1-methyl-3-isobutylxanthine has been researched along with Asthma in 7 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The contents of histamine and cyclic nucleotides were studied in leukocytes before and after a bronchoprovocation test on patients with extrinsic asthma." | 7.66 | Changes in histamine and cyclic nucleotide levels after bronchoprovocation in patients with extrinsic asthma. ( Andersson, RG; Brundin, A; Lindgren, BR, 1978) |
| "The contents of histamine and cyclic nucleotides were studied in leukocytes before and after a bronchoprovocation test on patients with extrinsic asthma." | 3.66 | Changes in histamine and cyclic nucleotide levels after bronchoprovocation in patients with extrinsic asthma. ( Andersson, RG; Brundin, A; Lindgren, BR, 1978) |
| "Amitriptyline is a drug of high potential, which inhibits acute bronchoconstriction and induces bronchodilatation in pre-contracted airways." | 1.91 | Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways. ( Böll, S; Braunschweig, T; Hempel, P; Klein, V; Martin, C; Michely, A; Rieg, AD; Spillner, J; Tenbrock, K; Verjans, E; von Stillfried, S; Wagner, N, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Hempel, P | 1 |
| Klein, V | 1 |
| Michely, A | 1 |
| Böll, S | 1 |
| Rieg, AD | 1 |
| Spillner, J | 1 |
| Braunschweig, T | 1 |
| von Stillfried, S | 1 |
| Wagner, N | 1 |
| Martin, C | 1 |
| Tenbrock, K | 1 |
| Verjans, E | 1 |
| Lee, CD | 1 |
| Choi, WS | 2 |
| Choi, YG | 1 |
| Kang, HS | 2 |
| Lee, WT | 2 |
| Kim, HJ | 2 |
| Lee, JY | 2 |
| Sohn, UD | 1 |
| Anagnostopoulou, P | 1 |
| Dai, L | 1 |
| Schatterny, J | 1 |
| Hirtz, S | 1 |
| Duerr, J | 1 |
| Mall, MA | 1 |
| Lindgren, BR | 1 |
| Andersson, RG | 1 |
| Brundin, A | 1 |
| Torphy, TJ | 1 |
| Livi, GP | 1 |
| Balcarek, JM | 1 |
| White, JR | 1 |
| Chilton, FH | 1 |
| Undem, BJ | 1 |
| Bachelet, M | 1 |
| Vincent, D | 1 |
| Havet, N | 1 |
| Marrash-Chahla, R | 1 |
| Pradalier, A | 1 |
| Dry, J | 1 |
| Vargaftig, BB | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Asthma
| Article | Year |
|---|---|
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Colforsin; | 1992 |
6 other studies available for 1-methyl-3-isobutylxanthine and Asthma
| Article | Year |
|---|---|
Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Albuterol; Amitriptyline; Animals; Asthma; Bronchoconstr | 2023 |
Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Inhalation; Airway Resistance; Animals; Asthma; Broncho | 2020 |
Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Asthma; Chemokine CCL4; Dexamethason | 2021 |
Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice.
Topics: 1-Methyl-3-isobutylxanthine; Allergens; Amiloride; Animals; Aspergillus fumigatus; Asthma; Bronchoal | 2010 |
Changes in histamine and cyclic nucleotide levels after bronchoprovocation in patients with extrinsic asthma.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Allergens; Asthma; Bronchial Spasm; Cyclic AMP; Cycl | 1978 |
Reduced responsiveness of adenylate cyclase in alveolar macrophages from patients with asthma.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Albuterol; Asthma; Bronchoalveolar Lavage Fluid; Cel | 1991 |