1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with Bronchial Hyperreactivity in 79 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 69 (87.34) | 18.2507 |
2000's | 10 (12.66) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Ishii, S; Nagase, T; Ouchi, Y; Shimizu, T; Shindou, H; Takizawa, H | 1 |
Abo, M; Fujimura, M; Ishiura, Y; Myou, S; Nobata, K; Nonomura, A; Oribe, Y | 1 |
Choi, IW; Im, SY; Kim, JH; Kim, YS; Ko, HM; Lee, HK; Lee, JH; Lee, YC; Park, YM; You, HJ | 1 |
Cloutier, S; Richter, M; Sirois, P | 1 |
Abelli, L; Evangelista, S; Manzini, S; Page, CP; Perretti, F; Seeds, EA | 1 |
Inagaki, N; Iwama, T; Kitagaki, K; Koda, A; Nagai, H; Sakurai, T; Yamaguchi, S | 1 |
Martin, JG | 1 |
Haruta, Y; Hozawa, S; Ishioka, S; Yamakido, M | 1 |
Bindi, D; Franchi-Micheli, S; Gentilini, G; Mugnai, S; Zilletti, L | 1 |
Arima, M; Makino, S; Yukawa, T | 1 |
Bury, T; Corhay, JL; Degroote, D; Franchimont, P; Kayembe, JM; Louis, R; Radermecker, MF | 1 |
Lefort, J; Pretolani, M; Vargaftig, BB | 1 |
Desquand, S; Hatmi, M; Lefort, J; Pina, M; Priego, JG; Ruffié, C; Vargaftig, BB | 1 |
Manzini, S; Perretti, F | 1 |
Herd, CM; Page, CP; Sasaki, M | 1 |
Ballati, L; Evangelista, S; Maggi, CA; Manzini, S; Perretti, F | 1 |
Howell, RE; Kovalsky, MP; Laemont, KD | 1 |
Ho, CY; Tsai, JJ; Wang, SR | 1 |
Battram, CH; Jordan, R; Lewis, SA; Raeburn, D; Sharma, S; Souness, JE; Tomkinson, A; Underwood, SL; Webber, SE; Woodman, VR | 1 |
Bury, T; Corhay, JL; Louis, R; Radermecker, MF | 1 |
Chiba, Y; Misawa, M | 1 |
Bellofiore, S; Ciancio, N; Coco, G; Di Maria, GU; Novo, S; Passanisi, G; Pennisi, A; Ricciardolo, FL | 1 |
Donigi-Gale, D; Herd, CM; Kilfeather, SA; Okiji, SA; Page, CP; Shoupe, TS | 1 |
Coëffier, E; Joseph, D; Vargaftig, BB | 1 |
De Clerck, F; Folkerts, G; Nijkamp, FP; Reijnart, I; Span, P | 1 |
Campos, MG; Church, MK; Joseph, D; Lefort, J; Pretolani, M; Ruffié, C; Vargaftig, BB | 1 |
Adachi, M; Horikoshi, S; Idaira, K; Imai, T; Sugeta, A; Takahashi, T; Tanaka, Y | 1 |
Barnes, PJ; Chung, KF; Elwood, W; Sakamoto, T | 1 |
Broadley, KJ; Thorne, JR | 1 |
Hirata, K; Kanazawa, H; Kurihara, N; Takeda, T; Terakawa, K | 1 |
Kurosawa, M; Tsukagoshi, H | 1 |
Abraham, WM | 1 |
Barnes, PJ | 1 |
Pretolani, M; Vargaftig, BB | 1 |
Suko, M; Yoshida, K | 1 |
Misawa, M; Sugiyama, Y | 1 |
Pu, P; Wang, C; Wu, G | 1 |
Ikemura, T; Ishii, H; Kitamura, S; Ohmori, K; Sasaki, Y | 1 |
Kleeberger, SR; Longphre, M; Paquette, N; Zhang, LY | 1 |
Han, SH; Tsai, CF; Tsai, JJ; Wang, SR | 1 |
Donigi-Gale, D; Kilfeather, S; Okiji, S; Page, CP; Schoupe, TS; Seeds, EA | 1 |
Louis, RE; Radermecker, MF | 1 |
Ikuta, K; Ishii, S; Kume, K; Miyazaki, J; Nagase, T; Sato, S; Shimizu, T; Tashiro, F; Waga, I | 1 |
Antón, F; Berto, L; Carrasco, E; Cortijo, J; Grau, M; Martí-Cabrera, M; Morcillo, EJ | 1 |
Fukuchi, Y; Ishii, S; Katayama, H; Nagase, T; Ouchi, Y; Shimizu, T | 1 |
Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 1 |
Ikuta, K; Ishii, S; Komagata, Y; Kume, K; Maki, K; Miyazaki, J; Nagase, T; Nakatani, N; Ouchi, Y; Shimizu, T; Tashiro, F; Uozumi, N | 1 |
Bast, A; Buurman, WA; Kramer, K; Pennings, HJ; Wouters, EF | 1 |
Aizawa, H; Hara, N; Inoue, H; Koto, H; Matsumoto, K; Nakano, H; Shigyo, M; Takata, S | 1 |
Conroy, DM; Sirois, P | 1 |
Chi, EY; Dietsch, GN; Henderson, WR; Lu, J; Poole, KM | 1 |
Akuta, K; Kawasaki, H; Manabe, H; Ohmori, K | 1 |
Boichot, E; Braquet, P; Carre, C; Guinot, P; Lagente, V; Mencia-Huerta, JM | 1 |
Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Kitaura, M; Oike, M; Yoshie, O | 1 |
Foreman, JC; Maggs, JR; Turner, PJ | 1 |
Fukuoka, M; Haraguchi, R; Itoh, M; Kubo, H; Muraki, M; Nakajima, S; Tohda, Y | 1 |
Apostoliti, F; Breschi, MC; Martinotti, E; Nieri, P | 1 |
Hashimoto, T; Matsukawa, H; Toyoda, Y; Tsuriya, Y; Yanagihara, Y | 1 |
Lewis, SA; Raeburn, D; Underwood, SL | 2 |
Braquet, P; Kessels, GC; Nijkamp, FP; van Heuven-Nolsen, D | 1 |
Li, Q | 1 |
Bellofiore, S; Ciancio, N; Di Maria, GU; Mistretta, A; Ruggieri, F | 1 |
Morley, J | 1 |
Leduc, D; Lefort, J; Pretolani, M; Vargaftig, BB | 1 |
Asano, M; Hamada, K; Inamura, N; Isono, T; Kohsaka, M; Nagayoshi, A; Nakahara, K; Notsu, Y; Oku, T; Ono, T | 1 |
Frans, A; Massion, PB | 1 |
Bethel, RA; Tan, WC | 1 |
Makino, S | 1 |
Kortsik, C; Kroegel, C; Matthys, H; Virchow, JC | 1 |
Donigi-Gale, D; Herd, CM; Page, CP; Shoupe, TS | 1 |
Britten, KM; Djukanović, R; Holgate, ST; Howarth, PH; Lai, CK; Wilson, JW; Wilson, SJ | 1 |
Gebremichael, I; Leuenberger, P | 1 |
Arima, M; Makino, S; Sagara, H; Terashi, Y; Yukawa, T | 1 |
Bittinger, M; Dorsch, W; Kaas, A; Kreher, B; Müller, A; Wagner, H | 1 |
Abraham, WM; Ahmed, A; Cortes, A; Garcia, L; Lansing, MW; Lauredo, IT; Mansour, E; Wanner, A | 1 |
Katayama, K; Katayama, S; Sakuma, Y; Shirato, M; Tsunoda, H; Yamatsu, I | 1 |
Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J | 1 |
Hibi, M; Iwama, T; Sakashita, M; Shikada, K; Tanaka, S; Yamamoto, A | 1 |
6 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Bronchial Hyperreactivity
Article | Year |
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[Animal models of bronchial hyperreactivity].
Topics: Adenosine; Animals; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Cytokines; Dextrans; Disease Models, Animal; Dogs; Guinea Pigs; Inflammation; Leukotrienes; Lipoxygenase; Mast Cells; Ozone; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Tachykinins | 1994 |
Effect of nedocromil sodium on platelet-activating factor-induced airway responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Hyperreactivity; Bronchoconstriction; Drug Interactions; Eosinophils; Humans; Nedocromil; Platelet Activating Factor; Quinolones | 1993 |
From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models?
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Guinea Pigs; Humans; Lymphocytes; Platelet Activating Factor; Respiratory Hypersensitivity | 1993 |
[The potential role and mechanism of leukotriene and platelet-activating factor in allergic disease].
Topics: Asthma; Bronchial Hyperreactivity; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; Leukotrienes; Platelet Activating Factor | 1993 |
[Role of platelet activating factor and its antagonists in bronchial asthma].
Topics: Asthma; Bronchial Hyperreactivity; Histamine Release; Humans; Platelet Activating Factor | 1992 |
Cytokines, platelet activating factor and eosinophils in asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Eosinophils; Humans; Platelet Activating Factor | 1992 |
6 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Bronchial Hyperreactivity
Article | Year |
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Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Changes in bronchial responsiveness, circulating leucocytes and ex vivo cytokine production by blood monocytes after PAF inhalation in allergic asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Leukocyte Count; Leukocytes, Mononuclear; Male; Methacholine Chloride; Platelet Activating Factor; Single-Blind Method; Tumor Necrosis Factor-alpha | 1995 |
Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Bronchial Hyperreactivity; Cross-Over Studies; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Activating Factor; Receptor, Bradykinin B2 | 2000 |
[Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects].
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chlorpheniramine; Double-Blind Method; Humans; Lung; Male; Methacholine Chloride; Platelet Activating Factor; Respiratory Function Tests | 1992 |
Nedocromil sodium inhibits the increase in airway reactivity induced by platelet activating factor in humans.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Nedocromil; Platelet Activating Factor; Quinolones; Vital Capacity | 1992 |
Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Cell Degranulation; Double-Blind Method; Eosinophils; Female; Humans; Male; Mast Cells; Methacholine Chloride; Placebos; Platelet Activating Factor | 1992 |
67 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Bronchial Hyperreactivity
Article | Year |
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Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Leukotrienes; Lung; Male; Mice; Mice, Inbred C57BL; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled | 2004 |
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Guanidines; Guinea Pigs; Histamine; Male; Platelet Activating Factor | 2005 |
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytosol; Disease Models, Animal; Enzyme Activation; Histamine; Inflammation; Leukotriene B4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Phospholipases A; Platelet Activating Factor; Pulmonary Eosinophilia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.
Topics: Animals; Antihypertensive Agents; Bronchial Hyperreactivity; Carbachol; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Fragments; Phospholipid Ethers; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptor, Endothelin B; Thromboxane A2 | 2007 |
Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Albuterol; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Capsaicin; Dextrans; Dyspnea; Fluorescein-5-isothiocyanate; Guinea Pigs; Histamine; Leukocytes; Male; Ovalbumin; Platelet Activating Factor | 1993 |
Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats.
Topics: Aminophylline; Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Female; Guinea Pigs; Histamine; Histamine Release; Hypersensitivity; Leukocyte Count; Leukotriene B4; Male; Muscle Relaxation; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Phosphodiesterase Inhibitors; Platelet Activating Factor; Purinones; Rats; Rats, Wistar; Superoxides; Trachea | 1993 |
GABA-mediated inhibition of the anaphylactic response in the guinea-pig trachea.
Topics: Anaphylaxis; Animals; beta-Alanine; Bronchial Hyperreactivity; Capsaicin; Drug Interactions; Epithelial Cells; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Histamine Release; Macrophage Activation; Macrophages, Alveolar; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Nipecotic Acids; Ovalbumin; Platelet Activating Factor; Proline; Receptors, GABA; Tetrodotoxin; Trachea | 1995 |
Effect of YM264 on the airway hyperresponsiveness and the late asthmatic response in a guinea pig model of asthma.
Topics: Aerosols; Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Male; Ovalbumin; Piperazines; Platelet Activating Factor; Random Allocation; Statistics, Nonparametric; Thiazoles; Thiazolidines; Time Factors; Trachea | 1995 |
Inhibition by nedocromil sodium of recombinant human interleukin-5-induced lung hyperresponsiveness to platelet-activating factor in actively sensitized guinea pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Histamine Release; Interleukin-5; Male; Nedocromil; Platelet Activating Factor; Quinolones; Recombinant Proteins; Thromboxane B2 | 1993 |
Compound PCA-4248 interferes with bronchopulmonary anaphylaxis and with in vitro hyperresponsiveness to platelet-activating factor.
Topics: Anaphylaxis; Animals; Blood Cell Count; Bronchial Hyperreactivity; Bronchoconstriction; Dihydropyridines; Female; Guinea Pigs; Histamine Release; Immunization; In Vitro Techniques; Injections, Intravenous; Lung; Male; Platelet Activating Factor; Radioimmunoassay; Thromboxane B2 | 1993 |
Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs.
Topics: Anesthesia; Animals; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Nerve Fibers; Platelet Activating Factor; Ruthenium Red; Serum Albumin, Bovine; Time Factors; Triazoles | 1993 |
Effect of heparin and a low-molecular weight heparinoid on PAF-induced airway responses in neonatally immunized rabbits.
Topics: Airway Resistance; Animals; Animals, Newborn; Anticoagulants; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chondroitin Sulfates; Dermatan Sulfate; Female; Glycosaminoglycans; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Histamine; Immunization; Lung; Lung Compliance; Male; Platelet Activating Factor; Polyglutamic Acid; Rabbits; Respiratory Function Tests | 1993 |
Antibronchospastic activity of MEN10,627, a novel tachykinin NK2 receptor antagonist, in guinea-pig airways.
Topics: Acetylcholine; Air Pressure; Amino Acid Sequence; Animals; Biphenyl Compounds; Bronchial Hyperreactivity; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Histamine; Hypnotics and Sedatives; In Vitro Techniques; Male; Molecular Sequence Data; Muscle, Smooth; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System | 1995 |
Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
Topics: Aerosols; Albuterol; Animals; Arachidonic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Diamines; Drug Synergism; Gallamine Triethiodide; Guinea Pigs; Histamine; Male; Muscarinic Antagonists; Ovalbumin; Parasympatholytics; Piperazines; Piperidines; Platelet Activating Factor; Propranolol; Receptors, Muscarinic | 1994 |
Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis.
Topics: Adolescent; Adult; Allergens; Antigens, Dermatophagoides; Bronchial Hyperreactivity; Eosinophils; Female; Glycoproteins; Humans; Leukocyte Count; Leukotriene B4; Leukotriene C4; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Platelet Activating Factor; Rhinitis, Allergic, Perennial | 1995 |
Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor.
Topics: Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bronchial Hyperreactivity; Bronchial Spasm; Bronchodilator Agents; Capillary Permeability; Guinea Pigs; Hemodynamics; Histamine; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1994 |
Acute bronchial and hematologic effects following inhalation of a single dose of PAF. Comparison between asthmatics and normal subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Monocytes; Neutrophils; Platelet Activating Factor; Time Factors | 1994 |
Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist).
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Bronchial Hyperreactivity; Dinitrobenzenes; Lung; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; Respiration; Thromboxane A2; Thromboxane-A Synthase; Vaccination | 1994 |
Inhaled platelet-activating factor increases airway sensitivity but not maximal airway narrowing to methacholine in normal subjects.
Topics: Administration, Inhalation; Adult; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow Rate; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Peak Expiratory Flow Rate; Platelet Activating Factor; Pulmonary Ventilation; Total Lung Capacity; Vital Capacity | 1994 |
Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits.
Topics: Administration, Inhalation; Airway Resistance; Animals; Binding Sites; Blood Platelets; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dose-Response Relationship, Drug; Eosinophils; Female; Histamine; Immunization; Isoquinolines; Male; Neutrophils; Platelet Activating Factor; Rabbits | 1994 |
Modulation of the enhanced migration of eosinophils from the airways of sensitized guinea pigs: role of IL-5.
Topics: Administration, Inhalation; Animals; Antibodies, Monoclonal; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Immunization; Interleukin-5; Leukotriene B4; Male; Ovalbumin; Platelet Activating Factor | 1994 |
Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells.
Topics: Aerosols; Albumins; Animals; Bronchial Hyperreactivity; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Inflammation; Luminescent Measurements; Lung; Male; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Platelet Activating Factor; Therapeutic Irrigation; Trachea | 1993 |
Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs.
Topics: Animals; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Eosinophil Granule Proteins; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Leukotriene B4; Male; Methacholine Chloride; Ovalbumin; Peroxidases; Platelet Activating Factor; Proteins; Respiratory Hypersensitivity; Ribonucleases | 1994 |
[Relation of platelet activating factor induced airway hyperresponsiveness to thromboxane A2 and neutrophil in dogs].
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dogs; Female; Neutrophils; Platelet Activating Factor; Thromboxane A2 | 1993 |
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Hypersensitivity, Immediate; Male; Methysergide; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred BN; Serotonin; Triazoles | 1994 |
Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs.
Topics: Adenosine; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol; Guinea Pigs; Immunization; Male; Ovalbumin; Ozone; Platelet Activating Factor | 1994 |
Hyporesponsiveness to inhibitory agents of alveolar macrophages and polymorphonuclear leukocytes primed by platelet activating factor.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Cells, Cultured; Dexamethasone; Female; Humans; Leukotriene B4; Lymphocyte Activation; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Neutrophils; Phthalazines; Platelet Activating Factor; Superoxides | 1993 |
[Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs].
Topics: Adrenocorticotropic Hormone; Animals; Bronchial Hyperreactivity; Guinea Pigs; Histamine; Histamine Antagonists; Hydrocortisone; Infusions, Intravenous; Male; Platelet Activating Factor | 1993 |
Effect of nedocromil sodium on specific mediator- and antigen-induced airway responses in allergic sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris; Bradykinin; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Drug Evaluation, Preclinical; Nedocromil; Platelet Activating Factor; Quinolones; Respiratory Hypersensitivity; Sheep; Time Factors | 1993 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromones; Depression, Chemical; Dinitrophenols; Disease Models, Animal; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; SRS-A; Thromboxane-A Synthase; Tissue Extracts | 1993 |
[Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation].
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Guinea Pigs; Leukocyte Count; Male; Peroxidase; Platelet Activating Factor | 1995 |
[Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs].
Topics: Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dibenzoxepins; Guinea Pigs; Ketotifen; Leukocyte Count; Male; Olopatadine Hydrochloride; Platelet Activating Factor; Rabbits | 1995 |
PAF-induced airways hyperreactivity is modulated by mast cells in mice.
Topics: Acetylcholine; Analysis of Variance; Animals; Azepines; Blood Cell Count; Bone Marrow Transplantation; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Evans Blue; Hematocrit; Lung; Male; Mast Cells; Mice; Mice, Inbred AKR; Mice, Mutant Strains; Nedocromil; Permeability; Platelet Activating Factor; Prostaglandin D2; Species Specificity; Trachea; Triazoles | 1996 |
The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Antagonists; Male; Methacrylates; Ovalbumin; Platelet Activating Factor; Thromboxane-A Synthase; Time Factors | 1995 |
Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration.
Topics: Animals; Benzofurans; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Guinea Pigs; Histamine; Humans; Leukotriene Antagonists; Lipoxygenase; Lipoxygenase Inhibitors; Male; Ovalbumin; Platelet Activating Factor; Pulmonary Eosinophilia; Quinolines | 1995 |
Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Tachyphylaxis | 1996 |
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Endotoxins; Female; Fertility; Guinea Pigs; Male; Melanoma, Experimental; Methacholine Chloride; Mice; Mice, Transgenic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sex Ratio; Shock, Septic; Skin Neoplasms | 1997 |
Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Capillary Permeability; Guinea Pigs; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrazines; Superoxides; Thiadiazines | 1997 |
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Methacrylates; Mice; Mice, Transgenic; Phenylpropionates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Thromboxanes; Triazoles | 1997 |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles | 1997 |
Role of cytosolic phospholipase A2 in allergic response and parturition.
Topics: Anaphylaxis; Animals; Bronchial Hyperreactivity; Chimera; Cloning, Molecular; Cytosol; Eicosanoids; Female; Gene Targeting; Hypersensitivity; Labor, Obstetric; Macrophages, Peritoneal; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pregnancy | 1997 |
Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro.
Topics: Airway Resistance; Animals; Azepines; Bronchial Hyperreactivity; Culture Techniques; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Triazoles; Tumor Necrosis Factor-alpha | 1998 |
Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Nicotiana; Plants, Toxic; Platelet Activating Factor; Pulmonary Eosinophilia; Smoke; Time Factors; Triazoles | 1998 |
Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Dextrans; Guinea Pigs; Indicators and Reagents; Platelet Activating Factor; Thromboxane A2; Vasodilator Agents | 1999 |
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-5; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Phospholipases A; Platelet Activating Factor; Recombinant Proteins | 2000 |
The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Male; Naphthyridines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pneumonia; Rolipram; Specific Pathogen-Free Organisms; Vasodilator Agents | 2000 |
Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs.
Topics: Acetylcholine; Aerosols; Animals; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Diterpenes; Eosinophilia; Ginkgo biloba; Ginkgolides; Guinea Pigs; Lactones; Leukotriene B4; Lung Diseases; Male; Molecular Structure; Ovalbumin; Plants, Medicinal; Platelet Activating Factor; Specific Pathogen-Free Organisms; Thienopyridines; Triazoles | 1993 |
Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Cytokines; Eosinophilia; Eosinophils; Guinea Pigs; Interleukin-5; Leukocyte Count; Leukotriene D4; Male; Platelet Activating Factor | 2000 |
Role of chemical mediators in airway hyperresponsiveness in an asthmatic model.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Indomethacin; Leukotriene C4; Leukotriene D4; Male; Ovalbumin; Platelet Activating Factor; Probability; Reference Values; Sensitivity and Specificity; Thromboxane A2 | 2001 |
Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Guinea Pigs; Histamine; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Protective Agents; Silymarin; Substance P; Time Factors | 2002 |
[Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs].
Topics: Animals; Aspirin; Bronchial Hyperreactivity; Guinea Pigs; Histamine Antagonists; Male; ortho-Aminobenzoates; Platelet Activating Factor; Tetrazoles | 1992 |
RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Albuterol; Anesthesia; Animals; Antigens; Asthma; Benzimidazoles; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dextrans; Ethanolamines; Fluorescein-5-isothiocyanate; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Time Factors; Trachea | 1992 |
Reversal of the endotoxin-induced bronchial hyperreactivity to histamine by the platelet activating factor antagonist BN 52021.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Diterpenes; Endotoxins; Ginkgolides; Guinea Pigs; Histamine; Lactones; Male; Platelet Activating Factor; Premedication | 1992 |
Asthma mortality and inhaled beta agonist therapy.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans; Isomerism; Isoproterenol; Platelet Activating Factor | 1992 |
Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Guinea Pigs; Histamine Release; In Vitro Techniques; Interleukin-5; Lung; Male; Muscle Contraction; Perfusion; Platelet Activating Factor; Recombinant Proteins; Respiratory Hypersensitivity; Thromboxane B2 | 1992 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles | 1992 |
The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Eosinophils; Furans; Guinea Pigs; Male; Methacholine Chloride; Ozone; Platelet Activating Factor; Respiratory Function Tests | 1992 |
[Features and treatment of immediate and late asthmatic responses].
Topics: Animals; Asthma; Bronchial Hyperreactivity; Eosinophils; Guinea Pigs; Humans; Immunosuppressive Agents; Male; Platelet Activating Factor | 1992 |
Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits.
Topics: Administration, Inhalation; Allergens; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Female; Histamine; Immunization; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Quinolines; Rabbits; SRS-A | 1992 |
Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Follow-Up Studies; Forced Expiratory Flow Rates; Humans; Male; Platelet Activating Factor; Spirometry | 1992 |
[Platelet activating factor (PAF)-induced late asthmatic response in sensitized but not in non-sensitized guinea pigs].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Male; Platelet Activating Factor | 1992 |
Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Gallic Acid; Guinea Pigs; Male; Ovalbumin; Phytotherapy; Plant Extracts; Platelet Activating Factor; Quercetin | 1992 |
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles | 1992 |
Lipid mediators contribute to oxygen-radical-induced airway responses in sheep.
Topics: Animals; Arachidonic Acid; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eicosanoids; Female; Free Radical Scavengers; Free Radicals; Oxygen; Platelet Activating Factor; Premedication; Sheep | 1991 |
Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs.
Topics: Administration, Oral; Analysis of Variance; Animals; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Calcium; Eosinophils; Guinea Pigs; Lung; Male; Platelet Activating Factor; Triazoles | 1991 |
Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Chemotaxis, Leukocyte; Guinea Pigs; Male; Platelet Activating Factor; Prednisolone; Theophylline | 1991 |
Effect of NZ-107 on late-phase airway responses and airway hyperreactivity in guinea pigs.
Topics: Aerosols; Animals; Antigens; Bronchial Hyperreactivity; Bronchoconstriction; Drug Hypersensitivity; Guinea Pigs; Histamine; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyridazines; Respiratory Hypersensitivity | 1991 |