1-hexadecyl-2-acetyl-glycero-3-phosphocholine has been researched along with Asthma, Bronchial in 373 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 114 (30.56) | 18.7374 |
| 1990's | 218 (58.45) | 18.2507 |
| 2000's | 33 (8.85) | 29.6817 |
| 2010's | 7 (1.88) | 24.3611 |
| 2020's | 1 (0.27) | 2.80 |
| Authors | Studies |
|---|---|
| Abohassan, M; Al Shahrani, M; Alshahrani, MY; Begum, N; Radhakrishnan, S; Rajagopalan, P | 1 |
| Smith, LJ | 3 |
| Antunes, E; Grotta, MB; Mazon, SB; Ribeiro, JD; Ribeiro, MA; Squebola-Cola, DM; Toro, AA | 1 |
| Calder, PC; Campos, RM; Dias, BC; Massaro, MC; Michelotto, PV; Miles, EA; Miranda, DT; Nishiyama, A; West, AL; Zanatta, AL | 1 |
| Bai, C; Gao, YT; Gebretsadik, T; Gross, M; Hartert, TV; Hartman, TJ; Jin, M; Larkin, EK; Roberts, LJ; Shu, XO; Wen, W; Wu, P; Yang, G | 1 |
| Gill, P; Jagdis, A; Jindal, NL; Vadas, P | 1 |
| Bartuzi, Z; Pałgan, K | 1 |
| Brzoza, Z; Kasperska-Zajac, A; Rogala, B | 2 |
| Gao, F; Li, F; Liu, L | 1 |
| Abal, AT; Abul, HT; Haines, DD; Mahmoud, FF; Wise, JA | 1 |
| Furukawa, M; Ogura, M; Tsuji, H; Tsutsumi, T; Yamashita, T | 1 |
| Braathen, LR; Dummer, R; Levi-Schaffer, F; Menz, G; Plötz, S; Seitzer, U; Simon, D; Simon, HU; Straumann, A | 1 |
| Fernandes, LB; Goldie, RG | 1 |
| Ishida, A; Miyakuni, Y; Nakagawa, T; Takafuji, S | 1 |
| Acuña, A; Chung, KF; Gabrijelcic, J; Paternò, A; Profita, M; Rodríguez-Roisin, R; Vignola, AM | 1 |
| Barberà, JA; Casas, A; Chung, KF; Gabrijelcic, J; Rabinovich, RA; Roca, J; Rodríguez-Roisin, R | 1 |
| Asano, K; Fukunaga, K; Ishizaka, A; Nakajima, T; Naoki, K; Niimi, K; Oguma, T; Satoh, N; Shiomi, T; Shiraishi, Y; Suzuki, Y; Yamaguchi, K | 1 |
| Ishii, S; Nagase, T; Ouchi, Y; Shimizu, T; Shindou, H; Takizawa, H | 1 |
| Abo, M; Fujimura, M; Ishiura, Y; Myou, S; Nobata, K; Nonomura, A; Oribe, Y | 1 |
| Barberà, JA; Echazarreta, AL; MacNee, W; Peinado, V; Rahman, I; Roca, J; Rodríguez-Roisin, R | 1 |
| Choi, IW; Im, SY; Kim, JH; Kim, YS; Ko, HM; Lee, HK; Lee, JH; Lee, YC; Park, YM; You, HJ | 1 |
| Amendoeira, FC; Bandeira-Melo, C; Bozza, PT; Castro-Faria-Neto, HC; Chedier, LM; Figueiredo, MR; Frutuoso, VS; Gomes, GS; Kaplan, MA; Vieira-de-Abreu, A; Weller, PF; Zanon, C | 1 |
| Hagiwara, K; Kanazawa, M; Kikuchi, I; Kikuchi, S; Kobayashi, T; Nagata, M; Sakamoto, Y | 1 |
| Karabina, SA; Ninio, E | 1 |
| Blyth, T; Cass, D; Gold, M; Lack, G; Liss, GM; Perelman, B; Simons, FE; Simons, KJ; Vadas, P; Yeung, J | 1 |
| Abdallah, MF; Ibe, BO; Raj, JU | 1 |
| Morley, J; Page, CP; Sanjar, S | 5 |
| Kazimierczak, W; Knauer, KA; Lichtenstein, LM; Meier, HL; Plaut, M | 1 |
| Kay, AB | 1 |
| Basran, GS; Dewar, A; Morley, J; Page, CP; Paul, W; Wood, L | 1 |
| Basran, GS; Morley, J; Page, CP; Paul, W | 3 |
| Akutsu, I; Fukuda, T; Makino, S; Motojima, S; Numao, T; Toda, M | 1 |
| Martin, JG | 1 |
| Arakawa, H; Maeda, S; Morikawa, A; Tokuyama, K | 1 |
| Holgate, ST; Howarth, PH; Polosa, R; Redington, AE; Walls, AF | 1 |
| Haruta, Y; Hozawa, S; Ishioka, S; Yamakido, M | 1 |
| Shindo, K | 1 |
| Arima, M; Makino, S; Yukawa, T | 1 |
| Meltzer, EO | 1 |
| Bury, T; Corhay, JL; Degroote, D; Franchimont, P; Kayembe, JM; Louis, R; Radermecker, MF | 1 |
| Fujimura, M; Matsuda, T; Ogawa, H; Saito, M | 2 |
| Angus, RM; Barnes, NC; Barnes, PJ; Bone, MF; Chung, KF; Fairfax, AJ; Higenbotham, TW; Kuitert, LM; O'Connor, BJ; Piotrowska, B | 1 |
| Bonavida, B; Mencia-Huerta, JM | 1 |
| Albert, DH; Summers, JB | 1 |
| Taylor, IK | 1 |
| Bewtra, AK; Eda, R; Gillen, MS; Hopp, RJ; Townley, RG | 1 |
| Chand, N; Harrison, JE; Sofia, RD | 1 |
| Augert, G; Cottin, M; Demonchaux, P; Dupassieux, P; Jasserand, D; Lenoir, P; Paris, D; Peck, MJ | 1 |
| Tsai, JJ; Wang, SR; Wang, TF | 1 |
| Beer, JH; von Felten, A; Wüthrich, B | 1 |
| Mita, H; Shida, T | 1 |
| Barnes, NC | 1 |
| Bury, T; Corhay, JL; Louis, R; Radermecker, MF | 1 |
| Davies, BH; Gray, M; Hughes, KT; Jones, KP; Reynolds, SP; Rolf, S | 1 |
| Dobiás, J; Dobrota, D; Lazár, J; Péc, M; Visnovský, P | 1 |
| Barberà, JA; Chung, KF; Félez, MA; Roca, J; Rodriguez-Roisin, R; Rotger, M; Santos, C | 1 |
| Eda, R; Hopp, RJ; Townley, RG | 1 |
| Betz, S; Braun, RK; Bruijnzeel, PL; Rihs, S; Walker, C | 1 |
| De Vos, C; Ghosh, SK; Patel, KR; Rafferty, P | 1 |
| Iwamoto, I; Kawashima, T; Nakagawa, N; Tomioka, H; Yoshida, S | 1 |
| Li, HP; Zhang, RX | 1 |
| Calverley, PM; Dhillon, P; Higgins, C; Holgate, ST; Johnston, SL; Ramhamadany, E; Spence, DP; Turner, S; Winning, A; Winter, J | 1 |
| Henderson, WR; Koenig, JQ; Luchtel, DL; McBride, DE; Williams, PV | 1 |
| Kurimoto, F; Kurosawa, M; Yamashita, T | 1 |
| Blaser, K; Mills, GB; Siminovitch, KA; Simon, HU; Tsao, PW | 1 |
| Tsai, JJ; Wang, SR; Yu, LN | 1 |
| Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T | 1 |
| Bewtra, AK; Eda, R; Hopp, RJ; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Barnes, PJ; Chung, KF; Elwood, W; Sakamoto, T | 1 |
| Hartnell, A; Kay, AB; Robinson, DS; Wardlaw, AJ | 1 |
| Chen, ZN | 1 |
| Broadley, KJ; Thorne, JR | 1 |
| Nishino, K; Ohashi, M; Uno, T | 1 |
| Eastwood, C; Freitag, A; Matsos, G; O'Byrne, PM; Watson, RM | 1 |
| Johnston, JM; Kanda, Y; Maki, N; Miyauchi, K; Suzuki, T; Wada, Y | 1 |
| Bury, T; Corhay, JL; Louis, R; Radermecker, M | 1 |
| Hirata, K; Kanazawa, H; Kurihara, N; Takeda, T; Terakawa, K | 1 |
| Akkerman, JW; Bruynzeel, PL; Burgers, JA; Kreukniet, J; Mengelers, HJ | 1 |
| Fu, J; Li, PS; Yu, HP | 2 |
| Barnes, NC; Burke, W; Hui, KP; Kuitert, LM; Newland, AC; Uden, S; Uthayarkumar, S | 1 |
| Dohi, Y; Kimura, I; Kiuchi, H; Nagata, M; Sakamoto, Y; Tabe, K; Yamamoto, H; Yamamoto, K | 1 |
| Hsieh, KH; Ng, CK | 1 |
| Pretolani, M; Vargaftig, BB | 1 |
| Seow, WK; Thong, YH; Wong, CW | 1 |
| Stewart, GA; Taylor, ML; Thompson, PJ | 1 |
| Kroegel, C; Matthys, H | 1 |
| Björck, T; Dahlén, SE | 1 |
| Barnes, PJ; Chung, KF; Dewar, A; Kroegel, C; Venge, P; Yukawa, T | 1 |
| Suko, M; Yoshida, K | 1 |
| Fukuda, T | 1 |
| Alabaster, VA; Moore, BA | 1 |
| Misawa, M; Sugiyama, Y | 1 |
| Kayahara, H; Matsuzaki, M; Nakamata, M; Tsukioka, K | 1 |
| Bruijnzeel, PL; Koenderman, L; Mengelers, HJ; Raaijmakers, JA; Warringa, RA | 1 |
| Nadel, JA | 1 |
| Han, SH; Tsai, CF; Tsai, JJ; Wang, SR | 1 |
| Agrawal, DK; Miyagawa, H; Nabe, M; Sarmiento, EU; Townley, RG | 1 |
| Fukumura, M; Hirai, Y; Koide, K; Shindo, K; Sumitomo, M | 1 |
| Cortijo, J; Martí-Cabrera, M; Morcillo, EJ; Ortiz, JL; Vallés, JM | 1 |
| Barnes, PJ; Evans, DJ; Lindsay, MA; O'Connor, BJ | 1 |
| Anderson, R; Cole, PJ; Feldman, C; Ramafi, G; Theron, AJ; Wilson, R | 1 |
| Liang, G; Shi, H; Xu, H | 1 |
| Koyama, S; Kubo, K; Nomura, H; Sato, E; Sekiguchi, M | 1 |
| Barnes, NC; Kuitert, L | 1 |
| Misso, NL; Stewart, GA; Taylor, ML; Thompson, PJ | 1 |
| Louis, RE; Radermecker, MF | 1 |
| Knol, EF; Lie, WJ; Mul, FP; Roos, D; Verhoeven, AJ | 1 |
| Knol, EF; Mul, FP; Roos, D; Tool, AT; Verhoeven, AJ | 1 |
| Cortijo, J; Farré, AJ; Gutierrez, B; Morcillo, EJ | 1 |
| Fujimura, M; Matsuda, T; Myou, S; Songür, N; Tsujiura, M | 1 |
| Igarashi, Y; Kurosawa, M; Miyachi, Y; Tsukagoshi, H | 1 |
| Fukuda, T; Makino, S; Sagara, H | 1 |
| Fukumura, M; Shindo, K | 2 |
| Fukuda, T; Ishikawa, A; Makino, S; Okada, T; Sagara, H | 1 |
| Anderson, R; Feldman, C; Theron, AJ | 1 |
| Koenderman, L | 1 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 1 |
| Lin, CC; Lin, CY | 1 |
| Itoh, K; Makino, S; Miyamoto, T; Mue, S; Nakajima, S; Shida, T; Takishima, T; Tamura, G | 1 |
| Fukumura, M; Hirai, Y; Koide, K; Shindo, K | 1 |
| Horie, S; Hossain, M; Isobe, M; Momose, T; Okubo, Y; Sekiguchi, M; Suzuki, J | 1 |
| Barnes, PJ; Cluzel, M; Evans, DJ; O'Connor, BJ | 1 |
| Barberà, JA; Chung, KF; Díaz, O; Marrades, R; Roca, J; Rodriguez-Roisin, R | 1 |
| Ambrosio, G; Carratù, L; De Marino, V; Faraone, S; Marone, G; Sofia, M; Triggiani, M | 1 |
| Fukumura, M; Koide, K; Shindo, K | 3 |
| Rodríguez Roisin, R | 1 |
| Antczak, A; Bialasiewicz, P; Krol, M; Nowak, D | 1 |
| Fukuda, T; Izumi, T; Kishimoto, S; Makino, S; Sagara, H; Shimadzu, W; Shimizu, T; Sugiura, T; Waku, K | 1 |
| Alger, LE; Carson, SS; Garland, A; Leff, AR; McAllister, K; Necheles, J; Neeley, SP; Solway, J; White, SR | 1 |
| Akuta, K; Manabe, H; Ohmori, K; Okamura, K | 1 |
| Anderson, J; Chen, E; Shamsuddin, M; Smith, LJ | 1 |
| Fukumura, M; Hirai, Y; Machida, M; Shindo, K | 1 |
| Haruta, Y; Ishioka, S; Kambe, M; Moritani, C; Yamakido, M | 1 |
| Chung, KF | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Iglesia, R; Roca, J; Rodriguez-Roisin, R | 1 |
| Agustí, C; Grattan, KM; Lausier, JA; Lou, YP; Nadel, JA; Takeyama, K; Ueki, IF | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Peinado, VI; Roca, J; Rodriguez-Roisin, R | 1 |
| Inagaki, N; Koda, A; Nagai, H; Ueno, M | 1 |
| Berends, C; de Monchy, JG; Dijkhuizen, B; Kauffman, HF; Spoelstra, FM | 1 |
| Chihara, J; Hayashi, N; Honda, K; Kayaba, H; Kurachi, D; Saito, N; Urayama, O; Yamamoto, T | 1 |
| Asano, K; Fukunaga, K; Iwata, M; Kanazawa, M; Naoki, K; Satoh, N; Yamaguchi, K | 1 |
| Bossé, M; Ferland, C; Flamand, N; Guilbert, M; Lavigne, S; Laviolette, M | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Iglesia, R; Marrades, RM; Roca, J; Rodriguez-Roisin, RM | 1 |
| Achaval, M; Barberà, JA; Chung, KF; Echazarreta, AL; Gómez, FP; Ribas, J; Roca, J; Rodriguez-Roisin, R | 1 |
| Aslander, MM; Brinkman, L; Grutters, JC; Koenderman, L; Lammers, JW; van den Bosch, JM | 1 |
| Akiyama, Y; Iwane, S; Komatsu, H; Mizuki, M; Tsuda, T | 1 |
| Dent, G; Djukanović, R; Hidi, R; Holgate, ST; Liu, E; Schudt, C; Timmermans, S | 1 |
| Chi, EY; Dietsch, GN; Henderson, WR; Lu, J; Poole, KM | 1 |
| Akuta, K; Kawasaki, H; Manabe, H; Ohmori, K | 1 |
| Aitken, ML; Henderson, WR; Henig, NR; Liu, MC; Yu, AS | 1 |
| Kobayashi, Y; Nagata, M; Sakamoto, Y; Yamamoto, H | 1 |
| Bochner, BS; Brummet, ME; Davenpeck, KL; Hudson, SA; Mayer, RJ | 1 |
| Fukuoka, M; Haraguchi, R; Itoh, M; Kubo, H; Muraki, M; Nakajima, S; Tohda, Y | 1 |
| Chakir, J; Davoine, F; Ferland, C; Flamand, N; Guilbert, M; Laviolette, M | 1 |
| Bock, S; Faehndrich, S; Luttmann, W; Matthys, H; Nassenstein, C; Virchow, JC | 1 |
| Stafforini, DM | 1 |
| Christie, PE; Henderson, WR | 1 |
| Kohno, S; Nabe, T | 1 |
| Agrawal, DK; Suwaki, T; Townley, RG | 1 |
| Acuña, AA; Barberà, JA; Chung, KF; Gabrijelcic, J; Rabinovich, R; Roca, J; Rodriguez-Roisin, R; Uribe, EM | 1 |
| Lewis, SA; Raeburn, D; Underwood, SL | 1 |
| Li, Q | 1 |
| Banks-Schlegel, SP; Barnes, PJ; Henson, PM | 1 |
| Cromwell, O; Kay, AB; Kurihara, K; Sehmi, R; Waltmann, P; Wardlaw, AJ | 1 |
| Townley, RG; Wang, S | 1 |
| Lindstaedt, R; Schmidt, J; Szelenyi, I | 1 |
| Li, CL; Wang, YY | 1 |
| Bewtra, AK; Hopp, RJ; Miyagawa, H; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Crea, AE; Lee, TH; Nakhosteen, JA | 1 |
| Page, C | 1 |
| Beusenberg, FD; Bonta, IL; Brouwers, JW; Hekking, PR; Hoogsteden, HC; Schermers, HP; Van Amsterdam, JG | 1 |
| Morley, J | 4 |
| Bousquet, J; Chanez, P; Godard, P; Lacoste, JY; Michel, FB | 1 |
| Barnes, PJ; Chung, KF; Hayes, JP; Lotvall, JO; Newman Taylor, AJ | 1 |
| Yano, S | 1 |
| Frans, A; Massion, PB | 1 |
| Chavis, C; Crastes de Paulet, A; Damon, M; Godard, P; Radeau, T | 1 |
| Calderón, E; Lockey, RF | 1 |
| Makino, S | 2 |
| Bewtra, AK; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Townley, G | 1 |
| Kortsik, C; Kroegel, C; Matthys, H; Virchow, JC | 1 |
| Heuer, HO | 2 |
| Britten, KM; Djukanović, R; Holgate, ST; Howarth, PH; Lai, CK; Wilson, JW; Wilson, SJ | 1 |
| Gebremichael, I; Leuenberger, P | 1 |
| Jäger, R; Koch, B; Michl, U; Rieger, CH; Schauer, U | 1 |
| Arima, M; Makino, S; Sagara, H; Terashi, Y; Yukawa, T | 2 |
| Denizot, Y; Nathan, N | 1 |
| Clarke, CC; Gundel, RH; Letts, LG; Torcellini, CA; Wegner, CD | 1 |
| Bruijnzeel, PL; Koenderman, L; Kuijper, PH; Mengelers, HJ; Raaijmakers, JA; Warringa, RA | 1 |
| Bittinger, M; Dorsch, W; Kaas, A; Kreher, B; Müller, A; Wagner, H | 1 |
| Iwama, T; Koda, A; Nagai, H; Suda, H | 1 |
| Manning, PJ; O'Byrne, PM | 1 |
| Barnes, PJ; Chung, KF | 4 |
| Imanishi, N; Morooka, S; Uchida, M | 1 |
| Spencer, DA | 1 |
| Akutsu, I; Fukuda, T; Makino, S; Numao, T | 1 |
| Barnes, PJ | 6 |
| Busse, WW; Sedgwick, JB; Vrtis, RR; Zoratti, EM | 1 |
| Dollery, CT; Fuller, RW; Taylor, GW; Taylor, IK; Ward, PS | 1 |
| Jäger, R; Leinhaas, C; Rieger, CH; Schauer, U | 1 |
| Su, SN; Tsai, JJ; Wang, SR; Yu, LN | 1 |
| Tattersfield, AE | 1 |
| Hattori, H; Kishimoto, S; Miyatake, A; Okuda, Y; Takashima, T; Tsuyuguchi, I; Yamatodani, A | 1 |
| Ishihara, H; Masuda, T; Sasaki, H; Sasaki, T; Satoh, M; Shimura, S; Takishima, T | 1 |
| Demoulin, S; Dorsch, W; Gropp, M; Ring, J; Stuppner, H; Wagner, H | 1 |
| Bousquet, J; Braquet, P; Chanez, P; Damon, M; Godard, P; Mencia Huerta, JM; Michel, FB; Rabier, M | 1 |
| Becker, WM; Schade, U; Schaubschläger, WW; Schlaak, M; Zabel, P | 1 |
| Bruijnzeel, P; Bruijnzeel-Koomen, C; Menz, G; Storz, E | 1 |
| Page, CP | 5 |
| Abraham, WM; Ahmed, A; Cortes, A; Garcia, L; Lansing, MW; Lauredo, IT; Mansour, E; Wanner, A | 1 |
| Ishii, Y; Kitamura, S; Kobayashi, J | 1 |
| Katayama, K; Katayama, S; Sakuma, Y; Shirato, M; Tsunoda, H; Yamatsu, I | 1 |
| Li, CL; Shen, YZ | 1 |
| Harada, K; Katayama, K; Katayama, S; Muramoto, K; Sakuma, Y; Tsunoda, H | 1 |
| Horii, T; Kino, M; Kobayashi, Y; Okazaki, H; Saito, K; Satouchi, K | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T; Uchida, M | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T | 1 |
| Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J | 1 |
| Kowalczyk, M; Matusiewicz, R; Urbankowska, B | 1 |
| Iwamoto, I | 1 |
| Kulikov, VI; Lipatkina, LIu; Orlov, SM; Savel'eva, VF; Vlasov, AA | 1 |
| Agrawal, DK; Bewtra, AK; Hopp, RJ; Townley, RG | 3 |
| Hill, MR; Kamada, AK | 1 |
| Goldie, RG; Paterson, JW; Pedersen, KE; Rigby, PJ | 1 |
| Heuer, H; Meade, CJ | 1 |
| Hsieh, KH | 1 |
| Fraj Lázaro, J; Hinojosa Macías, M; Puyana Ruiz, J | 1 |
| Fukuda, T; Makino, S | 1 |
| Kantengwa, S; Polla, BS | 1 |
| Bobkov, EV; Chuchalin, AG; Emirova, AS; Tatarskiĭ, AR | 1 |
| Braquet, P; Hosford, D; Mencia-Huerta, JM | 1 |
| Agrawal, DK; Bewtra, AK; Gordy, C; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Sugiyama, H; Townley, RG | 1 |
| Block, LH; Emmons, LR; Imhof, E; Perruchoud, AP; Roth, M | 1 |
| Pauwels, R | 1 |
| Kroegel, C | 1 |
| Egan, RW; Fernandez, X; Gulbenkian, AR; Kreutner, W; Kung, T; Minnicozzi, M; Watnick, AS | 1 |
| Chavis, C; Crastes de Paulet, A; Damon, M; Godard, PH; Michel, FB; Radeau, T | 1 |
| Bövers, J; Fabel, H; Fröhlich, JC; Uffmann, J; Wilkens, H; Wilkens, JH | 1 |
| Emirova, AS; Tatarskiĭ, AR | 1 |
| Agrawal, DK; Bewtra, AK; Hopp, RJ; Nabe, M; Townley, RG | 1 |
| Akutsu, I; Amagai, M; Fukuda, T; Makino, S; Motojima, S; Numao, T | 1 |
| Fitton, A; Goa, KL; Grant, SM; Sorkin, EM | 1 |
| Agrawal, DK; Bewtra, AK; Hopp, RJ; Miyagawa, H; Nabe, M; Townley, RG | 1 |
| Daume, U; Gemsa, D; Müller, R; Riedel, F; Rieger, CH; Schauer, U | 1 |
| Holgate, ST; Lai, CK | 1 |
| Costello, JF; Evans, JM; Green, SE; Piper, PJ; Spencer, DA | 1 |
| Mikhailidis, DP; Peplow, PV | 1 |
| Barnes, PJ; Chanez, P; Chung, KF; Dent, G; Yukawa, T | 1 |
| Bövers, J; Fabel, H; Frölich, JC; Uffmann, J; Wilkens, H; Wilkens, JH | 1 |
| Hamano, S; Ikeda, S; Kikuchi, S; Komatsu, H; Kusama, H; Okegawa, T; Takehana, Y | 1 |
| Aoki, S; Boubekeur, K; Chapman, ID; Kings, MA; Morley, J; Sanjar, S; Smith, D | 1 |
| Court, EN; Duddridge, M; Goadby, P; Hendrick, DJ; Kelly, CA; Kingston, WP; Stenton, SC; Walters, EH; Ward, C | 1 |
| Morris, HG | 1 |
| Homburger, HA | 1 |
| Frei, PC; Pécoud, A | 1 |
| Okuda, Y; Tsuyuguchi, I; Yamatodani, A | 1 |
| Abraham, WM; Wanner, A | 1 |
| Bayer, T; Dorsch, W; Fessler, B; Hein, G; Ring, J; Scheftner, P; Sieber, W; Strasser, T; Wagner, H; Weiss, E | 1 |
| Kasai, H; Matsui, S; Ninomiya, K; Yanagihara, Y | 1 |
| Xiao, HS | 1 |
| Bachelet, M; Lefort, J; Lellouch-Tubiana, A; Pretolani, M; Vargaftig, BB | 1 |
| Bernstein, PR; Handley, DA; Harris, KE; Krell, RD; Patterson, R; Saunders, RN | 1 |
| Uhl, D | 1 |
| Beume, R; Kilian, U | 1 |
| Barnes, PJ; Boschetto, P; Roberts, NM; Rogers, DF | 1 |
| Chapman, I; Kristersson, A; Mazzoni, L; Morley, J; Sanjar, S; Schaeublin, E; Smith, D | 1 |
| Marone, G | 1 |
| Morley, J; Sanjar, S; Smith, D | 1 |
| Aoki, S; Boubekeur, K; Burrows, L; Chapman, I; Colditz, I; Morley, J; Sanjar, S | 1 |
| Ferrer-Lopez, P; Pretolani, M; Vargaftig, BB | 1 |
| Bousquet, J; Chanez, P; Clauzel, AM; Godard, P; Michel, FB; Pujol, JL | 1 |
| Coyle, AJ; Page, CP | 1 |
| Lee, TH | 1 |
| Barnes, PJ; Chung, KF; Lammers, JW; McCusker, M; Nichol, GM; Roberts, NM | 1 |
| Page, CP; Spina, D | 1 |
| Fabel, H; Flüge, T; Wagner, TO | 1 |
| Braquet, P; Kessels, GC; Nijkamp, FP; van Heuven-Nolsen, D | 1 |
| Abraham, WM; Garrido, R; Stevenson, JS | 1 |
| Ashida, Y; Kato, K; Kuriki, H; Matsumoto, T; Shiraishi, M; Terao, S | 1 |
| Barnes, PJ; Boschetto, P; Rogers, DF | 1 |
| Nolte, D | 2 |
| Bousquet, J; Braquet, P; Chanez, P; Damon, M; Godard, P; Mencia-Huerta, JM; Michel, FB; Rabier, M | 1 |
| Bruijnzeel, PL; Koenderman, L | 1 |
| Dergousov, AA; Kulikov, VI; Lipatkina, LIu; Orlov, SM; Vlasov, AA | 1 |
| Anderson, GP; Fennessy, MR; Stewart, AG | 1 |
| Arnoux, B; Benveniste, J; Denjean, A | 1 |
| Abraham, WM | 1 |
| Sybrecht, GW; Ukena, D | 1 |
| Grasselli, S; Gresele, P; Nenci, GG; Todisco, T | 1 |
| Bourgain, RH; Braquet, P; Etienne, A; Lefort, J; Touvay, C; Vargaftig, BB | 1 |
| Criscuoli, M; Del Monte, M; Subissi, A | 1 |
| Bylin, G | 1 |
| Wasserman, SI | 4 |
| Chavis, C; Crastes De Paulet, A; Damon, M; Godard, P; Michel, FB | 1 |
| Henderson, WR | 1 |
| Brecht, HM; Frey, G; Lichterfeld, A | 1 |
| Coyle, AJ; Page, CP; Robertson, DN | 1 |
| Czarnetzki, BM | 1 |
| Mazzoni, L; Morley, J; Page, CP; Sanjar, S | 1 |
| Burka, JF | 1 |
| Picado, C; Plaza, V | 1 |
| Becher, G; Kühn, H; Schewe, T; Schilling, W; Slapke, J | 1 |
| Anderson, GP; Fennessy, MR | 1 |
| Miadonna, A; Tedeschi, A | 1 |
| Patterson, R; Rubin, AH; Smith, LJ | 2 |
| Davies, B; Pawłowicz, A; Williams, WR | 1 |
| Aoki, S; Boubekeur, K; Kristersson, A; Morley, J; Sanjar, S | 1 |
| Criscuoli, M; Subissi, A | 1 |
| Page, CP; Robertson, DN | 2 |
| Chitnis, AS; Mathur, RS; Shah, JR | 1 |
| Braquet, P; Coyle, AJ; Page, CP; Touvay, C; Urwin, SC; Villain, B | 1 |
| Bonvoisin, B; Brambilla, C; Braquet, P; Cournot, A; Duchier, J; Guinot, P | 1 |
| Newhouse, MT; Sears, MR | 1 |
| Morley, J; Sanjar, S | 2 |
| Böttiger, J; Menz, G; Schmitz-Schumann, M; Virchow, C | 1 |
| Chang, RE; Farr, RS; Grandel, KE; Schul, JL; Wardlow, ML | 1 |
| Krzanowski, M; Musial, J; Nizankowska, E; Szczeklik, A | 1 |
| de Souza, V; Matthys, H; Menz, G; Schäufele, A; Schmitz-Schumann, M; Virchow, C; von Felten, A | 1 |
| Hahn, HL; Hansen, D; Lang, M | 1 |
| Alvemini, D; Morley, J; Page, CP; Sanjar, S | 1 |
| Birch, J; Martin, JF; Milner, PC; Szczeklik, A; Watkins, J | 1 |
| Bayer, T; Dorsch, W; Ettl, M; Hein, G; Scheftner, P; Wagner, H; Weber, J | 1 |
| Kurgan, J | 1 |
| Morley, J; Page, CP | 1 |
| Ishihara, K; Ito, K; Kuriyama, M; Miyamoto, T; Morita, Y; Nakamura, T | 1 |
| Archer, CB; MacDonald, DM; Morley, J; Page, CP; Paul, W | 1 |
| Ip, M; Kwan, S; Lam, WK; So, SY | 1 |
| Morley, J; Page, CP; Sanjar, S; Tomiak, RH | 1 |
| Guerreiro, D; Morley, J; Page, CP; Sanjar, S | 1 |
| Archer, CB; Guerreiro, D; Morley, J; Page, CP | 1 |
96 review(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Asthma, Bronchial
| Article | Year |
|---|---|
Platelet activating factor in allergies.
Topics: Anaphylaxis; Asthma; Eosinophils; Humans; Mast Cells; Platelet Activating Factor; Urticaria | 2015 |
Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Drug Delivery Systems; Humans; Patents as Topic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; United States | 2008 |
The single mediator approach to asthma therapy: is it so unreasonable?
Topics: Asthma; Cholinergic Antagonists; Endothelin A Receptor Antagonists; Histamine H1 Antagonists; Humans; Inflammation Mediators; Leukotriene Antagonists; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activating Factor; Receptors, Leukotriene | 2003 |
Plasma PAF-acetylhydrolase: an unfulfilled promise?
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Anti-Inflammatory Agents; Asthma; Atherosclerosis; Biomarkers; Disease Models, Animal; Humans; Inflammation; Lipoproteins, LDL; Macrophages; Oxidation-Reduction; Phosphatidylcholines; Platelet Activating Factor; Recombinant Proteins; Sepsis | 2006 |
Platelet activating factor as a mediator and therapeutic approach in bronchial asthma.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Humans; Inflammation Mediators; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction | 2008 |
Mediators of hypersensitivity and inflammatory cells in the pathogenesis of bronchial asthma.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Asthma, Exercise-Induced; Bronchitis; Chemotactic Factors; Humans; Hypersensitivity; Immunoglobulin E; Interleukin-8; Mast Cells; Platelet Activating Factor; SRS-A | 1983 |
[Animal models of bronchial hyperreactivity].
Topics: Adenosine; Animals; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Cytokines; Dextrans; Disease Models, Animal; Dogs; Guinea Pigs; Inflammation; Leukotrienes; Lipoxygenase; Mast Cells; Ozone; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Tachykinins | 1994 |
Role of mast cells and basophils in asthma.
Topics: Asthma; Basophils; Biomarkers; Chymases; Cytokines; Endopeptidases; Histamine Release; Humans; Leukotriene Antagonists; Leukotrienes; Lipid Metabolism; Mast Cells; Platelet Activating Factor; Proteoglycans; Serine Endopeptidases; Tryptases | 1995 |
The use of anti-H1 drugs in mild asthma.
Topics: Allergens; Asthma; Bronchoconstriction; Cetirizine; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Platelet Activating Factor | 1995 |
Platelet-activating factor and the cytokine network in inflammatory processes.
Topics: Animals; Asthma; Cytokines; Endothelium, Vascular; Humans; Inflammation; Lymphocytes; Platelet Activating Factor | 1994 |
Platelet activating factor antagonists.
Topics: Animals; Asthma; Humans; Ischemia; Models, Biological; Pancreatitis; Platelet Activating Factor; Reperfusion Injury; Shock, Septic | 1995 |
Release of urinary leukotriene E4 in asthmatic subjects: a review.
Topics: Asthma; Glucocorticoids; Humans; Leukotriene Antagonists; Leukotriene E4; Lipoxygenase Inhibitors; Platelet Activating Factor | 1994 |
New developments in the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Humans; Immunosuppression Therapy; Leukotriene Antagonists; Lung Diseases, Obstructive; Platelet Activating Factor; Thromboxanes | 1993 |
[The role of platelet activating factor in the pathogenesis of asthma].
Topics: Asthma; Humans; Platelet Activating Factor | 1993 |
[Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs].
Topics: Animals; Asthma; Benzofurans; Diterpenes; Drugs, Chinese Herbal; Furans; Ginkgolides; Humans; Lactones; Lignans; Plant Extracts; Platelet Activating Factor | 1993 |
From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models?
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Guinea Pigs; Humans; Lymphocytes; Platelet Activating Factor; Respiratory Hypersensitivity | 1993 |
[The potential role and mechanism of leukotriene and platelet-activating factor in allergic disease].
Topics: Asthma; Bronchial Hyperreactivity; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; Leukotrienes; Platelet Activating Factor | 1993 |
[The eosinophil and bronchial asthma].
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Humans; Hypersensitivity, Delayed; Platelet Activating Factor; SRS-A | 1993 |
New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future.
Topics: Asthma; Forecasting; Humans; Inflammation; Leukotrienes; Platelet Activating Factor; Technology, Pharmaceutical | 1993 |
PAF and asthma--time for an appraisal?
Topics: Animals; Asthma; Humans; Platelet Activating Factor | 1995 |
The role of basophils in allergic disease.
Topics: Asthma; Basophils; Bronchoalveolar Lavage Fluid; Calcium; Cell Degranulation; Chymases; Complement C5a; Cytokines; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histamine Release; Humans; Hypersensitivity; Interleukin-3; Interleukin-5; N-Formylmethionine Leucyl-Phenylalanine; Nasal Lavage Fluid; Phorbol Esters; Platelet Activating Factor; Prostaglandin D2; Receptors, IgE; Serine Endopeptidases; Skin; Tetradecanoylphorbol Acetate; Thapsigargin; Tryptases | 1996 |
[PAF receptor antagonist in asthma therapy].
Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles | 1996 |
PAF acetylhydrolase gene polymorphisms and asthma severity.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Asthma; Genetic Linkage; Humans; Phospholipases A; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 2001 |
Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor.
Topics: Animals; Asthma; Eicosanoids; Humans; Hypersensitivity; Inflammation; Inflammation Mediators; Leukotrienes; Lipid Metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Platelet Activating Factor; Prostaglandins | 2002 |
[Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)].
Topics: Arachidonic Acid; Asthma; Endothelins; Humans; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Platelet Activating Factor; Receptors, Leukotriene; Tachykinins; Thromboxane A2 | 2001 |
Bioactive mediators in asthma.
Topics: Asthma; Eicosanoic Acids; Humans; Immunity, Cellular; Leukotriene E4; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins; SRS-A; Thromboxane A2 | 1992 |
[Platelet-activating factor antagonists and asthma].
Topics: Animals; Asthma; Bronchodilator Agents; Humans; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1992 |
Asthma as a chronic inflammatory disease and the implications for future therapy.
Topics: Adrenergic beta-Agonists; Asthma; Blood Platelets; Bronchoconstriction; Bronchodilator Agents; Chronic Disease; Eosinophils; Humans; Inflammation; Lung; Platelet Activating Factor | 1992 |
[Mediators and neuromediators in asthma].
Topics: Asthma; Atrial Natriuretic Factor; Cytokines; Histamine; Humans; Leukotrienes; Parasympathetic Nervous System; Platelet Activating Factor; Prostaglandins; Substance P; Sympathetic Nervous System; Sympathomimetics; Vasoactive Intestinal Peptide | 1992 |
[Role of platelet activating factor and its antagonists in bronchial asthma].
Topics: Asthma; Bronchial Hyperreactivity; Histamine Release; Humans; Platelet Activating Factor | 1992 |
A possible role for adhesion molecules in asthma.
Topics: Asthma; Basophils; Cell Adhesion Molecules; Cytokines; Eosinophils; Genes, Immunoglobulin; Histamine; Humans; Hydrogen Peroxide; Integrins; Leukotrienes; Mast Cells; Platelet Activating Factor | 1992 |
Cytokines, platelet activating factor and eosinophils in asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Eosinophils; Humans; Platelet Activating Factor | 1992 |
Current status of PAF antagonists.
Topics: Animals; Asthma; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Humans; Platelet Activating Factor | 1992 |
Clinical relevance of lipid mediators in asthma.
Topics: Animals; Arachidonic Acid; Asthma; Humans; Leukotrienes; Lipids; Platelet Activating Factor; Prostaglandins; Thromboxanes | 1992 |
Role of inflammatory mediators in asthma.
Topics: Asthma; Bronchi; Histamine; Humans; Lipoxygenase; Platelet Activating Factor; Prostaglandins | 1992 |
An update on PAF.
Topics: Animals; Asthma; Bronchoconstriction; Humans; Leukotrienes; Platelet Activating Factor | 1992 |
Platelet activating factor and asthma.
Topics: Animals; Asthma; Humans; Inflammation; Models, Biological; Muscle, Smooth; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Physiological Phenomena; Respiratory System | 1991 |
Prospects for bronchodilating drugs in the 1990s.
Topics: Adrenergic beta-Agonists; Arachidonic Acid; Asthma; Bronchodilator Agents; Forecasting; Humans; Muscarine; Narcotics; Phosphodiesterase Inhibitors; Platelet Activating Factor; Potassium Channels; Signal Transduction | 1991 |
Mechanisms of hyperresponsiveness: platelet-activating factor.
Topics: Animals; Asthma; Humans; Platelet Activating Factor; Respiratory System | 1992 |
The effects of hetrazepine PAF antagonists in preclinical models of asthma.
Topics: Anaphylaxis; Animals; Antigens; Asthma; Azepines; Blood Platelets; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Movement; Eosinophils; Lung; Platelet Activating Factor; Respiratory Hypersensitivity; Triazoles | 1991 |
[The pathophysiological role of the platelet activating factor].
Topics: Animals; Asthma; Blood Pressure; Cardiac Output; Humans; Inflammation; Myocardial Contraction; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Shock | 1991 |
Role for platelet-activating factor in asthma.
Topics: Animals; Asthma; Azepines; Eosinophils; Humans; Muscle, Smooth; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles | 1991 |
The contribution of platelet-activating factor to allergen-induced eosinophil infiltration and bronchial hyperresponsiveness.
Topics: Allergens; Animals; Asthma; Eosinophils; Humans; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System | 1991 |
[Eosinophil-induced lung injury].
Topics: Animals; Arylsulfatases; Asthma; Blood Proteins; Eosinophil Granule Proteins; Eosinophil Peroxidase; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Lymphocyte Activation; Neurotoxins; Peroxidases; Phospholipase D; Platelet Activating Factor; Pulmonary Eosinophilia; Ribonucleases; SRS-A | 1991 |
Pathogenesis of asthma: therapeutic implications.
Topics: Asthma; Autonomic Nervous System; Bronchodilator Agents; Humans; Leukocytes; Macrophages; Mast Cells; Platelet Activating Factor | 1991 |
PAF antagonism as an approach to the treatment of airway hyperreactivity.
Topics: Allergens; Animals; Asthma; Azepines; Bronchoconstriction; Diterpenes; Ginkgolides; Humans; Lactones; Platelet Activating Factor; Triazoles | 1991 |
The role of platelet-activating factor in asthma.
Topics: Animals; Asthma; Biochemical Phenomena; Biochemistry; Humans; Leukotrienes; Platelet Activating Factor | 1991 |
[Platelet activating factor in the physiopathology of bronchial asthma].
Topics: Asthma; Humans; Platelet Activating Factor | 1991 |
Heat shock proteins and inflammation.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Arthritis; Asthma; Cytokines; Extracellular Matrix; Fever; Heat-Shock Proteins; Humans; Inflammation; Leukotrienes; Metallothionein; Phagocytosis; Platelet Activating Factor; Prostaglandins | 1991 |
Platelet-activating factor (PAF) and PAF antagonists in asthma.
Topics: Animals; Asthma; Humans; Hypersensitivity; Platelet Activating Factor | 1990 |
The pharmacology of airway hyperresponsiveness and inflammation.
Topics: Airway Resistance; Animals; Asthma; Autonomic Nervous System; Bronchitis; Disease Models, Animal; Humans; Leukotrienes; Muscle, Smooth; Platelet Activating Factor; Respiratory Hypersensitivity | 1990 |
The role of eosinophils in asthma.
Topics: Airway Resistance; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophils; Humans; Platelet Activating Factor | 1990 |
[The role of the thrombocytes in the pathogenesis of certain forms of bronchial asthma].
Topics: Antigens, Differentiation, B-Lymphocyte; Asthma; Blood Platelets; Humans; Immunoglobulin E; Platelet Activating Factor; Platelet Aggregation; Receptors, Fc; Receptors, IgE | 1990 |
Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.
Topics: Asthma; Bronchi; Humans; Hypersensitivity; Ketotifen; Platelet Activating Factor | 1990 |
Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism.
Topics: Animals; Arachidonic Acids; Asthma; Humans; Hypertension; Leukotrienes; Pancreatitis; Platelet Activating Factor; Prostaglandins | 1990 |
Mechanisms of glucocorticoid action in pulmonary disease.
Topics: Animals; Annexins; Arachidonic Acid; Arachidonic Acids; Asthma; Calcium-Binding Proteins; Chemotactic Factors; Glucocorticoids; Glycoproteins; Histamine Release; Humans; Inflammation; Lung; Lung Diseases; Platelet Activating Factor; Protein Biosynthesis; Pulmonary Gas Exchange; Receptors, Glucocorticoid; Status Asthmaticus | 1985 |
Diagnosis of allergy: in vitro testing.
Topics: Age Factors; Allergens; Antibody Formation; Asthma; Blood Coagulation Factors; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin Fragments; Platelet Activating Factor; Receptors, Fc; Receptors, IgE; Receptors, Immunologic; Skin Tests; SRS-A | 1986 |
Inflammatory mediators of asthma.
Topics: Asthma; Chemotactic Factors; Histamine Release; Humans; Hypersensitivity, Immediate; Leukotriene B4; Peptides; Platelet Activating Factor; Prostaglandins; SRS-A | 1988 |
[Relation of blood platelets and the cause of bronchial asthma].
Topics: Animals; Asthma; beta-Thromboglobulin; Blood Platelets; Humans; Platelet Activating Factor; Platelet Factor 4; Serotonin; Thromboxane A2 | 1989 |
PAF-acether and experimental anaphylaxis as a model for asthma.
Topics: Anaphylaxis; Animals; Asthma; Eosinophils; Guinea Pigs; Leukotrienes; Lung; Macrophages; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1989 |
[The significance of platelet activating factor and its antagonists in bronchial asthma].
Topics: Airway Resistance; Animals; Asthma; Humans; Muscle, Smooth; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1989 |
The role of basophils and mast cells in the pathogenesis of pulmonary diseases.
Topics: Anaphylaxis; Arachidonic Acid; Arachidonic Acids; Asthma; Basophils; Blood Platelets; Bronchial Provocation Tests; Calmodulin; Cyclic AMP; Deuterium; Deuterium Oxide; Histamine Release; Humans; Lung Diseases; Mast Cells; Peptide Hydrolases; Phospholipids; Platelet Activating Factor; Platelet Factor 4; Prostaglandin D2; Prostaglandins D; Receptors, IgE; Receptors, Immunologic; Serotonin; Water | 1985 |
From anti-asthma drugs to PAF-acether antagonism and back. Present status.
Topics: Animals; Asthma; Autonomic Nervous System; Bronchi; Endothelium; Humans; Leukocytes; Platelet Activating Factor | 1989 |
[Platelet-activating factor and disease].
Topics: Anaphylaxis; Animals; Asthma; Capillary Permeability; Humans; Muscle Contraction; Platelet Activating Factor; Platelet Aggregation; Shock, Septic | 1989 |
Platelet-activating factor and airway reactivity.
Topics: Animals; Asthma; Blood Platelets; Bronchial Spasm; Humans; Inflammation; Platelet Activating Factor; Respiratory Hypersensitivity | 1989 |
[Physiopathology of asthma].
Topics: Allergens; Animals; Arachidonic Acids; Asthma; Autonomic Nervous System; Basophils; Guinea Pigs; Histamine; Humans; Immunoglobulin E; Mast Cells; Platelet Activating Factor; Rats | 1989 |
The interaction between PAF, platelets and eosinophils in bronchial asthma.
Topics: Asthma; Blood Platelets; Eosinophils; Humans; Platelet Activating Factor | 1989 |
Asthma and allergic rhinitis.
Topics: Asthma; Humans; Inflammation; Mast Cells; Microcirculation; Nervous System; Platelet Activating Factor; Rhinitis | 1989 |
The therapeutic relevance of PAF antagonists.
Topics: Asthma; Humans; Platelet Activating Factor | 1989 |
[The significance of endocrine, neurocrine and paracrine mediators in the regulation of bronchial reactivity].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Humans; Muscle, Smooth; Neuropeptides; Parasympathetic Nervous System; Platelet Activating Factor; Sympathetic Nervous System | 1989 |
Asthma pharmacology: industrial/clinical interface.
Topics: Asthma; Blood Platelets; Humans; Platelet Activating Factor | 1989 |
Lipid mediators of anaphylaxis and increased airways reactivity.
Topics: Anaphylaxis; Arachidonic Acids; Asthma; Bronchitis; Histamine; Humans; Leukotriene B4; Lipid Metabolism; Platelet Activating Factor; SRS-A | 1987 |
The role of leukotrienes in allergen-induced late responses in allergic sheep.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchial Spasm; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Leukotriene B4; Models, Biological; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Sheep; SRS-A | 1988 |
[Function of platelet activating factor in asthma].
Topics: Animals; Asthma; Bronchi; Guinea Pigs; Humans; Models, Biological; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1988 |
Lipid-derived and other chemical mediators of inflammation in the lung.
Topics: Anaphylatoxins; Arachidonic Acid; Arachidonic Acids; Asthma; Eicosanoic Acids; Fatty Acids; Humans; Leukocytes; Leukotriene B4; Lung; Macrophage Activation; Mucus; Platelet Activating Factor; Pneumonia; Prostaglandin-Endoperoxide Synthases; Respiratory Distress Syndrome; SRS-A | 1987 |
[Platelet activating factor and its possible role in bronchial asthma].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Humans; Platelet Activating Factor | 1988 |
Inflammatory mechanisms and nocturnal asthma.
Topics: Adenosine; Asthma; Blood Platelets; Circadian Rhythm; Eosinophils; Epithelium; Histamine; Humans; Inflammation; Lymphocytes; Macrophages; Mast Cells; Neutrophils; Platelet Activating Factor; Prostaglandins; SRS-A | 1988 |
Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs.
Topics: Animals; Asthma; Blood Platelets; Humans; Inflammation; Lung; Platelet Activating Factor | 1988 |
Platelet-activating factor as a mediator of bronchial asthma.
Topics: Animals; Asthma; Humans; Platelet Activating Factor | 1988 |
[Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system].
Topics: Asthma; Blood Coagulation Factors; Humans; Leukocytes; Leukotrienes; Mast Cells; Platelet Activating Factor | 1987 |
Platelet activating factor and asthma.
Topics: Animals; Asthma; Cromolyn Sodium; Eosinophils; Humans; Mast Cells; Platelet Activating Factor | 1986 |
The interaction of histamine with other bronchoconstrictor mediators.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Histamine; Humans; Muscle Contraction; Platelet Activating Factor | 1987 |
[Asthma and platelets].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Drug Tolerance; Humans; Platelet Activating Factor | 1988 |
[Mediators of immunologic inflammation of the respiratory tract].
Topics: Allergens; Arachidonic Acid; Arachidonic Acids; Asthma; Blood Platelets; Bronchial Provocation Tests; Histamine; Humans; Inflammation; Kinins; Leukocytes; Leukotrienes; Macrophages; Mast Cells; Nasal Provocation Tests; Platelet Activating Factor; Prostaglandins; Respiratory Hypersensitivity; Rhinitis, Allergic, Seasonal | 1988 |
The role of platelet-activating factor in asthma.
Topics: Asthma; Bronchi; Humans; Platelet Activating Factor | 1988 |
Platelet-activating factor and asthma.
Topics: Asthma; Bronchi; Capillary Permeability; Humans; Inflammation; Muscle, Smooth; Platelet Activating Factor | 1988 |
PAF antagonists. Their potential therapeutic role in asthma.
Topics: Animals; Asthma; Humans; Platelet Activating Factor | 1988 |
The role of PAF in altered airway responsiveness.
Topics: Animals; Asthma; Bronchial Spasm; Humans; Inflammation; Platelet Activating Factor | 1988 |
A role for platelet activating factor and platelets in the induction of bronchial hyperreactivity.
Topics: Animals; Asthma; Blood Platelets; Bronchi; Eosinophils; Humans; Mast Cells; Platelet Activating Factor | 1987 |
The changing face of asthma.
Topics: Asthma; Autonomic Nervous System; Eosinophils; Humans; Platelet Activating Factor | 1987 |
New concepts in the pathogenesis of bronchial hyperresponsiveness.
Topics: Asthma; Axons; Eosinophils; Epithelial Cells; Humans; Inflammation; Macrophages; Mast Cells; Muscle Contraction; Neuropeptides; Platelet Activating Factor; Reflex | 1987 |
Properties of PAF relevant to asthma.
Topics: Animals; Asthma; Bronchi; Humans; Inflammation; Platelet Activating Factor | 1987 |
PAF and airway hyperreactivity; prospects for novel prophylactic anti-asthma drugs.
Topics: Animals; Asthma; Bronchi; Humans; Inflammation; Platelet Activating Factor | 1987 |
Current concepts in asthma.
Topics: Asthma; Female; Humans; Mast Cells; Platelet Activating Factor; Pregnancy; Pregnancy Complications | 1987 |
Inflammatory mediators of asthma.
Topics: Airway Resistance; Allergens; Animals; Asthma; Blood Platelets; Bronchial Provocation Tests; Bronchial Spasm; Humans; Inflammation; Mast Cells; Platelet Activating Factor; Respiratory Hypersensitivity | 1986 |
Mast cell mediators in the blood of patients with asthma.
Topics: Adenosine; Antigens; Asthma; Bronchial Spasm; Chemotactic Factors; Histamine; Humans; Mast Cells; Platelet Activating Factor; Urticaria | 1985 |
35 trial(s) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Asthma, Bronchial
| Article | Year |
|---|---|
Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression.
Topics: Adult; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Inflammation Mediators; Leukotriene B4; Male; Neutrophils; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Sputum | 2003 |
Formoterol protects against platelet-activating factor-induced effects in asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Airway Resistance; Asthma; Cough; Cross-Over Studies; Double-Blind Method; Dyspnea; Ethanolamines; Female; Flushing; Formoterol Fumarate; Humans; Male; Neutropenia; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio | 2004 |
Lack of systemic oxidative stress during PAF challenge in mild asthma.
Topics: Administration, Inhalation; Adult; Analysis of Variance; Antioxidants; Asthma; Bronchi; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Female; Humans; Inflammation Mediators; Leukotriene E4; Lipid Peroxidation; Lipids; Male; Oxidative Stress; Platelet Activating Factor; Respiratory Function Tests | 2005 |
Effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing response caused by inflammatory mediators in asthmatic children.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bradykinin; Child; Cross-Over Studies; Female; Histamine; Humans; Male; Platelet Activating Factor; Procaterol; Skin; Skin Tests; Substance P | 1995 |
Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Changes in bronchial responsiveness, circulating leucocytes and ex vivo cytokine production by blood monocytes after PAF inhalation in allergic asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Leukocyte Count; Leukocytes, Mononuclear; Male; Methacholine Chloride; Platelet Activating Factor; Single-Blind Method; Tumor Necrosis Factor-alpha | 1995 |
Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma.
Topics: Adult; Aged; Asthma; Dihydropyridines; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Imidazoles; Male; Middle Aged; Peak Expiratory Flow Rate; Platelet Activating Factor; Quality of Life; Single-Blind Method | 1995 |
The effect of RP 59227, a platelet-activating factor antagonist, against antigen challenge and eosinophil and neutrophil chemotaxis in asthmatics.
Topics: Administration, Oral; Adult; Antigens; Asthma; Chemotaxis, Leukocyte; Cross-Over Studies; Double-Blind Method; Eosinophils; Humans; Male; Neutrophils; Platelet Activating Factor; Pyridines; Skin Tests; Thiazoles | 1994 |
Effect of cetirizine, a potent H1 antagonist, on platelet activating factor induced bronchoconstriction in asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchoconstriction; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Platelet Activating Factor | 1993 |
The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Albuterol; Asthma; Azepines; Beclomethasone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Platelet Activating Factor; Triazoles | 1994 |
Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms.
Topics: Adult; Asthma; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Radioimmunoassay | 1994 |
Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses.
Topics: Administration, Oral; Adult; Asthma; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor; Respiratory Hypersensitivity; Time Factors; Triazoles | 1993 |
Occupancy of platelet receptors for platelet-activating factor in asthmatic patients during an allergen-induced bronchoconstrictive reaction.
Topics: Adolescent; Adult; Allergens; Asthma; Binding Sites; Blood Platelets; Bronchoconstriction; Buffers; Erythrocyte Count; Female; Humans; Leukocyte Count; Male; Middle Aged; Platelet Activating Factor; Platelet Activation; Platelet Count; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sensitivity and Specificity; Tritium | 1993 |
Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Dihydropyridines; Double-Blind Method; Forced Expiratory Volume; Humans; Imidazoles; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation | 1993 |
Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan.
Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Treatment Outcome; Triazoles | 1996 |
Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses.
Topics: Adult; Allergens; Asthma; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor; Thiazoles | 1997 |
Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Ipratropium; Male; Muscarinic Antagonists; Platelet Activating Factor; Pulmonary Gas Exchange | 1997 |
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma.
Topics: Adult; Airway Resistance; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Neutropenia; Oxygen; Platelet Activating Factor; Pulmonary Gas Exchange; Respiratory Mechanics; Ventilation-Perfusion Ratio | 1998 |
Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma.
Topics: Adult; Airway Resistance; Asthma; Blood Gas Analysis; Female; Humans; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Pulmonary Gas Exchange; Thiazoles | 1998 |
Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Blood Cell Count; Cells, Cultured; Down-Regulation; Drug Synergism; Eosinophils; Female; Flow Cytometry; Humans; In Vitro Techniques; Isoproterenol; L-Selectin; Macrophage-1 Antigen; Male; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Theophylline; Up-Regulation | 1998 |
Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study.
Topics: Acute Disease; Adult; Airway Resistance; Asthma; Blood Flow Velocity; Blood Gas Analysis; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Pilot Projects; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Ventilation-Perfusion Ratio | 1999 |
Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Blood Gas Analysis; Bronchoconstriction; Creatinine; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Furosemide; Humans; Leukocyte Count; Leukotriene E4; Male; Nebulizers and Vaporizers; Platelet Activating Factor; Pulmonary Gas Exchange | 1999 |
Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Asthma; Beclomethasone; Blood Proteins; Bronchial Provocation Tests; Double-Blind Method; Drug Therapy, Combination; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Platelet Activating Factor; Reactive Oxygen Species; Respiratory Burst; Ribonucleases; Salmeterol Xinafoate; Treatment Outcome; Zymosan | 1999 |
Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Asthma; Cross-Over Studies; Double-Blind Method; Humans; Injections, Intravenous; Phospholipases A; Platelet Activating Factor; Recombinant Proteins | 2000 |
Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma.
Topics: Administration, Inhalation; Adult; Androstadienes; Asthma; Blood Gas Analysis; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Fluticasone; Humans; Male; Platelet Activating Factor; Pulmonary Gas Exchange; Pulmonary Ventilation; Respiratory Mucosa; Time Factors; Treatment Outcome | 2002 |
[Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects].
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chlorpheniramine; Double-Blind Method; Humans; Lung; Male; Methacholine Chloride; Platelet Activating Factor; Respiratory Function Tests | 1992 |
Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Cell Degranulation; Double-Blind Method; Eosinophils; Female; Humans; Male; Mast Cells; Methacholine Chloride; Placebos; Platelet Activating Factor | 1992 |
Skin eosinophilia in patients with allergic and nonallergic asthma and atopic dermatitis.
Topics: Adult; Asthma; Dermatitis, Atopic; Eosinophilia; Female; Humans; Hypersensitivity; Male; Middle Aged; Platelet Activating Factor; Skin | 1992 |
Terfenadine effect on the bronchoconstriction, dermal response, and leukopenia induced by platelet-activating factor.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Histamine; Humans; Leukopenia; Male; Platelet Activating Factor; Skin Tests; Terfenadine; Time Factors | 1991 |
Effects of PAF antagonist, BN52021, on the PAF-, methacholine-, and allergen-induced bronchoconstriction in asthmatic children.
Topics: Allergens; Asthma; Blood Cell Count; Bronchial Provocation Tests; Bronchoconstriction; Child; Diterpenes; Double-Blind Method; Female; Ginkgolides; Humans; Lactones; Male; Methacholine Chloride; Plant Extracts; Platelet Activating Factor | 1991 |
[Effect of the platelet-activating factor antagonist BN 52063 on exertional asthma].
Topics: Administration, Inhalation; Administration, Oral; Asthma; Asthma, Exercise-Induced; beta-Thromboglobulin; Exercise Test; Humans; Lactones; Plant Extracts; Platelet Activating Factor; Platelet Factor 4; Randomized Controlled Trials as Topic | 1990 |
Effects of a PAF-antagonist (BN 52063) on bronchoconstriction and platelet activation during exercise induced asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Airway Resistance; Asthma; Asthma, Exercise-Induced; Bronchi; Humans; Lactones; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Thyroglobulin | 1990 |
Effect of theophylline on airway responses to inhaled platelet-activating factor in man.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor; Randomized Controlled Trials as Topic; Theophylline | 1989 |
Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study.
Topics: Acetylcholine; Adult; Airway Resistance; Allergens; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Humans; Lactones; Male; Plant Extracts; Platelet Activating Factor | 1987 |
Bleeding time and PAF-acether-induced platelet aggregation in atopy.
Topics: Adult; Aspirin; Asthma; Bleeding Time; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Function Tests; Rhinitis, Allergic, Seasonal | 1987 |
242 other study(ies) available for 1-hexadecyl-2-acetyl-glycero-3-phosphocholine and Asthma, Bronchial
| Article | Year |
|---|---|
FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Benzylidene Compounds; Cytokines; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Inflammation; Macrophages; MAP Kinase Signaling System; Models, Animal; NF-kappa B; Platelet Activating Factor; Rats; Th2 Cells | 2022 |
Leukotrienes and sex: strange bedfellows?
Topics: Aspirin; Asthma; Eicosanoids; Female; Humans; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor | 2017 |
Obesity increases eosinophil activity in asthmatic children and adolescents.
Topics: Adolescent; Asthma; Case-Control Studies; Cell Adhesion; Chemokine CCL11; Chemokine CCL5; Chemotaxis; Child; Cross-Sectional Studies; Eosinophils; Female; Humans; Immunoglobulin E; Leptin; Male; Obesity; Peroxidase; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 2013 |
Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats.
Topics: Animals; Asthma; Dietary Supplements; Fish Oils; Lung; Male; Oxidative Stress; Platelet Activating Factor; Rats; Rats, Wistar | 2014 |
New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adult; Age of Onset; Aged; alpha-Tocopherol; Antioxidants; Asthma; Biomarkers; Case-Control Studies; China; F2-Isoprostanes; Female; Humans; Micronutrients; Middle Aged; Oxidative Stress; Platelet Activating Factor; Prospective Studies; Protective Factors; Risk Factors | 2015 |
Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anaphylaxis; Asthma; Blood Platelets; Eosinophils; Gene Expression Regulation; Humans; Mast Cells; Neutrophils; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Sepsis; Signal Transduction | 2015 |
[The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude].
Topics: Adult; Aged; Altitude; Asthma; Case-Control Studies; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Platelet Activating Factor; Young Adult | 2010 |
In vitro effects of ginkgolide B combined with cyclosporin A on T-lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects.
Topics: Adult; Asthma; Cells, Cultured; Cyclosporine; Cytokines; Diterpenes; Female; Flow Cytometry; Ginkgolides; Humans; In Vitro Techniques; Interleukin-5; Kuwait; Lactones; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Phytotherapy; Platelet Activating Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2002 |
Presence of platelet-activating factor in nasal polyps and eosinophils.
Topics: Aspirin; Asthma; Chromatography, Thin Layer; Drug Hypersensitivity; Eosinophils; Humans; Leukocyte Count; Leukotrienes; Nasal Mucosa; Nasal Polyps; Platelet Activating Factor; Radioimmunoassay | 2002 |
Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome.
Topics: Asthma; Blood Proteins; Cell Degranulation; Dermatitis, Atopic; Drug Synergism; Eosinophil Granule Proteins; Eosinophilia; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypereosinophilic Syndrome; Interleukin-2; Interleukin-5; Platelet Activating Factor; Receptors, Interleukin-2; Ribonucleases; Syndrome | 2003 |
Matrix metalloproteinase-9 release from human leukocytes.
Topics: Asthma; Complement C5a; Cytochalasin B; Dose-Response Relationship, Drug; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Leukocytes; Leukocytes, Mononuclear; Matrix Metalloproteinase 9; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Pulmonary Disease, Chronic Obstructive | 2003 |
PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Administration, Inhalation; Adult; Alleles; Asthma; Bronchoconstriction; Female; Heterozygote; Homozygote; Humans; Japan; Kinetics; Lymphocytes; Male; Neutropenia; Platelet Activating Factor; Respiratory Function Tests | 2004 |
Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Leukotrienes; Lung; Male; Mice; Mice, Inbred C57BL; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled | 2004 |
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Guanidines; Guinea Pigs; Histamine; Male; Platelet Activating Factor | 2005 |
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytosol; Disease Models, Animal; Enzyme Activation; Histamine; Inflammation; Leukotriene B4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Phospholipases A; Platelet Activating Factor; Pulmonary Eosinophilia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx.
Topics: Animals; Anti-Allergic Agents; Asthma; Bromeliaceae; Bronchoalveolar Lavage Fluid; Cell Movement; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Inclusion Bodies; Inflammation Mediators; Interleukin-13; Lipid Metabolism; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Ovalbumin; Plant Extracts; Plant Leaves; Platelet Activating Factor; Pleurisy; Pulmonary Eosinophilia; Spleen; Time Factors | 2005 |
Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils.
Topics: Adult; Antibodies, Monoclonal; Asthma; Azepines; Basement Membrane; Chemotaxis, Leukocyte; Coculture Techniques; Collagen; Culture Media, Conditioned; Drug Combinations; Eosinophils; Humans; Interleukin-8; Laminin; Leukotriene B4; Matrix Metalloproteinase 9; Neutrophil Activation; Neutrophils; Paracrine Communication; Platelet Activating Factor; Protease Inhibitors; Proteoglycans; Pulmonary Eosinophilia; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Aged; Anaphylaxis; Asthma; Biomarkers; Case-Control Studies; Child; Child, Preschool; Drug Hypersensitivity; Epinephrine; Female; Humans; Injections, Intramuscular; Insect Bites and Stings; Male; Peanut Hypersensitivity; Platelet Activating Factor; Prospective Studies; Retrospective Studies; Risk Factors; Severity of Illness Index | 2008 |
Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation.
Topics: Albuterol; Asthma; Blotting, Western; Bronchodilator Agents; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Drug Synergism; Humans; I-kappa B Kinase; Interleukin-6; Myocytes, Smooth Muscle; NF-kappa B; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Platelet-Derived Growth Factor; Receptors, G-Protein-Coupled; Retinoblastoma Protein | 2008 |
The platelet in asthma.
Topics: Airway Resistance; Asthma; Blood Platelets; Bronchial Spasm; Cromolyn Sodium; Humans; Lung; Muscle, Smooth; Platelet Activating Factor; Time Factors | 1984 |
Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step.
Topics: Asthma; Basophils; Blood Platelets; Deuterium; Deuterium Oxide; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Leukocytes; Platelet Activating Factor; Water | 1984 |
PAF-acether: a putative mediator of asthma and inflammation.
Topics: Animals; Asthma; Guinea Pigs; Humans; Inflammation; Leukocytes; Lung; Platelet Activating Factor; Serum Albumin; Skin | 1983 |
Platelet-activating factor: a possible mediator of the dual response to allergen?
Topics: Adult; Allergens; Asthma; Humans; Hypersensitivity, Delayed; Male; Platelet Activating Factor; Skin Tests; Time Factors | 1984 |
Cromoglycate (DSCG) inhibits responses to platelet-activating factor (PAF-acether) in man: an alternative mode of action for DSCG in asthma?
Topics: Adult; Asthma; Cromolyn Sodium; Humans; Mast Cells; Platelet Activating Factor | 1982 |
Platelet activation in asthma.
Topics: Asthma; Humans; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation | 1982 |
Inhibition of leukotriene C4 and B4 release by human eosinophils with the new 5-lipoxygenase inhibitor 6-hydroxy-2(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride.
Topics: Asthma; Calcimycin; Dose-Response Relationship, Drug; Eosinophils; Humans; In Vitro Techniques; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Platelet Activating Factor; Thiazoles | 1995 |
Inhibitory effect of azelastine on platelet activating factor-like activity in eosinophils in asthmatic patients.
Topics: Asthma; Eosinophils; Humans; Phthalazines; Platelet Activating Factor; Platelet Aggregation Inhibitors | 1995 |
Effect of YM264 on the airway hyperresponsiveness and the late asthmatic response in a guinea pig model of asthma.
Topics: Aerosols; Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Male; Ovalbumin; Piperazines; Platelet Activating Factor; Random Allocation; Statistics, Nonparametric; Thiazoles; Thiazolidines; Time Factors; Trachea | 1995 |
Role of thromboxane A2 and platelet-activating factor in allergic bronchoconstriction in guinea pig airway in vivo.
Topics: Administration, Inhalation; Animals; Antigens; Asthma; Azepines; Bridged Bicyclo Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Male; Platelet Activating Factor; Receptors, Prostaglandin; Thromboxane A2; Triazoles | 1995 |
Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach.
Topics: Administration, Oral; Allergens; Animals; Asthma; Atmosphere Exposure Chambers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophilia; Guinea Pigs; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Thiazoles | 1994 |
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application i
Topics: Animals; Asthma; Female; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolines; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Skin Tests; Structure-Activity Relationship | 1995 |
The inhibitory effect of methotrexate on PAF-induced neutrophil and eosinophil locomotion in asthmatic patients.
Topics: Asthma; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Humans; Leukocytes, Mononuclear; Leukotriene B4; Methotrexate; Neutrophils; Platelet Activating Factor | 1994 |
Allergen exposure in acute asthma causes the release of platelet-activating factor (PAF) as demonstrated by the desensitization of platelets to PAF.
Topics: Adolescent; Adult; Asthma; beta-Thromboglobulin; Bronchial Provocation Tests; Collagen; Drug Synergism; Humans; In Vitro Techniques; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Serotonin | 1995 |
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; Immunoglobulin E; In Vitro Techniques; Ketotifen; Leukocytes; Leukotriene C4; Neutrophils; Piperazines; Platelet Activating Factor | 1995 |
Acute bronchial and hematologic effects following inhalation of a single dose of PAF. Comparison between asthmatics and normal subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Monocytes; Neutrophils; Platelet Activating Factor; Time Factors | 1994 |
Salivary PAF in acute myocardial infarction and angina: changes during hospital treatment and relationship to cardiac enzymes.
Topics: Angina Pectoris; Asthma; Creatine Kinase; Enzyme-Linked Immunosorbent Assay; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Activating Factor; Radioimmunoassay; Receptors, Interleukin-2; Saliva; Tuberculosis, Pulmonary | 1994 |
Inhaled platelet-activating factor worsens gas exchange in mild asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Asthma; Female; Hemodynamics; Humans; Leukocyte Count; Male; Platelet Activating Factor; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio | 1994 |
Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.
Topics: Adult; Asthma; Calcimycin; Cell Degranulation; Cell Separation; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Female; Humans; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rhinitis; Superoxides; Terfenadine | 1994 |
Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers.
Topics: Antigens, CD; Asthma; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytokines; Endothelium, Vascular; Eosinophils; HLA-DR Antigens; Humans; Intercellular Adhesion Molecule-1; Macrophage-1 Antigen; Platelet Activating Factor; Receptors, Very Late Antigen | 1993 |
Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils.
Topics: Asthma; Blood Proteins; Calcimycin; Eosinophil Granule Proteins; Eosinophils; Humans; In Vitro Techniques; Leukotriene C4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyridines; Pyrimidinones; Ribonucleases; Secretory Rate | 1994 |
Measurement of platelet-activating factor in human blood by high performance thin layer chromatography and its clinical application.
Topics: Asthma; Chromatography, High Pressure Liquid; Chronic Disease; Humans; Platelet Activating Factor; Pulmonary Heart Disease | 1993 |
Inflammatory effects of ozone in the upper airways of subjects with asthma.
Topics: Adolescent; Adult; Asthma; Female; Histamine; Humans; Inflammation; Interleukin-8; Leukocyte Count; Leukotriene B4; Male; Nasal Lavage Fluid; Ozone; Platelet Activating Factor; Respiratory Mechanics; Respiratory System | 1994 |
Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma.
Topics: Asthma; B-Lymphocytes; Calcium; Cell Membrane; Eosinophils; Gene Expression; Granulocytes; Humans; In Vitro Techniques; Lymphocyte Activation; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; T-Lymphocytes | 1994 |
Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5.
Topics: Asthma; Diterpenes; Eosinophils; Ginkgolides; Humans; Interleukin-5; Lactones; Luminescent Measurements; Luminol; Macrophage-1 Antigen; Phagocytosis; Platelet Activating Factor; Receptors, Complement; Receptors, Complement 3b; Rhinitis; Time Factors | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Epoprostenol; Guinea Pigs; In Vitro Techniques; Male; Peroxidases; Platelet Activating Factor; Pulmonary Alveoli; Superoxides; Thiophenes; Thromboxane A2; Thromboxane-A Synthase | 1993 |
Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation.
Topics: Adult; Albuterol; Asthma; Blood Proteins; Cell Degranulation; Chemotaxis, Leukocyte; Dose-Response Relationship, Immunologic; Eosinophil Granule Proteins; Eosinophils; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Propranolol; Ribonucleases | 1993 |
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Hypersensitivity, Immediate; Male; Methysergide; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred BN; Serotonin; Triazoles | 1994 |
CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cycloheximide; Cytokines; Dexamethasone; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Lectins, C-Type; Platelet Activating Factor | 1993 |
Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs.
Topics: Adenosine; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol; Guinea Pigs; Immunization; Male; Ovalbumin; Ozone; Platelet Activating Factor | 1994 |
Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis.
Topics: Acetylcholine; Anaphylaxis; Animals; Arachidonate 5-Lipoxygenase; Asthma; Bronchoconstriction; Bronchodilator Agents; Calcimycin; Chromones; Guinea Pigs; Male; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pyrazoles; Pyridines; SRS-A | 1993 |
[Analysis of platelet-activating factor and its effect on the lung].
Topics: Animals; Asthma; Biological Assay; Bronchoconstriction; Bronchopulmonary Dysplasia; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infant, Newborn; Lung; Mass Spectrometry; Platelet Activating Factor; Pregnancy; Pulmonary Surfactants; Rabbits; Radioimmunoassay | 1993 |
No increase in plasma histamine during PAF-induced airway obstruction in allergic asthmatics.
Topics: Adult; Airway Resistance; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Forced Expiratory Volume; Histamine; Humans; Leukocyte Count; Male; Maximal Midexpiratory Flow Rate; Platelet Activating Factor; Platelet Count; Skin Tests; Vital Capacity | 1993 |
Hyporesponsiveness to inhibitory agents of alveolar macrophages and polymorphonuclear leukocytes primed by platelet activating factor.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Cells, Cultured; Dexamethasone; Female; Humans; Leukotriene B4; Lymphocyte Activation; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Neutrophils; Phthalazines; Platelet Activating Factor; Superoxides | 1993 |
[Bioassay of Lyso-PAF platelet activating factor and it's role in bronchial asthma].
Topics: Adolescent; Adult; Animals; Asthma; Biological Assay; Female; Guinea Pigs; Humans; Lung; Male; Middle Aged; Ovalbumin; Platelet Activating Factor; Thromboxane B2 | 1993 |
Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.
Topics: Animals; Asthma; Azepines; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor; Pyridines; Pyrimidinones; Respiratory Hypersensitivity; Tetrazoles; Triazoles | 1993 |
The evidence of platelet activation in bronchial asthma.
Topics: Adolescent; Adult; Asthma; beta-Thromboglobulin; Bronchial Provocation Tests; Chronic Disease; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Platelet Activating Factor; Platelet Activation; Platelet Factor 4; Status Asthmaticus | 1993 |
Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy.
Topics: Acute Disease; Animals; Asthma; Calcimycin; Child; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Granulocytes; Humans; Immunotherapy; Mites; Osmolar Concentration; Platelet Activating Factor; Reference Values | 1993 |
Comparative effects of tetrandrine and berbamine on guineapig airway microvascular leakage induced by platelet-activating factor and other allergic mediators.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Benzylisoquinolines; Bradykinin; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Histamine; Hypersensitivity; Male; Platelet Activating Factor; Respiratory System; SRS-A | 1993 |
The differential effect of aspirin on human platelet activation in aspirin-sensitive asthmatics and normal subjects.
Topics: Adenosine Triphosphate; Adult; Analysis of Variance; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Regression Analysis | 1993 |
Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics.
Topics: Asthma; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Humans; Ibuprofen; Leukocytes; Platelet Activating Factor; Prostaglandins; Thromboxane B2 | 1993 |
Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects.
Topics: Adult; Aged; Asthma; Bronchi; Cyclooxygenase Inhibitors; Female; Histamine; Histamine Antagonists; Humans; Immunoglobulin E; In Vitro Techniques; Leukotriene Antagonists; Leukotrienes; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Receptors, Immunologic; SRS-A | 1993 |
Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma.
Topics: Adult; Asthma; Blood Proteins; Cells, Cultured; Cytoplasmic Granules; Dose-Response Relationship, Drug; Eosinophil Granule Proteins; Eosinophils; Humans; Male; Microscopy, Electron; Platelet Activating Factor; Ribonucleases; Stimulation, Chemical | 1993 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromones; Depression, Chemical; Dinitrophenols; Disease Models, Animal; Male; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Wistar; SRS-A; Thromboxane-A Synthase; Tissue Extracts | 1993 |
[Increased plasma levels of platelet-activating factor (PAF) and low serum PAF acetylhydrolase (PAFAH) activity in adult patients with bronchial asthma].
Topics: Adolescent; Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Phospholipases A; Platelet Activating Factor; Radioimmunoassay | 1993 |
Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Complement C5a; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Up-Regulation | 1993 |
Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Asthma; Humans; Inflammation; Phospholipases A; Platelet Activating Factor | 1996 |
The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Antagonists; Male; Methacrylates; Ovalbumin; Platelet Activating Factor; Thromboxane-A Synthase; Time Factors | 1995 |
Increased hypodense eosinophils after activation with PAF-acether and calcium ionophore in asthmatic subjects.
Topics: Adult; Asthma; Calcimycin; Centrifugation, Density Gradient; Eosinophils; Female; Humans; Inflammation Mediators; Ionophores; Leukocyte Count; Male; Platelet Activating Factor | 1996 |
Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients.
Topics: Adult; Aged; Asthma; Calcimycin; Chromatography, High Pressure Liquid; Eosinophils; Humans; In Vitro Techniques; Leukotriene C4; Male; Middle Aged; Platelet Activating Factor; Stimulation, Chemical | 1996 |
Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Male; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Respiratory System; Rolipram | 1996 |
Priming of circulating human eosinophils following late response to allergen challenge.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cell Survival; Complement C5a; Eosinophils; Humans; Hydrogen Peroxide; Immunization; Platelet Activating Factor | 1996 |
Anti-inflammatory, membrane-stabilizing interactions of salmeterol with human neutrophils in vitro.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Calcium; Cell Membrane; Ethanolamines; Fenoterol; Formoterol Fumarate; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; Neutrophils; Oxygen Consumption; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Salmeterol Xinafoate; Superoxides | 1996 |
[Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways].
Topics: Animals; Asthma; Blood Cell Count; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Interleukin-2; Interleukin-5; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Thiazoles | 1995 |
Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity.
Topics: Animals; Asthma; Bradykinin; Bronchoalveolar Lavage Fluid; Cattle; Chemotactic Factors, Eosinophil; Cytokines; Dose-Response Relationship, Drug; Humans; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages, Alveolar; Molecular Weight; Monocyte Chemoattractant Proteins; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4 | 1996 |
Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects.
Topics: Adult; Antigens, CD; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Cell Adhesion Molecules; Collagen; Drug Hypersensitivity; Drug Interactions; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Tetraspanin 30 | 1996 |
Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Tachyphylaxis | 1996 |
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chemotaxis; Complement C5a; Cyclic AMP; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Guinea Pigs; Humans; Leukotriene C4; Platelet Activating Factor; Salmeterol Xinafoate; Sulfonamides | 1996 |
Antiasthma activity of the novel antihistamine E-4716 in guinea pigs in vivo.
Topics: Analysis of Variance; Animals; Asthma; Benzimidazoles; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Lung; Male; Platelet Activating Factor; Respiratory Hypersensitivity | 1996 |
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Asthma; Azepines; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hypersensitivity; Immunization; Inflammation Mediators; Injections, Intravenous; Male; Platelet Activating Factor; Propranolol; Respiration, Artificial; Time Factors; Triazoles | 1996 |
CV6209 inhibits airway wall thickening and airway hyperresponsiveness to histamine induced by intravenous administration of platelet-activating factor in guinea pigs.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Guinea Pigs; Histamine; Histamine Antagonists; Lung; Male; Platelet Activating Factor; Pyridinium Compounds | 1996 |
Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine H1 Antagonists; Humans; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Platelet Activating Factor; Platelet Aggregation | 1996 |
Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils.
Topics: Asthma; Eosinophils; Humans; Macrophage-1 Antigen; Platelet Activating Factor; Rhinitis, Allergic, Seasonal; Theophylline; Up-Regulation | 1996 |
Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils.
Topics: Adult; Anti-Asthmatic Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Azithromycin; Calcimycin; Cell Membrane; Clarithromycin; Erythromycin; Humans; Ionophores; Luminescent Measurements; Lysophosphatidylcholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Roxithromycin; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1996 |
Priming of circulating human eosinophils following late response to allergen challenge.
Topics: Allergens; Asthma; Cell Movement; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-5; NADP; Phenotype; Platelet Activating Factor | 1997 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles | 1997 |
Bronchoconstriction and eosinophil recruitment in guinea pig lungs after platelet activating factor administration.
Topics: Acetylcholine; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Dose-Response Relationship, Drug; Eosinophilia; Female; Guinea Pigs; Inflammation; Lung; Lung Compliance; Lymphocyte Count; Macrophages; Male; Neutrophils; Platelet Activating Factor; Respiratory Function Tests | 1997 |
Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils.
Topics: Asthma; Biological Assay; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phthalazines; Platelet Activating Factor; Platelet Aggregation | 1997 |
Inhibitory effects of theophylline and procaterol on eosinophil function.
Topics: Asthma; Bronchodilator Agents; CD11 Antigens; CD18 Antigens; Cell Adhesion Molecules; Cell Degranulation; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Platelet Activating Factor; Procaterol; Recombinant Proteins; Theophylline | 1997 |
Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adult; Aged; Asthma; Bronchoalveolar Lavage Fluid; Female; Humans; Lung; Male; Middle Aged; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pulmonary Fibrosis; Reference Values | 1997 |
PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro.
Topics: Adult; Albuterol; Asthma; Cell Separation; Centrifugation, Density Gradient; Chemotaxis, Leukocyte; Eosinophils; Forced Expiratory Volume; Humans; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values | 1997 |
[Platelet activating factor and bronchial asthma. Is it relevant?].
Topics: Animals; Asthma; Humans; Platelet Activating Factor; Ventilation-Perfusion Ratio | 1997 |
Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients.
Topics: Adult; Asthma; Calcium; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Signal Transduction | 1997 |
Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients.
Topics: Adult; Asthma; Eosinophils; Humans; Middle Aged; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcription, Genetic | 1997 |
Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
Topics: Animals; Animals, Newborn; Asthma; Capsaicin; Cells, Cultured; Coculture Techniques; Cytochalasin B; Enzyme-Linked Immunosorbent Assay; Eosinophils; Ganglia, Spinal; Humans; Myelin Basic Protein; N-Formylmethionine Leucyl-Phenylalanine; Neurons; Platelet Activating Factor; Polylysine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; Substance P; Tissue Extracts | 1997 |
KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Electric Stimulation; Eosinophils; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Naphthyridines; Neurokinin A; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Pyrrolidinones; Respiratory Therapy; Rolipram; Substance P | 1997 |
Regulation of leukotriene and platelet-activating factor synthesis in human alveolar macrophages.
Topics: Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Arachidonic Acids; Asthma; Benzenesulfonates; Bronchoalveolar Lavage Fluid; Calcimycin; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; Humans; Ionophores; Leukotriene B4; Leukotrienes; Macrophages, Alveolar; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Urea | 1997 |
Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages.
Topics: Adult; Asthma; Dose-Response Relationship, Drug; Humans; Macrophages, Alveolar; Male; Middle Aged; Phthalazines; Platelet Activating Factor; Platelet Aggregation Inhibitors | 1997 |
Activation of platelets in bronchial asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Blood Platelets; Bronchodilator Agents; Calcium; Case-Control Studies; Chemokine CCL5; Female; Gene Expression Regulation; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Theophylline; Thrombin; Thromboxane A2 | 1998 |
Platelet activating factor revisited.
Topics: Asthma; Basophils; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Humans; Leukotrienes; Lung; Neutrophil Activation; Platelet Activating Factor; Pulmonary Gas Exchange | 1997 |
Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor.
Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Calcimycin; Calcium; Cells, Cultured; Cytosol; Female; Humans; Ionophores; Leukotriene B4; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Stimulation, Chemical | 1997 |
Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Cell Extracts; Dose-Response Relationship, Drug; Guinea Pigs; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Platelet Activating Factor; Platelet Aggregation | 1998 |
Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways.
Topics: Animals; Asthma; Bronchi; Gene Expression Regulation; Guinea Pigs; Hyperplasia; In Situ Hybridization; Male; Mucins; Mucous Membrane; Platelet Activating Factor; Rats; Rats, Inbred F344; Trachea; Tumor Necrosis Factor-alpha | 1998 |
Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients.
Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Bronchoalveolar Lavage Fluid; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Cytosol; Female; Humans; Inflammation Mediators; Ionophores; Leukotriene B4; Macrophages, Alveolar; Male; Middle Aged; Osmolar Concentration; Platelet Activating Factor; Reference Values | 1998 |
Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophilia; Eosinophils; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; Ketotifen; Male; Passive Cutaneous Anaphylaxis; Piperidines; Platelet Activating Factor; Pyridines; Rats; Rats, Wistar | 1998 |
Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1).
Topics: Asthma; Bronchodilator Agents; CD18 Antigens; Humans; Integrins; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridines; Tumor Cells, Cultured | 1998 |
Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Asthma; Female; Genotype; Humans; Japan; Male; Middle Aged; Mutation, Missense; Phenotype; Phospholipases A; Platelet Activating Factor | 1999 |
5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils.
Topics: Adult; Arachidonic Acids; Asthma; Basement Membrane; Cell Movement; Chemotactic Factors; Collagenases; Dose-Response Relationship, Drug; Eosinophils; Female; Humans; Hydroxamic Acids; Interleukin-5; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Platelet Activating Factor; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Time Factors; Urokinase-Type Plasminogen Activator | 1999 |
Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor.
Topics: Adult; Antigens, CD; Asthma; Azepines; Blood Proteins; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophil Granule Proteins; Eosinophils; Female; Fibronectins; Humans; Integrin alpha1; Intercellular Adhesion Molecule-1; Leukocyte Count; Macrophage-1 Antigen; Male; Middle Aged; Platelet Activating Factor; Ribonucleases; Triazoles | 1999 |
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Rolipram; T-Lymphocytes; Theophylline | 2000 |
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-5; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Phospholipases A; Platelet Activating Factor; Recombinant Proteins | 2000 |
The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Male; Naphthyridines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pneumonia; Rolipram; Specific Pathogen-Free Organisms; Vasodilator Agents | 2000 |
[Inhibitory effect of suplatast tosilate on eosinophil migration].
Topics: Anti-Allergic Agents; Arylsulfonates; Asthma; Cell Movement; Eosinophils; Histamine Antagonists; Humans; In Vitro Techniques; Interleukin-6; Platelet Activating Factor; Sulfonium Compounds | 2000 |
Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro.
Topics: Allergens; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Adhesion; Cell Separation; Down-Regulation; Edetic Acid; Enzyme Inhibitors; Eosinophils; Humans; L-Selectin; Leukocytes; Ligands; Membrane Glycoproteins; Monocytes; Neutrophil Activation; Neutrophils; P-Selectin; Platelet Activating Factor; Pollen; Rheology; Solubility; Tetradecanoylphorbol Acetate | 2000 |
Role of chemical mediators in airway hyperresponsiveness in an asthmatic model.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Indomethacin; Leukotriene C4; Leukotriene D4; Male; Ovalbumin; Platelet Activating Factor; Probability; Reference Values; Sensitivity and Specificity; Thromboxane A2 | 2001 |
Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system.
Topics: Adult; Arachidonic Acids; Asthma; Cell Movement; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Collagen; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Activation; Eosinophils; Female; Fibrinolysin; Humans; Hydroxamic Acids; Kinetics; Laminin; Male; Matrix Metalloproteinase Inhibitors; Plasminogen; Platelet Activating Factor; Proteoglycans; Receptors, CCR3; Receptors, Cell Surface; Receptors, Chemokine; Receptors, Urokinase Plasminogen Activator | 2001 |
Effect of a specific cysteinyl leukotriene-receptor 1-antagonist (montelukast) on the transmigration of eosinophils across human umbilical vein endothelial cells.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Cell Movement; Cell Survival; Chemotaxis, Leukocyte; Cyclopropanes; Endothelium, Vascular; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-13; Leukotriene Antagonists; Male; Membrane Proteins; Platelet Activating Factor; Quinolines; Receptors, Leukotriene; RNA, Messenger; Sensitivity and Specificity; Sulfides; Umbilical Veins | 2001 |
Modification of eosinophil function by suplatast tosilate (IPD), a novel anti-allergic drug.
Topics: Anti-Allergic Agents; Arylsulfonates; Asthma; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Eosinophils; Gene Expression Regulation; Humans; Integrin alpha4beta1; Integrins; Interleukin-4; Platelet Activating Factor; Pulmonary Eosinophilia; Receptors, Lymphocyte Homing; Respiratory Hypersensitivity; Sulfonium Compounds; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2001 |
RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Albuterol; Anesthesia; Animals; Antigens; Asthma; Benzimidazoles; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dextrans; Ethanolamines; Fluorescein-5-isothiocyanate; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Time Factors; Trachea | 1992 |
NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities.
Topics: Asthma; Cardiovascular Diseases; Humans; Lung Diseases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1992 |
Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects.
Topics: Asthma; Chemotaxis, Leukocyte; Eosinophilia; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rhinitis | 1992 |
Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes.
Topics: Adult; Analysis of Variance; Asthma; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Isoproterenol; Lymphocytes; Male; Platelet Activating Factor; Theophylline | 1992 |
Characterization of platelet-activating factor induced superoxide anion generation by guinea-pig alveolar macrophages.
Topics: Animals; Asthma; Calcium; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Luminescent Measurements; Macrophages, Alveolar; Male; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Superoxides | 1992 |
The effect of a selective alpha 2-adrenergic receptor antagonist (midaglizole) on the cyclic 3',5'-adenosine monophosphate production in human mononuclear cells.
Topics: Adrenergic alpha-Antagonists; Adult; Asthma; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imidazoles; Isoproterenol; Leukocytes, Mononuclear; Male; Platelet Activating Factor | 1992 |
Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Autacoids; Bronchoalveolar Lavage Fluid; Cell Count; Chromatography, High Pressure Liquid; Histamine; Humans; Hypersensitivity, Immediate; Leukotrienes; Platelet Activating Factor; Prostaglandin D2 | 1992 |
Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and beta-sympathicomimetics.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Cyclic AMP; Dinoprostone; Female; Histamine; Humans; Isoproterenol; Lung Diseases, Obstructive; Macrophages, Alveolar; Male; Middle Aged; Platelet Activating Factor; Smoking | 1992 |
Asthma mortality and inhaled beta agonist therapy.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans; Isomerism; Isoproterenol; Platelet Activating Factor | 1992 |
Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs.
Topics: Allergens; Animals; Antibodies; Arachidonate 5-Lipoxygenase; Asthma; Bronchoconstriction; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Histamine Release; Immunization; Immunoglobulin G; Occupational Diseases; Phthalic Anhydrides; Platelet Activating Factor; Respiratory System; Serum Albumin | 1992 |
[Drug therapy of asthma by antiallergic agents].
Topics: Asthma; Cromolyn Sodium; Histamine Antagonists; Humans; Ketotifen; ortho-Aminobenzoates; Phthalazines; Platelet Activating Factor; SRS-A | 1992 |
Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients.
Topics: Adult; Asthma; Calcimycin; Cell Migration Inhibition; Chromatography, High Pressure Liquid; Esterification; Humans; Hydroxyeicosatetraenoic Acids; Middle Aged; Neutrophils; Platelet Activating Factor; Reference Values | 1992 |
[Features and treatment of immediate and late asthmatic responses].
Topics: Animals; Asthma; Bronchial Hyperreactivity; Eosinophils; Guinea Pigs; Humans; Immunosuppressive Agents; Male; Platelet Activating Factor | 1992 |
The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.
Topics: Adult; Asthma; Azepines; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Triazoles | 1992 |
Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Follow-Up Studies; Forced Expiratory Flow Rates; Humans; Male; Platelet Activating Factor; Spirometry | 1992 |
Enhanced production of platelet activating factor by peripheral granulocytes from children with asthma.
Topics: Adolescent; Asthma; Cells, Cultured; Child; Child, Preschool; Eosinophils; Female; Granulocytes; Humans; Male; Platelet Activating Factor; Respiratory Function Tests; SRS-A; Surveys and Questionnaires | 1992 |
[Platelet activating factor (PAF)-induced late asthmatic response in sensitized but not in non-sensitized guinea pigs].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Male; Platelet Activating Factor | 1992 |
Putative role of platelet-activating factor in the mechanism of virus-induced asthma.
Topics: Asthma; Humans; Influenza, Human; Platelet Activating Factor; Respiratory Syncytial Viruses; Respirovirus Infections | 1992 |
Effects of single and multiple inhalations of platelet-activating factor on airway cell composition and responsiveness in monkeys.
Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Eosinophils; Macaca fascicularis; Male; Neutrophils; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System | 1992 |
In vivo priming of platelet-activating factor-induced eosinophil chemotaxis in allergic asthmatic individuals.
Topics: Asthma; Chemotaxis, Leukocyte; Complement C5a; Cytokines; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Platelet Activating Factor | 1992 |
Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Gallic Acid; Guinea Pigs; Male; Ovalbumin; Phytotherapy; Plant Extracts; Platelet Activating Factor; Quercetin | 1992 |
Effects of NZ-107 on bronchoconstriction in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchoconstriction; Cromolyn Sodium; Disease Models, Animal; Guinea Pigs; Histamine; Hydrocortisone; Male; Metyrapone; Platelet Activating Factor; Prednisolone; Pyridazines; Respiration; Time Factors | 1992 |
Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.
Topics: Anaphylaxis; Animals; Asthma; Bronchi; Guinea Pigs; Histamine; Male; Ovalbumin; Platelet Activating Factor; Platelet Count; Pyridinium Compounds; Respiratory Function Tests; SRS-A; Thiazoles; Thiazolidines | 1992 |
[Effects of anti-asthmatic drugs on human eosinophil chemotaxis].
Topics: Aminophylline; Asthma; Cells, Cultured; Chemotaxis, Leukocyte; Dexamethasone; Eosinophils; Humans; Isoproterenol; Leukotriene B4; Platelet Activating Factor | 1991 |
The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils.
Topics: Adult; Asthma; Azepines; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Eosinophils; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Rhinitis; Superoxides; Triazoles | 1991 |
Inhaled PAF stimulates leukotriene and thromboxane A2 production in humans.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchoconstrictor Agents; Eicosanoids; Endothelium, Vascular; Epoprostenol; Female; Humans; Leukotriene E4; Leukotrienes; Male; Methacholine Compounds; Platelet Activating Factor; Prostaglandins; SRS-A; Stimulation, Chemical; Thromboxane A2 | 1991 |
Enhanced superoxide generation by eosinophils from asthmatic children.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Neutrophils; Platelet Activating Factor; Superoxides | 1991 |
The identification of PAF-release-enhancing activity in culture supernatant of mononuclear cells from asthmatics. Correlation between lymphocyte responses and immediate type hypersensitivity.
Topics: Asthma; Cells, Cultured; Culture Media; Humans; Hypersensitivity, Immediate; Leukocytes, Mononuclear; Leukotriene B4; Lymphocyte Activation; Neutrophils; Platelet Activating Factor; Pollen | 1991 |
Basophil histamine release by platelet-activating factor in aspirin-sensitive subjects with asthma.
Topics: Adult; Aged; Aspirin; Asthma; Basophils; Cytochalasin B; Dexamethasone; Female; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Male; Middle Aged; Platelet Activating Factor | 1990 |
[Airway hyperresponsiveness and mucus secretion].
Topics: Asthma; Autonomic Nervous System; Bronchi; Exocrine Glands; Humans; Mucus; Platelet Activating Factor; Substance P | 1990 |
Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs.
Topics: Acetates; Airway Obstruction; Allergens; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Chloroform; Chromatography, Gel; Complement C5a; Dose-Response Relationship, Drug; Glycosides; Guinea Pigs; Histamine Release; Immunoglobulin E; Male; Neutrophils; Plants, Medicinal; Platelet Activating Factor; Plethysmography | 1991 |
Neutrophil chemotactic activity of PAF, histamine and neuromediators in bronchial asthma.
Topics: Adolescent; Adult; Asthma; Chemotaxis, Leukocyte; Histamine; Humans; Middle Aged; Neuropeptides; Neutrophils; Platelet Activating Factor; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1991 |
Release of mediators from human gastric mucosa and blood in adverse reactions to benzoate.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Aged; Asthma; Benzoates; Benzoic Acid; Dermatitis, Atopic; Endoscopy, Gastrointestinal; Female; Food Additives; Gastric Mucosa; Histamine; Histamine Release; Humans; Male; Middle Aged; Monocytes; Platelet Activating Factor; Urticaria | 1991 |
Lipid mediators contribute to oxygen-radical-induced airway responses in sheep.
Topics: Animals; Arachidonic Acid; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eicosanoids; Female; Free Radical Scavengers; Free Radicals; Oxygen; Platelet Activating Factor; Premedication; Sheep | 1991 |
[Roles of arachidonic acid cascade and related substances in respiratory diseases].
Topics: Animals; Arachidonic Acid; Asthma; Bronchi; Humans; Lung Diseases; Macrophages; Muscle Tonus; Platelet Activating Factor; Pulmonary Fibrosis; Respiratory Tract Diseases; Sarcoidosis; Smoking | 1991 |
Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs.
Topics: Administration, Oral; Analysis of Variance; Animals; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Calcium; Eosinophils; Guinea Pigs; Lung; Male; Platelet Activating Factor; Triazoles | 1991 |
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; Triazoles | 1991 |
[Experimental and clinical study of activated platelet in allergic asthma].
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Animals; Asthma; Diterpenes; Female; Ginkgolides; Guinea Pigs; Humans; Lactones; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Factor 4 | 1991 |
Platelet-activating factor detected in bronchoalveolar lavage fluids from an asthmatic patient.
Topics: Asthma; Bronchoalveolar Lavage Fluid; Child, Preschool; Chromatography, Thin Layer; Female; Furans; Humans; Infant; Infant, Newborn; Laryngostenosis; Lung; Male; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.
Topics: Animals; Antigens; Asthma; Cromolyn Sodium; Disease Models, Animal; Fenoterol; Guinea Pigs; Leukocytes; Lung; Male; Ovalbumin; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Thiazoles; Thiazolidines | 1991 |
Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Chemotaxis, Leukocyte; Guinea Pigs; Male; Platelet Activating Factor; Prednisolone; Theophylline | 1991 |
[Effect of platelet activating factor (PAF) on granulocyte migration in vivo in patients with atopic asthma].
Topics: Adolescent; Adult; Asthma; Chemotaxis, Leukocyte; Female; Forearm; Humans; Injections, Subcutaneous; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Skin Window Technique | 1991 |
[Effects of phospholipid platelet activation factor on proliferation of B-lymphocytes of the peripheral blood of healthy donors and patients with bronchial asthma].
Topics: Adult; Asthma; B-Lymphocytes; Cell Division; Cells, Cultured; Female; Humans; Immunoglobulin E; Immunoglobulin G; Indomethacin; Lymphocyte Activation; Male; Middle Aged; Platelet Activating Factor; Pokeweed Mitogens | 1991 |
PAF receptors in guinea-pig and human lung.
Topics: Animals; Asthma; Autoradiography; Azepines; Bronchi; Guinea Pigs; Humans; In Vitro Techniques; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Tissue Distribution; Trachea; Triazoles | 1990 |
[Allergy and PAF].
Topics: Anaphylaxis; Animals; Asthma; Humans; Leukocytes; Macrophages; Mast Cells; Platelet Activating Factor; Rhinitis, Allergic, Perennial; Urticaria | 1991 |
[Use of plateletpheresis in the treatment of bronchial asthma].
Topics: Adult; Asthma; Calcium; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Plateletpheresis; Remission Induction | 1991 |
[Involvement of platelet activating factor (PAF) in ovalbumin antigen-induced late asthmatic response and increase of airway hyperresponsiveness in a guinea pig experimental model of asthma].
Topics: Airway Resistance; Animals; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Delayed; Male; Ovalbumin; Platelet Activating Factor; Triazoles | 1991 |
Density distribution and density conversion of neutrophils in allergic subjects.
Topics: Asthma; Cell Separation; Centrifugation, Density Gradient; Chemotaxis, Leukocyte; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypersensitivity; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor | 1990 |
PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Adult; Asthma; Blood Platelets; Bronchoconstriction; Female; Humans; Inositol 1,4,5-Trisphosphate; Male; Phosphatidylinositols; Platelet Activating Factor; Platelet Count | 1990 |
Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224.
Topics: Albumins; Anaphylaxis; Animals; Asthma; Azepines; Betamethasone; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Guinea Pigs; Histamine; Immunization; Indomethacin; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Naphthyridines; Ovalbumin; Platelet Activating Factor; Pyrazoles; Thromboxanes; Triazoles | 1990 |
Enhanced arachidonic acid metabolism and human neutrophil migration in asthma.
Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Asthma; Calcimycin; Chemotaxis, Leukocyte; Humans; Leukotrienes; Middle Aged; Neutrophils; Platelet Activating Factor | 1990 |
Effect of PAF-acether inhalation on nonspecific bronchial reactivity and adrenergic response in normal and asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Isoproterenol; Leukocyte Count; Male; Methacholine Chloride; Platelet Activating Factor | 1990 |
[Antigen-induced biphasic eosinophil infiltration in the airways of actively sensitized guinea pigs and its inhibition by PAF antagonist and cyclosporin A].
Topics: Animals; Asthma; Bronchi; Cyclosporins; Eosinophilia; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridinium Compounds; Time | 1990 |
Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation.
Topics: Administration, Inhalation; Adult; Asthma; Chemotaxis, Leukocyte; Humans; Leukocyte Count; Neutrophils; Platelet Activating Factor | 1990 |
Relationship between LTC4 generation of hypodense eosinophils and bronchial hyperreactivity in asthmatic children.
Topics: Adolescent; Asthma; Bronchi; Child; Eosinophils; Humans; Platelet Activating Factor; SRS-A | 1990 |
Does inhaled PAF cause airway hyperresponsiveness in humans?
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Humans; Hypersensitivity, Immediate; Platelet Activating Factor | 1990 |
Platelet activating factor does not cause a reproducible increase in bronchial responsiveness in normal man.
Topics: Acute Disease; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Humans; Male; Neutrophils; Pilot Projects; Platelet Activating Factor; Respiratory Function Tests | 1990 |
Generation of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester.
Topics: Adult; Aged; Asthma; Eosinophils; Female; Free Radicals; Humans; Luminescent Measurements; Male; Middle Aged; Oxygen; Oxygen Consumption; Platelet Activating Factor; Pulmonary Eosinophilia; Rhinitis; Tetradecanoylphorbol Acetate | 1990 |
[Inhibitory effects of OKY-046.HCl, a selective thromboxane (TX) A2 synthetase inhibitor, on platelet activating factor (PAF)-induced airway hyperresponsiveness in guinea pigs].
Topics: Acrylates; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Male; Methacrylates; Platelet Activating Factor; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.
Topics: Aerosols; Animals; Asthma; Blood Platelets; Bronchi; Eosinophils; Guinea Pigs; In Vitro Techniques; Lung; Male; Neutrophils; Platelet Activating Factor; Time Factors | 1990 |
Platelet-activating factor in bronchoalveolar lavage fluid from asthmatic subjects.
Topics: Adolescent; Adult; Aged; Asthma; Bronchoalveolar Lavage Fluid; Bronchoscopy; Female; Humans; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Platelet Aggregation | 1990 |
[Developmental trends in allergologic-immunologic research].
Topics: Allergens; Anaphylaxis; Asthma; Blood Coagulation Factors; Bronchi; Cytoplasmic Granules; Histamine Release; Humans; Hypersensitivity; Immunoglobulin E; Mast Cells; Platelet Activating Factor; Prostaglandins; Receptors, Fc; Respiratory Hypersensitivity; SRS-A | 1986 |
Histamine release from human leukocytes by platelet-activating factor.
Topics: Adult; Asthma; Basophils; Cytochalasin B; Edetic Acid; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Leukocytes; Phospholipid Ethers; Platelet Activating Factor; Stimulation, Chemical | 1988 |
Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.
Topics: Allergens; Allium; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Drug Interactions; Guinea Pigs; Histamine Release; Humans; Leukocytes; Leukotrienes; Lipoxygenase Inhibitors; Plant Extracts; Platelet Activating Factor; Sulfinic Acids; Thromboxanes | 1988 |
Immunopharmacological studies on TBX, a new antiallergic drug (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs.
Topics: Animals; Asthma; Bronchi; Dinoprost; Guinea Pigs; Histamine Antagonists; Histamine Release; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation; Pyridines; Pyrimidinones; SRS-A; Trachea | 1989 |
Effects of combined receptor antagonists of leukotriene D4 (LTD4) and platelet-activating factor (PAF) on rhesus airway responses to LTD4, PAF and antigen.
Topics: Animals; Ascaris; Asthma; Drug Therapy, Combination; Female; Immunoglobulin E; Indazoles; Macaca mulatta; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyrazoles; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1989 |
[Platelet activating factor and platelet activating factor antagonists. New methods in asthma therapy?].
Topics: Airway Resistance; Asthma; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled | 1989 |
Effect of antiasthma drugs on microvascular leakage in guinea pig airways.
Topics: Adrenergic alpha-Agonists; Animals; Asthma; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Lung; Male; Microcirculation; Platelet Activating Factor | 1989 |
PAF antagonists in asthma.
Topics: Administration, Inhalation; Asthma; Humans; Platelet Activating Factor | 1989 |
The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity.
Topics: Animals; Asthma; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Infusions, Intravenous; Lipoxygenase Inhibitors; Lung; Male; Mast Cells; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Serotonin Antagonists | 1989 |
The effect of prophylactic anti-asthma drugs on PAF-induced platelet accumulation in the thorax of the guinea pig.
Topics: Airway Resistance; Animals; Asthma; Blood Platelets; Guinea Pigs; Indium Radioisotopes; Male; Platelet Activating Factor; Thorax | 1989 |
Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Injections, Intraperitoneal; Lung; Platelet Activating Factor; Therapeutic Irrigation | 1989 |
Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Isoproterenol; Leukocyte Count; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor | 1989 |
Effect of platelet-activating factor inhalation on nonspecific bronchial reactivity in man.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Platelet Activating Factor; Time Factors | 1989 |
Role of platelet activating factor in the endotoxin induced tracheal hyperreactivity to histamine in the guinea pig.
Topics: Animals; Asthma; Endotoxins; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Trachea | 1989 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chromones; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Indomethacin; Lung; Platelet Activating Factor; Reference Values; Sheep; SRS-A; Triazines; Triazoles | 1989 |
A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Administration, Oral; Animals; Asthma; Benzoquinones; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Heptanoic Acids; Histamine Antagonists; Male; Platelet Activating Factor; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Quinones; Rabbits; Rats; Rats, Inbred Strains; SRS-A; Trachea | 1989 |
Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo.
Topics: Animals; Asthma; Bronchi; Evans Blue; Exudates and Transudates; Guinea Pigs; Larynx; Lung; Male; Plasma; Platelet Activating Factor; Serum Albumin, Radio-Iodinated; Trachea | 1989 |
[Platelet activating factor produces platelet activating factor, comes to nothing].
Topics: Airway Resistance; Asthma; Humans; Muscle, Smooth; Platelet Activating Factor; Respiratory Hypersensitivity | 1989 |
Inhibition by histamine of platelet-activating-factor-induced neutrophil chemotaxis in bronchial asthma.
Topics: Asthma; Chemotaxis, Leukocyte; Histamine; Humans; In Vitro Techniques; Neutrophils; Platelet Activating Factor | 1989 |
Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals.
Topics: Asthma; Dermatitis, Atopic; Eosinophils; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor | 1989 |
[Mechanism of suppression of human peripheral blood lymphocyte proliferation by platelet activation factor].
Topics: Adult; Asthma; Cell Division; Cells, Cultured; Female; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocytes; Male; Platelet Activating Factor; T-Lymphocytes | 1989 |
Effect of PAF-acether in non-human primates.
Topics: Airway Resistance; Animals; Asthma; Bronchial Spasm; Constriction, Pathologic; Cromolyn Sodium; Ketotifen; Lung Compliance; Lung Volume Measurements; Nedocromil; Papio; Platelet Activating Factor; Quinolines | 1988 |
Platelets and asthma.
Topics: Asthma; Humans; Platelet Activating Factor; Platelet Aggregation | 1985 |
Platelets and asthma.
Topics: Asthma; beta-Thromboglobulin; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Factor 4 | 1985 |
Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021.
Topics: Animals; Asthma; Bronchi; Diterpenes; Ginkgolides; Guinea Pigs; Humans; Lactones; Male; Plant Extracts; Platelet Activating Factor | 1985 |
PAF and airway hyperreactivity.
Topics: Acute Disease; Animals; Asthma; Bronchi; Humans; Platelet Activating Factor | 1985 |
Platelets in asthma.
Topics: Animals; Asthma; Blood Platelets; Guinea Pigs; Humans; Platelet Activating Factor | 1985 |
Effects of anti-asthma drugs on PAF-induced death in mice.
Topics: Adrenalectomy; Adrenergic beta-Agonists; Animals; Asthma; Bronchodilator Agents; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Histamine Antagonists; Mice; Models, Biological; Nedocromil; Phthalazines; Platelet Activating Factor; Pyridazines; Quinolones; Serotonin Antagonists | 1988 |
[Platelet activating factor--a new agent to control asthma].
Topics: Adult; Asthma; Child; Humans; Platelet Activating Factor | 1989 |
The mast cell and theophylline in asthma.
Topics: Adenosine Triphosphate; Asthma; Chemotactic Factors; Chondroitin Sulfates; Cyclic AMP; Heparin; Histamine; Humans; Mast Cells; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; SRS-A; Theophylline | 1985 |
Chemical mediators of anaphylaxis released by alveolar macrophages in bronchial asthma.
Topics: Anaphylaxis; Arachidonic Acid; Arachidonic Acids; Asthma; Blood Proteins; Humans; Leukotriene B4; Macrophages; Platelet Activating Factor; Pulmonary Alveoli | 1986 |
Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis.
Topics: Albuterol; Asthma; Cromolyn Sodium; Humans; Hypersensitivity; Injections, Intravenous; Ketotifen; Lung; Mast Cells; Platelet Activating Factor; Platelet Aggregation; Theophylline; Time Factors | 1986 |
[Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension].
Topics: Animals; Arachidonic Acids; Asthma; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Hypertension, Pulmonary; Lipoxygenase Inhibitors; Platelet Activating Factor; Pulmonary Artery; Rabbits | 1988 |
Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.
Topics: Animals; Asthma; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene Antagonists; Leukotrienes; Lipoxygenase; Platelet Activating Factor; Respiratory System | 1988 |
Basic mechanisms in asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Asthma; Biopsy; Bronchi; Bronchial Spasm; Humans; Lung; Mast Cells; Neuropeptides; Platelet Activating Factor; Prostaglandin D2; Prostaglandins D; Respiratory System; Skin; SRS-A | 1988 |
Mechanism of platelet activating factor-induced bronchoconstriction in humans.
Topics: Adolescent; Adult; Asthma; Atropine; Bronchi; Bronchial Provocation Tests; Chlorpheniramine; Dose-Response Relationship, Drug; Humans; Indomethacin; Platelet Activating Factor; Respiratory Function Tests | 1988 |
Plates and anti-asthma drugs.
Topics: Animals; Asthma; Bronchi; Bronchial Spasm; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Platelet Activating Factor; Rabbits | 1988 |
Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor.
Topics: Allergens; Animals; Asthma; Drug Evaluation; Eosinophilia; Guinea Pigs; Platelet Activating Factor; Respiratory System | 1988 |
Effects of LG 30435 on different platelet activating factor-induced responses.
Topics: Animals; Asthma; Blood Platelets; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Lung; Mice; Phenothiazines; Platelet Activating Factor; Rats | 1988 |
The bronchoconstrictor properties of platelet-activating factor in humans.
Topics: Adolescent; Adult; Aerosols; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor; Tachyphylaxis | 1987 |
[Bronchial hyperreactivity: pingpong between cells, nerves and mediators].
Topics: Animals; Asthma; Bronchial Spasm; Humans; Mice; Muscle, Smooth; Platelet Activating Factor | 1988 |
The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation.
Topics: Animals; Antigens; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Diterpenes; Eosinophils; Ginkgolides; Guinea Pigs; Lactones; Male; Ovalbumin; Platelet Activating Factor | 1988 |
Platelet activating factor, ketotifen and asthma.
Topics: Asthma; Humans; Ketotifen; Platelet Activating Factor | 1986 |
Ketotifen and asthma.
Topics: Asthma; Humans; Ketotifen; Platelet Activating Factor | 1986 |
Platelet activating factor, ketotifen and asthma.
Topics: Animals; Asthma; Humans; Ketoprofen; Phenylpropionates; Platelet Activating Factor | 1986 |
PAF, ketotifen and asthma.
Topics: Asthma; Humans; Ketotifen; Platelet Activating Factor | 1987 |
PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986.
Topics: Animals; Asthma; Blood Platelets; Humans; Platelet Activating Factor | 1987 |
Lack of PAF release in extrinsic asthma.
Topics: Asthma; Bronchial Provocation Tests; Collagen; Humans; Platelet Activating Factor | 1987 |
Platelet abnormalities in asthma--do they exist in humans?
Topics: Adult; Asthma; Blood Platelets; Female; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor | 1987 |
Evidence of PAF release and platelet activation in analgesics-asthma-syndrome.
Topics: Aspirin; Asthma; Blood Platelets; Collagen; Drug Synergism; Female; Humans; Male; Platelet Activating Factor; Syndrome | 1987 |
Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets.
Topics: Animals; Asthma; Blood Cells; Ferrets; Mucus; Phospholipid Ethers; Platelet Activating Factor; Thiazoles | 1987 |
Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever.
Topics: Adenosine Diphosphate; Adult; Asthma; Bleeding Time; Collagen; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Platelet Function Tests; Rhinitis, Allergic, Seasonal; Thromboxane B2 | 1986 |
Antiasthmatic effects of onions. Inhibition of platelet-activating factor-induced bronchial obstruction by onion oils.
Topics: Allium; Animals; Asthma; Blood Platelets; Bronchial Provocation Tests; Cells, Cultured; Fibroblasts; Guinea Pigs; Humans; Plant Oils; Platelet Activating Factor; Thromboxane B2 | 1987 |
[Blood platelets and asthma and other lung diseases].
Topics: Asthma; Bronchial Spasm; Humans; Lung Diseases; Platelet Activating Factor | 1987 |
Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma.
Topics: Asthma; Bronchi; Eosinophils; Humans; Inflammation; Mucus; Platelet Activating Factor; Respiratory System; SRS-A | 1986 |
Platelet-activating factor in late asthmatic response.
Topics: Asthma; Female; Humans; Hypersensitivity, Immediate; Male; Platelet Activating Factor; Platelet Aggregation; Time Factors | 1987 |
Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether.
Topics: Adult; Asthma; Codeine; Cromolyn Sodium; Histamine; Humans; Mast Cells; Platelet Activating Factor; Skin | 1985 |
Pharmacology of the late response to allergen and its relevance to asthma prophylaxis.
Topics: Airway Resistance; Allergens; Asthma; Blood Platelets; Cromolyn Sodium; Humans; Immunoglobulin E; Mast Cells; Platelet Activating Factor; Pollen; Time Factors | 1985 |
Changing concepts on pathogenesis of asthma.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Chemotactic Factors; Child; Epithelium; Humans; Inflammation; Macrophages; Mast Cells; Platelet Activating Factor; Pulmonary Alveoli; Vagus Nerve | 1985 |
Mediators and asthma.
Topics: Adenosine; Asthma; Bradykinin; Bronchial Spasm; Chemotactic Factors; Chemotaxis, Leukocyte; Histamine; Humans; Lipoxygenase; Nerve Tissue Proteins; Platelet Activating Factor; Prostaglandins; SRS-A | 1985 |
Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs.
Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Asthma; Blood Platelets; Bronchodilator Agents; Guinea Pigs; Male; Platelet Activating Factor | 1985 |
Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation.
Topics: Airway Resistance; Allergens; Animals; Asthma; Humans; Platelet Activating Factor; Rabbits; Time Factors | 1985 |
Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma.
Topics: Asthma; Edema; Eosinophils; Humans; Inflammation; Platelet Activating Factor | 1985 |