1-hydroxy-3-amino-2-pyrrolidone has been researched along with Peripheral Nervous System Diseases in 3 studies
1-hydroxy-3-amino-2-pyrrolidone: a CNS depressant; structure in first source
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the ability of the functional antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, (+)-(1-Hydroxy-3-aminopyrrolodine-2-one) ((+)-HA966), to modulate the antinociceptive action of systemic morphine in a rat model of neuropathic pain produced by chronic constriction injury to the sciatic nerve." | 3.70 | The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. ( Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V, 1998) |
| "Tolerance to the analgesic effect of morphine complicates the management of chronic pain states." | 3.70 | Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats. ( Christensen, D; Guilbaud, G; Kayser, V, 2000) |
| "Thermal hyperalgesia to radiant heat was assessed by using a foot-withdrawal test and NMDA/non-NMDA receptor antagonists were administered intrathecally onto the lumbar spinal cord before and after nerve injury." | 1.28 | Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Christensen, D | 2 |
| Idänpään-Heikkilä, JJ | 1 |
| Guilbaud, G | 2 |
| Kayser, V | 2 |
| Mao, J | 1 |
| Price, DD | 1 |
| Hayes, RL | 1 |
| Lu, J | 1 |
| Mayer, DJ | 1 |
3 other studies available for 1-hydroxy-3-amino-2-pyrrolidone and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response | 1998 |
Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Excitatory Amino Acid Antagonists; In | 2000 |
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Hot Temperature; Hyperalgesia; I | 1992 |