1-arabinofuranosylcytosine-5--stearylphosphate and Monosomy

We encountered a male patient with marked basophilia and eosinophilia complicated by anemia, thrombocytopenia, myelofibrosis, and hyperhistaminemia. Since morphological abnormalities were unclear and since chromosome analysis showed 45,XY,-7, a diagnosis of basophilic-eosinophilic myeloproliferative disorder was made. After administration of prednisolone and cytarabine ocfosfate, basophil and eosinophil levels decreased, but blasts transiently appeared in the peripheral blood. Chromosome analysis performed at the time of appearance of blasts showed a clone with 45,XY,-7,del(16)(q22). Subsequently, pancytopenia developed, after which white blood cell count and its classification were normal, as were chromosome findings. In this patient, monosomy 7 seemed to have induced myeloproliferative disorder with basophilia and eosinophilia, and del(16)(q22) may have enhanced the eosinophilia.

Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Arabinonucleotides; Basophils; Chromosomes, Human, Pair 7; Cytidine Monophosphate; Eosinophilia; Histamine; Humans; Karyotyping; Male; Monosomy; Myeloproliferative Disorders; Prednisolone

A 42-year-old man was admitted to our hospital because of pancytopenia in April 1992. A diagnosis of refractory anemia was made. The karyotype was normal male type on the initial study. Subcutaneous administration of granulocyte colony-stimulating factor (G-CSF) initially increased the peripheral neutrophil count, bat in January 1993, although blast cells did not increase, neutrophils had decreased in spite of the continuation of G-CSF administration. Chromosome analysis showed 46XY, +Y, -7 at this point. By adding 50 mg of cytarabine ocfosfate (SPAC) daily, the peripheral neutrophil count again rose dramatically. However, anemia, thrombocytopenia and the chromosomal abnormality were unchanged. These results indicate that SPAC may upregulate the effect of G-CSF on granulopoiesis in patients with myelodysplastic syndrome.

Topics: Adult; Arabinonucleotides; Chromosomes, Human, Pair 7; Cytidine Monophosphate; Drug Resistance; Granulocyte Colony-Stimulating Factor; Humans; Karyotyping; Leukocyte Count; Male; Monosomy; Myelodysplastic Syndromes