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1-methyl-3-isobutylxanthine and Acute Promyelocytic Leukemia

1-methyl-3-isobutylxanthine has been researched along with Acute Promyelocytic Leukemia in 4 studies

1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR)."3.79Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. ( Bruserud, O; Døskeland, SO; Gausdal, G; Gjertsen, BT; Havemann, U; Herfindal, L; Kleppe, R; Lanotte, M; McCormack, E; Nguyen, E; Pendino, F; Rouhee, N; Schwede, F; Ségal-Bendirdjian, E; Skavland, J; Wergeland, A, 2013)
"The human acute promyelocytic leukemia (APL) cell line HL-60 differentiates to functionally mature granulocytes by incubation with all-trans-retinoic acid (RA)."1.293,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells. ( Miyoshi, Y; Nakamura, H; Nakao, K; Sasaki, S; Tagami, T, 1994)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gausdal, G1
Wergeland, A1
Skavland, J1
Nguyen, E1
Pendino, F1
Rouhee, N1
McCormack, E1
Herfindal, L1
Kleppe, R1
Havemann, U1
Schwede, F1
Bruserud, O1
Gjertsen, BT1
Lanotte, M1
Ségal-Bendirdjian, E1
Døskeland, SO1
Miyoshi, Y1
Nakamura, H1
Tagami, T1
Sasaki, S1
Nakao, K1
van der Weyden, L1
Rakyan, V1
Luttrell, BM1
Morris, MB1
Conigrave, AD1
Lindvall, L1
Lantz, M1
Gullberg, U1
Olsson, I1

Other Studies

4 other studies available for 1-methyl-3-isobutylxanthine and Acute Promyelocytic Leukemia

ArticleYear
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
    Cell death & disease, 2013, Feb-28, Volume: 4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-Associated Death P

2013
3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells.
    Molecular and cellular endocrinology, 1994, Volume: 103, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Binding Sites; Cell Differentiation; Cell Nucleus; Cyclic AMP; Drug Syn

1994
Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells.
    Immunology and cell biology, 2000, Volume: 78, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Ant

2000
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
    Biochemical and biophysical research communications, 1990, Oct-30, Volume: 172, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regu

1990