1-alpha-24-dihydroxyvitamin-d3 and Colorectal-Neoplasms

1-alpha-24-dihydroxyvitamin-d3 has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 1-alpha-24-dihydroxyvitamin-d3 and Colorectal-Neoplasms

ArticleYear
Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase.
    The Journal of steroid biochemistry and molecular biology, 2019, Volume: 190

    5-Fluorouracil (5-FU) is an anticancer drug that is most frequently used to treat colorectal cancer (CRC) patients, but unfortunately it shows limited efficacy. We recently demonstrated that vitamin D analogs (VDAs), particularly tacalcitol (coded as PRI-2191), potentiate its anticancer activity in an in vivo mouse and human CRC model. The purpose of this study was to explain the mechanism underlying the enhancement of 5-FU efficacy by PRI-2191 towards human HT-29 CRC cells. We showed that PRI-2191 induces the CDKN1A (gene encoding p21

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydroxycholecalciferols; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; HT29 Cells; Humans; Thymidylate Synthase

2019