1-hydroxymethylmidazolam has been researched along with Sensitivity and Specificity in 18 studies
*Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Meid, AD; Mikus, G; Wiebe, ST | 1 |
| Beijnen, JH; Maas-Bakker, RF; Meijerman, I; Mooiman, KD; Rosing, H; Schellens, JH | 1 |
| Henion, J; Oliveira, RV; Wickremsinhe, ER | 1 |
| Akhlaghi, F; Chitnis, SD; Dostalek, M; Ionita, IA; Macwan, JS | 1 |
| de Jonge, H; de Loor, H; Kuypers, DR; Vanrenterghem, Y; Verbeke, K | 1 |
| Chen, L; de Boer, T; den Daas, I; Meulman, E; Renkema, G; Reuvers, M; van Iersel, T; Wemer, J; Wieling, J | 1 |
| Jarho, P; Kaartama, R; Kokki, H; Lehtonen, M; Savolainen, J | 1 |
| Chen, YL; Eerkes, A; Jiang, X; Magis, L; Naidong, W; Shou, WZ; Tang, YQ | 1 |
| Gregory, A; Lennard, MS; Rostami-Hodjegan, A; Shiran, MR; Tucker, GT | 1 |
| Inoue, Y; Tateishi, T; Yasui-Furukori, N | 1 |
| Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Preston, L; Ward, SA | 1 |
| Bonato, PS; Coelho, EB; Dos Santos, NA; Jabor, VA; Lanchote, VL | 1 |
| Li, W; Luo, S; Smith, HT; Tse, FL | 1 |
| Donati, F; Mastey, V; Panneton, AC; Varin, F | 1 |
| Boulieu, R; Lehmann, B | 1 |
| Banditt, P; Martens, J | 1 |
| De Winne, AJ; Desager, JP; Eeckhoudt, SL; Horsmans, Y; Verbeeck, RK | 1 |
| Baudin, O; Dupuy, JL; François, B; Gaulier, JM; Lacassie, E; Lachâtre, G; Marquet, P | 1 |
18 other study(ies) available for 1-hydroxymethylmidazolam and Sensitivity and Specificity
| Article | Year |
|---|---|
Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity.
Topics: Adult; Area Under Curve; Biological Variation, Population; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Sensitivity and Specificity; Young Adult | 2020 |
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
Topics: Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Stability; Humans; Microsomes, Liver; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
Automated high-capacity on-line extraction and bioanalysis of dried blood spot samples using liquid chromatography/high-resolution accurate mass spectrometry.
Topics: Automation; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Linear Models; Male; Midazolam; Models, Chemical; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2014 |
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry.
Topics: Chromatography, Liquid; Humans; Least-Squares Analysis; Microsomes, Liver; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2010 |
A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Kidney Transplantation; Midazolam; Nonlinear Dynamics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.
Topics: Adult; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Stability; Female; Humans; Linear Models; Male; Midazolam; Patient Satisfaction; Phenotype; Phlebotomy; Reproducibility of Results; Sensitivity and Specificity; Surveys and Questionnaires; Tandem Mass Spectrometry | 2011 |
Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam.
Topics: Administration, Sublingual; Animals; Area Under Curve; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Least-Squares Analysis; Male; Methane; Midazolam; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction | 2011 |
Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns.
Topics: Animals; Chromatography, Liquid; Humans; Macaca fascicularis; Midazolam; Morphine; Morphine Derivatives; Reproducibility of Results; Sensitivity and Specificity; Silicon Dioxide; Solvents; Spectrum Analysis | 2002 |
Determination of midazolam and 1'-hydroxymidazolam by liquid chromatography-mass spectrometry in plasma of patients undergoing methadone maintenance treatment.
Topics: Adjuvants, Anesthesia; Anti-Anxiety Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Midazolam; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Sensitive determination of midazolam and 1'-hydroxymidazolam in plasma by liquid-liquid extraction and column-switching liquid chromatography with ultraviolet absorbance detection and its application for measuring CYP3A activity.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Female; Humans; Male; Midazolam; Oxidoreductases, N-Demethylating; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2004 |
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Topics: Anticonvulsants; Child; Chromatography, High Pressure Liquid; Humans; Kenya; Malaria, Falciparum; Midazolam; Reproducibility of Results; Seizures; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: applications to drug metabolism.
Topics: Adult; Chromatography, Liquid; Female; Humans; Mass Spectrometry; Midazolam; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Simultaneous determination of midazolam and 1'-hydroxymidazolam in human plasma by liquid chromatography with tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Midazolam; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2007 |
Determination of midazolam and two of its metabolites in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydroxylation; Midazolam; Sensitivity and Specificity | 1994 |
Determination of midazolam and its unconjugated 1-hydroxy metabolite in human plasma by high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Midazolam; Reproducibility of Results; Sensitivity and Specificity | 1995 |
Simultaneous determination of midazolam and its metabolites 1-hydroxymidazolam and 4-hydroxymidazolam in human serum using gas chromatography-mass spectrometry.
Topics: Anesthetics, Intravenous; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Midazolam; Sensitivity and Specificity | 1997 |
Sensitive assay for midazolam and its metabolite 1'-hydroxymidazolam in human plasma by capillary high-performance liquid chromatography.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Evaluation Studies as Topic; Humans; Midazolam; Oxidoreductases, N-Demethylating; Rifampin; Sensitivity and Specificity | 1998 |
Sensitive and specific determination of midazolam and 1-hydroxymidazolam in human serum by liquid chromatography-electrospray mass spectrometry.
Topics: Anesthetics, Intravenous; Chromatography, Liquid; Humans; Hypnotics and Sedatives; Mass Spectrometry; Midazolam; Respiration, Artificial; Sensitivity and Specificity | 1999 |