1-hydroxy-3-amino-2-pyrrolidone has been researched along with Ache in 10 studies
1-hydroxy-3-amino-2-pyrrolidone: a CNS depressant; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the ability of the functional antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, (+)-(1-Hydroxy-3-aminopyrrolodine-2-one) ((+)-HA966), to modulate the antinociceptive action of systemic morphine in a rat model of neuropathic pain produced by chronic constriction injury to the sciatic nerve." | 3.70 | The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. ( Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V, 1998) |
| "Tolerance to the analgesic effect of morphine complicates the management of chronic pain states." | 3.70 | Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats. ( Christensen, D; Guilbaud, G; Kayser, V, 2000) |
| "Thermal hyperalgesia to radiant heat was assessed by using a foot-withdrawal test and NMDA/non-NMDA receptor antagonists were administered intrathecally onto the lumbar spinal cord before and after nerve injury." | 1.28 | Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martins, MA | 1 |
| De Castro Bastos, L | 1 |
| Melo, NE | 1 |
| Tonussi, CR | 1 |
| Buritova, J | 2 |
| Le Guen, S | 1 |
| Fournié-Zaluski, MC | 1 |
| Roques, BP | 1 |
| Besson, JM | 2 |
| Fischer, BD | 1 |
| Carrigan, KA | 1 |
| Dykstra, LA | 1 |
| Adam, F | 1 |
| Bonnet, F | 1 |
| Le Bars, D | 1 |
| Millan, MJ | 2 |
| Seguin, L | 2 |
| Chapman, V | 1 |
| Honoré, P | 1 |
| Christensen, D | 2 |
| Idänpään-Heikkilä, JJ | 1 |
| Guilbaud, G | 2 |
| Kayser, V | 2 |
| Mao, J | 1 |
| Price, DD | 1 |
| Hayes, RL | 1 |
| Lu, J | 1 |
| Mayer, DJ | 1 |
10 other studies available for 1-hydroxy-3-amino-2-pyrrolidone and Ache
| Article | Year |
|---|---|
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibit | 2003 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dr | 2005 |
Tolerance to morphine analgesia: evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Drug Tolerance; Electric Stimulation; Heart Rate; Injec | 2006 |
Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Acetic Acid; Animals; Anticonvulsants; Cycloserine; Dizocilpi | 1994 |
(+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice.
Topics: Animals; Formaldehyde; Glycine; Hindlimb; Male; Mice; Pain; Pyrrolidinones; Receptors, N-Methyl-D-As | 1993 |
The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory pain.
Topics: Animals; Carrageenan; Disease Models, Animal; Drug Interactions; Edema; Male; Myelitis; Pain; Proto- | 1995 |
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response | 1998 |
Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Excitatory Amino Acid Antagonists; In | 2000 |
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Hot Temperature; Hyperalgesia; I | 1992 |