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1-anilino-8-naphthalenesulfonate and Hypothyroidism

1-anilino-8-naphthalenesulfonate has been researched along with Hypothyroidism in 47 studies

1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd
8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"We have studied the effects of L-thyroxine substitution on lipoprotein concentrations, on the activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and on the elimination rate of exogenous triglyceride in a homogeneous group of patients with hypothyroidism of pituitary origin."7.66Dyslipoproteinaemia in hypothyroidism of pituitary origin: effects of L-thyroxine substitution on lipoprotein lipase, hepatic lipase, and on plasma lipoproteins. ( Hedner, P; Nilsson-Ehle, P; Valdemarsson, S, 1983)
" Before and after 6 months of levothyroxine (L-T(4)) treatment, we determined total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), apoB levels, hepatic lipase (HL) activity in postheparin plasma samples, the chemical composition and copper-induced oxidation in isolated LDL and homeostasis model assessment (HOMA), quantitative insulin sensitivity check index, and insulinogenic index."3.74Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T(4) treatment. ( Arias, P; Berg, G; Brenta, G; Muzzio, ML; Schnitman, M; Schreier, L; Sinay, I; Zago, V, 2007)
"The aim of this study was to evaluate the effect of thyroxine (T4) and GH replacement therapy on serum lipoproteins in rats with primary and secondary hypothyroidism and to see whether recovery of GH activity was associated with normalization of serum lipoproteins."3.68Growth hormone and thyroxine affect lipoprotein metabolism in hypothyroid and hypophysectomized rats. ( Birkenhäger, JC; Hoogerbrugge-vd Linden, N; Jansen, H; Wounters, NM, 1990)
"Male Sprague-Dawley rats were treated for up to 4 weeks with propylthiouracil in a study designed to determine the effects of experimental hypothyroidism on plasma lipoproteins."3.67Effects of experimental hypothyroidism on the distribution of lipids and lipoproteins in the plasma of rats. ( Barter, PJ; Ha, YC; Meyer, BJ, 1989)
"We have determined the effects of chronic amiodarone treatment on lipid metabolism and compared them with those of hypothyroidism in the rat."3.67Effect of amiodarone on serum lipids, lipoprotein lipase, and hepatic triglyceride lipase. ( Bagchi, N; Brown, TR; Kasim, SE; Khilnani, S, 1987)
"Plasma lipoprotein concentrations, activities of hepatic lipase and lipoprotein lipase in post-heparin plasma, and the removal rate of exogenous triglyceride were measured in fourteen patients with severe primary hypothyroidism before and after 4 months substitution therapy with 1-thyroxine."3.66Reversal of decreased hepatic lipase and lipoprotein lipase activities after treatment of hypothyroidism. ( Hedner, P; Nilsson-Ehle, P; Valdemarsson, S, 1982)
"We have studied the effects of L-thyroxine substitution on lipoprotein concentrations, on the activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and on the elimination rate of exogenous triglyceride in a homogeneous group of patients with hypothyroidism of pituitary origin."3.66Dyslipoproteinaemia in hypothyroidism of pituitary origin: effects of L-thyroxine substitution on lipoprotein lipase, hepatic lipase, and on plasma lipoproteins. ( Hedner, P; Nilsson-Ehle, P; Valdemarsson, S, 1983)
"Chronic hypothyroidism is frequently associated with atherosclerosis due to increased cholesterol plasma levels; nevertheless, the contribution of impaired reverse cholesterol transport (RCT) in this process has not been completely elucidated."1.32Decreased activity of lecithin:cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: implications for reverse cholesterol transport. ( Castro, G; Franco, M; Huesca-Gómez, C; Medina, A; Montaño, LF; Pérez-Méndez, O; Posadas-Romero, C; Ramírez, S; Regalado, JC; Romero, L, 2003)
"Eight patients with primary hypothyroidism were compared to eleven euthyroid subjects with regard to the effects of a single i."1.27Hepatic lipase and the clearing reaction: studies in euthyroid and hypothyroid subjects. ( Nilsson-Ehle, P; Valdemarsson, S, 1987)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199025 (53.19)18.7374
1990's11 (23.40)18.2507
2000's9 (19.15)29.6817
2010's2 (4.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brenta, G3
Berg, G3
Miksztowicz, V1
Lopez, G1
Lucero, D1
Faingold, C1
Murakami, M1
Machima, T1
Nakajima, K1
Schreier, L3
Zago, V2
Muzzio, ML2
Schnitman, M2
Sinay, I2
Arias, P2
Endo, T1
Kobayashi, T1
Franco, M1
Castro, G1
Romero, L1
Regalado, JC1
Medina, A1
Huesca-Gómez, C1
Ramírez, S1
Montaño, LF1
Posadas-Romero, C1
Pérez-Méndez, O1
Frank, N2
Sojka, JE2
Latour, MA2
LEITES, FL1
RAO, R1
CHITRA, DR1
LAKSHMINARAYANA, G1
Kinoshita, M1
Madhava, K1
Hartley, A1
Ridgway, N1
Dolphin, PJ1
Valdemarsson, S5
Hansson, P3
Hedner, P3
Nilsson-Ehle, P6
Murase, T2
Yamada, N1
Uchimura, H2
Coates, PM1
Hoffman, GM1
Finegold, DN1
Lee, PC1
Fu, CL1
Borysewicz, R1
Werlin, SL1
Packard, CJ2
Shepherd, J2
Lindsay, GM1
Gaw, A1
Taskinen, MR2
Hoogerbrugge, N2
Jansen, H3
Staels, B2
Seip, MJ1
Birkenhäger, JC3
Neve, BP1
Verhoeven, AJ1
Tan, KC1
Shiu, SW1
Kung, AW1
Asami, T1
Ciomartan, T1
Uchiyama, M1
Berti, JA1
Amaral, ME1
Boschero, AC1
Nunes, VS1
Harada, LM1
Castilho, LN1
Oliveira, HC1
Matsuura, F1
Hirano, K1
Flynn, TJ1
Deshmukh, DS1
Pieringer, RA1
Hülsmann, WC1
Oerlemans, MC1
Geelhoed-Mieras, MM1
Jubelin, J1
Lam Van, G1
Boyer, J1
Hoogerbrugge-vd Linden, N1
Wounters, NM1
Van Tol, A1
Chan, L1
Will, H1
Verhoeven, G1
Auwerx, J1
Berg, AL1
Hammarström, LE1
Holmin, T1
Jensen, E1
Florén, CH1
Meyer, BJ1
Ha, YC1
Barter, PJ1
Tenenbaum, D1
Gambert, P1
Fischbach, M1
d'Athis, P1
Nivelon, JL1
Lallemant, C1
Kuusi, T1
Nikkilä, EA1
Kasim, SE1
Bagchi, N1
Brown, TR1
Khilnani, S1
Lam, KS1
Chan, MK1
Yeung, RT1
Heyden, S1
Krauss, RM1
Levy, RI1
Fredrickson, DS1
Boonnamsiri, V1
Pleehachinda, R2
Anuman-Rajadhon, Y1
Triprom, N1
Khaikham, K1
Sritongkul, M1
Suwanik, R2
Pattanachak, C1
Pattanachak, S1
Yalow, RS1
Savastano, S1
Tommaselli, AP1
Valentino, R1
Dorato, M1
Scarpitta, MT1
Persechino, A1
Ciaramella, P1
Lombardi, G1
Young, DW1
Sartin, JL1
Kemppainen, RJ1

Reviews

3 reviews available for 1-anilino-8-naphthalenesulfonate and Hypothyroidism

ArticleYear
[Hepatic triglyceride lipase (HTGL)].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 12

    Topics: Arteriosclerosis; Biomarkers; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol, HD

2004
Lipoprotein metabolism in lipase deficient states: studies in primary and secondary hyperlipidaemia.
    Biochemical Society transactions, 1993, Volume: 21, Issue:2

    Topics: Humans; Hyperlipidemias; Hypothyroidism; Lipase; Lipoprotein Lipase; Lipoproteins; Liver; Nephrotic

1993
[Familial hepatic lipase deficiency].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 3

    Topics: Diagnosis, Differential; Humans; Hyperlipoproteinemias; Hypothyroidism; Lipase; Liver; Liver Cirrhos

2001

Other Studies

44 other studies available for 1-anilino-8-naphthalenesulfonate and Hypothyroidism

ArticleYear
Atherogenic Lipoproteins in Subclinical Hypothyroidism and Their Relationship with Hepatic Lipase Activity: Response to Replacement Treatment with Levothyroxine.
    Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:3

    Topics: Adult; Aged; Asymptomatic Diseases; Biomarkers; Case-Control Studies; Cholesterol; Cross-Sectional S

2016
Proatherogenic mechanisms in subclinical hypothyroidism: hepatic lipase activity in relation to the VLDL remnant IDL.
    Thyroid : official journal of the American Thyroid Association, 2008, Volume: 18, Issue:11

    Topics: Adult; Aged; Atherosclerosis; Case-Control Studies; Cholesterol; Female; Humans; Hypothyroidism; Lip

2008
Expression of functional TSH receptor in white adipose tissues of hyt/hyt mice induces lipolysis in vivo.
    American journal of physiology. Endocrinology and metabolism, 2012, Jun-15, Volume: 302, Issue:12

    Topics: Adipose Tissue, White; Amino Acid Substitution; Animals; Codon; Electroporation; Epididymis; Female;

2012
Decreased activity of lecithin:cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: implications for reverse cholesterol transport.
    Molecular and cellular biochemistry, 2003, Volume: 246, Issue:1-2

    Topics: Animals; Biological Transport, Active; Cholesterol; Chronic Disease; Hypothyroidism; Lecithin Choles

2003
Effects of hypothyroidism and withholding of feed on plasma lipid concentrations, concentration and composition of very-low-density lipoprotein, and plasma lipase activity in horses.
    American journal of veterinary research, 2003, Volume: 64, Issue:7

    Topics: Animals; Cholesterol; Fatty Acids, Nonesterified; Female; Food Deprivation; Horses; Hypothyroidism;

2003
[ON THE ROLE OF LIPOLYTIC ENZYMES IN THE PATHOGENESIS AND PATHOLOGY OF ATHEROSCLEROSIS].
    Vestnik Akademii meditsinskikh nauk SSSR, 1963, Volume: 18

    Topics: Animals; Arteriosclerosis; Atherosclerosis; Diabetes Mellitus, Experimental; Esterases; Hyperthyroid

1963
SERUM TRIBUTYRINASE LEVELS IN HEALTH AND DISEASE.
    The Indian journal of medical research, 1963, Volume: 51

    Topics: Anemia; Anemia, Macrocytic; Clinical Enzyme Tests; Diabetes Mellitus; Dyspepsia; Female; Glomerulone

1963
Effect of hypothyroidism on the blood lipid response to higher dietary fat intake in mares.
    Journal of animal science, 2004, Volume: 82, Issue:9

    Topics: Animals; Cholesterol; Cross-Over Studies; Dietary Fats; Female; Horse Diseases; Horses; Hypothyroidi

2004
Hypothyroidism in thyroid carcinoma follow-up: orlistat may inhibit the absorption of thyroxine.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2005, Volume: 17, Issue:6

    Topics: Carcinoma, Papillary; Enzyme Inhibitors; Female; Humans; Hypothyroidism; Lactones; Lipase; Middle Ag

2005
Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T(4) treatment.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:5

    Topics: Adult; Aged; Cholesterol, LDL; Female; Humans; Hypothyroidism; Insulin Resistance; Lipase; Lipoprote

2007
Lipoprotein lipase-mediated sequestration of long-chain polyunsaturated triacylglycerols in serum LDL from normal and hypothyroid rats.
    Biochimica et biophysica acta, 1984, Oct-24, Volume: 796, Issue:1

    Topics: Animals; Chylomicrons; Fatty Acids, Unsaturated; Hypothyroidism; Lipase; Lipoprotein Lipase; Lipopro

1984
Plasma lipoprotein alterations in thyroid dysfunction. Roles of lipoprotein lipase, hepatic lipase and LCAT.
    Acta endocrinologica. Supplementum, 1983, Volume: 255

    Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Humans; Hyperthyroidism; Hypothyroidism; Lipase; Li

1983
Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations.
    Acta endocrinologica, 1983, Volume: 104, Issue:1

    Topics: Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hyperthyroidism; Hypothyroid

1983
Reversal of decreased hepatic lipase and lipoprotein lipase activities after treatment of hypothyroidism.
    European journal of clinical investigation, 1982, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypothyroidism;

1982
Accumulation of intermediate density lipoprotein in the plasma of cholesterol-fed hypothyroid rats.
    Metabolism: clinical and experimental, 1983, Volume: 32, Issue:2

    Topics: Animals; Cholesterol, Dietary; Hypothyroidism; Lipase; Lipoprotein Lipase; Lipoproteins; Lipoprotein

1983
Dyslipoproteinaemia in hypothyroidism of pituitary origin: effects of L-thyroxine substitution on lipoprotein lipase, hepatic lipase, and on plasma lipoproteins.
    Acta endocrinologica, 1983, Volume: 103, Issue:2

    Topics: Adolescent; Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypothyroi

1983
Effect of thyroid hormones on human mononuclear leukocyte lysosomal acid lipase activity.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Hyperthyroidism; Hypothyroidism; Lipase; Lymphoc

1982
A selective decline of postheparin plasma hepatic triglyceride lipase in hypothyroid rats.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:8

    Topics: Animals; Cholesterol; Heparin; Hyperthyroidism; Hypothyroidism; Lipase; Lipoprotein Lipase; Lipoprot

1980
Thyroidal regulation of lingual lipase development in suckling rats.
    Biology of the neonate, 1993, Volume: 64, Issue:2-3

    Topics: Animals; Animals, Suckling; Body Weight; Dose-Response Relationship, Drug; Hypothyroidism; Lipase; M

1993
Thyroid replacement therapy and its influence on postheparin plasma lipases and apolipoprotein-B metabolism in hypothyroidism.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:5

    Topics: Adult; Aged; Apolipoproteins B; Enzymes; Female; Heparin; Humans; Hypothyroidism; Kinetics; Lipase;

1993
Growth hormone normalizes hepatic lipase in hypothyroid rat liver.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:6

    Topics: Analysis of Variance; Animals; Growth Hormone; Hypothyroidism; Insulin-Like Growth Factor I; Lipase;

1993
Growth hormone restores hepatic lipase mRNA levels but the translation is impaired in hepatocytes of hypothyroid rats.
    Biochimica et biophysica acta, 1997, Apr-01, Volume: 1345, Issue:2

    Topics: Animals; Gene Expression Regulation, Enzymologic; Human Growth Hormone; Hypothyroidism; Lipase; Live

1997
Effect of thyroid dysfunction on high-density lipoprotein subfraction metabolism: roles of hepatic lipase and cholesteryl ester transfer protein.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:8

    Topics: Adult; Apolipoprotein A-I; Body Mass Index; Carrier Proteins; Centrifugation, Density Gradient; Chol

1998
Thyroxine inversely regulates serum intermediate density lipoprotein levels in children with congenital hypothyroidism.
    Pediatrics international : official journal of the Japan Pediatric Society, 1999, Volume: 41, Issue:3

    Topics: Apolipoproteins; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Conge

1999
Thyroid hormone increases plasma cholesteryl ester transfer protein activity and plasma high-density lipoprotein removal rate in transgenic mice.
    Metabolism: clinical and experimental, 2001, Volume: 50, Issue:5

    Topics: Animals; Carrier Proteins; Cholesterol; Cholesterol Ester Transfer Proteins; Chromatography, High Pr

2001
Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.
    The Journal of biological chemistry, 1977, Aug-25, Volume: 252, Issue:16

    Topics: Acyltransferases; Aging; Animals; Animals, Newborn; Brain; Diglycerides; Galactosidases; Galactoside

1977
Effect of hypothyroidism, diabetes and polyunsaturated fatty acids on heparin-releasable rat liver lipase.
    Biochemical and biophysical research communications, 1977, Dec-07, Volume: 79, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Dietary Fats; Fatty Acids, Unsaturated; Glycerides; Hepari

1977
Effect of hypothyroidism on the heparin-stimulated release of lipase from the isolated perfused rat liver.
    The Journal of endocrinology, 1978, Volume: 76, Issue:2

    Topics: Animals; Heparin; Hypothyroidism; Lipase; Liver; Male; Rats

1978
Growth hormone and thyroxine affect lipoprotein metabolism in hypothyroid and hypophysectomized rats.
    The Journal of endocrinology, 1990, Volume: 125, Issue:3

    Topics: Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Growth Hormone; Hypophysectomy; Hypothyroi

1990
Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats.
    Endocrinology, 1990, Volume: 127, Issue:3

    Topics: Animals; Apolipoproteins; Gene Expression Regulation; Hyperthyroidism; Hypothyroidism; Intestinal Mu

1990
Hepatic lipase activity after liver denervation in hypothyroid rats.
    Acta endocrinologica, 1990, Volume: 123, Issue:1

    Topics: Animals; Cholesterol; Cholesterol, HDL; Denervation; Hypothyroidism; Lipase; Lipids; Lipoproteins; L

1990
Thyroid hormones stimulate the release of hepatic lipase from cultured rat hepatocytes.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1986, Volume: 18, Issue:2

    Topics: Animals; Antithyroid Agents; Cells, Cultured; Heparin; Hypothyroidism; Lipase; Liver; Male; Rats; Ra

1986
Effects of experimental hypothyroidism on the distribution of lipids and lipoproteins in the plasma of rats.
    Biochimica et biophysica acta, 1989, Jul-17, Volume: 1004, Issue:1

    Topics: Animals; Cholesterol; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Hypothyroidism; Lipa

1989
Alterations of serum high-density lipoproteins and hepatic lipase activity in congenital hypothyroidism.
    Biology of the neonate, 1988, Volume: 54, Issue:5

    Topics: Congenital Hypothyroidism; Humans; Hypothyroidism; Infant; Infant, Newborn; Lipase; Lipolysis; Lipop

1988
Lipoproteins, lipolytic enzymes, and hormonal status in hypothyroid women at different levels of substitution.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 66, Issue:1

    Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Gonadal Steroid Hormones; Huma

1988
Hepatic lipase and the clearing reaction: studies in euthyroid and hypothyroid subjects.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:1

    Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypothyroidism; Lipase

1987
Effect of amiodarone on serum lipids, lipoprotein lipase, and hepatic triglyceride lipase.
    Endocrinology, 1987, Volume: 120, Issue:5

    Topics: Adipose Tissue; Amiodarone; Animals; Cholesterol; Hypothyroidism; Lipase; Lipids; Lipoprotein Lipase

1987
High-density lipoprotein cholesterol, hepatic lipase and lipoprotein lipase activities in thyroid dysfunction--effects of treatment.
    The Quarterly journal of medicine, 1986, Volume: 59, Issue:229

    Topics: Adult; Cholesterol, HDL; Female; Humans; Hyperthyroidism; Hypothyroidism; Lipase; Lipids; Lipoprotei

1986
[Classification and diet therapy of hyperlipemia].
    Deutsche medizinische Wochenschrift (1946), 1974, Jan-25, Volume: 99, Issue:4

    Topics: Adult; Age Factors; Alcoholism; Blood Protein Electrophoresis; Cholesterol; Diabetes Complications;

1974
Selective measurement of two lipase activities in postheparin plasma from normal subjects and patients with hyperlipoproteinemia.
    The Journal of clinical investigation, 1974, Volume: 54, Issue:5

    Topics: Adipose Tissue; Adolescent; Adult; Blood Glucose; Blood Protein Disorders; Child; Child, Preschool;

1974
Serum triiodothyronine by radioimmunoassay in normal Thai subjects and in various thyroid disorders.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1984, Volume: 67, Issue:1

    Topics: Anilino Naphthalenesulfonates; Female; Fetal Blood; Humans; Hyperthyroidism; Hypothyroidism; Pregnan

1984
Experiences with radioimmunoassay of thyroid hormones (triiodothyronine and tetraiodothyronine) after the biblical work of Solomon A. Berson and Rosalyn S. Yalow.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1982, Volume: 65, Issue:12

    Topics: Anilino Naphthalenesulfonates; Animals; Humans; Hyperthyroidism; Hypothyroidism; Rabbits; Radioimmun

1982
Usefulness of a chromatographic method to detect circulating antithyroid hormone autoantibodies in canine serum.
    Journal of endocrinological investigation, 1996, Volume: 19, Issue:11

    Topics: Anilino Naphthalenesulfonates; Animals; Autoantibodies; Chromatography; Dog Diseases; Dogs; Fluoresc

1996
Abnormal canine triiodothyronine-binding factor characterized as a possible triiodothyronine autoantibody.
    American journal of veterinary research, 1985, Volume: 46, Issue:6

    Topics: Anilino Naphthalenesulfonates; Animals; Autoantibodies; Dog Diseases; Dogs; Hot Temperature; Hypothy

1985