1-hydroxyprevitamin-d3 and Chronic-Kidney-Disease-Mineral-and-Bone-Disorder

Comparative assessment of the action of vitamin D2 in high doses, of oxydevit and rocaltrol applied in renal osteopathies has demonstrated that they are equally effective in elevating the calcium concentration in blood serum occurring at the expense of its increased absorption by the intestine. At the same time certain differences have been discovered in the action of these agents on endocrine regulation. The data obtained provide evidence in favour of the use of vitamin D2 in high doses or of its metabolites not only in renal osteopathies at the stage of chronic renal failure but also in the management of the disorders of phosphorus-calcium metabolism in patients with the nephrotic syndrome in the functional-compensation stage after continuous use of corticosteroids, heparin and diuretics.

Topics: Adolescent; Calcitriol; Calcium; Child; Child, Preschool; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disorder; Clinical Trials as Topic; Ergocalciferols; Glomerulonephritis; Humans; Hydroxycholecalciferols; Phosphorus

Amino acid analysis and investigation of nitrogen, calcium and phosphorus balance were done in two groups of patients with renal failure and osteodystrophy on vitamin D metabolites and analogues treatment. The results of the investigation confirm vitamin D metabolites influence on free amino acid metabolism and on nitrogen, calcium, phosphorus balance. We observed significant decreases of blood amino acids and good influence on renal osteodystrophy in patients treated with vitamin D metabolites. Vitamin D metabolites didn't influence retention, urinary and fecal excretion of endogenous nitrogen in patients with renal failure.

Topics: Adolescent; Calcifediol; Calcium; Child; Chronic Kidney Disease-Mineral and Bone Disorder; Fatty Acids, Nonesterified; Humans; Hydroxycholecalciferols; Kidney Failure, Chronic; Nitrogen; Phosphorus; Time Factors