobutylxanthine has been researched along with Autoimmune Diabetes in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with IDDM had increased platelet aggregation (PA, expressed as microM ADP threshold concentration) before Rd was detectable in comparison to control subjects (P less than 0." | 1.27 | Platelet enzyme activities in diabetes mellitus in relation to endothelial damage. ( Janka, HU; Mehnert, H; Schramm, W; Standl, E, 1983) |
| "In human IDDM, similar abnormalities to those seen in the BB model were observed." | 1.27 | Platelets and vascular smooth muscle: abnormalities of phosphodiesterase, aggregation, and cell growth in experimental and human diabetes. ( Franks, DJ; Hamet, P; Sugimoto, H; Umeda, F, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janka, HU | 1 |
| Standl, E | 1 |
| Schramm, W | 1 |
| Mehnert, H | 1 |
| Hamet, P | 1 |
| Sugimoto, H | 1 |
| Umeda, F | 1 |
| Franks, DJ | 1 |
| Chen, MC | 1 |
| Proost, P | 1 |
| Gysemans, C | 1 |
| Mathieu, C | 1 |
| Eizirik, DL | 1 |
| Weir, GC | 1 |
| Leahy, JL | 1 |
| Bonner-Weir, S | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Autoimmune Diabetes
| Article | Year |
|---|---|
Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Blood Glucose; Cyclic AMP; Diabete | 1986 |
3 other studies available for 1-methyl-3-isobutylxanthine and Autoimmune Diabetes
| Article | Year |
|---|---|
Platelet enzyme activities in diabetes mellitus in relation to endothelial damage.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenylyl Cyclases; Adolescent; Adult; Aged; beta | 1983 |
Platelets and vascular smooth muscle: abnormalities of phosphodiesterase, aggregation, and cell growth in experimental and human diabetes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1983 |
Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Chemokine CCL2; Diabetes Mellitus, Type 1; Fe | 2001 |