1-butanol has been researched along with Vitiligo in 17 studies
1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.
butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Vitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo." | 9.12 | Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo. ( Abe, Y; Inoue, S; Ito, A; Ito, S; Katayama, I; Masui, Y; Matsunaga, K; Sumikawa, Y; Suzuki, K; Suzuki, T; Tanemura, A; Yagami, A; Yoshikawa, M, 2021) |
| "A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo." | 5.12 | Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo. ( Abe, Y; Inoue, S; Ito, A; Ito, S; Katayama, I; Masui, Y; Matsunaga, K; Sumikawa, Y; Suzuki, K; Suzuki, T; Tanemura, A; Yagami, A; Yoshikawa, M, 2021) |
| "Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD-induced leukoderma (RIL) after repeated application." | 3.96 | Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma. ( Abe, Y; Aoyama, Y; Araki, Y; Fukai, K; Hayashi, M; Hozumi, Y; Ito, A; Katayama, I; Kobayashi, Y; Masui, Y; Matsunaga, K; Nagai, H; Naka, I; Nishigori, C; Ohashi, J; Oiso, N; Okamura, K; Saito, T; Suzuki, T; Tanemura, A; Yagami, A; Yamashita, T, 2020) |
| "Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis." | 1.56 | Expression of discoidin domain receptor 1 and E-cadherin in epidermis affects melanocyte behavior in rhododendrol-induced leukoderma mouse model. ( Abe, Y; Hozumi, Y; Okamura, K; Suzuki, T, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (76.47) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Arase, N | 4 |
| Tanemura, A | 6 |
| Jin, H | 1 |
| Nishioka, M | 2 |
| Aoyama, Y | 2 |
| Oiso, N | 2 |
| Matsunaga, K | 7 |
| Suzuki, T | 12 |
| Nishigori, C | 2 |
| Kawamura, T | 1 |
| Shimizu, T | 1 |
| Ito, A | 3 |
| Fukai, K | 2 |
| Abe, Y | 10 |
| Yang, L | 3 |
| Tsuruta, D | 1 |
| Takeoka, K | 1 |
| Iwatani, Y | 1 |
| Hidaka, Y | 1 |
| Nishida, M | 1 |
| Yamauchi-Takihara, K | 1 |
| Arase, H | 2 |
| Fujimoto, M | 1 |
| Katayama, I | 6 |
| Kim, M | 1 |
| Lee, CS | 1 |
| Lim, KM | 1 |
| Okamura, K | 6 |
| Naka, I | 1 |
| Ohashi, J | 1 |
| Yagami, A | 2 |
| Kobayashi, Y | 1 |
| Masui, Y | 2 |
| Yamashita, T | 1 |
| Nagai, H | 1 |
| Araki, Y | 2 |
| Saito, T | 1 |
| Hayashi, M | 4 |
| Hozumi, Y | 7 |
| Yasuda, M | 1 |
| Sekiguchi, A | 1 |
| Kishi, C | 1 |
| Toki, S | 1 |
| Takahashi, A | 1 |
| Yang, F | 2 |
| Hamada, T | 1 |
| Ishikawa, O | 1 |
| Inoue, S | 2 |
| Ito, S | 2 |
| Sumikawa, Y | 1 |
| Yoshikawa, M | 1 |
| Suzuki, K | 1 |
| Watabe, A | 2 |
| Yamasaki, K | 2 |
| Asano, M | 1 |
| Kanbayashi, Y | 1 |
| Nasu-Tamabuchi, M | 1 |
| Terui, H | 1 |
| Furudate, S | 1 |
| Kakizaki, A | 1 |
| Tsuchiyama, K | 1 |
| Kimura, Y | 1 |
| Ito, Y | 1 |
| Kikuchi, K | 2 |
| Aiba, S | 2 |
| Tsutsumi, R | 1 |
| Sugita, K | 1 |
| Yamada, N | 1 |
| Yoshida, Y | 1 |
| Yamamoto, O | 1 |
| Sasaki, M | 1 |
| Kondo, M | 1 |
| Sato, K | 1 |
| Umeda, M | 1 |
| Kawabata, K | 1 |
| Takahashi, Y | 2 |
| Kuroda, Y | 1 |
| Sakaguchi, H | 1 |
| Tanaka, A | 1 |
| Ohe, R | 1 |
| Ueki, M | 1 |
| Tamiya, G | 1 |
| Yamakawa, M | 1 |
| Kawaguchi, M | 1 |
| Aoki, H | 1 |
| Kunisada, T | 1 |
| Wakamatsu, K | 1 |
| Inoue, M | 1 |
| Suenaga, T | 1 |
| Suzuki, M | 1 |
| Tanaka, T | 1 |
| Nakano, S | 1 |
| Yoshizawa, J | 1 |
| Inoie, M | 1 |
1 review available for 1-butanol and Vitiligo
| Article | Year |
|---|---|
Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo.
Topics: Butanols; Humans; Hypopigmentation; Melanocytes; Vitiligo | 2021 |
2 trials available for 1-butanol and Vitiligo
| Article | Year |
|---|---|
Efficacy of oral cholecalciferol on rhododendrol-induced vitiligo: A blinded randomized clinical trial.
Topics: Administration, Oral; Adult; Aged; Butanols; Calcifediol; Cholecalciferol; Female; Humans; Middle Ag | 2018 |
Leukoderma induced by rhododendrol is different from leukoderma of vitiligo in pathogenesis: A novel comparative morphological study.
Topics: Adult; Aged; Aged, 80 and over; Animals; Butanols; Female; Humans; Melanocytes; Mice; Middle Aged; N | 2019 |
14 other studies available for 1-butanol and Vitiligo
| Article | Year |
|---|---|
Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Butanols; Child, Preschool; Female; Huma | 2019 |
Rhododenol Activates Melanocytes and Induces Morphological Alteration at Sub-Cytotoxic Levels.
Topics: Animals; Butanols; Cell Line, Tumor; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Gene E | 2019 |
Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma.
Topics: Alleles; Butanols; Cadherins; Epidermis; Gene Knockdown Techniques; Genetic Predisposition to Diseas | 2020 |
Immunohistochemical analysis of rhododendrol-induced leukoderma in improved and aggravated cases.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antigens, CD; Butanols; Cadherins; Case-C | 2020 |
Expression of discoidin domain receptor 1 and E-cadherin in epidermis affects melanocyte behavior in rhododendrol-induced leukoderma mouse model.
Topics: Animals; Butanols; Cadherins; Discoidin Domain Receptor 1; Epidermis; Melanocytes; Mice; Vitiligo | 2020 |
Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mouse model of rhododendrol-induced vitiligo.
Topics: Administration, Oral; Animals; Butanols; Disease Models, Animal; Humans; Janus Kinase Inhibitors; Mi | 2019 |
Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.
Topics: Agaricales; Apoptosis; Butanols; Caspase 3; Catalytic Domain; Cell Survival; Cells, Cultured; Chelat | 2014 |
Depigmentation of the skin induced by 4-(4-hydroxyphenyl)-2-butanol is spontaneously re-pigmented in brown and black guinea pigs.
Topics: Animals; Butanols; Disease Models, Animal; Epidermal Cells; Female; Guinea Pigs; Melanocytes; Pigmen | 2014 |
Possible involvement of CCR4+ CD8+ T cells and elevated plasma CCL22 and CCL17 in patients with rhododenol-induced leukoderma.
Topics: Butanols; CD8-Positive T-Lymphocytes; Chemokine CCL17; Chemokine CCL22; Cosmetics; Humans; Hypopigme | 2015 |
Immunohistopathological analysis of frizzled-4-positive immature melanocytes from hair follicles of patients with Rhododenol-induced leukoderma.
Topics: Biomarkers; Butanols; Frizzled Receptors; Hair Follicle; Humans; Immunohistochemistry; Melanocytes; | 2015 |
Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin.
Topics: Administration, Topical; Animals; Asian People; Autophagy; Butanols; Cell Count; Disease Models, Ani | 2016 |
The spectrophotometrical analysis of rhododendrol-induced leucoderma using a novel multispectral camera.
Topics: Adult; Aged; Butanols; Case-Control Studies; Diagnosis, Differential; Female; Humans; Hypopigmentati | 2016 |
The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase.
Topics: Butanols; Cells, Cultured; Dermatitis, Contact; Humans; Melanocytes; Monophenol Monooxygenase; NF-ka | 2016 |
A novel three dimensional imaging method for the measurement of area in vitiligo and chemical leukoderma.
Topics: Adolescent; Adult; Aged; Butanols; Cellular Senescence; Cosmetics; Female; Humans; Hypopigmentation; | 2016 |