1-methyl-3-isobutylxanthine has been researched along with Anaplastic Astrocytoma in 19 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradykinin causes a concentration-dependent, transient rise in intracellular Ca2+ and a sustained inhibition of forskolin-, dopamine- and 5'-N-ethyl-carboxamidoadenosine (NECA)-stimulated cAMP accumulation in D384 astrocytoma cells." | 7.68 | Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. ( Altiok, N; Fredholm, BB, 1993) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 7.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| "An adenosine receptor has been characterized to unambiguously demonstrate that the inhibitory guanine nucleotide regulatory protein, Gi, of 1321N1 human astrocytoma cells is fully capable of functionally coupling to adenylate cyclase." | 7.67 | Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. ( Harden, TK; Hughes, AR, 1986) |
| "Inflammatory cytokines (interleukin 1 alpha, 1 beta and tumor necrosis factor-alpha) induce the formation of nitrite by C6 astrocytoma cells in a manner that was blocked by inhibitors of NO synthase such as NG-monomethylarginine." | 3.68 | IL1 and TNF alpha induce cGMP formation in C6 astrocytoma cells via the nitridergic pathway. ( Damais, C; Frelin, C; Vigne, P, 1993) |
| "Bradykinin causes a concentration-dependent, transient rise in intracellular Ca2+ and a sustained inhibition of forskolin-, dopamine- and 5'-N-ethyl-carboxamidoadenosine (NECA)-stimulated cAMP accumulation in D384 astrocytoma cells." | 3.68 | Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. ( Altiok, N; Fredholm, BB, 1993) |
| "Exposure of 1321N1 human astrocytoma cells to fresh medium containing fetal bovine serum induced a marked increase in the subsequent ability of isoproterenol and forskolin to stimulate cAMP accumulation in intact cells, compared with cells exposed to fresh medium without serum." | 3.68 | Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells. ( Arneson-Rotert, LJ; Hoffman, JM; Johnson, RA; Toews, ML, 1991) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 3.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| "An adenosine receptor has been characterized to unambiguously demonstrate that the inhibitory guanine nucleotide regulatory protein, Gi, of 1321N1 human astrocytoma cells is fully capable of functionally coupling to adenylate cyclase." | 3.67 | Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. ( Harden, TK; Hughes, AR, 1986) |
| "Agonist occupation of muscarinic cholinergic receptors of 1321N1 human astrocytoma cells results in an activation of phosphodiesterase and a resultant 50-75% attenuation of isoproterenol-stimulated cyclic AMP accumulation." | 3.67 | Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. ( Harden, TK; Martin, MW; Tanner, LI; Wells, JN, 1986) |
| "C6-2B rat astrocytoma cells were used to test whether the increase of cellular nerve growth factor (NGF) content and secretion induced by isoproterenol treatment are associated with an increase in the content of mRNA that encodes NGF (NGF mRNA)." | 3.67 | Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells. ( Brooker, G; Costa, E; Dal Toso, R; De Bernardi, MA; Mocchetti, I, 1988) |
| "Intracellular cyclic AMP was increased more than 100-fold when rat C6-2B astrocytoma cells were treated with isoproterenol in the cold (4 degrees C)." | 3.66 | Temperature sensitivity of cyclic AMP production and catecholamine-induced refractoriness in a rat astrocytoma cell line. ( Brooker, G; Nickols, GA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nickols, GA | 3 |
| Brooker, G | 5 |
| Moylan, RD | 1 |
| Barovsky, K | 1 |
| Meeker, RB | 1 |
| Harden, TK | 4 |
| Cadman, ED | 1 |
| Naugles, DD | 1 |
| Lee, CM | 1 |
| Toews, ML | 3 |
| Arneson-Rotert, LJ | 2 |
| Liewer, SA | 1 |
| Vigne, P | 1 |
| Damais, C | 1 |
| Frelin, C | 1 |
| Altiok, N | 2 |
| Fredholm, BB | 2 |
| Braunewell, KH | 1 |
| Gundelfinger, ED | 1 |
| Slamon, ND | 1 |
| Pentreath, VW | 1 |
| Johnson, RA | 2 |
| Hoffman, JM | 1 |
| Nakahata, N | 1 |
| Martin, MW | 2 |
| Hughes, AR | 2 |
| Hepler, JR | 1 |
| Tanner, LI | 1 |
| Wells, JN | 1 |
| Dal Toso, R | 1 |
| De Bernardi, MA | 1 |
| Costa, E | 1 |
| Mocchetti, I | 1 |
| Balmforth, AJ | 1 |
| Yasunari, K | 1 |
| Vaughan, PF | 1 |
| Ball, SG | 1 |
19 other studies available for 1-methyl-3-isobutylxanthine and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Potentiation of cholera toxin-stimulated cyclic AMP production in cultured cells by inhibitors of RNA and protein synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytoma; Cell Line; Cholera Toxin; Cyclic AMP; Cycloheximi | 1980 |
N6,O2'-Dibutyryl cyclic AMP and cholera toxin-induced beta-adrenergic receptor loss in cultured cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytoma; Bucladesine; Cell Line; Cholera Toxin; Isoprotere | 1982 |
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Astro | 1982 |
cAMP is not involved in interleukin-1-induced interleukin-6 release from human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Astrocytoma; Bucladesine; Colforsin; Cyclic AMP; Hum | 1994 |
Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Astrocytoma; Bicarbonates; Blood Physiological Phenomena; Colforsin; Cy | 1993 |
IL1 and TNF alpha induce cGMP formation in C6 astrocytoma cells via the nitridergic pathway.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Cyclic GMP; Interleukin-1; Nitrites; omega-N-Met | 1993 |
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibito | 1993 |
Low level expression of calcium-sensor protein VILIP induces cAMP-dependent differentiation in rat C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytoma; Calcium-Binding Proteins; Cell Differentiation; C | 1997 |
Antioxidant defense against antidepressants in C6 and 1321N1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Antidepressive Agents; Antimetabolit | 2000 |
Temperature sensitivity of cyclic AMP production and catecholamine-induced refractoriness in a rat astrocytoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; Astrocytoma; Cell Line; Cyclic AMP; Isoproterenol; Kinetics; Temperatur | 1978 |
Induction of refractoriness to isoproterenol by prior treatment of C6-2B rat astrocytoma cells with cholera toxin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Astrocytoma; Cell Line; Cholera Toxin; Cycl | 1979 |
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Bradykinin; Colforsin; Cyclic AMP; Cyclic GMP; D | 1992 |
Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Carbachol; Colforsin; Cyclic AMP; | 1990 |
Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Astrocytoma; Blo | 1991 |
H1-histamine receptors on human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Calcium; Carbachol; Cells, Cultur | 1986 |
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adenylate Cyclase Toxin; Adenylyl Cycla | 1986 |
Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Astrocytoma; Calcium; Carba | 1986 |
Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Astrocytoma; Cell Line; Isoproterenol; Male; Mice | 1988 |
Characterization of dopamine and beta-adrenergic receptors linked to cyclic AMP formation in intact cells of the clone D384 derived from a human astrocytoma.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic | 1988 |