1-hydroxy-3-amino-2-pyrrolidone has been researched along with Seizures in 9 studies
1-hydroxy-3-amino-2-pyrrolidone: a CNS depressant; structure in first source
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptic seizures have been reported in patients on imipenem/cilastatin (Imi/Cil) therapy." | 7.72 | Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats. ( Lovic, OS; Susic, V; Zivanovic, D, 2004) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 7.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "Epileptic seizures have been reported in patients on imipenem/cilastatin (Imi/Cil) therapy." | 3.72 | Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats. ( Lovic, OS; Susic, V; Zivanovic, D, 2004) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 3.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| " In mice, (+)-HA-966 antagonized sound and N-methyl-DL-aspartic acid (NMDLA)-induced seizures with ED50 values of 52." | 3.68 | Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. ( Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L, 1990) |
| "Coma and convulsions develop in neonates in typical GE while psychomotor retardation and behavioral abnormalities in infancy and childhood are observed in mild GE." | 1.35 | Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor. ( Aoki, Y; Ichinohe, A; Kamada, F; Kanno, J; Kojima-ishii, K; Komatsuzaki, S; Kure, S; Matsubara, Y; Mizoi, K; Nakahara, D; Narisawa, A; Oda, M; Shinka, T; Sugawara, T; Yokoyama, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zivanovic, D | 1 |
| Lovic, OS | 1 |
| Susic, V | 1 |
| Kojima-ishii, K | 1 |
| Kure, S | 1 |
| Ichinohe, A | 1 |
| Shinka, T | 1 |
| Narisawa, A | 1 |
| Komatsuzaki, S | 1 |
| Kanno, J | 1 |
| Kamada, F | 1 |
| Aoki, Y | 1 |
| Yokoyama, H | 1 |
| Oda, M | 1 |
| Sugawara, T | 1 |
| Mizoi, K | 1 |
| Nakahara, D | 1 |
| Matsubara, Y | 1 |
| Rabbani, M | 1 |
| Wright, EJ | 1 |
| Little, HJ | 1 |
| Starr, MS | 1 |
| Starr, BS | 1 |
| Croucher, MJ | 1 |
| Bradford, HF | 1 |
| Singh, L | 1 |
| Donald, AE | 1 |
| Foster, AC | 1 |
| Hutson, PH | 1 |
| Iversen, LL | 1 |
| Iversen, SD | 1 |
| Kemp, JA | 1 |
| Leeson, PD | 1 |
| Marshall, GR | 1 |
| Oles, RJ | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Wardas, J | 1 |
| Graham, J | 1 |
| Gale, K | 1 |
| Sheardown, MJ | 1 |
| Drejer, J | 1 |
| Jensen, LH | 1 |
| Stidsen, CE | 1 |
| Honoré, T | 1 |
9 other studies available for 1-hydroxy-3-amino-2-pyrrolidone and Seizures
| Article | Year |
|---|---|
Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.
Topics: Acetamides; Animals; Binding Sites; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinat | 2004 |
Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor.
Topics: Aggression; Amino Acid Oxidoreductases; Animals; Anxiety; Binding Sites; Brain Diseases, Metabolic; | 2008 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; | 1995 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Di | 1993 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dop | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic A | 1990 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gam | 1989 |