1-anilino-8-naphthalenesulfonate has been researched along with Bile Duct Obstruction in 26 studies
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd
8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum concentrations of bile acids and tyrosine were determined in 14 premature infants with late metabolic acidosis and in 13 comparable controls without acidosis (protein intake 2 g/kg X d)." | 3.67 | Cholestasis in late metabolic acidosis of prematurely born infants. ( Beyreiss, K; Boehm, G; Braun, W; Senger, H, 1987) |
| "Primary sclerosing cholangitis predominantly affects males and is an important indication for liver transplantation." | 1.39 | A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis. ( Brune, M; Friedrich, K; Gotthardt, DN; Hov, JR; Karlsen, TH; Runz, H; Rupp, C; Sauer, P; Schaefer, PK; Schemmer, P; Schirmacher, P; Steinebrunner, N; Stiehl, A; Stremmel, W; Weiss, KH, 2013) |
| "In patients with liver cirrhosis, low levels of VLDL, HDL, apo B, and Lp(a) were observed, as well as a change in the composition of HDL particles, with increases in the relative proportion of triglyceride and free cholesterol." | 1.29 | Cholesteryl ester transfer activity in liver disease and cholestasis, and its relation with fatty acid composition of lipoprotein lipids. ( Alvarez, JJ; Arranz, M; Herrera, E; Iglesias, A; Lasunción, MA; Perales, J; Villar, J, 1996) |
| "Pancreatitis was induced in the opossum by occluding the common bile duct above or below the entrance of the pancreatic duct." | 1.27 | The role of biliary obstruction in the pathogenesis of acute pancreatitis in the opossum. ( Coelho, JC; Moody, FG; Senninger, N; Van Buren, DH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (53.85) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedrich, K | 1 |
| Rupp, C | 1 |
| Hov, JR | 1 |
| Steinebrunner, N | 1 |
| Weiss, KH | 1 |
| Stiehl, A | 1 |
| Brune, M | 1 |
| Schaefer, PK | 1 |
| Schemmer, P | 1 |
| Sauer, P | 1 |
| Schirmacher, P | 1 |
| Runz, H | 1 |
| Karlsen, TH | 1 |
| Stremmel, W | 1 |
| Gotthardt, DN | 1 |
| Gubergrits, NB | 1 |
| Lukashevich, GM | 1 |
| Zimmer, V | 1 |
| Lammert, F | 1 |
| Santana, DG | 1 |
| Santos, CA | 1 |
| Santos, AD | 1 |
| Nogueira, PC | 1 |
| Thomazzi, SM | 1 |
| Estevam, CS | 1 |
| Antoniolli, AR | 1 |
| Camargo, EA | 1 |
| Kim, DH | 1 |
| Lee, EH | 1 |
| Hwang, JC | 1 |
| Jeung, JH | 1 |
| Kim, DY | 1 |
| Cheong, JY | 1 |
| Cho, SW | 1 |
| Kim, YB | 1 |
| Baba, N | 2 |
| Suzuki, T | 2 |
| Tobe, T | 2 |
| Marinella, MA | 1 |
| Kueppers, PM | 1 |
| Russell, DH | 1 |
| Moody, FG | 2 |
| Hossain, A | 1 |
| Hornick, CA | 1 |
| Iglesias, A | 1 |
| Arranz, M | 1 |
| Alvarez, JJ | 1 |
| Perales, J | 1 |
| Villar, J | 1 |
| Herrera, E | 1 |
| Lasunción, MA | 1 |
| Muehldorfer, SM | 1 |
| Hahn, EG | 1 |
| Ell, C | 1 |
| Schleicher, C | 1 |
| Baas, JC | 1 |
| Elser, H | 1 |
| Senninger, N | 2 |
| Pöge, AW | 1 |
| Schwokowski, CF | 1 |
| Brachmann, K | 1 |
| Miller, JP | 1 |
| Coelho, JC | 1 |
| Van Buren, DH | 1 |
| Inoue, K | 1 |
| Chowdhury, P | 1 |
| Chang, LW | 1 |
| Rayford, PL | 1 |
| Gowen, GF | 1 |
| Senger, H | 1 |
| Boehm, G | 1 |
| Beyreiss, K | 1 |
| Braun, W | 1 |
| Müller, G | 1 |
| Müller, P | 1 |
| Felin, R | 1 |
| Lambrecht, J | 1 |
| Agostini, B | 1 |
| Wieland, H | 1 |
| Rost, W | 1 |
| Seidel, D | 1 |
| Bergmann, M | 1 |
| Gaida, P | 1 |
| Kubsch, J | 1 |
| Steuer, E | 1 |
| Leithäuser, W | 1 |
| Rohde, L | 1 |
| Rehpenning, W | 1 |
| Hauzeur, F | 1 |
| Schoenemann, J | 1 |
| Warnes, TW | 1 |
| Hine, P | 1 |
| Kay, G | 1 |
| Nana, A | 1 |
| Mircioiu, C | 1 |
| Holan, T | 1 |
| Nana, M | 1 |
| Trelea, E | 1 |
| Neumann, E | 1 |
| Schröder, H | 1 |
| Göring, G | 1 |
| Leyland, FC | 1 |
| Fosbrooke, AS | 1 |
| Lloyd, JK | 1 |
| Segall, MM | 1 |
| Tamir, I | 1 |
| Tomkins, R | 1 |
| Wolff, OH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?[NCT03368066] | Phase 3 | 100 participants (Actual) | Interventional | 2018-01-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients who died within 30 days of enrollment (NCT03368066)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 4 |
| Relative Adrenal Insufficiency | 4 |
Patients who died within 6 months of enrollment (NCT03368066)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 9 |
| Relative Adrenal Insufficiency | 15 |
Patients who died within 90 days of enrollment (NCT03368066)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 5 |
| Relative Adrenal Insufficiency | 12 |
Patients who died within the same hospitalization as enrollment (NCT03368066)
Timeframe: Within Hospitalization
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 1 |
| Relative Adrenal Insufficiency | 1 |
Patients who received a liver transplant within 6 months of enrollment (NCT03368066)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 8 |
| Relative Adrenal Insufficiency | 6 |
Patients who received a liver transplant within 90 days of enrollment (NCT03368066)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 6 |
| Relative Adrenal Insufficiency | 5 |
A percent quantification of serum cholesterol esterification will be measured via blood draw. Low values represent deficiency in esterification, which is a surrogate measure of lecthicin-cholesterol acetyltransferase (LCAT) enzymatic deficiency. (NCT03368066)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 10 |
| Relative Adrenal Insufficiency | 11 |
Patients will have their free cortisol levels measured to assess for deficiency. (NCT03368066)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 6 |
| Relative Adrenal Insufficiency | 1 |
A baseline total cortisol level will be obtained and then patients will receive a standard-dose synthetic ACTH (250mcg of Cosyntropin) stimulation test to assess for the presence of adrenal insufficiency. RAI is defined as a change in the total cortisol level in response to the stimulation test of <9mcg/dL when measured 60 minutes after the Cosyntropin is administered. (NCT03368066)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Hospitalized Cirrhosis Patients | 37 |
A peripheral blood smear will be obtained and assessed for presence of acanthocytes (spur cells). Spur cell anemia is defined as a serum hemoglobin < 10g/dL and the presence of >= 5% spur cells on blood smear. (NCT03368066)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 6 |
| Relative Adrenal Insufficiency | 8 |
Transplant and Death are considered equivalent outcomes (NCT03368066)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Normal Adrenal Response | 41 |
| Relative Adrenal Insufficiency | 16 |
4 reviews available for 1-anilino-8-naphthalenesulfonate and Bile Duct Obstruction
| Article | Year |
|---|---|
[Cholestasis and pancreatic insufficiency: how to start treatment?].
Topics: Cholestasis; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Replacement Therapy; Ex | 2014 |
Genetics in liver disease: new concepts.
Topics: Autoimmune Diseases; Cholestasis; Fatty Liver; Genetic Predisposition to Disease; Genome-Wide Associ | 2011 |
Dyslipoproteinaemia of liver disease.
Topics: Cholestasis; Humans; Hypolipoproteinemias; Lipase; Lipoprotein-X; Lipoproteins, HDL; Lipoproteins, L | 1990 |
[Pathogenesis of hyperlipoproteinemias].
Topics: Adipose Tissue; Animals; Autoantibodies; Autoimmune Diseases; Cholestasis; Cholesterol; Chylomicrons | 1974 |
22 other studies available for 1-anilino-8-naphthalenesulfonate and Bile Duct Obstruction
| Article | Year |
|---|---|
A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis.
Topics: Adult; Alleles; Animals; Bile Ducts; Cholangitis, Sclerosing; Cholestasis; Constriction, Pathologic; | 2013 |
Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
Topics: Abdominal Pain; Acute Disease; Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Caes | 2012 |
[A case of acute cholestatic hepatitis associated with Orlistat].
Topics: Acute Disease; Adult; Anti-Obesity Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Fema | 2002 |
[The pancreatico-trophic effect of obstructive jaundice in rats].
Topics: Amylases; Animals; Cholestasis; Lipase; Male; Organ Size; Pancreas; Rats; Rats, Inbred Strains | 1982 |
Biliary sludging in trauma patients.
Topics: Amylases; Cholecystitis; Cholestasis; Critical Illness; Humans; Lipase; Pancreatitis; Wounds and Inj | 1995 |
Reversibility of pancreatitis after temporary pancreaticobiliary duct obstruction in rats.
Topics: Acute Disease; Amylases; Animals; Bilirubin; Catheterization; Cholestasis; Disease Models, Animal; L | 1993 |
Androgenic modulation of lipid metabolism at subcellular sites in cholestatic rats.
Topics: Animals; Cholestasis; Female; Lipase; Lipid Metabolism; Lipolysis; Liver; Organelles; Rats; Rats, Sp | 1994 |
Cholesteryl ester transfer activity in liver disease and cholestasis, and its relation with fatty acid composition of lipoprotein lipids.
Topics: Adult; Aged; Carrier Proteins; Cholestasis; Cholesterol Ester Transfer Proteins; Cholesterol Esters; | 1996 |
Botulinum toxin injection as a diagnostic tool for verification of sphincter of Oddi dysfunction causing recurrent pancreatitis.
Topics: Acute Disease; Adult; Amylases; Anti-Dyskinesia Agents; Botulinum Toxins; Cholestasis; Common Bile D | 1997 |
Reticuloendothelial system blockade promotes progression from mild to severe acute pancreatitis in the opossum.
Topics: Acute Disease; Amylases; Animals; Carrageenan; Cholelithiasis; Cholestasis; Female; Lipase; Mononucl | 2001 |
[Texocrine pancreatic diagnosis. 2. Continuing course controls of alpha-amylase reactivity and alpha-amylase excretion in urine, comparative studies of lipase- and alpha-amylase activity in serum and urine as well as diagnostic consequences and data of a
Topics: Acute Disease; Adolescent; Adult; Aged; Amylases; Cholelithiasis; Cholestasis; Clinical Enzyme Tests | 1976 |
The role of biliary obstruction in the pathogenesis of acute pancreatitis in the opossum.
Topics: Acute Disease; Amylases; Animals; Bile Ducts; Bile Reflux; Calcium; Cholestasis; Female; Lipase; Mal | 1986 |
Influence of obstructive jaundice on pancreatic growth and on basal plasma levels of cholecystokinin and gastrin in rats.
Topics: Amylases; Animals; Cholecystokinin; Cholestasis; DNA; Female; Gastrins; Lipase; Male; Organ Size; Pa | 1986 |
A second look at the neostigmine morphine test.
Topics: Alkaline Phosphatase; Ampulla of Vater; Amylases; Aspartate Aminotransferases; Bilirubin; Cholecyste | 1989 |
Cholestasis in late metabolic acidosis of prematurely born infants.
Topics: Acidosis; Bile Acids and Salts; Cholestasis; Duodenum; Enzymes; Feces; Humans; Hydrogen-Ion Concentr | 1987 |
Hypertriglyceridaemia secondary to liver disease.
Topics: Adult; Aged; Bilirubin; Cholestasis; Electrophoresis, Polyacrylamide Gel; Hepatitis; Humans; Hyperli | 1974 |
[Glucoamylase in biliary tract-pancreatic diseases].
Topics: Alanine Transaminase; Alkaline Phosphatase; Amylases; Aspartate Aminotransferases; Bile Ducts; Bilia | 1974 |
[Critical studies on the diagnostic significance of alanine aminopeptidase and its isoenzymes in pancreatic diseases].
Topics: Adolescent; Adult; Alanine; Alkaline Phosphatase; Aminopeptidases; Amylases; Cholestasis; Clinical E | 1972 |
The action of secretin and pancreozymin on small-intestinal alkaline phosphatase.
Topics: Alkaline Phosphatase; Amylases; Bilirubin; Cholecystokinin; Cholestasis; Electrophoresis, Polyacryla | 1974 |
[Utilization of radiotriolein in the study of the effectiveness of selective vagotomy].
Topics: Animals; Cholestasis; Dogs; Gastrectomy; Gastroenterostomy; Humans; Jejunum; Lipase; Microscopy, Ele | 1972 |
[Reactive involvement of the pancreas in biliary tract disorders].
Topics: Amylases; Animals; Bile Ducts; Biliary Tract Diseases; Cholestasis; Humans; Ligation; Lipase; Pancre | 1971 |
Use of medium-chain triglyceride diets in children with malabsorption.
Topics: Bile; Celiac Disease; Child; Child, Preschool; Cholestasis; Cholestyramine Resin; Diet Therapy; Diet | 1969 |