1-methyl-3-isobutylxanthine has been researched along with Alloxan Diabetes in 34 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves revealed that 1 microgram/ml of glibenclamide (in the presence of 3." | 1.27 | Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. ( Efendić, S; Grill, V; Nylén, A; Ostenson, CG, 1983) |
| "In human IDDM, similar abnormalities to those seen in the BB model were observed." | 1.27 | Platelets and vascular smooth muscle: abnormalities of phosphodiesterase, aggregation, and cell growth in experimental and human diabetes. ( Franks, DJ; Hamet, P; Sugimoto, H; Umeda, F, 1983) |
| "When mannoheptulose was introduced 15 min after starting perfusion with 27 mM glucose, inhibition was apparent in non-diabetic rats, but not in STZ." | 1.27 | B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia. ( Grill, V; Ostenson, CG; Westberg, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (47.06) | 18.7374 |
| 1990's | 15 (44.12) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, J | 1 |
| Ahn, S | 2 |
| Kim, HJ | 1 |
| Lee, M | 1 |
| Kim, J | 1 |
| Jin, SH | 1 |
| Lee, E | 1 |
| Kim, G | 1 |
| Cheong, JH | 1 |
| Jacobson, KA | 1 |
| Jeong, LS | 1 |
| Noh, M | 1 |
| Hope, KM | 1 |
| Tran, PO | 1 |
| Zhou, H | 1 |
| Oseid, E | 1 |
| Leroy, E | 1 |
| Robertson, RP | 1 |
| Siegel, EG | 1 |
| Wollheim, CB | 1 |
| Herberg, L | 1 |
| Sharp, GW | 1 |
| Renold, AE | 2 |
| Trimble, ER | 1 |
| Gerber, PP | 1 |
| Noel, J | 1 |
| Rabinovitch, A | 1 |
| Olson, L | 1 |
| Kyriakides, G | 1 |
| Miller, J | 1 |
| Mintz, DH | 1 |
| Ostenson, CG | 3 |
| Grill, V | 6 |
| Nylén, A | 1 |
| Efendić, S | 2 |
| Hamet, P | 1 |
| Sugimoto, H | 1 |
| Umeda, F | 1 |
| Franks, DJ | 1 |
| Leahy, JL | 3 |
| Bonner-Weir, S | 3 |
| Weir, GC | 3 |
| Craven, PA | 1 |
| Studer, RK | 1 |
| DeRubertis, FR | 1 |
| Wong, KK | 1 |
| Shindo, H | 1 |
| Tawata, M | 1 |
| Onaya, T | 1 |
| Manuel Keenoy, B | 1 |
| Maggetto, C | 1 |
| Malaisse, WJ | 1 |
| Van Tine, BA | 1 |
| Azizeh, BY | 1 |
| Trivedi, D | 1 |
| Phelps, JR | 1 |
| Houslay, MD | 1 |
| Johnson, DG | 1 |
| Hruby, VJ | 1 |
| Dachicourt, N | 1 |
| Serradas, P | 1 |
| Giroix, MH | 1 |
| Gangnerau, MN | 1 |
| Portha, B | 1 |
| Kamata, K | 1 |
| Kondoh, H | 1 |
| Varone, CL | 1 |
| Canepa, ET | 1 |
| Llambias, EB | 1 |
| Grinstein, M | 1 |
| Gando, S | 1 |
| Hattori, Y | 1 |
| Akaishi, Y | 1 |
| Nishihira, J | 1 |
| Kanno, M | 1 |
| Gray, AM | 3 |
| Flatt, PR | 3 |
| Mamujee, SN | 1 |
| Zhou, D | 1 |
| Wheeler, MB | 1 |
| Vacek, I | 1 |
| Sun, AM | 1 |
| Piemonti, L | 1 |
| Bertuzzi, F | 1 |
| Nano, R | 1 |
| Leone, BE | 1 |
| Socci, C | 1 |
| Pozza, G | 1 |
| Di Carlo, V | 1 |
| Abdel-Wahab, YH | 1 |
| Chamras, H | 1 |
| Hershman, JM | 1 |
| Sako, Y | 1 |
| Jalkanen, P | 1 |
| Solomon, SS | 1 |
| Heckemeyer, CM | 1 |
| Barker, JA | 1 |
| Duckworth, WC | 1 |
| Kenno, KA | 1 |
| Severson, DL | 1 |
| Rundfeldt, M | 1 |
| Westberg, M | 2 |
| Sheppard, MS | 1 |
| Eatock, BA | 1 |
| Bala, RM | 1 |
| Sharp, PA | 1 |
| Gillham, MJ | 1 |
| Thomas, JH | 1 |
1 review available for 1-methyl-3-isobutylxanthine and Alloxan Diabetes
| Article | Year |
|---|---|
Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Blood Glucose; Cyclic AMP; Diabete | 1986 |
33 other studies available for 1-methyl-3-isobutylxanthine and Alloxan Diabetes
| Article | Year |
|---|---|
Polypharmacology of N
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; | 2017 |
Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Drug Administration Schedule; | 2004 |
Defective Ca++ handling and insulin release in islets of diabetic hamsters and mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cricetinae; Cricetulus; Diabetes Mellitus, Experiment | 1981 |
Abnormalities of pancreatic somatostatin secretion corrected by in vivo insulin treatment of streptozotocin-diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Sec | 1981 |
A method for large-scale, high-yield isolation of canine pancreatic islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Cell Separation; Diabetes Mellitus, Experimenta | 1982 |
Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 1983 |
Platelets and vascular smooth muscle: abnormalities of phosphodiesterase, aggregation, and cell growth in experimental and human diabetes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1983 |
Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Blood Glucose; Diabetes Mellitus, | 1984 |
Abnormal D cell secretion in alloxan-diabetes: influence by drug and aberrant metabolism.
Topics: 1-Methyl-3-isobutylxanthine; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experi | 1984 |
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 al | 1994 |
Cardiac response to autonomic drugs in atria of diabetic mouse.
Topics: 1-Methyl-3-isobutylxanthine; Alloxan; Animals; Bethanechol; Blood Glucose; Diabetes Mellitus, Experi | 1994 |
Cyclic adenosine 3',5'-monophosphate enhances sodium, potassium-adenosine triphosphatase activity in the sciatic nerve of streptozotocin-induced diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cilostazol; Cyclic AMP; Diabetes Mellitus, Experi | 1993 |
Is glycolysis impaired in erythrocytes of diabetic rats?
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Bucladesine; Diabetes Mellitus, Experimental; E | 1993 |
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amrinone; Animals; Blood Glucose; Cyclic A | 1996 |
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Diabetes | 1996 |
Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Experimental | 1996 |
Glucose inhibits phenobarbital-induced delta-aminolevulinate synthase expression in normal but not in diabetic rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 5-Aminolevulinate Synthetase; Aden | 1996 |
Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylyl Cyclases; Adrenergic beta-Agonis | 1997 |
Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Biological Transport; Culture Techniq | 1997 |
Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).
Topics: 1-Methyl-3-isobutylxanthine; Abdominal Muscles; Agaricus; Alanine; Animals; Biological Transport; Bl | 1998 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabe | 1997 |
Effects of cryopreservation on in vitro and in vivo long-term function of human islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cryopreservation; Diabetes Mellitus, Experimental; G | 1999 |
The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Glu | 2000 |
Effect of diabetes mellitus on thyrotropin release from isolated rat thyrotrophs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; In Vitro Techniques; Kinetics | 1990 |
Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Caprylates; Diabetes Mellitus, Experimental; | 1991 |
Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Gluc | 1985 |
Hormonal control of lipolysis in perifused adipocytes from diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Ep | 1985 |
Lipolysis in isolated myocardial cells from diabetic rat hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Cell Separation; Cyclic AMP; Diabetes Mellitus, | 1985 |
Abnormalities of insulin responses after ambient and previous exposure to glucose in streptozocin-diabetic and dexamethasone-treated rats. Role of hyperglycemia and increased B-cell demands.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Dexamethasone; Diabetes Mellitus, Experimental; | 1986 |
B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Diabetes Melli | 1987 |
Abnormal B-cell function in neonatally streptozotocin-diabetic rats: insensitivity to alloxan toxicity.
Topics: 1-Methyl-3-isobutylxanthine; Alloxan; Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Gl | 1987 |
Altered release of growth hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats. II. Effects of a phorbol ester and secretagogues which increase cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Diabetes Mellitus, Exper | 1989 |
Effect of insulin on the cyclic AMP response of cultured glomerular mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Cells, Cultured; Cyclic AMP; Diabetes Mellitus | 1989 |