1-anilino-8-naphthalenesulfonate and Cystic Fibrosis of Pancreas studies

1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd
8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.

Research Excerpts

Excerpt	Relevance	Reference
"Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination."	9.05	Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980)
"Measurements of breath 13CO2 do not consistently reflect the gastrointestinal handling of emulsified 13C labelled tripalmitin because of differences in digestion and absorption in cystic fibrosis."	7.70	Metabolic handling of 13C labelled tripalmitin in healthy controls and patients with cystic fibrosis. ( Jones, AE; Laiho, KM; Murphy, JL; Wootton, SA, 1998)
"Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrations were measured in faecal samples from nine patients with cystic fibrosis and nine healthy age matched controls."	7.69	Faecal interleukin-8 and tumour necrosis factor-alpha concentrations in cystic fibrosis. ( Briars, GL; Dean, TP; Murphy, JL; Rolles, CJ; Warner, JO, 1995)
"Serum immunoreactive pancreatic lipase and cationic trypsinogen are elevated in young infants with cystic fibrosis (CF) and may be useful neonatal screening tests for CF."	7.67	Age-related alterations in immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis. ( Benjamin, L; Cleghorn, G; Corey, M; Dati, F; Durie, P; Forstner, G, 1985)
"Cimetidine was effective in reducing acid secretion in such patients and led to small improvements in fat absorption."	6.65	The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis. ( Cameron, DJ; Ghale, GK; Harries, JT; Matthew, DJ; Milla, PJ; More, J; Pitcher-Wilmott, R, 1982)
"Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination."	5.05	Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980)
"To evaluate the antibacterial and antibiofilm mechanisms of usnic acid (USN) against methicillin-resistant Staphylococcus aureus from cystic fibrosis patients."	3.83	Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus. ( Angelucci, S; Barone, L; Crocetta, V; Di Bonaventura, G; Di Giulio, A; Di Giuseppe, F; Di Ilio, C; Pompilio, A; Pomponio, S; Riviello, A; Sulpizio, M, 2016)
"Measurements of breath 13CO2 do not consistently reflect the gastrointestinal handling of emulsified 13C labelled tripalmitin because of differences in digestion and absorption in cystic fibrosis."	3.70	Metabolic handling of 13C labelled tripalmitin in healthy controls and patients with cystic fibrosis. ( Jones, AE; Laiho, KM; Murphy, JL; Wootton, SA, 1998)
"Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrations were measured in faecal samples from nine patients with cystic fibrosis and nine healthy age matched controls."	3.69	Faecal interleukin-8 and tumour necrosis factor-alpha concentrations in cystic fibrosis. ( Briars, GL; Dean, TP; Murphy, JL; Rolles, CJ; Warner, JO, 1995)
" The slight increase in the ratio hw/hs of maleimide bound to membrane protein-SH groups of erythrocytes in cystic fibrosis may ensue the lowered membrane protein immobilization in the plane of lipid bilayer, especially at the intrinsic, more slowly reacting thiol groups."	3.68	Cystic fibrosis--V. Does cystic fibrosis alter the values of dynamic parameters of erythrocyte membrane ghosts? ( Jedrychowska, K; Piasecki, W; Watała, C; Witas, H, 1993)
"Serum immunoreactive pancreatic lipase and cationic trypsinogen are elevated in young infants with cystic fibrosis (CF) and may be useful neonatal screening tests for CF."	3.67	Age-related alterations in immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis. ( Benjamin, L; Cleghorn, G; Corey, M; Dati, F; Durie, P; Forstner, G, 1985)
"The chronically reserpine-treated rat, an experimental model for cystic fibrosis, exhibits generalized exocrinopathy, impaired pancreatic secretion, and decreased pancreatic amylase."	3.67	Effects of malnutrition and chronic reserpine treatment on pancreatic exocrine function. ( Brannon, PM; Hazlett, D; Korc, M, 1986)
" Symptoms and adverse events were evaluated as secondary endpoints."	2.82	Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial. ( Ahrens, RC; Forssmann, K; Graff, G; Heubi, JE; Jain, R; Schaeffer, D; Sollo, N; Strausbaugh, S; Witte, S, 2016)
" PA bioavailability estimates for CF subjects without pancreatic enzyme administration (1."	2.80	Malabsorption blood test: Assessing fat absorption in patients with cystic fibrosis and pancreatic insufficiency. ( Barrett, JS; Mascarenhas, MR; Mondick, J; Schall, JI; Stallings, VA; Wilson, M, 2015)
" All of the patients were required to discontinue their long-term use of porcine PERTs at the time of enrollment."	2.77	Liprotamase long-term safety and support of nutritional status in pancreatic-insufficient cystic fibrosis. ( Borowitz, D; Brettman, LR; Campion, M; Stevens, C; Thompson, H; Wilschanski, M, 2012)
"Postprandial hyperglycemia is an important clinical problem in cystic fibrosis (CF), but the contribution of fat malabsorption, rapid gastric emptying, and the incretin axis has not been widely considered."	2.76	Gastric emptying, incretin hormone secretion, and postprandial glycemia in cystic fibrosis--effects of pancreatic enzyme supplementation. ( Chapman, I; Greville, H; Hetzel, D; Horowitz, M; Jones, KL; Kuo, P; Maddox, A; Rayner, CK; Russo, A; Stevens, JE; Wishart, JM, 2011)
" At the other dosing levels, the mean coefficient of fat and nitrogen absorption increases were 19."	2.72	Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients. ( Ahrens, R; Aitken, ML; Borowitz, D; Dunitz, J; Goss, CH; Hayes, D; Hendeles, L; Konstan, MW; Mahl, TC; Moss, R; Murray, FT; Newman, L; O'Rourke, A; Oermann, CM; Orenstein, D; Stevens, C; Wagener, J; Young, KR, 2006)
" No adverse events related to study drug were reported."	2.71	Ultrase MT12 and Ultrase MT20 in the treatment of exocrine pancreatic insufficiency in cystic fibrosis: safety and efficacy. ( Colin, P; Duggan, C; Eigen, H; Konstan, MW; Sherman, JM; Stern, RC; Trout, JR; Wagener, JS; Wohl, ME, 2004)
" A high-strength preparation is thought to release relatively less enzyme activity in the small intestine, forcing patients to increase their dosage and possibly creating a dangerous enzyme hyperconcentration in the large intestine."	2.68	High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. ( Cabrini, G; Lancellotti, L; Mastella, G; Zanolla, L, 1996)
" Steatorrhoea was assessed by 3 day faecal fat analysis and dosage of medication, stool frequency and consistency; abdominal pain and appetite were documented by a patient-kept diary card."	2.67	A comparison of enteric coated microspheres with enteric coated tablet pancreatic enzyme preparations in cystic fibrosis. A controlled study. ( Matthew, DJ; Milla, PJ; Vyas, H, 1990)
"a double blind, crossover study of two pH sensitive microsphere preparations of pancreatin (Creon, Pancrease), given in equivalent lipase dosage to 27 children with cystic fibrosis, was conducted."	2.67	A comparison of two pancreatin microsphere preparations in cystic fibrosis. ( Akroyd, RM; Elliott, RB; Escobar, LC; Lees, HR; Reilly, HC, 1992)
" Capsule dosage was adjusted to a ratio of approximately 3:1."	2.67	Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis. ( Bowden, MW; Byers, CA; Dodge, JA; Guilford, SA; McCracken, KJ; Morrison, G; Morrison, JM; Redmond, AO, 1992)
"Twenty-one stable hospitalized cystic fibrosis patients with malabsorption syndrome participated in an open-label crossover clinical trial to evaluate the efficacy of two-period dosing regimens of a pancreatic microtablet enzyme preparation in the treatment of steatorrhea."	2.67	Comparison of weight-based dosages of enteric-coated microtablet enzyme preparations in patients with cystic fibrosis. ( Beker, LT; Chaney, HR; Evans, E; Fink, RJ; Kluft, J; Schidlow, DV; Shamsa, FH, 1994)
"In an attempt to critically examine the therapeutic efficacy of pH-sensitive enteric-coated pancreatic enzyme preparations in patients with pancreatic insufficiency due to cystic fibrosis, postprandial duodenal concentration and recovery of orally administered pancreatic enzymes, duodenal pH, and coefficient of fat absorption were determined in eight cases after ingestion of equivalent dosage of enteric-coated as well as conventional enzyme preparations."	2.66	Critical examination of therapeutic efficacy of a pH-sensitive enteric-coated pancreatic enzyme preparation in treatment of exocrine pancreatic insufficiency secondary to cystic fibrosis. ( Appler, M; Dutta, SK; Hubbard, VS, 1988)
" With Pancrease, the number of daily dosage units is decreased even when fat intake is increased."	2.66	Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages. ( Ansaldi-Balocco, N; Santini, B; Sarchi, C, 1988)
"Cimetidine was effective in reducing acid secretion in such patients and led to small improvements in fat absorption."	2.65	The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis. ( Cameron, DJ; Ghale, GK; Harries, JT; Matthew, DJ; Milla, PJ; More, J; Pitcher-Wilmott, R, 1982)
" The FDA recently required all manufacturers to submit New Drug Applications to continue to market these agents because published data demonstrated variation in formulation, bioavailability and shelf-life while providing limited data about efficacy and safety."	2.45	Systematic review: pancreatic enzyme treatment of malabsorption associated with chronic pancreatitis. ( Conwell, DL; Dimagno, MJ; Schoenfeld, PS; Waljee, AK; Wu, BU, 2009)
"To establish the diagnosis of acute pancreatitis the estimation of amylase in serum and urine, lipase and radio-immunoreactive trypsin in the serum are useful."	2.36	[Examination of pancreatic function in children with special reference to the PABA-test (author's transl)]. ( Dockter, G; Sitzmann, FC, 1980)
" The proposed method can be considered as a first approach for an evidence-based method in PERT dosing based on food characteristics."	1.51	Clinical validation of an evidence-based method to adjust Pancreatic Enzyme Replacement Therapy through a prospective interventional study in paediatric patients with Cystic Fibrosis. ( Andrés, A; Boon, M; Bulfamante, A; Calvo-Lerma, J; Claes, I; Colombo, C; Crespo-Escobar, P; de Boeck, K; Fornés-Ferrer, V; Garriga, M; Hulst, J; Martínez-Barona, S; Masip, E; Ribes-Koninckx, C; Roca, M; Ruperto, M; van der Wiel, E; Woodcock, S, 2019)
"Patients with cystic fibrosis have to take enzymatic supplements to allow for food digestion."	1.51	A first approach for an evidence-based in vitro digestion method to adjust pancreatic enzyme replacement therapy in cystic fibrosis. ( Andrés, A; Calvo-Lerma, J; Fornés-Ferrer, V; Heredia, A; Peinado, I; Ribes-Koninckx, C, 2019)
"In this study population, no correlation between an enzyme dosage and the degree of fat malabsorption was found; however, a CFA below 85% was found in 24% of the measurements."	1.42	Pancreatic Enzyme Replacement Therapy and Coefficient of Fat Absorption in Children and Adolescents With Cystic Fibrosis. ( Houwen, RH; van der Ent, CK; Woestenenk, JW, 2015)
"Patients attending US cystic fibrosis programs achieving highest nutritional outcomes, measured by mean BMI percentile, have higher enzyme dosing than those attending programs at lower performance levels."	1.40	Pancreatic enzyme replacement therapy dosing and nutritional outcomes in children with cystic fibrosis. ( Haupt, ME; Kwasny, MJ; McColley, SA; Schechter, MS, 2014)
"The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base."	1.39	Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: a reconsideration. ( Borowitz, D; Gelfond, D; Heubi, JE; Maguiness, K; Ramsey, B, 2013)
" There were no further serious suspected adverse drug reactions related to pancreatin 40,000 and no cases of fibrosing colonopathy."	1.37	A 2-year post-authorization safety study of high-strength pancreatic enzyme replacement therapy (pancreatin 40,000) in cystic fibrosis. ( Connett, GJ; Henniges, F; Littlewood, JM; Sander-Struckmeier, S, 2011)
"Cystic fibrosis is associated with pancreatic insufficiency and acidic intraluminal conditions that limit the action of pancreatic enzyme replacement therapy, especially that of lipase."	1.36	Modification of pancreatic lipase properties by directed molecular evolution. ( Colin, DY; Deprez-Beauclair, P; Infantes, L; Kerfelec, B; Silva, N, 2010)
"However, pancreatitis was also reported for 15 patients with PI from 11 centers in 9 different countries."	1.33	Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype. ( De Boeck, K; Kerem, E; Proesmans, M; Weren, M, 2005)
"Ursodiol, the drug of choice for the treatment of cystic fibrosis liver disease, may offer a safe method of using high-dose IBU in these patients by ameliorating the enteropathy."	1.31	Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. ( Beno, DW; Jiyamapa-Serna, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 2001)
"Children with cystic fibrosis have variable degrees of exocrine pancreatic insufficiency which, if untreated, is the main cause of fat malabsorption."	1.30	13Carbon mixed triglyceride breath test and pancreatic enzyme supplementation in cystic fibrosis. ( Amarri, S; Coward, WA; Evans, TJ; Harding, M; Weaver, LT, 1997)
" The following aspects of the patients' history were recorded (a) current type of pancreatic enzyme medication; (b) total dosage per day (with reference to lipase units); (c) duration of therapy with standard-strength pancreatic enzyme (SSPE) preparations (< or = 10,000 lipase units per capsule) and HSPE preparations (> or = 20,000 lipase units per capsule); (d) gastrointestinal complication (distal intestinal obstruction syndrome, meconium ileus, abdominal surgery, intussusception), diabetes mellitus, and hepatobiliary complications."	1.30	Ultrasound studies of the intestinal wall in patients with cystic fibrosis. ( Krackhardt, B; Lembcke, B; Pohl, M; Posselt, HG, 1997)
"We retrospectively reviewed pancreatic enzyme dosing for 267 cystic fibrosis patients with pancreatic insufficiency."	1.30	Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. ( Chong, SK; Heilman, DK; Hollingsworth, J; Maguiness, KM; Stevens, JC, 1998)
" Mean PES dosage was significantly decreased in 15 patients from 18,380 to 8647 units lipase/kg/day."	1.30	Maintenance of growth in cystic fibrosis despite reduction in pancreatic enzyme supplementation. ( Doull, IJ; Goodchild, MC; Lowdon, J; Ryley, HC, 1998)
" There was no relationship between enzyme dosage and colon thickness but simple regression identified a significant relationship (P < 0."	1.30	Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis. ( Atchley, JT; Connett, GJ; Fairhurst, JJ; Lucas, JS; Rolles, CJ, 1999)
" Patients with high dosage requirements could benefit from changing the pattern of their pancreatin supplementation."	1.30	Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis. ( Frier, M; Ghosal, S; Hillel, PG; Read, N; Senior, S; Taylor, CJ; Tindale, WB, 1999)
"Excessive dosage of pancreatic enzymes in cystic fibrosis (CF) patients can be associated with irreversible colonic stricture."	1.29	Cystic fibrosis and colonic strictures. A new "iatrogenic" disease. ( Lloyd-Still, JD, 1995)
"Biochemical vitamin E deficiency and low plasma lipids are frequent findings in patients with cystic fibrosis (CF)."	1.29	Response to a single oral dose of all-rac-alpha-tocopheryl acetate in patients with cystic fibrosis and in healthy individuals. ( Molinari, L; Shmerling, DH; Tuchschmid, PE; Winklhofer-Roob, BM, 1996)
"Pancreatic enzyme products are formulated, manufactured, and sold without submitting efficacy or bioavailability data to the Food and Drug Administration because of a quirk in the law."	1.28	Treatment failure after substitution of generic pancrelipase capsules. Correlation with in vitro lipase activity. ( Dorf, A; Hendeles, L; Stecenko, A; Weinberger, M, 1990)
"The uric acid excretion was lower than in the nocturnal period before the test."	1.28	Uric acid serum concentrations in CF-children after pancreatic enzyme supplementation. ( Ballke, EH; Paul, W; Wiersbitzky, S; Wolf, E, 1989)
"Patients with cystic fibrosis have been found to have abnormal serum concentrations of immunoreactive trypsin and abnormal activities of pancreatic isoamylase."	1.27	Serum pancreatic lipase activity in cystic fibrosis. ( Batten, JC; Dandona, P; Hodson, ME; Junglee, D; Katrak, A; Penketh, A, 1983)
" Based on the dissolution pH profiles of current enteric-coated pancreatic enzyme products, the duodenal postprandial pH in CF subjects may be too acidic to permit rapid dissolution of current enteric-coated dosage forms."	1.27	Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects. ( Amidon, GL; Berardi, RR; Dressman, JB; Howatt, WF; Hyneck, ML; Meyer, JH; Youngberg, CA, 1987)
"The article reports on a study to determine the influence of different dosage schedules of a pancreas enzyme preparation on the digestion of fat and protein and on the lipolytic, tryptic and chymotryptic activity of the faeces in children suffering from mucoviscidose."	1.26	[Digestion of fat and protein and its relation to the activity of faecal enzymes in mucoviscidosis infants under substitution therapy with pancreatic enzymes (author's transl)]. ( Kutschera, J; Lohmann, A; Tolckmitt, W, 1981)
"Patients with pancreatic insufficiency have a ravenous appetite but fail to thrive from malnutrition."	1.26	[Exocrine pancreatic insufficiency (author's transl)]. ( Götze, H, 1980)
"Two patients were diagnosed as having acute pancreatitis before the diagnosis of CF was made, thus indicating that acute pancreatitis may be the presenting complaint in the young adult with CF."	1.25	Recurrent acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymes. ( Khaw, KT; Lebenthal, E; Shwachman, H, 1975)

Research

Studies (228)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

Long Chain Polyunsaturated Fatty Acid Plasma Concentration (Intent to Treat Population)

Timeframe	Studies, this research(%)	All Research%
pre-1990	96 (42.11)	18.7374
1990's	82 (35.96)	18.2507
2000's	24 (10.53)	29.6817
2010's	23 (10.09)	24.3611
2020's	3 (1.32)	2.80

Authors	Studies
Olsen, MF	1
Kjøller-Svarre, MS	1
Møller, G	1
Katzenstein, TL	1
Nielsen, BU	1
Pressler, T	1
Lewis, JI	1
Mathiesen, IH	1
Mølgaard, C	1
Faurholt-Jepsen, D	1
Ganesh, PS	1
Vishnupriya, S	1
Vadivelu, J	1
Mariappan, V	1
Vellasamy, KM	1
Shankar, EM	1
Sathe, MN	1
Patel, D	1
Stone, A	1
First, E	1
Freedman, S	1
Orenstein, D	2
Black, P	1
Brown, P	1
McCoy, K	1
Stevens, J	1
Grujic, D	1
Clayton, R	1
Wang, GL	1
Zhao, CN	1
Zhou, J	1
Yu, FH	1
Shen, HQ	1
Zhang, J	1
Zhao, SY	1
Xu, XW	1
Hill, PJ	1
Scordo, JM	1
Arcos, J	1
Kirkby, SE	1
Wewers, MD	1
Wozniak, DJ	1
Torrelles, JB	1
Alkaade, S	1
Vareedayah, AA	1
Venuti, E	1
Shishmarev, D	1
Kuchel, PW	2
Dutt, S	1
Blumenthal, CS	1
Gaskin, KJ	4
Calvo-Lerma, J	2
Fornés-Ferrer, V	2
Peinado, I	1
Heredia, A	1
Ribes-Koninckx, C	2
Andrés, A	2
Hulst, J	1
Boon, M	1
Colombo, C	1
Masip, E	1
Ruperto, M	1
van der Wiel, E	1
Claes, I	1
Garriga, M	1
Roca, M	1
Crespo-Escobar, P	1
Bulfamante, A	1
Woodcock, S	1
Martínez-Barona, S	1
de Boeck, K	4
Borowitz, D	6
Gelfond, D	1
Maguiness, K	1
Heubi, JE	2
Ramsey, B	1
Haupt, ME	1
Kwasny, MJ	1
Schechter, MS	1
McColley, SA	1
Declercq, D	1
Van Biervliet, S	1
Robberecht, E	1
Mascarenhas, MR	1
Mondick, J	1
Barrett, JS	1
Wilson, M	1
Stallings, VA	2
Schall, JI	2
Woestenenk, JW	1
van der Ent, CK	1
Houwen, RH	1
Loli, H	1
Narwal, SK	1
Saun, NK	1
Gupta, R	1
van der Haak, N	1
Boase, J	1
Davidson, G	1
Butler, R	1
Miller, M	1
Kaambwa, B	1
Kritas, S	1
Schaeffer, D	1
Ahrens, RC	1
Sollo, N	1
Strausbaugh, S	1
Graff, G	1
Jain, R	1
Witte, S	1
Forssmann, K	1
Pompilio, A	1
Riviello, A	1
Crocetta, V	1
Di Giuseppe, F	1
Pomponio, S	1
Sulpizio, M	1
Di Ilio, C	1
Angelucci, S	1
Barone, L	1
Di Giulio, A	1
Di Bonaventura, G	1
Herzog, DC	1
Delvin, EE	1
Albert, C	1
Marcotte, JE	1
Pelletier, VA	1
Seidman, EG	1
Waljee, AK	1
Dimagno, MJ	1
Wu, BU	1
Schoenfeld, PS	1
Conwell, DL	1
Colin, DY	1
Deprez-Beauclair, P	1
Silva, N	1
Infantes, L	1
Kerfelec, B	1
Littlewood, JM	8
Connett, GJ	3
Sander-Struckmeier, S	1
Henniges, F	1
Kuo, P	1
Stevens, JE	1
Russo, A	1
Maddox, A	1
Wishart, JM	1
Jones, KL	1
Greville, H	1
Hetzel, D	1
Chapman, I	1
Horowitz, M	1
Rayner, CK	1
Wier, HA	1
Kuhn, RJ	1
Stevens, C	3
Brettman, LR	2
Campion, M	2
Chatfield, B	1
Cipolli, M	1
Wilschanski, M	2
Thompson, H	1
Proesmans, M	2
Virgilis, D	1
Rivkin, L	1
Samueloff, A	1
Picard, E	1
Goldberg, S	1
Faber, J	2
Kerem, E	3
BACHMANN, KD	1
WANG, DY	1
SLACK, J	1
NAIR, S	1
TRAISMAN, H	1
BECKER, G	1
MAHLER, S	1
HSIA, DY	2
STEIGMANN, F	1
SNYDER, D	1
FERNANDEZ, A	1
TURNER, EJ	1
JAKOVCIC, S	1
BRECKENRIDGE, RL	1
LYNCH, PV	1
ROSENBERG, IR	1
JANOWITZ, HD	1
SIGLER, RM	1
REEVES, HH	1
LYNN, HB	1
BURKE, EC	1
Symonds, EL	1
Omari, TI	1
Webster, JM	1
Davidson, GP	2
Butler, RN	1
Armand, M	1
Hamosh, M	1
Philpott, JR	1
Resnik, AK	1
Rosenstein, BJ	3
Hamosh, A	1
Perman, JA	1
Hamosh, P	1
Walkowiak, J	2
Nousia-Arvanitakis, S	1
Lisowska, A	2
Piotrowski, R	1
Strzykala, K	1
Bychowiec, B	1
Songin, T	1
Galli-Tsinopoulou, A	1
Sands, D	1
Pidonia, I	1
Krawczynski, M	2
Milanowski, A	1
Herzig, KH	2
Przyslawski, J	1
Grzymislawski, M	1
Mosler, K	1
von Kries, R	1
Vermeer, C	1
Saupe, J	1
Schmitz, T	1
Schuster, A	1
Konstan, MW	3
Stern, RC	1
Trout, JR	1
Sherman, JM	1
Eigen, H	1
Wagener, JS	1
Duggan, C	1
Wohl, ME	1
Colin, P	1
Weren, M	1
Kalnins, D	1
Corey, M	4
Ellis, L	1
Durie, PR	9
Pencharz, PB	1
Monroe, L	1
Nowicki, M	1
Giles, H	1
Ruiz, F	1
Goss, CH	2
Hayes, D	1
Newman, L	1
O'Rourke, A	1
Wagener, J	1
Moss, R	1
Hendeles, L	3
Ahrens, R	1
Oermann, CM	1
Aitken, ML	1
Mahl, TC	1
Young, KR	1
Dunitz, J	1
Murray, FT	2
Limauro, S	1
Blake, K	1
Casey, S	1
Quittner, AL	1
Bentley, T	1
Dalal, S	1
Singh, PK	1
Raghava, S	1
Rawat, S	1
Gupta, MN	1
Ingomar, CJ	1
Terslev, E	1
Gow, R	1
Bradbear, R	1
Francis, P	1
Shepherd, R	1
Hammond, KB	2
Ask, CG	1
Watts, DC	1
Niessen, KH	1
Shaul, S	1
Goldstein, R	1
Levy, E	1
Bronza, N	1
Freier, S	1
Dockter, G	1
Sitzmann, FC	1
Götze, H	1
Longnecker, DS	1
Piantino, P	1
Garrone, C	1
Gallo, V	1
Pecchio, F	1
Corno, F	1
Bonardi, O	1
Cattaneo, U	1
Junglee, D	1
Penketh, A	1
Katrak, A	1
Hodson, ME	2
Batten, JC	3
Dandona, P	1
Forstner, G	3
Gaskin, K	1
Durie, P	4
Weber, AM	3
Roy, CC	3
Langbaum, TS	1
Lee, L	1
Hill, R	1
Forstner, GG	5
Tolckmitt, W	1
Lohmann, A	1
Kutschera, J	1
Mitchell, EA	1
Quested, C	1
Marks, RE	1
Pinnock, RE	1
Elliott, RB	2
Cameron, DJ	1
Pitcher-Wilmott, R	1
Milla, PJ	2
More, J	1
Ghale, GK	1
Matthew, DJ	2
Harries, JT	2
Fredrikzon, B	2
Hernell, O	1
Bläckberg, L	2
Muller, DP	2
Stafford, RJ	1
Grand, RJ	3
Hill, RE	1
Adriaenssens, K	1
Van Riel, L	1
Warwick, WJ	1
Budd, JR	1
Mischler, EH	1
Parrell, S	1
Farrell, PM	1
Odell, GB	1
Roulet, M	1
Paradis, Y	1
Chartrand, L	1
Lasalle, R	2
Morin, CL	2
Pivetta, OH	1
Vaccaro, MI	1
Maillie, AJ	1
Boyle, BJ	1
Long, WB	1
Balistreri, WF	1
Widzer, SJ	1
Huang, N	1
Bell, L	1
Linton, W	1
Corey, ML	2
Smyth, RL	2
Ashby, D	1
O'Hea, U	1
Burrows, E	1
Lewis, P	1
van Velzen, D	3
Dodge, JA	4
Croft, NM	1
Marshall, TG	1
Ferguson, A	1
Oades, PJ	2
Bush, A	2
Ong, PS	1
Brereton, RJ	1
Burdge, GC	1
Goodale, AJ	1
Hill, CM	1
Halford, PJ	1
Lambert, EJ	1
Postle, AD	1
Rolles, CJ	4
Mac Sweeney, EJ	1
Buchdahl, R	1
Rosenthal, M	1
Jones, R	1
Franklin, K	1
Spicer, R	1
Berry, J	1
Lloyd-Still, JD	3
Tomasik, P	1
Tursi, JM	2
Phair, PG	2
Barnes, GL	2
Pedroli, G	1
Liechti-Gallati, S	1
Mauri, S	1
Birrer, P	1
Kraemer, R	1
Foletti-Jäggi, C	1
Bianchetti, MG	1
Briars, GL	1
Dean, TP	1
Murphy, JL	2
Warner, JO	1
Bowler, IM	1
Wolfe, SP	2
Owens, HM	1
Sheldon, TA	1
Walters, MP	4
Shah, A	1
Dinwiddie, R	1
Madge, S	1
Prescott, P	1
Hudson, G	1
Gan, KH	1
Heijerman, HG	1
Geus, WP	1
Bakker, W	1
Lamers, CB	2
Macpherson, C	1
Beker, LT	1
Fink, RJ	1
Shamsa, FH	1
Chaney, HR	1
Kluft, J	1
Evans, E	1
Schidlow, DV	2
Smyth, AR	1
Lloyd, DA	1
Heaf, DP	1
Taylor, CJ	3
Pettei, MJ	1
Leonidas, JC	1
Levine, JJ	1
Gorvoy, JD	1
Jones, NL	1
Hofley, PM	1
Zylberberg, P	1
Delchier, JC	1
Kraisinger, M	1
Hochhaus, G	1
Stecenko, A	2
Bowser, E	1
Ramakrishna, J	1
Henker, J	2
Hoffmann, D	1
Paul, D	1
Hein, J	1
Paditz, E	1
Doull, I	1
Langton-Hewer, S	1
Winklhofer-Roob, BM	2
Tuchschmid, PE	2
Molinari, L	1
Shmerling, DH	4
Freiman, JP	1
FitzSimmons, SC	2
Kapadia, C	1
Regele, S	1
Münch, R	2
Barbier, Y	1
Stern, M	1
Lancellotti, L	1
Cabrini, G	1
Zanolla, L	1
Mastella, G	1
Barraclough, M	1
Ip, WF	1
Bronsveld, I	1
Kent, G	1
Seal, S	1
McClean, P	1
Walters, M	1
Harding, M	2
Coward, W	1
Reichard, KW	1
Vinocur, CD	2
Franco, M	1
Crisci, KL	2
Flick, JA	1
Billmire, DF	1
Weintraub, WH	1
Gavin, J	1
Ellis, J	1
Dewar, AL	1
Greenberg, SB	1
Wolfson, BJ	1
Geller, E	1
Pawel, BR	1
de Chadarévian, JP	1
Franco, ME	1
Burkhart, GA	1
Hammerstrom, T	1
Lowenfels, AB	1
Amarri, S	2
Coward, WA	1
Evans, TJ	1
Weaver, LT	2
Lee, J	1
Ip, W	1
Pohl, M	1
Krackhardt, B	1
Posselt, HG	1
Lembcke, B	1
Swart, GR	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
A 90 Day, Phase 3, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on Parenteral Nutrition[NCT03530852]		32 participants (Anticipated)	Interventional	2018-11-21	Recruiting
Study to Evaluate Safety, Tolerability and Fat Absorption Using a Novel Enteral Feeding In-line Digestive Enzyme Cartridge (RELIZORB) in Patients With Cystic Fibrosis Receiving Enteral Feeding[NCT02598128]		34 participants (Actual)	Interventional	2015-11-30	Completed
A 90 Day Observational Study as an Extension to the Phase 3, Open Labeled, Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on PN[NCT05635747]		32 participants (Anticipated)	Observational	2022-09-29	Enrolling by invitation
Proton Pump Inhibitors (PPI) and Fat Absorption in Subjects With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)[NCT03551691]	Phase 2	19 participants (Actual)	Interventional	2018-08-07	Completed
A Randomized, Double-blind, Multicenter, Two-period Crossover Study to Assess the Efficacy and Tolerability of NM-BL (Burlulipase) in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis[NCT01710644]	Phase 1/Phase 2	35 participants (Actual)	Interventional	2013-05-31	Completed
A Single-Center Prospective Randomized Placebo Controlled Trial of Pancreatic Enzyme Supplements (Pancrelipase) for Treating Pain in Patients With Chronic Pancreatitis[NCT02706236]	Phase 2	0 participants (Actual)	Interventional	2016-04-30	Withdrawn (stopped due to no funding was awarded)
The Incidence of Pancreatic Exocrine Insufficiency and the Benefits of Pancreatic Enzyme Supplementation in Critically Ill Adult Patients[NCT01753024]		362 participants (Actual)	Observational [Patient Registry]	2012-01-31	Completed
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Crossover Study to Evaluate the Effectiveness and Safety of PANCRECARB® MS-16 (Pancrelipase) in Reducing Steatorrhea in Children and Adults With Cystic Fibrosis[NCT00432861]	Phase 3	29 participants (Actual)	Interventional	2007-01-31	Completed
A Phase III Randomized Double Blind Placebo Controlled Trial of CM-AT in Children With Autism[NCT00881452]	Phase 3	182 participants (Actual)	Interventional	2009-05-31	Completed
Evaluation of Physiological Responses During the Use of Interactive Video Game and the Cardiopulmonary Exercise Test in Cystic Fibrosis and Healthy Individuals[NCT03229213]		55 participants (Actual)	Observational	2017-08-30	Completed
Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536]	Phase 2	110 participants (Actual)	Interventional	2007-01-31	Completed
A Pilot Study Evaluating Single, High-dose Pharmacokinetics/Pharmacodynamics of Vitamin D3 in CF[NCT03734744]		6 participants (Actual)	Interventional	2019-06-17	Terminated (stopped due to Clinical research currently on hold)
Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis[NCT00956839]	Phase 4	40 participants (Actual)	Interventional	2009-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

AUC analysis of plasma fatty acid concentration for DHA + EPA baseline adjusted over 24-hours (NCT02598128)
Timeframe: Day 1 first intervention and Day 9 second intervention.

Ease of Use of RELiZORB (Per-Protocol Population)

Intervention	ug*h/mL (Mean)
RELiZORB	536.98
Control	192.18

Effect of enteral nutrition on select activities of daily living. Patients judged the size of breakfast after overnight enteral tube feeding with the following choices: No breakfast; Small breakfast; Normal breakfast; Big breakfast; Other. (NCT02598128)
Timeframe: Period C: Single assessment on Day 19 or 20

Number of Patients With Adverse Events and Unanticipated Adverse Device Effects

Intervention	Participants (Count of Participants)
	No breakfast	Small breakfast	Normal breakfast	Big breakfast	Other
Clinical Treatment Practice and Relizorb: Period C: Days 12-20	11	14	6	0	1

1) Frequency and severity of adverse events; 2) Patients with at least one unanticipated adverse device effects (UADE) (NCT02598128)
Timeframe: 27 days

Percentage of Patients With Serum 25 Hydroxy Vitamin D3 > 30 ng/ml

Intervention	Participants (Count of Participants)
	Patients With Adverse Events	Adverse Event by Severity (Mild)	Adverse Event by Severity (Moderate)	Adverse Event by Severity (Severe)	Patients With At Least One UADE
Clinical Treatment Practice + RELiZORB: Period C: Days 12-20	2	0	1	1	0
Clinical Treatment Practice: Period A: Days -7 to -1	4	2	2	0	0
Crossover Period B: Placebo	6	6	0	0	0
Crossover Period B: RELiZORB	1	1	0	0	0

Percentage of patients in each group with serum 25 hydroxy vitamin D >30 ng/ml (NCT00956839)
Timeframe: 6 months post intervention

Serum Total Calcium

Intervention	percentage of patients (Number)
IM Vitamin D3 3,00,000 Units	85
IM Vitamin D3 6,00,000 Units	29
Oral Vitamin D3	0

Serum total calcium (mg/dL) at time points 0, 1, 3 and 6 months (NCT00956839)
Timeframe: 0, 1, 3, 6 months post intervention

Reviews

21 reviews available for 1-anilino-8-naphthalenesulfonate and Cystic Fibrosis of Pancreas

Trials

39 trials available for 1-anilino-8-naphthalenesulfonate and Cystic Fibrosis of Pancreas

Other Studies

169 other studies available for 1-anilino-8-naphthalenesulfonate and Cystic Fibrosis of Pancreas

Intervention	mg/dL (Mean)
	baseline	1 month	3 months	6 months
IM Vitamin D3 3,00,000 Units	9.20	9.28	9.40	9.40
IM Vitamin D3 6,00,000 Units	9.56	9.52	9.44	9.40
Oral Vitamin D3	9.24	9.28	9.40	9.28

Article	Year
Intracellular survival and innate immune evasion of Burkholderia cepacia: Improved understanding of quorum sensing-controlled virulence factors, biofilm, and inhibitors. Microbiology and immunology, 2020, Volume: 64, Issue:2 Topics: Animals; Biofilms; Burkholderia cepacia; Burkholderia cepacia complex; Burkholderia Infections; Comm	2020
A primer on exocrine pancreatic insufficiency, fat malabsorption, and fatty acid abnormalities. The American journal of managed care, 2017, Volume: 23, Issue:12 Suppl Topics: Age Factors; Age of Onset; Cystic Fibrosis; Dietary Fats; Digestive System Surgical Procedures; Enzy	2017
Lipases in Medicine: An Overview. Mini reviews in medicinal chemistry, 2015, Volume: 15, Issue:14 Topics: Alzheimer Disease; Animals; Atherosclerosis; Cystic Fibrosis; Humans; Lipase; Medicine; Neoplasms; O	2015
Systematic review: pancreatic enzyme treatment of malabsorption associated with chronic pancreatitis. Alimentary pharmacology & therapeutics, 2009, Feb-01, Volume: 29, Issue:3 Topics: Amylases; Biological Availability; Cystic Fibrosis; Enzyme Therapy; Feces; Female; Humans; Lipase; M	2009
Pancreatic enzyme supplementation. Current opinion in pediatrics, 2011, Volume: 23, Issue:5 Topics: Amylases; Cystic Fibrosis; Drug Approval; Enzyme Replacement Therapy; Exocrine Pancreatic Insufficie	2011
THE PANCREAS. IV. Gastroenterology, 1965, Volume: 48 Topics: Amylases; Anatomy; Aprotinin; Cystic Fibrosis; Hypothermia; Hypothermia, Induced; Iron; Lipase; Panc	1965
[Diseases of the exocrine pancreas in infants and children. A review. 1. Organic pancreatic diseases]. Fortschritte der Medizin, 1980, Feb-28, Volume: 98, Issue:8 Topics: Amino Acid Metabolism, Inborn Errors; Amylases; Child, Preschool; Cholecystokinin; Cystic Fibrosis;	1980
[Examination of pancreatic function in children with special reference to the PABA-test (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1980, Volume: 128, Issue:12 Topics: 4-Aminobenzoic Acid; Acute Disease; Aminobenzoates; Amylases; Child; Child, Preschool; Chronic Disea	1980
Disorders of lipid absorption. Clinics in gastroenterology, 1982, Volume: 11, Issue:1 Topics: Abetalipoproteinemia; Abnormalities, Multiple; Bile Acids and Salts; Bile Ducts; Celiac Disease; Chi	1982
Hereditary disease of the exocrine pancreas. Clinics in gastroenterology, 1982, Volume: 11, Issue:1 Topics: Adolescent; Adult; alpha 1-Antitrypsin Deficiency; Child; Child, Preschool; Cystic Fibrosis; Exocrin	1982
[The physiological and pathologic role of human gastric lipase]. Przeglad lekarski, 1995, Volume: 52, Issue:6 Topics: Adult; Aging; Child; Cystic Fibrosis; Dietary Fats; Humans; Infant; Lipase; Lipolysis; Neoplasms; Pa	1995
Colonic strictures in cystic fibrosis. Journal of the Royal Society of Medicine, 1995, Volume: 88 Suppl 25 Topics: Colonic Diseases; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Humans; Intestinal Diseases; I	1995
[Treatment of exocrine pancreatic insufficiency: what gastroprotection do pancreatic enzymes provide?]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:11 Topics: Adolescent; Adult; Antacids; Capsules; Child; Chronic Disease; Cystic Fibrosis; Enzymes, Immobilized	1993
Clinical pharmacology of pancreatic enzymes in patients with cystic fibrosis and in vitro performance of microencapsulated formulations. Journal of clinical pharmacology, 1994, Volume: 34, Issue:2 Topics: Adolescent; Chemistry, Pharmaceutical; Child; Child, Preschool; Cystic Fibrosis; Exocrine Pancreatic	1994
The pathology of fibrosing colonopathy of cystic fibrosis: a study of 12 cases and review of the literature. Human pathology, 1997, Volume: 28, Issue:4 Topics: Biopsy; Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis; Female; Humans; Infant; I	1997
Current management of cystic fibrosis. Advances in pediatrics, 1976, Volume: 23 Topics: Adolescent; Adult; Aerosols; Amylases; Bronchodilator Agents; Child; Child, Preschool; Cystic Fibros	1976
Pancreatic enzyme replacement therapy. The American journal of the medical sciences, 1989, Volume: 298, Issue:5 Topics: Adult; Capsules; Celiac Disease; Child; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Humans;	1989
Nutritional management and pancreatic enzyme therapy in cystic fibrosis patients: state of the art in 1987 and projections into the future. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Body Constitution; Celiac Disease; Cystic Fibrosis; Forecasting; Humans; Lipase; Microspheres; Pancr	1988
[Comparative study of the effect of kreon and cotazyme forte in children with cystic fibrosis]. Orvosi hetilap, 1988, May-08, Volume: 129, Issue:19 Topics: Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Drug Evaluation; Fe	1988
Chronic diarrhea in infants and children. I. Southern medical journal, 1973, Volume: 66, Issue:9 Topics: Adolescent; Bile Acids and Salts; Child; Child, Preschool; Chronic Disease; Cystic Fibrosis; Diarrhe	1973
Current concepts: pancreatic extracts. The New England journal of medicine, 1969, Jul-24, Volume: 281, Issue:4 Topics: Adolescent; Adult; Animals; Bicarbonates; Cattle; Celiac Disease; Child; Cystic Fibrosis; Dietary Fa	1969

Article	Year
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Double-	2017
Malabsorption blood test: Assessing fat absorption in patients with cystic fibrosis and pancreatic insufficiency. Journal of clinical pharmacology, 2015, Volume: 55, Issue:8 Topics: Adolescent; Adult; Child; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Fatty Acids; Female; H	2015
Preliminary report of the (13)C-mixed triglyceride breath test to assess timing of pancreatic enzyme replacement therapy in children with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2016, Volume: 15, Issue:5 Topics: Adolescent; Breath Tests; Child; Cystic Fibrosis; Dietary Fats; Drug Administration Schedule; Enzyme	2016
Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial. The Journal of pediatrics, 2016, Volume: 176 Topics: Adolescent; Child; Cross-Over Studies; Cystic Fibrosis; Double-Blind Method; Exocrine Pancreatic Ins	2016
Gastric emptying, incretin hormone secretion, and postprandial glycemia in cystic fibrosis--effects of pancreatic enzyme supplementation. The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:5 Topics: Adult; Blood Glucose; Cystic Fibrosis; Dietary Carbohydrates; Dietary Fats; Double-Blind Method; Fem	2011
International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2011, Volume: 10, Issue:6 Topics: Adolescent; Adult; Amylases; Child; Cystic Fibrosis; Double-Blind Method; Enzyme Replacement Therapy	2011
Liprotamase long-term safety and support of nutritional status in pancreatic-insufficient cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:2 Topics: Adolescent; Adult; Amylases; Child; Cystic Fibrosis; Drug Administration Schedule; Enzyme Replacemen	2012
Ultrase MT12 and Ultrase MT20 in the treatment of exocrine pancreatic insufficiency in cystic fibrosis: safety and efficacy. Alimentary pharmacology & therapeutics, 2004, Volume: 20, Issue:11-12 Topics: Adolescent; Adult; Aged; Child; Cross-Over Studies; Cystic Fibrosis; Double-Blind Method; Exocrine P	2004
Combining unprotected pancreatic enzymes with pH-sensitive enteric-coated microspheres does not improve nutrient digestion in patients with cystic fibrosis. The Journal of pediatrics, 2005, Volume: 146, Issue:4 Topics: Adolescent; Amylases; Child; Child, Preschool; Cross-Over Studies; Cystic Fibrosis; Female; Gastroin	2005
Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients. Pancreas, 2006, Volume: 32, Issue:3 Topics: Adolescent; Adult; Amylases; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Female; Humans; Lip	2006
Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis. The Journal of pediatrics, 2006, Volume: 149, Issue:5 Topics: Adolescent; Adult; Amylases; Analysis of Variance; Blood Glucose; Child; Cystic Fibrosis; Dose-Respo	2006
Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine. Lancet (London, England), 1981, Nov-14, Volume: 2, Issue:8255 Topics: Adolescent; Antacids; Celiac Disease; Child; Cimetidine; Clinical Trials as Topic; Cystic Fibrosis;	1981
The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis. Human nutrition. Clinical nutrition, 1982, Volume: 36, Issue:6 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Double-Blind Method; Gastric Acid;	1982
Comparison of effectiveness of pancreatic enzyme preparations in cystic fibrosis. American journal of diseases of children (1960), 1982, Volume: 136, Issue:12 Topics: Adolescent; Child; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Humans; Lipase; Malabsorption	1982
Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis. Gastroenterology, 1980, Volume: 78, Issue:5 Pt 1 Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Diet; Drug Com	1980
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut, 1980, Volume: 21, Issue:9 Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The	1980
A double blind lipase for lipase comparison of a high lipase and standard pancreatic enzyme preparation in cystic fibrosis. Archives of disease in childhood, 1993, Volume: 68, Issue:2 Topics: Adolescent; Amylases; Bromelains; Capsules; Child; Child, Preschool; Cystic Fibrosis; Double-Blind M	1993
High dose Nutrizym 22 in cystic fibrosis. European journal of pediatrics, 1993, Volume: 152, Issue:9 Topics: Adolescent; Amylases; Analysis of Variance; Bromelains; Child; Cystic Fibrosis; Double-Blind Method;	1993
Comparison of a high lipase pancreatic enzyme extract with a regular pancreatin preparation in adult cystic fibrosis patients. Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:6 Topics: Adult; Cystic Fibrosis; Feces; Female; Humans; Lipase; Lipid Metabolism; Male; Middle Aged; Nitrogen	1994
Comparison of weight-based dosages of enteric-coated microtablet enzyme preparations in patients with cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1994, Volume: 19, Issue:2 Topics: Absorption; Adolescent; Adult; Body Weight; Celiac Disease; Child; Child, Preschool; Cross-Over Stud	1994
Indirect parameters of pancreatic function in cystic fibrosis (CF) during a controlled double-blind trial of pancreatic supplementation. Journal of pediatric gastroenterology and nutrition, 1996, Volume: 22, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Chymotrypsin; Cystic Fibrosis; Double-Blind Method; Exoc	1996
High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. Journal of pediatric gastroenterology and nutrition, 1996, Volume: 22, Issue:1 Topics: Adolescent; Adult; Child; Cross-Over Studies; Cystic Fibrosis; Dietary Fats; Exocrine Pancreatic Ins	1996
Lipid digestion in cystic fibrosis: comparison of conventional and high-lipase enzyme therapy using the mixed-triglyceride breath test. Journal of pediatric gastroenterology and nutrition, 1998, Volume: 26, Issue:4 Topics: Adolescent; Breath Tests; Caprylates; Carbon Isotopes; Child; Cystic Fibrosis; Dietary Fats; Digesti	1998
Colonic changes in cystic fibrosis: clinical-ultrasonographic features and their value for treatment. Italian journal of gastroenterology and hepatology, 1998, Volume: 30, Issue:2 Topics: Adolescent; Adult; Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis; Dose-Response	1998
Colonic wall thickness, pancreatic enzyme dose and type of preparation in cystic fibrosis. Archives of disease in childhood, 1998, Volume: 79, Issue:4 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Colon; Cystic Fibrosis; Female; Humans; I	1998
Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis. Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:5 Topics: Adolescent; Adult; Chemistry, Pharmaceutical; Child; Child, Preschool; Cystic Fibrosis; Dose-Respons	1992
A comparison of two pancreatin microsphere preparations in cystic fibrosis. The New Zealand medical journal, 1992, Mar-25, Volume: 105, Issue:930 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats; Double-Blind Method; Energy Inta	1992
Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis. Pancreas, 1992, Volume: 7, Issue:3 Topics: Acids; Adult; Aspergillus niger; Celiac Disease; Cystic Fibrosis; Dietary Fats; Fungal Proteins; Hum	1992
A comparison of enteric coated microspheres with enteric coated tablet pancreatic enzyme preparations in cystic fibrosis. A controlled study. European journal of pediatrics, 1990, Volume: 149, Issue:4 Topics: Adolescent; Amylases; Analysis of Variance; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis	1990
Two enteric coated microspheres in cystic fibrosis. Archives of disease in childhood, 1990, Volume: 65, Issue:6 Topics: Adolescent; Body Weight; Capsules; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats; Exocrine	1990
In vivo and in vitro studies of microsphere pancreatic supplements. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Adolescent; Adult; Albumins; Amylases; Bile Acids and Salts; Biological Availability; Child; Cystic	1988
High compared with standard dose lipase pancreatic supplement. Archives of disease in childhood, 1989, Volume: 64, Issue:1 Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Delayed-Action Prepa	1989
Efficacy of pancrease: crossover comparative study versus eurobiol in cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Adolescent; Biological Availability; Celiac Disease; Child; Clinical Trials as Topic; Cystic Fibrosi	1988
Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Adolescent; Age Factors; Celiac Disease; Child; Child, Preschool; Cimetidine; Clinical Trials as Top	1988
Critical examination of therapeutic efficacy of a pH-sensitive enteric-coated pancreatic enzyme preparation in treatment of exocrine pancreatic insufficiency secondary to cystic fibrosis. Digestive diseases and sciences, 1988, Volume: 33, Issue:10 Topics: Adult; Cystic Fibrosis; Delayed-Action Preparations; Drug Evaluation; Duodenum; Exocrine Pancreatic	1988
[Comparative study of the effect of kreon and cotazyme forte in children with cystic fibrosis]. Orvosi hetilap, 1988, May-08, Volume: 129, Issue:19 Topics: Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Drug Evaluation; Fe	1988
Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis. Gut, 1985, Volume: 26, Issue:9 Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Chemical Precipitation; Cimetidine; Cystic	1985
[Comparative double blind experience of a polyenzymatic preparation in chronic pancreatic insufficiency (author's transl)]. Acta gastro-enterologica Belgica, 1973, Volume: 36, Issue:9 Topics: Adolescent; Adult; Amylases; Bromelains; Celiac Disease; Chronic Disease; Clinical Trials as Topic;	1973
Comparative trial of pancrex V forte and nutrizym in treatment of malabsorption in cystic fibrosis. British medical journal, 1974, Sep-21, Volume: 3, Issue:5933 Topics: Adolescent; Amylases; Bromelains; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis	1974

Article	Year
Correlates of Pancreatic Enzyme Replacement Therapy Intake in Adults with Cystic Fibrosis: Results of a Cross-Sectional Study. Nutrients, 2022, Mar-22, Volume: 14, Issue:7 Topics: Adult; Cross-Sectional Studies; Cystic Fibrosis; Enzyme Replacement Therapy; Exocrine Pancreatic Ins	2022
Evaluation of the Effectiveness of In-line Immobilized Lipase Cartridge in Enterally Fed Patients With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2021, 01-01, Volume: 72, Issue:1 Topics: Adolescent; Adult; Body Weight; Child; Child, Preschool; Cystic Fibrosis; Enteral Nutrition; Humans;	2021
[Clinical analysis of 11 children with pancreatic cystic fibrosis]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2017, May-04, Volume: 55, Issue:5 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Diarrhea; Female; Genetic Testing; Humans; Inf	2017
Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells. Scientific reports, 2017, 07-06, Volume: 7, Issue:1 Topics: Adolescent; Adult; Biofilms; Bronchoalveolar Lavage Fluid; Cell Wall; Child; Cystic Fibrosis; Female	2017
Bile salt stimulated lipase: Inhibition by phospholipids and relief by phospholipase A Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017, Volume: 16, Issue:6 Topics: Cystic Fibrosis; Dietary Fats; Exocrine Pancreatic Insufficiency; Humans; Lipase; Magnetic Resonance	2017
A first approach for an evidence-based in vitro digestion method to adjust pancreatic enzyme replacement therapy in cystic fibrosis. PloS one, 2019, Volume: 14, Issue:2 Topics: Computer Simulation; Cystic Fibrosis; Digestion; Enzyme Replacement Therapy; Evidence-Based Medicine	2019
Clinical validation of an evidence-based method to adjust Pancreatic Enzyme Replacement Therapy through a prospective interventional study in paediatric patients with Cystic Fibrosis. PloS one, 2019, Volume: 14, Issue:3 Topics: Adolescent; Age Factors; Body Mass Index; Child; Cystic Fibrosis; Diet; Dietary Fats; Enzyme Replace	2019
Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: a reconsideration. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2013, Volume: 12, Issue:6 Topics: Cystic Fibrosis; Enzyme Replacement Therapy; Humans; Infant; Infant Nutritional Physiological Phenom	2013
Pancreatic enzyme replacement therapy dosing and nutritional outcomes in children with cystic fibrosis. The Journal of pediatrics, 2014, Volume: 164, Issue:5 Topics: Adolescent; Body Mass Index; Child; Child, Preschool; Cystic Fibrosis; Drug Administration Schedule;	2014
Nutrition and pancreatic enzyme intake in patients with cystic fibrosis with distal intestinal obstruction syndrome. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2015, Volume: 30, Issue:1 Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats; Eat	2015
Pancreatic Enzyme Replacement Therapy and Coefficient of Fat Absorption in Children and Adolescents With Cystic Fibrosis. Journal of pediatric gastroenterology and nutrition, 2015, Volume: 61, Issue:3 Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Cystic Fibrosis; Diet Records; Enzyme	2015
Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus. Future microbiology, 2016, Volume: 11 Topics: Adhesins, Bacterial; Anti-Bacterial Agents; Bacterial Proteins; Benzofurans; Biofilms; Carrier Prote	2016
13C-labeled mixed triglyceride breath test (13C MTG-BT) in healthy children and children with cystic fibrosis (CF) under pancreatic enzyme replacement therapy (PERT): a pilot study. Clinical biochemistry, 2008, Volume: 41, Issue:18 Topics: Adolescent; Breath Tests; Child; Cystic Fibrosis; Female; Humans; Lipase; Male; Pancreas; Pilot Proj	2008
Modification of pancreatic lipase properties by directed molecular evolution. Protein engineering, design & selection : PEDS, 2010, Volume: 23, Issue:5 Topics: Amino Acid Substitution; Base Sequence; Cystic Fibrosis; Directed Molecular Evolution; DNA Primers;	2010
New drug information: Zenpep. JAAPA : official journal of the American Academy of Physician Assistants, 2010, Volume: 23, Issue:4 Topics: Amylases; Animals; Cystic Fibrosis; Lipase; Pancreas; Peptide Hydrolases; Swine	2010
A 2-year post-authorization safety study of high-strength pancreatic enzyme replacement therapy (pancreatin 40,000) in cystic fibrosis. Expert opinion on drug safety, 2011, Volume: 10, Issue:2 Topics: Adolescent; Adult; Body Weight; Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Female; Ga	2011
Evaluation of dietary fiber intake in Belgian children with cystic fibrosis: is there a link with gastrointestinal complaints? Journal of pediatric gastroenterology and nutrition, 2002, Volume: 35, Issue:5 Topics: Adolescent; Adult; Belgium; Child; Child, Preschool; Constipation; Cystic Fibrosis; Diet Surveys; Di	2002
Cystic fibrosis, pregnancy, and recurrent, acute pancreatitis. Journal of pediatric gastroenterology and nutrition, 2003, Volume: 36, Issue:4 Topics: Acute Disease; Adult; Amylases; Cesarean Section; Cystic Fibrosis; Female; Gestational Age; Humans;	2003
[On indirect evaluation of lipase activity by oral administration of iodized oil]. Zeitschrift fur Kinderheilkunde, 1960, Volume: 84 Topics: Administration, Oral; Cystic Fibrosis; Humans; Iodized Oil; Lipase	1960
Lipoprotein lipase in cystic fibrosis of the pancreas. The Journal of laboratory and clinical medicine, 1962, Volume: 59 Topics: Cystic Fibrosis; Humans; Lipase; Lipoprotein Lipase; Lipoproteins	1962
Pancreatic enzyme replacement therapy in malabsorption of pancreatic, hepatic, and gastric origin. The American journal of digestive diseases, 1962, Volume: 7 Topics: Celiac Disease; Cystic Fibrosis; Disease; Enzyme Replacement Therapy; Enzyme Therapy; Enzymes; Gallb	1962
Symptomatic treatment of mucoviscidosis with IMP 39. Applied therapeutics, 1962, Volume: 4 Topics: Amylases; Cystic Fibrosis; Humans; Inosine Monophosphate; Lipase; Trypsin	1962
Studies on mechanism for decreased lipoprotein lipase in cystic fibrosis of the pancrease. The Journal of pediatrics, 1963, Volume: 62 Topics: Cystic Fibrosis; Humans; Lipase; Lipoprotein Lipase; Lipoproteins; Pancrelipase	1963
LABORATORY DIAGNOSIS OF PANCREATIC DISEASE. GP, 1964, Volume: 30 Topics: Amylases; Clinical Enzyme Tests; Cystic Fibrosis; Disease; Feces; Humans; Intubation; Intubation, Ga	1964
CYSTIC FIBROSIS WITH FECAL RETENTION (MECONIUM ILEUS EQUIVALENT): REPORT OF TWO CASES. Mayo Clinic proceedings, 1965, Volume: 40 Topics: Adolescent; Child; Cystic Fibrosis; Diagnosis; Diet; Diet Therapy; Drug Therapy; Feces; Humans; Ileu	1965
Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosis. The Journal of pediatrics, 2003, Volume: 143, Issue:6 Topics: Adolescent; Breath Tests; Caprylates; Child; Cystic Fibrosis; Dietary Fats; Digestion; Female; Gastr	2003
Gastric function in children with cystic fibrosis: effect of diet on gastric lipase levels and fat digestion. Pediatric research, 2004, Volume: 55, Issue:3 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Diet; Fats; Female; Gastric Emptying; Humans;	2004
Serum lipase after secretin stimulation detects mild pancreatic involvement in cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 2004, Volume: 38, Issue:4 Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Child; Cystic Fibrosis; Exocrine Pancreatic Ins	2004
Faecal elastase-1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis. Acta paediatrica (Oslo, Norway : 1992), 2004, Volume: 93, Issue:8 Topics: Adolescent; Adult; Case-Control Studies; Child; Cystic Fibrosis; Feces; Female; Humans; Lipase; Male	2004
Assessment of vitamin K deficiency in CF--how much sophistication is useful? Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2003, Volume: 2, Issue:2 Topics: Adolescent; Adult; Apolipoproteins E; Biomarkers; Bone Diseases, Metabolic; Case-Control Studies; Ch	2003
Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype. Pediatrics, 2005, Volume: 115, Issue:4 Topics: Adult; Amylases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exocrine Panc	2005
Clinical quiz. Diagnosis: fibrosing colonopathy. Journal of pediatric gastroenterology and nutrition, 2006, Volume: 42, Issue:3 Topics: Barium Sulfate; Colon; Constriction, Pathologic; Contrast Media; Cystic Fibrosis; Dose-Response Rela	2006
Meal patterns, dietary fat intake and pancreatic enzyme use in preadolescent children with cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 2006, Volume: 43, Issue:5 Topics: Anthropometry; Child; Cystic Fibrosis; Dietary Fats; Energy Intake; Exocrine Pancreatic Insufficienc	2006
Purification and properties of the alkaline lipase from Burkholderia cepacia A.T.C.C. 25609. Biotechnology and applied biochemistry, 2008, Volume: 51, Issue:Pt 1 Topics: Base Sequence; Burkholderia cepacia; Circular Dichroism; Cystic Fibrosis; Detergents; Electrophoresi	2008
Chronic diarrhoeas in infancy and childhood. II. Enzyme content of duodenal juice. Archives of disease in childhood, 1967, Volume: 42, Issue:223 Topics: Amylases; Celiac Disease; Child; Child, Preschool; Chronic Disease; Cystic Fibrosis; Diarrhea; Diarr	1967
Immunoreactive pancreatic lipase test for neonatal detection of cystic fibrosis. Lancet (London, England), 1984, Jan-07, Volume: 1, Issue:8367 Topics: Clinical Enzyme Tests; Cystic Fibrosis; Humans; Infant, Newborn; Lipase; Pancreas	1984
Serum lipase and trypsin in neonatal detection of cystic fibrosis. Lancet (London, England), 1984, Apr-28, Volume: 1, Issue:8383 Topics: Age Factors; Clinical Enzyme Tests; Cystic Fibrosis; Humans; Infant; Infant, Newborn; Lipase; Trypsi	1984
[The duodenal contents during digestion of a standard meal in cystic fibrosis]. Harefuah, 1980, Apr-15, Volume: 98, Issue:8 Topics: Amylases; Child; Cystic Fibrosis; Digestion; Duodenum; Food; Humans; Hydrogen-Ion Concentration; Int	1980
[Exocrine pancreatic insufficiency (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1980, Volume: 128, Issue:12 Topics: Amino Acid Metabolism, Inborn Errors; Amylases; Cystic Fibrosis; Enteropeptidase; Enzyme Therapy; Ex	1980
Pathology and pathogenesis of diseases of the pancreas. The American journal of pathology, 1982, Volume: 107, Issue:1 Topics: Acute Disease; Adenoma, Islet Cell; Amylases; Ascitic Fluid; Chronic Disease; Cystic Fibrosis; Diabe	1982
[Immunotrypsinogen and amylase isoenzymes in pancreatic diseases]. Minerva medica, 1983, Jan-14, Volume: 74, Issue:1-2 Topics: Adolescent; Amylases; Child; Child, Preschool; Chronic Disease; Cystic Fibrosis; Humans; Infant; Iso	1983
Serum pancreatic lipase activity in cystic fibrosis. British medical journal (Clinical research ed.), 1983, May-28, Volume: 286, Issue:6379 Topics: Adolescent; Adult; Child; Cystic Fibrosis; Humans; Lipase; Pancreas; Trypsin	1983
Pancreatic lipase, colipase, and cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3 Suppl 1 Topics: Colipases; Cystic Fibrosis; Humans; Lipase; Pancreas; Proteins	1984
Intraduodenal events in cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3 Suppl 1 Topics: Adolescent; Bile Acids and Salts; Cystic Fibrosis; Digestion; Duodenum; Humans; Hydrogen-Ion Concent	1984
Lingual lipase activity in cystic fibrosis. Nutrition reviews, 1984, Volume: 42, Issue:10 Topics: Adult; Animals; Cattle; Celiac Disease; Cystic Fibrosis; Dietary Fats; Digestion; Duodenum; Gastric	1984
Incidence of distal intestinal obstruction syndrome in cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1983, Volume: 2, Issue:2 Topics: Adolescent; Child; Cystic Fibrosis; Humans; Intestinal Obstruction; Lipase; Pancreatic Extracts; Pan	1983
Colipase and lipase secretion in childhood-onset pancreatic insufficiency. Delineation of patients with steatorrhea secondary to relative colipase deficiency. Gastroenterology, 1984, Volume: 86, Issue:1 Topics: Adolescent; Adult; Celiac Disease; Child; Child, Preschool; Colipases; Cystic Fibrosis; Exocrine Pan	1984
[Digestion of fat and protein and its relation to the activity of faecal enzymes in mucoviscidosis infants under substitution therapy with pancreatic enzymes (author's transl)]. Klinische Padiatrie, 1981, Volume: 193, Issue:5 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats; Dietary Proteins; Feces; Humans;	1981
Comparative trial of viokase, pancreatin and Pancrease pancrelipase (enteric coated beads) in the treatment of malabsorption in cystic fibrosis. Australian paediatric journal, 1982, Volume: 18, Issue:2 Topics: Celiac Disease; Child; Cystic Fibrosis; Female; Humans; Lipase; Male; Pancreatic Extracts; Pancreati	1982
Lingual lipase. Its role in lipid digestion in infants with low birthweight and/or pancreatic insufficiency. Acta paediatrica Scandinavica. Supplement, 1982, Volume: 296 Topics: Bile Acids and Salts; Cystic Fibrosis; Dietary Fats; Exocrine Pancreatic Insufficiency; Humans; Infa	1982
Steatorrhea and pancreatic insufficiency in Shwachman syndrome. Gastroenterology, 1982, Volume: 83, Issue:1 Pt 1 Topics: Adolescent; Aging; Agranulocytosis; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis; Dietar	1982
Serum pancreatic lipase as a screening test for cystic fibrosis. Archives of disease in childhood, 1982, Volume: 57, Issue:7 Topics: Cystic Fibrosis; Humans; Infant; Infant, Newborn; Lipase; Mass Screening; Pancreas; Trypsin	1982
Comparison of two forms of enteric-coated pancrelipase In six teenagers with cystic fibrosis. Clinical therapeutics, 1982, Volume: 5, Issue:1 Topics: Adolescent; Cystic Fibrosis; Diet; Feces; Female; Humans; Lipase; Male; Pancreatic Extracts; Pancrel	1982
Gastric emptying and lingual lipase activity in cystic fibrosis. Pediatric research, 1980, Volume: 14, Issue:12 Topics: Adolescent; Butter; Cystic Fibrosis; Gastric Emptying; Gastric Juice; Glycerides; Humans; Lipase; Li	1980
Lingual lipase: an important lipase in the digestion of dietary lipids in cystic fibrosis? Pediatric research, 1980, Volume: 14, Issue:12 Topics: Adult; Animals; Biological Assay; Child; Cystic Fibrosis; Dietary Fats; Duodenum; Gastric Mucosa; Hu	1980
Decreased lipase activity in pure pancreatic juice and duodenal content from mutant mice with some alterations resembling cystic fibrosis. Life sciences, 1981, May-18, Volume: 28, Issue:20 Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Duodenum; Feces; Female; Genotype; Lipase; Male; M	1981
Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985 Topics: Adolescent; Amylases; Bromelains; Case-Control Studies; Cathartics; Child; Child, Preschool; Cohort	1995
Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985 Topics: Adolescent; Albumins; alpha 1-Antitrypsin; Amylases; Bromelains; Case-Control Studies; Child; Child,	1995
High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889 Topics: Amylases; Bromelains; Cecum; Child, Preschool; Colon; Constriction, Pathologic; Cystic Fibrosis; Dru	1994
Plasma lipid concentrations in children with cystic fibrosis: the value of a high-fat diet and pancreatic supplementation. The British journal of nutrition, 1994, Volume: 71, Issue:6 Topics: Adolescent; Adult; Amylases; Child; Child, Preschool; Cholesterol; Chromatography, High Pressure Liq	1994
Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet (London, England), 1995, Mar-25, Volume: 345, Issue:8952 Topics: Adolescent; Adult; Amylases; Child; Child, Preschool; Colon; Cystic Fibrosis; Endopeptidases; Fibros	1995
Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet (London, England), 1995, Aug-19, Volume: 346, Issue:8973 Topics: Alginates; Aluminum Hydroxide; Amylases; Antacids; Anti-Ulcer Agents; Bromelains; Cisapride; Colon;	1995
Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet (London, England), 1995, Aug-19, Volume: 346, Issue:8973 Topics: Amylases; Animals; Bromelains; Colon; Colonic Diseases; Cystic Fibrosis; Drug Combinations; Fibrosis	1995
Cystic fibrosis and colonic strictures. A new "iatrogenic" disease. Journal of clinical gastroenterology, 1995, Volume: 21, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Colonic Diseases; Cystic Fibrosis; Humans; Iatrogenic Di	1995
Plant sources of acid stable lipases. Journal of paediatrics and child health, 1995, Volume: 31, Issue:4 Topics: Cystic Fibrosis; Duodenum; Humans; Hydrogen-Ion Concentration; Lipase; Plant Extracts	1995
Chronic metabolic alkalosis: not uncommon in young children with severe cystic fibrosis. American journal of nephrology, 1995, Volume: 15, Issue:3 Topics: Acidosis, Respiratory; Adolescent; Age Factors; Alkalosis; Body Weight; Case-Control Studies; Child;	1995
Faecal interleukin-8 and tumour necrosis factor-alpha concentrations in cystic fibrosis. Archives of disease in childhood, 1995, Volume: 73, Issue:1 Topics: Adolescent; Adult; Biomarkers; Child; Cystic Fibrosis; Feces; Humans; Interleukin-8; Lipase; Lung; P	1995
[Gene transfer in the gallbladder]. Zeitschrift fur Gastroenterologie, 1995, Volume: 33, Issue:4 Topics: Adenoviruses, Human; Animals; Cell Line; Cystic Fibrosis; DNA, Complementary; Gallbladder; Gene Expr	1995
Plant sources of acid stable lipases: potential therapy for cystic fibrosis. Journal of paediatrics and child health, 1994, Volume: 30, Issue:6 Topics: Chromatography, Thin Layer; Cystic Fibrosis; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Conc	1994
Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889 Topics: Abdominal Pain; Adolescent; Child; Child, Preschool; Colon; Colonic Diseases; Constriction, Patholog	1994
Colonic strictures in cystic fibrosis. Lancet (London, England), 1994, Mar-12, Volume: 343, Issue:8898 Topics: Colonic Diseases; Constriction, Pathologic; Cystic Fibrosis; Humans; Intestinal Obstruction; Lipase;	1994
Pancolonic disease in cystic fibrosis and high-dose pancreatic enzyme therapy. The Journal of pediatrics, 1994, Volume: 125, Issue:4 Topics: Child, Preschool; Chronic Disease; Chylous Ascites; Colon; Colonic Diseases; Cystic Fibrosis; Diarrh	1994
Pathophysiology of the pancreatic defect in Johanson-Blizzard syndrome: a disorder of acinar development. The Journal of pediatrics, 1994, Volume: 125, Issue:3 Topics: Case-Control Studies; Colipases; Consanguinity; Cystic Fibrosis; Exocrine Pancreatic Insufficiency;	1994
Gene therapy for exocrine pancreatic insufficiency. Gastroenterology, 1994, Volume: 106, Issue:6 Topics: Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Gallbladder; Genetic Therapy; Humans; Lipase; Pa	1994
[Long-term treatment of mucoviscidosis. Results with a microencapsulated pancreatic enzyme preparation]. Fortschritte der Medizin, 1993, Feb-10, Volume: 111, Issue:4 Topics: Adolescent; Capsules; Child; Child, Preschool; Cystic Fibrosis; Female; Follow-Up Studies; Humans; L	1993
Gut inflammation in children with cystic fibrosis on high-dose enzyme supplementation. Lancet (London, England), 1996, Feb-03, Volume: 347, Issue:8997 Topics: Amylases; Bromelains; Child; Child, Preschool; Cystic Fibrosis; Drug Combinations; Humans; Inflammat	1996
Response to a single oral dose of all-rac-alpha-tocopheryl acetate in patients with cystic fibrosis and in healthy individuals. The American journal of clinical nutrition, 1996, Volume: 63, Issue:5 Topics: Absorption; Administration, Oral; Adult; alpha-Tocopherol; Antioxidants; Biological Transport; Child	1996
Colonic strictures in patients with cystic fibrosis: results of a survey of 114 cystic fibrosis care centers in the United States. Journal of pediatric gastroenterology and nutrition, 1996, Volume: 22, Issue:2 Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis;	1996
Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Gastroenterology, 1996, Volume: 111, Issue:1 Topics: Amylases; Case-Control Studies; Colon; Colonic Diseases; Cystic Fibrosis; Endopeptidases; Fibrosis;	1996
Pancreatin preparations used in the treatment of cystic fibrosis--lipase content and in vitro release. Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:3 Topics: Bile Acids and Salts; Body Fluids; Buffers; Cystic Fibrosis; Duodenum; Gastrointestinal Agents; Hydr	1996
Twenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption. Journal of pediatric gastroenterology and nutrition, 1996, Volume: 23, Issue:1 Topics: Absorption; Acids; Child; Child, Preschool; Circadian Rhythm; Cystic Fibrosis; Dietary Fats; Duodenu	1996
Exocrine pancreatic alterations in long-lived surviving cystic fibrosis mice. Pediatric research, 1996, Volume: 40, Issue:2 Topics: Amylases; Animals; Animals, Suckling; Chymotrypsin; Cystic Fibrosis; Diet; Lipase; Longevity; Mice;	1996
Fibrosing colonopathy in children with cystic fibrosis. Postgraduate medical journal, 1996, Volume: 72 Suppl 2 Topics: Adolescent; Child; Child, Preschool; Colon; Cystic Fibrosis; Female; Fibrosis; Humans; Infant; Infan	1996
Stable isotope studies of pancreatic enzyme release in vivo. Postgraduate medical journal, 1996, Volume: 72 Suppl 2 Topics: Breath Tests; Carbon Isotopes; Child; Colon; Cystic Fibrosis; Female; Gastrointestinal Transit; Huma	1996
Management of malabsorption in cystic fibrosis: influence of recent developments on clinical practice. Postgraduate medical journal, 1996, Volume: 72 Suppl 2 Topics: Child; Child, Preschool; Clinical Protocols; Cystic Fibrosis; Follow-Up Studies; Humans; Infant; Lip	1996
Fibrosing colonopathy in children with cystic fibrosis. Journal of pediatric surgery, 1997, Volume: 32, Issue:2 Topics: Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis; Female; Fibrosis; Humans; Infant;	1997
Dietary fibre and the occurrence of gut symptoms in cystic fibrosis. Archives of disease in childhood, 1997, Volume: 76, Issue:1 Topics: Abdominal Pain; Adolescent; Child; Child, Preschool; Cystic Fibrosis; Diet Records; Dietary Fiber; H	1997
Contrast enema findings of fibrosing colonopathy. Pediatric radiology, 1997, Volume: 27, Issue:4 Topics: Barium Sulfate; Child, Preschool; Colonic Diseases; Contrast Media; Cystic Fibrosis; Enema; Female;	1997
High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. The New England journal of medicine, 1997, May-01, Volume: 336, Issue:18 Topics: Case-Control Studies; Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis; Dose-Respon	1997
13Carbon mixed triglyceride breath test and pancreatic enzyme supplementation in cystic fibrosis. Archives of disease in childhood, 1997, Volume: 76, Issue:4 Topics: Breath Tests; Carbon Isotopes; Child; Cystic Fibrosis; Female; Humans; Lipase; Male; Pancreatic Extr	1997
Is fibrosing colonopathy an immune mediated disease? Archives of disease in childhood, 1997, Volume: 77, Issue:1 Topics: Animals; Child; Child, Preschool; Colon; Cystic Fibrosis; Drug Administration Schedule; Female; Fibr	1997
Ultrasound studies of the intestinal wall in patients with cystic fibrosis. Journal of pediatric gastroenterology and nutrition, 1997, Volume: 25, Issue:3 Topics: Adolescent; Cecum; Child; Colon; Cystic Fibrosis; Female; Humans; Ileum; Intestines; Lipase; Male; P	1997
Evaluation studies of the 13C-mixed triglyceride breath test in healthy controls and adult cystic fibrosis patients with exocrine pancreatic insufficiency. Digestion, 1997, Volume: 58, Issue:5 Topics: Adult; Breath Tests; Calorimetry, Indirect; Carbon Dioxide; Carbon Isotopes; Case-Control Studies; C	1997
Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. Journal of pediatric gastroenterology and nutrition, 1998, Volume: 26, Issue:1 Topics: Adolescent; Child; Child, Preschool; Colon; Colonic Diseases; Cystic Fibrosis; Exocrine Pancreatic I	1998
Fat gram target. Journal of paediatrics and child health, 1997, Volume: 33, Issue:6 Topics: Cystic Fibrosis; Dietary Fats; Humans; Lipase; Pancreatic Extracts; Pancrelipase	1997
Pancreatic enzymes and colonic strictures with cystic fibrosis: a case-control study. Gastroenterology, 1998, Volume: 114, Issue:3 Topics: Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Humans; Infant; Intestinal Obstructi	1998
Discrepancies between males and females with cystic fibrosis in dietary intake and pancreatic enzyme use. Journal of pediatric gastroenterology and nutrition, 1998, Volume: 26, Issue:3 Topics: Adolescent; Child; Cross-Sectional Studies; Cystic Fibrosis; Diet; Dietary Fats; Energy Intake; Fema	1998
Progressive pan-colonic fibrosis secondary to oral administration of pancreatic enzymes. Pediatric surgery international, 1998, Volume: 13, Issue:2-3 Topics: Child; Colon; Constriction, Pathologic; Cystic Fibrosis; Disease Progression; Fibrosis; Humans; Inte	1998
Faecal immunoreactive lipase: a simple diagnostic test for cystic fibrosis. European journal of pediatrics, 1998, Volume: 157, Issue:4 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Feces; Female; Humans; Infant; Infant, Newborn	1998
Maintenance of growth in cystic fibrosis despite reduction in pancreatic enzyme supplementation. Archives of disease in childhood, 1998, Volume: 78, Issue:4 Topics: Child; Child, Preschool; Cystic Fibrosis; Drug Administration Schedule; Feces; Follow-Up Studies; Gr	1998
Effects of pancreatic enzyme preparations on erythrocyte glutathione peroxidase activities and plasma selenium concentrations in cystic fibrosis. Free radical biology & medicine, 1998, Jul-15, Volume: 25, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Cross-Sectional Studies; Cystic Fi	1998
Faecal bile acid and dietary residue excretion in cystic fibrosis: age group variations. Journal of pediatric gastroenterology and nutrition, 1998, Volume: 27, Issue:3 Topics: Adolescent; Adult; Aging; Bile Acids and Salts; Child; Child, Preschool; Cystic Fibrosis; Dietary Ca	1998
Metabolic handling of 13C labelled tripalmitin in healthy controls and patients with cystic fibrosis. Archives of disease in childhood, 1998, Volume: 79, Issue:1 Topics: Breath Tests; Carbon Isotopes; Child; Child, Preschool; Cystic Fibrosis; Digestive System; Feces; Fe	1998
Serum lipase levels pre and post Lundh meal: evaluation of exocrine pancreatic status in cystic fibrosis. International journal of clinical & laboratory research, 1998, Volume: 28, Issue:4 Topics: Adolescent; Adult; Child; Cystic Fibrosis; Dietary Fats; Humans; Lipase; Pancreas; Pancreatic Diseas	1998
Quorum sensing in Burkholderia cepacia: identification of the LuxRI homologs CepRI. Journal of bacteriology, 1999, Volume: 181, Issue:3 Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Burkholderia cepacia; Cloning, Molecular; Cy	1999
Effect of urokinase on the extracellular virulence properties of Pseudomonas aeruginosa and Burkholderia cepacia. Journal of basic microbiology, 1999, Volume: 39, Issue:1 Topics: Burkholderia cepacia; Culture Media; Cystic Fibrosis; Endopeptidases; Humans; Iron; Lipase; Oxygen;	1999
Immunoreactive pancreatic Reg protein in sera from cystic fibrosis patients with and without pancreatic insufficiency. Gut, 1999, Volume: 44, Issue:4 Topics: Adolescent; Adult; Calcium-Binding Proteins; Child; Child, Preschool; Chromatography, Gel; Chymotryp	1999
13C mixed triglyceride breath test. Gut, 1998, Volume: 43 Suppl 3 Topics: Adult; Age Factors; Breath Tests; Carbon Dioxide; Carbon Isotopes; Celiac Disease; Child; Cystic Fib	1998
Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis. European journal of gastroenterology & hepatology, 1999, Volume: 11, Issue:2 Topics: Adolescent; Age Factors; Child; Child, Preschool; Colon; Colonic Diseases; Constriction, Pathologic;	1999
Fecal immunoreactive lipase, a simple diagnostic test for cystic fibrosis. European journal of pediatrics, 1999, Volume: 158, Issue:4 Topics: Authorship; Cystic Fibrosis; Feces; Humans; Infant; Infant, Newborn; Lipase	1999
Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis. Archives of disease in childhood, 1999, Volume: 80, Issue:2 Topics: Adolescent; Adult; Breath Tests; Child; Child, Preschool; Cystic Fibrosis; Gastric Emptying; Gastroi	1999
Triglyceride oxidation in cystic fibrosis: a comparison between different 13C-labeled tracer substances. Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:2 Topics: Adolescent; Breath Tests; Carbon Dioxide; Carbon Isotopes; Child; Cystic Fibrosis; Diet; Female; Foo	1999
Fibrosing colonopathy. Gut, 2000, Volume: 46, Issue:2 Topics: Colon; Crohn Disease; Cystic Fibrosis; Diet; Dietary Fiber; Fibrosis; Humans; Lipase	2000
Imaging changes in the pancreas in cystic fibrosis: a retrospective evaluation of 55 cases seen over a period of 9 years. Journal of pediatric gastroenterology and nutrition, 2000, Volume: 30, Issue:2 Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Diagnostic Imaging; Female; Humans; Lip	2000
Serum lipase levels as a diagnostic marker in cystic fibrosis patients with normal or borderline sweat tests. Pediatric pulmonology, 2000, Volume: 30, Issue:4 Topics: Adult; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exocr	2000
Parallel secretion of pancreatic phospholipase A(2), phospholipase A(1), lipase, and colipase in children with exocrine pancreatic dysfunction. Pediatric research, 2000, Volume: 48, Issue:6 Topics: Adolescent; Child; Child, Preschool; Colipases; Cystic Fibrosis; Dietary Fats; Humans; Infant; Intes	2000
Early detection of impaired glucose tolerance in patients with cystic fibrosis and predisposition factors. Journal of pediatric endocrinology & metabolism : JPEM, 2001, Volume: 14, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Female; Glucose;	2001
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. The American journal of clinical nutrition, 2001, Volume: 73, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Bone Density; Case-Control Studies; Cysti	2001
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. The American journal of clinical nutrition, 2001, Volume: 73, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Bone Density; Case-Control Studies; Cysti	2001
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. The American journal of clinical nutrition, 2001, Volume: 73, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Bone Density; Case-Control Studies; Cysti	2001
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. The American journal of clinical nutrition, 2001, Volume: 73, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Bone Density; Case-Control Studies; Cysti	2001
Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. Journal of pediatric gastroenterology and nutrition, 2001, Volume: 32, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Cholagogues and Choleretics; Cyst	2001
Does that child really have cystic fibrosis? Lancet (London, England), 1978, Aug-19, Volume: 2, Issue:8086 Topics: Amylases; Bicarbonates; Child; Child, Preschool; Chlorides; Cholecystokinin; Cystic Fibrosis; Evalua	1978
[Determination of the ribonuclease activity of the duodenal contents of children as a test in the differential diagnosis of cystic fibrosis and pancreatic exocrine insufficiency]. Problemy medycyny wieku rozwojowego, 1979, Volume: 8 Topics: Amylases; Child; Child, Preschool; Cystic Fibrosis; Diagnosis, Differential; Duodenum; Exocrine Panc	1979
Staphylococcus aureus in cystic fibrosis: antibiotic sensitivity and phage types during the latest decade. Investigation of the occurrence of protein A and some other properties of recently isolated strains in relation to the occurrence of precipitating a Acta pathologica et microbiologica Scandinavica. Section B, Microbiology, 1975, Volume: 83, Issue:3 Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Proteins; Bacteriophage Typing; Chemical Pre	1975
Test meal for assessing intraluminal phase of absorption in childhood. Archives of disease in childhood, 1977, Volume: 52, Issue:11 Topics: Adolescent; Bile Acids and Salts; Child; Child, Preschool; Cystic Fibrosis; Diet; Esterases; Female;	1977
Minimal bile acid malabsorption and normal bile acid breath tests in cystic fibrosis and acquired pancreatic insufficiency. Gastroenterology, 1977, Volume: 72, Issue:4 Pt 1 Topics: Adult; Aged; Bile Acids and Salts; Breath Tests; Carbon Dioxide; Celiac Disease; Cystic Fibrosis; Di	1977
Recurrent acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymes. Pediatrics, 1975, Volume: 55, Issue:1 Topics: Acute Disease; Adolescent; Adult; Amylases; Chlorides; Cholecystokinin; Chymotrypsin; Cystic Fibrosi	1975
Cystic fibrosis. The Practitioner, 1975, Volume: 214, Issue:1284 Topics: Adolescent; Adult; Animals; Carbenicillin; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis;	1975
Nonoperative treatment of meconium ileus equivalent. American journal of diseases of children (1960), 1975, Volume: 129, Issue:10 Topics: Acetylcysteine; Child; Cystic Fibrosis; Enema; Feces; Female; Humans; Intestinal Obstruction; Lipase	1975
[Determination of exocrine pancreatic function in childhood with the pancreozymin-secretin test]. Kinderarztliche Praxis, 1992, Volume: 60, Issue:8 Topics: Amylases; Child; Child, Preschool; Cholecystokinin; Cystic Fibrosis; Diagnosis, Differential; Exocri	1992
Increased intragastric acid-resistant lipase activity and lipolysis in pancreatic steatorrhoea due to cystic fibrosis. Pancreas, 1992, Volume: 7, Issue:3 Topics: Adult; Animals; Celiac Disease; Cystic Fibrosis; Female; Gastric Acid; Humans; Hydrogen-Ion Concentr	1992
Pancreatic enzyme supplement dosage in cystic fibrosis. Lancet (London, England), 1991, Nov-02, Volume: 338, Issue:8775 Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Food, Fortified; Humans; Infant; Lipase; Pancr	1991
Evaluation of tests of exocrine and endocrine pancreatic function in older patients with cystic fibrosis. Pancreas, 1990, Volume: 5, Issue:1 Topics: 4-Aminobenzoic Acid; Adult; Age Factors; Amylases; Blood Glucose; Cystic Fibrosis; Female; Glucose T	1990
Non-invasive assessment of intraluminal lipolysis using a 13CO2 breath test. Archives of disease in childhood, 1990, Volume: 65, Issue:6 Topics: Breath Tests; Caprylates; Carbon Dioxide; Carbon Isotopes; Child; Child, Preschool; Cystic Fibrosis;	1990
Treatment failure after substitution of generic pancrelipase capsules. Correlation with in vitro lipase activity. JAMA, 1990, May-09, Volume: 263, Issue:18 Topics: Adult; Capsules; Child; Cystic Fibrosis; Female; Humans; Infant; Lipase; Male; Pancreatic Extracts;	1990
Effects of malnutrition and chronic reserpine treatment on pancreatic exocrine function. Pediatric research, 1986, Volume: 20, Issue:12 Topics: Amylases; Animals; Body Weight; Cystic Fibrosis; Disease Models, Animal; Eating; Lipase; Male; Nutri	1986
Alterations of pancreatic growth and of GP-2 content in the reserpinized rat model of cystic fibrosis. Pediatric research, 1989, Volume: 25, Issue:5 Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme P	1989
Effect of pancreatic enzyme supplements on iron absorption. American journal of diseases of children (1960), 1989, Volume: 143, Issue:8 Topics: Adolescent; Adult; Cystic Fibrosis; Female; Ferritins; Humans; Iron; Iron Deficiencies; Lipase; Male	1989
Uric acid serum concentrations in CF-children after pancreatic enzyme supplementation. Padiatrie und Grenzgebiete, 1989, Volume: 28, Issue:3 Topics: Adolescent; Adult; Child; Cystic Fibrosis; Female; Humans; Lipase; Male; Uric Acid	1989
Alginate lyase releases cell-bound lipase from mucoid strains of Pseudomonas aeruginosa. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1987, Volume: 266, Issue:3-4 Topics: Bacillus; Chromatography, Gel; Chromatography, Ion Exchange; Cystic Fibrosis; Electrophoresis, Polya	1987
Human gastric lipase: variations induced by gastrointestinal hormones and by pathology. Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:9 Topics: Adolescent; Adult; Aged; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Female; Gastric Mucosa;	1988
Production of lipase by clinical isolates of Pseudomonas cepacia. Journal of clinical microbiology, 1988, Volume: 26, Issue:5 Topics: Animals; Chromatography, Gel; Culture Media; Cystic Fibrosis; Electrophoresis, Polyacrylamide Gel; F	1988
The management of enzymatic therapy in cystic fibrosis patients by an individualized approach. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Adolescent; Body Weight; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats; Fem	1988
Malabsorption in cystic fibrosis: mechanisms and treatment. Journal of pediatric gastroenterology and nutrition, 1988, Volume: 7 Suppl 1 Topics: Acetylcysteine; Adolescent; Celiac Disease; Child; Cystic Fibrosis; Drug Administration Schedule; Dr	1988
Pancreatic and intestinal dysfunction in cystic fibrosis. Progress in clinical and biological research, 1987, Volume: 254 Topics: Biological Transport, Active; Cystic Fibrosis; Humans; Intestinal Absorption; Lipase; Pancreas; Panc	1987
[Activity of various pancreatic enzymes in children with mucoviscidosis]. Pediatriia, 1987, Issue:10 Topics: Adolescent; alpha 1-Antitrypsin; Child; Child, Preschool; Cystic Fibrosis; Humans; Lipase; Pancreas;	1987
Assay of human pancreatic lipase in biological fluids using a non-competitive enzyme immunoassay. Clinica chimica acta; international journal of clinical chemistry, 1986, Dec-15, Volume: 161, Issue:2 Topics: Amniotic Fluid; Body Fluids; Cystic Fibrosis; Humans; Immunoenzyme Techniques; Lipase; Lipid Metabol	1986
Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects. Digestive diseases and sciences, 1987, Volume: 32, Issue:5 Topics: Acid-Base Equilibrium; Adolescent; Adult; Child; Cystic Fibrosis; Duodenum; Female; Food; Humans; Hy	1987
Bile acid secretion in cystic fibrosis: evidence for a defect unrelated to fat malabsorption. Gut, 1986, Volume: 27, Issue:9 Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Colipases; Cystic Fibrosis; Exocrine Pancre	1986
Hypoalbuminemia at diagnosis as a marker for severe respiratory course in infants with cystic fibrosis identified by newborn screening. The Journal of pediatrics, 1985, Volume: 107, Issue:6 Topics: Cystic Fibrosis; Female; Humans; Infant; Infant, Newborn; Lipase; Male; Mass Screening; Pancreatic E	1985
Problems in the treatment of malabsorption in CF. Acta paediatrica Scandinavica. Supplement, 1985, Volume: 317 Topics: Bicarbonates; Bile Acids and Salts; Child; Cystic Fibrosis; Dietary Fats; Enzyme Therapy; Enzymes; G	1985
Enzyme immunoassay for pancreatic lipase: comparison with turbidimetric method in pancreatic diseases. Clinical biochemistry, 1985, Volume: 18, Issue:4 Topics: Acute Disease; Adult; Aged; Child, Preschool; Chronic Disease; Clinical Enzyme Tests; Cystic Fibrosi	1985
Serum immunoreactive pancreatic lipase and cationic trypsinogen for the assessment of exocrine pancreatic function in older patients with cystic fibrosis. Pediatrics, 1986, Volume: 77, Issue:3 Topics: Adolescent; Adult; Cations; Celiac Disease; Child; Child, Preschool; Cystic Fibrosis; Dietary Fats;	1986
Age-related alterations in immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis. The Journal of pediatrics, 1985, Volume: 107, Issue:3 Topics: Age Factors; Child; Child, Preschool; Cystic Fibrosis; Fetal Blood; Humans; Infant; Infant, Newborn;	1985
Pancreatic lipase and phospholipase A2 concentration in amniotic fluid and the prenatal diagnosis of cystic fibrosis. British journal of obstetrics and gynaecology, 1985, Volume: 92, Issue:9 Topics: Amniotic Fluid; Cystic Fibrosis; Female; Humans; Lipase; Pancreas; Phospholipases; Phospholipases A;	1985
Serum immunoreactive trypsin and pancreatic lipase in cystic fibrosis. European journal of pediatrics, 1985, Volume: 144, Issue:2 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystic Fibrosis; Female; Follow-Up Studies;	1985
[Activity of lipolytic enzymes in the sputum, duodenal juice and serum of children with mucoviscidosis]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1974, Nov-11, Volume: 29, Issue:45 Topics: Age Factors; Child; Cystic Fibrosis; Duodenum; Humans; Intestinal Secretions; Lipase; Phospholipases	1974
Mucoid enteritis of rabbits. Comparison to cholera and cystic fibrosis. Veterinary pathology, 1972, Volume: 9, Issue:1 Topics: Animals; Blood Glucose; Blood Proteins; Cecum; Cholera; Colon; Cystic Fibrosis; Enteritis; Female; H	1972
L-arginine and cystic fibrosis. Pediatrics, 1973, Volume: 51, Issue:3 Topics: Adolescent; Amylases; Arginine; Child; Cystic Fibrosis; Humans; Lipase; Pancreas; Trypsin	1973
Malabsorption of bile acids in children with cystic fibrosis. The New England journal of medicine, 1973, Nov-08, Volume: 289, Issue:19 Topics: Adolescent; Bile Acids and Salts; Celiac Disease; Child; Child, Preschool; Chromatography, Gas; Cyst	1973
[Exocrine pancreatic secretion in children. Study methods and results]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1973, Volume: 18, Issue:4 Topics: Amylases; Bicarbonates; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Infant; Infant, Ne	1973
Steatorrhea and azotorrhea and their relation to growth and nutrition in adolescents and young adults with cystic fibrosis. The Journal of pediatrics, 1974, Volume: 84, Issue:3 Topics: Adolescent; Adult; Body Height; Body Weight; Carboxypeptidases; Carotenoids; Celiac Disease; Child;	1974
Insulin secretion after tolbutamide and after secretin in patients with pancreatic diseases. Acta medica Scandinavica, 1972, Volume: 192, Issue:5 Topics: Adolescent; Adult; Aged; Amylases; Blood Glucose; Calcinosis; Cystic Fibrosis; Duodenum; Feces; Fema	1972
[Hereditary abnormalities of digestive enzymes]. Revue medico-chirurgicale des maladies du foie, 1971, Volume: 46, Issue:4 Topics: Cystic Fibrosis; Endopeptidases; Humans; Lipase; Malabsorption Syndromes; Metabolism, Inborn Errors;	1971
[Study of exocrine pancreatic function in mucoviscidosis]. Revue francaise d'etudes cliniques et biologiques, 1969, Volume: 14, Issue:9 Topics: Adolescent; Amylases; Bicarbonates; Child; Child, Preschool; Cholecystokinin; Chymotrypsin; Cystic F	1969
Pancreatic extracts. British medical journal, 1970, Apr-18, Volume: 2, Issue:5702 Topics: Adult; Aged; Bicarbonates; Bile Acids and Salts; Cystic Fibrosis; Humans; Infant; Lipase; Malabsorpt	1970
Kinetics of fat hydrolysis and micellar solubilisation in bile and lipase deficiencies. Acta paediatrica Scandinavica, 1971, Volume: 60, Issue:3 Topics: Bile; Bile Acids and Salts; Biliary Tract Diseases; Child, Preschool; Cystic Fibrosis; Fatty Acids,	1971
Pancreozymin secretin test of exocrine pancreatic funtion in cystic fribrosis and the significance of the result for the pathogenesis of the disease. Canadian Medical Association journal, 1968, Feb-24, Volume: 98, Issue:8 Topics: Adolescent; Adult; Amylases; Bicarbonates; Carboxypeptidases; Child; Child, Preschool; Chlorides; Ch	1968
[Hypoplasia of exocrine pancreas. Associated myoendocardial fibrosis in 1 of 2 brothers]. Annales de pediatrie, 1969, Jan-02, Volume: 16, Issue:1 Topics: Amylases; Chymotrypsin; Cystic Fibrosis; Endomyocardial Fibrosis; Humans; Infant; Infant, Newborn; L	1969
[Serum lipase in pancreatic diagnosis. Clinical experiences based on 498 determinations]. Schweizerische medizinische Wochenschrift, 1966, Jan-15, Volume: 96, Issue:2 Topics: Adult; Bile Duct Neoplasms; Clinical Enzyme Tests; Cystic Fibrosis; Female; Humans; Lipase; Male; Me	1966
Cystic fibrosis--V. Does cystic fibrosis alter the values of dynamic parameters of erythrocyte membrane ghosts? The International journal of biochemistry, 1993, Volume: 25, Issue:4 Topics: Anilino Naphthalenesulfonates; Child; Child, Preschool; Cystic Fibrosis; Diphenylhexatriene; Electro	1993