1-eicosapentaenoylglycerol and Adenocarcinoma

There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells.. The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft.. Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily. MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells.

Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Aquatic Organisms; Cell Proliferation; Colorectal Neoplasms; Eicosapentaenoic Acid; Female; HCT116 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Monoglycerides