1-methyl-3-isobutylxanthine has been researched along with Arrhythmias, Cardiac in 6 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this study were to determine whether a relationship exists between the occurrence of coronary artery occlusion-induced arrhythmias in the anaesthetized rat and the levels of cyclic AMP and cyclic GMP in both normal and ischaemic myocardium, and to assess whether such arrhythmias were modified by pretreatment with the phosphodiesterase inhibitors, quazodine and isobutyl methylxanthine (IBMX), or with the butyryl derivatives of cyclic AMP and cyclic GMP." | 3.67 | The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat. ( Kane, KA; Morcillo-Sanchez, EJ; Parratt, JR; Rodger, IW; Shahid, M, 1985) |
| "Beta4-Adrenoceptors mediate arrhythmias with smaller Ca2+ transients and smaller increases of L-type Ca2+ current than beta1-adrenoceptors, in line with different but still unknown mechanisms as previously suggested for the intact heart." | 1.30 | Beta4-adrenoceptors are more effective than beta1-adrenoceptors in mediating arrhythmic Ca2+ transients in mouse ventricular myocytes. ( Brown, D; Freestone, NS; Heubach, JF; Kaumann, AJ; Ravens, U; Wettwer, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, H | 1 |
| Shimada, H | 1 |
| Namekata, I | 1 |
| Kawanishi, T | 1 |
| Iida-Tanaka, N | 1 |
| Shigenobu, K | 1 |
| Scamps, F | 1 |
| Tran, G | 1 |
| Rinjard, P | 1 |
| Binet, P | 1 |
| Miocque, M | 1 |
| Vassort, G | 1 |
| Freestone, NS | 2 |
| Heubach, JF | 1 |
| Wettwer, E | 1 |
| Ravens, U | 1 |
| Brown, D | 1 |
| Kaumann, AJ | 2 |
| Sarsero, D | 1 |
| Molenaar, P | 1 |
| Holbrook, M | 1 |
| Coker, SJ | 1 |
| Kane, KA | 1 |
| Morcillo-Sanchez, EJ | 1 |
| Parratt, JR | 1 |
| Rodger, IW | 1 |
| Shahid, M | 1 |
6 other studies available for 1-methyl-3-isobutylxanthine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400.
Topics: 1-Methyl-3-isobutylxanthine; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardia | 2007 |
Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzylidene Com | 1993 |
Beta4-adrenoceptors are more effective than beta1-adrenoceptors in mediating arrhythmic Ca2+ transients in mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhyth | 1999 |
Putative beta 4-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[3H]-CGP 12177 binding.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhyth | 1999 |
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo | 1989 |
The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Arrhythmias, Cardiac; Bucladesine; Coronary Diseas | 1985 |