Compounds > 1-hydroxy-2-dodecyl-4(1h)quinolone

1-hydroxy-2-dodecyl-4(1h)quinolone and Toxoplasmosis--Animal

1-hydroxy-2-dodecyl-4(1h)quinolone has been researched along with Toxoplasmosis--Animal* in 1 studies

Other Studies

1 other study(ies) available for 1-hydroxy-2-dodecyl-4(1h)quinolone and Toxoplasmosis--Animal

Article	Year
In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 1-Hydroxy-2-dodecyl-4(1H)quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis. Topics: Animals; Antiparasitic Agents; Cells, Cultured; DNA, Protozoan; Female; Fibroblasts; Flow Cytometry; Humans; Liver; Lung; Mice; Peritoneal Cavity; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Toxoplasma; Toxoplasmosis, Animal; Toxoplasmosis, Cerebral	2010

Article

Year

In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.

Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

1-Hydroxy-2-dodecyl-4(1H)quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis.

Topics: Animals; Antiparasitic Agents; Cells, Cultured; DNA, Protozoan; Female; Fibroblasts; Flow Cytometry; Humans; Liver; Lung; Mice; Peritoneal Cavity; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Toxoplasma; Toxoplasmosis, Animal; Toxoplasmosis, Cerebral

2010