1-methyl-3-isobutylxanthine has been researched along with Acute Promyelocytic Leukemia in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Excerpt | Relevance | Reference |
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"We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR)." | 3.79 | Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. ( Bruserud, O; Døskeland, SO; Gausdal, G; Gjertsen, BT; Havemann, U; Herfindal, L; Kleppe, R; Lanotte, M; McCormack, E; Nguyen, E; Pendino, F; Rouhee, N; Schwede, F; Ségal-Bendirdjian, E; Skavland, J; Wergeland, A, 2013) |
"The human acute promyelocytic leukemia (APL) cell line HL-60 differentiates to functionally mature granulocytes by incubation with all-trans-retinoic acid (RA)." | 1.29 | 3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells. ( Miyoshi, Y; Nakamura, H; Nakao, K; Sasaki, S; Tagami, T, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (50.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Gausdal, G | 1 |
Wergeland, A | 1 |
Skavland, J | 1 |
Nguyen, E | 1 |
Pendino, F | 1 |
Rouhee, N | 1 |
McCormack, E | 1 |
Herfindal, L | 1 |
Kleppe, R | 1 |
Havemann, U | 1 |
Schwede, F | 1 |
Bruserud, O | 1 |
Gjertsen, BT | 1 |
Lanotte, M | 1 |
Ségal-Bendirdjian, E | 1 |
Døskeland, SO | 1 |
Miyoshi, Y | 1 |
Nakamura, H | 1 |
Tagami, T | 1 |
Sasaki, S | 1 |
Nakao, K | 1 |
van der Weyden, L | 1 |
Rakyan, V | 1 |
Luttrell, BM | 1 |
Morris, MB | 1 |
Conigrave, AD | 1 |
Lindvall, L | 1 |
Lantz, M | 1 |
Gullberg, U | 1 |
Olsson, I | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Acute Promyelocytic Leukemia
Article | Year |
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Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-Associated Death P | 2013 |
3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells.
Topics: 1-Methyl-3-isobutylxanthine; Binding Sites; Cell Differentiation; Cell Nucleus; Cyclic AMP; Drug Syn | 1994 |
Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Ant | 2000 |
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regu | 1990 |