1-methyl-3-isobutylxanthine has been researched along with Astrocytoma, Grade IV in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram-treated A172 or U87MG cell survival was lower in the presence of forskolin, adenylate cyclase activator, than that in its absence." | 1.38 | Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways. ( Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahin, Z | 1 |
| Biltekin, SN | 1 |
| Yurttas, L | 1 |
| Berk, B | 1 |
| Özhan, Y | 1 |
| Sipahi, H | 1 |
| Gao, ZG | 1 |
| Jacobson, KA | 1 |
| Demirayak, Ş | 1 |
| Moon, EY | 1 |
| Lee, GH | 1 |
| Lee, MS | 1 |
| Kim, HM | 1 |
| Lee, JW | 1 |
| Kuzhikandathil, EV | 2 |
| Molloy, GR | 2 |
4 other studies available for 1-methyl-3-isobutylxanthine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition.
Topics: Antineoplastic Agents; Binding Sites; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic Nuc | 2021 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neopla | 2012 |
Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Brain Neoplasms; Cloning, Molecular; | 1994 |
Proximal promoter of the rat brain creatine kinase gene lacks a consensus CRE element but is essential for the cAMP-mediated increased transcription in glioblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Base Sequence; Brain; Colforsin; Consensus Sequenc | 1999 |