1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh and Thyroid-Neoplasms

1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh has been researched along with Thyroid-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh and Thyroid-Neoplasms

Article	Year
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer research, 2002, Feb-15, Volume: 62, Issue:4 Oncogenic activation of the RET receptor tyrosine kinase is common in different human cancers. We found that the pyrazolo-pyrimidine PP1 inhibited RET-derived oncoproteins with a half maximal inhibitor concentration of 80 nM. Furthermore, RET/PTC3-transformed cells treated with 5 microM of PP1 lost proliferative autonomy and showed morphological reversion. PP1 prevented the growth of two human papillary thyroid carcinoma cell lines that carry spontaneous RET/PTC1 rearrangements and blocked anchorage-independent growth and tumorigenicity in nude mice of NIH3T3 fibroblasts expressing the RET/PTC3 oncogene. These findings suggest targeting RET oncogenes with PP1 or related compounds as a novel treatment strategy for RET-associated neoplasms. Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Drosophila Proteins; Enzyme Inhibitors; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Inbred BALB C; Oncogenes; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Tumor Cells, Cultured	2002

Article

Year

The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.

Cancer research, 2002, Feb-15, Volume: 62, Issue:4

Oncogenic activation of the RET receptor tyrosine kinase is common in different human cancers. We found that the pyrazolo-pyrimidine PP1 inhibited RET-derived oncoproteins with a half maximal inhibitor concentration of 80 nM. Furthermore, RET/PTC3-transformed cells treated with 5 microM of PP1 lost proliferative autonomy and showed morphological reversion. PP1 prevented the growth of two human papillary thyroid carcinoma cell lines that carry spontaneous RET/PTC1 rearrangements and blocked anchorage-independent growth and tumorigenicity in nude mice of NIH3T3 fibroblasts expressing the RET/PTC3 oncogene. These findings suggest targeting RET oncogenes with PP1 or related compounds as a novel treatment strategy for RET-associated neoplasms.

Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Drosophila Proteins; Enzyme Inhibitors; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Inbred BALB C; Oncogenes; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Tumor Cells, Cultured

2002