1-hydroxy-3-amino-2-pyrrolidone has been researched along with Anxiety in 4 studies
1-hydroxy-3-amino-2-pyrrolidone: a CNS depressant; structure in first source
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate if blockade of the modulatory glycine site of NMDA receptors in the dorsal periaqueductal grey (DPAG) would produce anxiolytic effects, groups of 9-14 rats received microinjections into this structure of 7-chloro-kynurenic acid (7-Cl-KY, 4 and 8 nmol) or 3-amino-1-hydroxypyrrolid-2-one (HA-966, 30 or 100 nmol), two selective antagonists at the strychnine-insensitive glycine modulatory site, and were submitted to the elevated plus-maze, an ethologically based animal model of anxiety." | 3.69 | Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey. ( Carobrez, AP; Graeff, FG; Guimarães, FS; Matheus, MG; Nogueira, RL, 1994) |
| "Coma and convulsions develop in neonates in typical GE while psychomotor retardation and behavioral abnormalities in infancy and childhood are observed in mild GE." | 1.35 | Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor. ( Aoki, Y; Ichinohe, A; Kamada, F; Kanno, J; Kojima-ishii, K; Komatsuzaki, S; Kure, S; Matsubara, Y; Mizoi, K; Nakahara, D; Narisawa, A; Oda, M; Shinka, T; Sugawara, T; Yokoyama, H, 2008) |
| "05) prevented the increase in the percentage of open-arm entries and the time spent in the open arms of elevated plus-maze test induced by ethanol, exhibiting a U-shaped dose-response curve." | 1.30 | D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze. ( Moraes Ferreira, VM; Morato, GS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kojima-ishii, K | 1 |
| Kure, S | 1 |
| Ichinohe, A | 1 |
| Shinka, T | 1 |
| Narisawa, A | 1 |
| Komatsuzaki, S | 1 |
| Kanno, J | 1 |
| Kamada, F | 1 |
| Aoki, Y | 1 |
| Yokoyama, H | 1 |
| Oda, M | 1 |
| Sugawara, T | 1 |
| Mizoi, K | 1 |
| Nakahara, D | 1 |
| Matsubara, Y | 1 |
| Matheus, MG | 1 |
| Nogueira, RL | 1 |
| Carobrez, AP | 1 |
| Graeff, FG | 1 |
| Guimarães, FS | 1 |
| Moraes Ferreira, VM | 1 |
| Morato, GS | 1 |
| Dunn, RW | 1 |
| Flanagan, DM | 1 |
| Martin, LL | 1 |
| Kerman, LL | 1 |
| Woods, AT | 1 |
| Camacho, F | 1 |
| Wilmot, CA | 1 |
| Cornfeldt, ML | 1 |
| Effland, RC | 1 |
| Wood, PL | 1 |
4 other studies available for 1-hydroxy-3-amino-2-pyrrolidone and Anxiety
| Article | Year |
|---|---|
Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor.
Topics: Aggression; Amino Acid Oxidoreductases; Animals; Anxiety; Binding Sites; Brain Diseases, Metabolic; | 2008 |
Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Electric Stimulation | 1994 |
D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Cycloserine; Dose-Response Relationship, Drug; Ethanol; Excitato | 1997 |
Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Male; Mice; Pyrrolidinones; Rats; | 1992 |