Compounds > 1-hydroxy-3-amino-2-pyrrolidone
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1-hydroxy-3-amino-2-pyrrolidone and Parkinson Disease

1-hydroxy-3-amino-2-pyrrolidone has been researched along with Parkinson Disease in 2 studies

1-hydroxy-3-amino-2-pyrrolidone: a CNS depressant; structure in first source

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"Treatments for Parkinson's disease based on replacement of lost dopamine have several problems."1.31Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. ( Brotchie, JM; Nash, JE, 2002)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nash, JE1
Brotchie, JM2
Carroll, CB1
Holloway, V1
Mitchell, IJ1

Other Studies

2 other studies available for 1-hydroxy-3-amino-2-pyrrolidone and Parkinson Disease

ArticleYear
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat.
    Movement disorders : official journal of the Movement Disorder Society, 2002, Volume: 17, Issue:3

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Dopamine; Dose-Response Relationsh

2002
Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.
    Psychopharmacology, 1995, Volume: 119, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding, Competitive; Corpus Striatum; Dose-

1995