1-methyl-3-isobutylxanthine has been researched along with Acute Promyelocytic Leukemia in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR)." | 3.79 | Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. ( Bruserud, O; Døskeland, SO; Gausdal, G; Gjertsen, BT; Havemann, U; Herfindal, L; Kleppe, R; Lanotte, M; McCormack, E; Nguyen, E; Pendino, F; Rouhee, N; Schwede, F; Ségal-Bendirdjian, E; Skavland, J; Wergeland, A, 2013) |
| "The human acute promyelocytic leukemia (APL) cell line HL-60 differentiates to functionally mature granulocytes by incubation with all-trans-retinoic acid (RA)." | 1.29 | 3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells. ( Miyoshi, Y; Nakamura, H; Nakao, K; Sasaki, S; Tagami, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gausdal, G | 1 |
| Wergeland, A | 1 |
| Skavland, J | 1 |
| Nguyen, E | 1 |
| Pendino, F | 1 |
| Rouhee, N | 1 |
| McCormack, E | 1 |
| Herfindal, L | 1 |
| Kleppe, R | 1 |
| Havemann, U | 1 |
| Schwede, F | 1 |
| Bruserud, O | 1 |
| Gjertsen, BT | 1 |
| Lanotte, M | 1 |
| Ségal-Bendirdjian, E | 1 |
| Døskeland, SO | 1 |
| Miyoshi, Y | 1 |
| Nakamura, H | 1 |
| Tagami, T | 1 |
| Sasaki, S | 1 |
| Nakao, K | 1 |
| van der Weyden, L | 1 |
| Rakyan, V | 1 |
| Luttrell, BM | 1 |
| Morris, MB | 1 |
| Conigrave, AD | 1 |
| Lindvall, L | 1 |
| Lantz, M | 1 |
| Gullberg, U | 1 |
| Olsson, I | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Acute Promyelocytic Leukemia
| Article | Year |
|---|---|
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-Associated Death P | 2013 |
3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells.
Topics: 1-Methyl-3-isobutylxanthine; Binding Sites; Cell Differentiation; Cell Nucleus; Cyclic AMP; Drug Syn | 1994 |
Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Ant | 2000 |
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regu | 1990 |