Compounds > 1,7-phenanthroline
Page last updated: 2024-08-24

1,7-phenanthroline and Neoplasms

1,7-phenanthroline has been researched along with Neoplasms in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.56)18.7374
1990's2 (3.28)18.2507
2000's6 (9.84)29.6817
2010's34 (55.74)24.3611
2020's15 (24.59)2.80

Authors

AuthorsStudies
Araújo, TG; da Costa Guerra, JF; de Oliveira Júnior, RJ; de Souza Bontempo, NJ; de Souza, TR; Goulart, LR; Guerra, W; Lima, PMAP; Lino, RC; Machado, PHA; Martins, IC; Morelli, S; Orsolin, PC; Paixão, DA; Sousa, LM; Teixeira, SC; Van Petten de Vasconcelos Azevedo, F1
Chen, H; Chen, JX; Chen, WC; Cui, X; Lee, CS; Li, S; Lu, G; Tian, S; Wan, Y; Xiao, YF; Zhang, Z1
Cui, Z; Fu, A; Fu, C; Keerthiga, R; Li, X; Tong, T; Yang, X; Zhang, Y; Zhao, Z1
Brindell, M; Gros, PC; Gurgul, I; Lekka, M; Mazuryk, O; Olszanecki, R; Stachyra, K; Suzenet, F; Łomzik, M1
Chen, C; Lv, H; Shen, C; Xu, H; Zhu, D1
Cabiddu, MG; Cadoni, E; Gabrielová, V; Havel, J; Masuri, S; Meloni, F; Moráň, L; Pečinka, L; Pivetta, T; Vaňhara, P; Vesselá, T1
Chen, J; Hu, H; Huang, C; Liang, L; Liu, H; Liu, Y; Wang, Y; Yang, Y; Zhang, H1
Aranđelović, S; Dojčinović, B; Gligorijević, N; Kaczmarek, AM; Radulović, S; Savić, A; Van Deun, R; Van Hecke, K1
P K, A; Paira, P1
Delasoie, J; Haeni, L; Hauser, D; Rossier, J; Rothen-Rutishauser, B; Zobi, F1
Amachawadi, RG; Ankegowda, VM; Armaković, S; Armaković, SJ; Elgorban, AM; Jain, AS; Kallimani, S; Marraiki, N; Pillai, RR; Pradeep, S; Prasad, KS; Prasad, SK; Shivamallu, C; Srinivasa, C; Syed, A1
Alí-Torres, J; Backman-Blanco, G; Cano-Sanchez, P; Flores-Gaspar, A; Hernandez-Ortega, S; Morales-Morales, D; Orjuela, AL; Ramírez-Apan, MT; Reyes-Martínez, R; Valdés, H1
Govindaraju, T; Murugan, NA; Satha, P; Suseela, YV1
Bai, Y; Chen, Y; Chen, Z; Fang, H; Guo, Z; Han, Z; He, W; Shi, X; Wang, Y; Yuan, H1
Crown, J; Duffy, MJ; O'Grady, S; Tang, M1
Ding, J; Han, G; Liu, Y; Meng, C; Meng, LH; Qing, L; Shi, J; Wang, Q; Wang, Y; Wang, Z; Yang, Y1
Kim, DE; Kim, S; Kim, SG; Kwon, TK; Lee, ES; Park, JW; Yooun, JH1
Eskandari, A; Laws, K; Lu, C; Suntharalingam, K1
Cao, JJ; Ji, LN; Mao, ZW; Tan, CP; Zhang, DY; Zhang, H; Zheng, Y1
Chang, CC; Ho, TF; Huang, LR; Lai, JS; Liao, EC; Lin, JY; Lu, CH; Ma, SW; Tsai, CS1
Kashanian, S; Khodaei, MM; Peyman, H; Roshanfekr, H1
Huang, HL; Jiang, GB; Liang, ZH; Lin, GJ; Liu, YJ; Xie, YY1
Bai, Y; Li, W; Liao, X; Liu, M; Lu, J; Ying, P; Zhao, P1
Kumar, YP; Nambigari, N; Reddy, MR; Reddy, PV; Satyanarayana, S; Srishailam, A1
Argüello, GA; Garcia, PF; Silvero, MJ; Toneatto, J1
Ge, X; Huang, W; Liu, J; Liu, Y; Peng, YX; Shi, L; Sun, L1
Aydın, R; Çinkılıç, N; Gençkal, HM; İnci, D; Vatan, Ö; Yılmaz, D; Zorlu, Y1
Chen, H; Liao, X; Lu, J; Yang, N; Ying, P; Zeng, P1
Choi, ES; Daher, C; Demirdjian, S; Hammud, HH; Hariri, E; Isber, S; Mirtamizdoust, B; Mroueh, M1
Cercek, A; Murray, PE; Saltz, L; Wheler, J; Zhou, S1
He, Y; Li, J; Liu, Y1
Chao, H; Ji, L; Qian, C; Wu, J1
Alcaro, S; Betari, N; Calcabrini, C; Catanzaro, E; Costa, G; Fimognari, C; Greco, ML; Marchetti, C; Milelli, A; Minarini, A; Moraca, F; Sissi, C; Tumiatti, V; Turrini, E1
Gupta, RC; Lehmler, HJ; Robertson, LW; Spencer, WA1
Ahmad, A; Azmi, AS; Hadi, SM; Hanif, S; Kumar, KS; Mohammad, RM; Nazeem, S1
Jiang, YL; Liu, ZP1
Bi, C; Chen, DI; Cui, Q; Dou, QP; Fan, Y; Xiao, Y; Zhang, X1
He, LX; Huang, HL; Liu, YJ; Wu, FH; Yao, JH; Zeng, CH1
Vollmar, AM; von Schwarzenberg, K1
Almeida, J; Bandarra, D; Brandão, P; Calhorda, MJ; Félix, V; Lopes, M; Lopes, T; Meireles, M; Nunes, CD; Saraiva, MS; Vasconcellos-Dias, M; Vaz, PD1
Hashimoto, S; Ikeda, T; Matsuzaki, T; Sawada, S; Yaegashi, T1
Babilas, P; Landthaler, M; Meier, RJ; Schreml, S; Szeimies, RM; Wolfbeis, OS1
Chen, QY; Fu, HJ; Gao, J; Ma, ZP; Qi, Y; Zhao, KD; Zhu, WH1
Buchtík, R; Dvořák, Z; Herchel, R; Trávníček, Z; Vančo, J1
Bortolotto, T; Neves, A; Pereira-Maia, EC; Silva, PP; Terenzi, H1
Gao, E; Gao, X; Guan, F; Liu, L; Sun, Y; Wang, C; Zhang, W; Zhu, M1
Jin, L; Liu, J; Shen, J; Tan, L; Weng, C; Zeng, L1
Downward, AM; Hartshorn, RM; Jane, RT; Moore, EG; Polson, MI1
Bi, C; Dong, L; Dou, QP; Fan, Y; Schmitt, SM; Zhang, Z; Zuo, J1
Chen, G; Chen, W; Huang, S; Lu, Y1
Jia, YS; Lu, C; Tong, ZS1
DWYER, FP; MAYHEW, E; ROE, EM; SHULMAN, A1
Harhaji, L; Miljkovic, D; Stosic-Grujicic, S; Trajkovic, V; Vuckovic, O1
Azmi, AS; Bhat, SH; Hadi, SM; Hanif, S1
Creaven, BS; Egan, DA; Kavanagh, K; Noble, A; Thati, B; Walsh, M1
Cole, LA; Kardana, A1
Glass, GA; Stark, AA; Zalit, I1
Ahmad, A; Farhan Asad, S; Hadi, SM; Singh, S1
Boggust, WA; McGauley, H1
Araki, E; Fukasawa, K; Harada, M; Kojima, K; Nagatsu, T; Sakai, T; Sakakibara, S1
Kleibel, F1

Reviews

5 review(s) available for 1,7-phenanthroline and Neoplasms

ArticleYear
MYC as a target for cancer treatment.
    Cancer treatment reviews, 2021, Volume: 94

    Topics: Animals; Antineoplastic Agents; Basic-Leucine Zipper Transcription Factors; Humans; Imidazoles; Molecular Targeted Therapy; Neoplasms; Phenanthrolines; Proto-Oncogene Proteins c-myc

2021
Metallo-organic G-quadruplex ligands in anticancer drug design.
    Mini reviews in medicinal chemistry, 2010, Volume: 10, Issue:8

    Topics: Antineoplastic Agents; Coordination Complexes; Drug Design; G-Quadruplexes; Humans; Ligands; Neoplasms; Phenanthrolines; Pyridines

2010
Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy.
    Cancer letters, 2013, May-28, Volume: 332, Issue:2

    Topics: Alkaloids; Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Aquatic Organisms; Biological Products; Bryostatins; Carbamates; Cell Proliferation; Depsipeptides; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Microtubules; Models, Chemical; Neoplasms; Phenanthrolines; Phenazines; Proteasome Endopeptidase Complex; Pyrones; Pyrroles; Quinolines; Spiro Compounds; Steroids; Tetrahydroisoquinolines; Thiazoles; Trabectedin

2013
Molecular evidence of cryptotanshinone for treatment and prevention of human cancer.
    Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Drugs, Chinese Herbal; Humans; Neoplasms; Phenanthrenes; Phenanthrolines; Salvia miltiorrhiza; TOR Serine-Threonine Kinases

2013
[The research progress of iron metabolism in cancer].
    Sheng li ke xue jin zhan [Progress in physiology], 2012, Volume: 43, Issue:5

    Topics: Animals; Cation Transport Proteins; Ferric Compounds; Humans; Iron; Neoplasms; Phenanthrolines; Transferrin

2012

Trials

1 trial(s) available for 1,7-phenanthroline and Neoplasms

ArticleYear
Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors.
    Investigational new drugs, 2015, Volume: 33, Issue:5

    Topics: Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Imidazoles; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Phenanthrolines

2015

Other Studies

55 other study(ies) available for 1,7-phenanthroline and Neoplasms

ArticleYear
A selective Cu
    Scientific reports, 2021, 12-27, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Copper; DNA Cleavage; Drug Discovery; Humans; Hydrazines; Mice; Neoplasms; Phenanthrolines

2021
Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy.
    ACS applied materials & interfaces, 2022, Feb-02, Volume: 14, Issue:4

    Topics: A549 Cells; Animals; Drug Carriers; Female; Humans; Imidazoles; Light; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; NIH 3T3 Cells; Phenanthrolines; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Reactive Oxygen Species; Tumor Hypoxia

2022
Synthesis of Hemiprotonic Phenanthroline-Phenanthroline
    Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cryptococcus neoformans; DNA-Binding Proteins; Encephalitis; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Mice, Inbred C57BL; Microbial Sensitivity Tests; Neoplasms; Phenanthrolines; Pneumonia; Protons; RNA-Binding Proteins; Transcription Factors

2022
Impact of Polypyridyl Ru Complexes on Angiogenesis-Contribution to Their Antimetastatic Activity.
    International journal of molecular sciences, 2022, Jul-12, Volume: 23, Issue:14

    Topics: 2,2'-Dipyridyl; Coordination Complexes; Endothelial Cells; Humans; Ligands; Neoplasms; Phenanthrolines; Ruthenium

2022
Cyclometalated Ru(II)-NHC complexes with phenanthroline ligands induce apoptosis mediated by mitochondria and endoplasmic reticulum stress in cancer cells.
    Dalton transactions (Cambridge, England : 2003), 2023, Feb-07, Volume: 52, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cisplatin; Coordination Complexes; Endoplasmic Reticulum Stress; HeLa Cells; Humans; Ligands; Mitochondria; Neoplasms; Phenanthrolines; Ruthenium

2023
A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines.
    Journal of inorganic biochemistry, 2023, Volume: 246

    Topics: Apoptosis; Cell Line; Copper; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Lipoxygenase Inhibitors; Molecular Docking Simulation; Neoplasms; Pancreatic Neoplasms; Phenanthrolines; Ursodeoxycholic Acid

2023
Synthesis, characterization, molecular docking, RNA-sequence and anticancer efficacy evaluation in vitro of ruthenium(II) complexes on B16 cells.
    Journal of inorganic biochemistry, 2023, Volume: 247

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Humans; Molecular Docking Simulation; Neoplasms; Phenanthrolines; Reactive Oxygen Species; RNA; Ruthenium

2023
Antitumor activity of organoruthenium complexes with chelate aromatic ligands, derived from 1,10-phenantroline: Synthesis and biological activity.
    Journal of inorganic biochemistry, 2020, Volume: 202

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cisplatin; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Neoplasms; Organometallic Compounds; Phenanthrolines; Ruthenium; Tumor Cells, Cultured

2020
Luminescent anticancer Ru(II)-arenebipyridine and phenanthroline complexes: Synthesis, characterization, DFT studies, biological interactions and cellular imaging application.
    Journal of inorganic biochemistry, 2020, Volume: 208

    Topics: Antineoplastic Agents; Coordination Complexes; DNA; HEK293 Cells; HeLa Cells; Humans; Luminescent Measurements; MCF-7 Cells; Neoplasms; Phenanthrolines; Pyridines; Ruthenium

2020
Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments.
    Journal of inorganic biochemistry, 2020, Volume: 209

    Topics: A549 Cells; Carbon Monoxide; Coordination Complexes; Crystallography, X-Ray; HT29 Cells; Humans; Ligands; Light; Manganese; MCF-7 Cells; Neoplasms; Organometallic Compounds; Phenanthrolines; Photolysis; Solubility; Vitamin B 12

2020
Tumoricidal Potential of Novel Amino-1,10-phenanthroline Derived Imine Ligands: Chemical Preparation, Structure, and Biological Investigations.
    Molecules (Basel, Switzerland), 2020, Jun-22, Volume: 25, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Humans; Imines; Ligands; Molecular Docking Simulation; Neoplasms; Phenanthrolines; Water

2020
Synthesis of Pt(II) complexes of the type [Pt(1,10-phenanthroline)(SArF
    Journal of inorganic biochemistry, 2020, Volume: 211

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coordination Complexes; Crystallography, X-Ray; Humans; In Vitro Techniques; Molecular Structure; Neoplasms; Organoplatinum Compounds; Phenanthrolines; Structure-Activity Relationship

2020
Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics.
    Theranostics, 2020, Volume: 10, Issue:23

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Cell Line, Tumor; DNA Damage; Female; G-Quadruplexes; HEK293 Cells; Humans; Intravital Microscopy; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Dynamics Simulation; Neoplasms; Oxidative Stress; Phenanthrolines; Precision Medicine; Proto-Oncogene Proteins c-bcl-2; Pyridinium Compounds; Spheroids, Cellular; Theranostic Nanomedicine; Xenograft Model Antitumor Assays

2020
Photoinduced synergistic cytotoxicity towards cancer cells
    Dalton transactions (Cambridge, England : 2003), 2020, Oct-20, Volume: 49, Issue:40

    Topics: Antineoplastic Agents; Cell Membrane Permeability; Cell Survival; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Ligands; MCF-7 Cells; Neoplasms; Phenanthrolines; Photochemotherapy; Pyridines; Ruthenium; Singlet Oxygen; Structure-Activity Relationship

2020
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
    Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Neoplasms; Phenanthrolines; Quinolizines; S Phase

2017
A novel anti-cancer agent, FPDHP, induces anoikis in various human cancer cells through activation of calpain, and downregulation of anoikis-related molecules.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:7

    Topics: Anoikis; Antineoplastic Agents; Apoptosis Regulatory Proteins; Calpain; Cell Adhesion; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Phenanthrolines; Signal Transduction; Tumor Cells, Cultured

2018
Highly Charged, Cytotoxic, Cyclometalated Iridium(III) Complexes as Cancer Stem Cell Mitochondriotropics.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Oct-12, Volume: 24, Issue:57

    Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Iridium; Mitochondria; Models, Molecular; Neoplasms; Neoplastic Stem Cells; Phenanthrolines; Reactive Oxygen Species

2018
Photodamaging of Mitochondrial DNA to Overcome Cisplatin Resistance by a Ru
    Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Dec-17, Volume: 24, Issue:71

    Topics: A549 Cells; Antineoplastic Agents; Cisplatin; Coordination Complexes; DNA Damage; DNA, Mitochondrial; HeLa Cells; Humans; Neoplasms; Organoplatinum Compounds; Phenanthrolines; Photochemotherapy; Photosensitizing Agents; Pyrimidines; Ruthenium

2018
Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen).
    Journal of bioscience and bioengineering, 2013, Volume: 116, Issue:4

    Topics: Abietanes; Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Inhibitory Concentration 50; Neoplasms; Phenanthrenes; Phenanthrolines; Plant Extracts; Poly(ADP-ribose) Polymerases; Salvia miltiorrhiza; TNF-Related Apoptosis-Inducing Ligand

2013
DNA interaction of [Cu(dmp)(phen-dion)] (dmp=4,7 and 2,9 dimethyl phenanthroline, phen-dion=1,10-phenanthroline-5,6-dion) complexes and DNA-based electrochemical biosensor using chitosan-carbon nanotubes composite film.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Volume: 114

    Topics: Antineoplastic Agents; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Chitosan; Coordination Complexes; Copper; DNA; Electrochemical Techniques; Humans; Nanotubes, Carbon; Neoplasms; Nucleic Acid Denaturation; Phenanthrolines

2013
Cytotoxicity, apoptosis, cell cycle arrest, reactive oxygen species, mitochondrial membrane potential, and Western blotting analysis of ruthenium(II) complexes.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2013, Volume: 18, Issue:8

    Topics: 2,2'-Dipyridyl; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Coordination Complexes; Humans; Membrane Potential, Mitochondrial; Neoplasms; Phenanthrolines; Phenazines; Pyridines; Reactive Oxygen Species; Ruthenium

2013
DNA binding, antitumor activities, and hydroxyl radical scavenging properties of novel oxovanadium (IV) complexes with substituted isoniazid.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2013, Volume: 18, Issue:8

    Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Apoptosis; Cattle; Cell Cycle; Cell Line, Tumor; Coordination Complexes; DNA; Intercalating Agents; Isoniazid; Neoplasms; Phenanthrolines; Vanadates

2013
Synthesis, characterization, DNA binding, light switch "on and off", docking studies and cytotoxicity, of ruthenium(II) and cobalt(III) polypyridyl complexes.
    Journal of fluorescence, 2014, Volume: 24, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Cell Survival; Cobalt; DNA; Intercalating Agents; Light; Magnetic Resonance Spectroscopy; Neoplasms; Organometallic Compounds; Phenanthrolines; Pyridines; Ruthenium; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

2014
Binding of [Cr(phen)3](3+) to transferrin at extracellular and endosomal pHs: potential application in photodynamic therapy.
    Biochimica et biophysica acta, 2014, Volume: 1840, Issue:9

    Topics: Chromium; Circular Dichroism; Drug Delivery Systems; Endosomes; Humans; Hydrogen-Ion Concentration; Neoplasms; Phenanthrolines; Photochemotherapy; Transferrin

2014
Multicolor (Vis-NIR) mesoporous silica nanospheres linked with lanthanide complexes using 2-(5-bromothiophen)imidazo[4,5-f][1,10]phenanthroline for in vitro bioimaging.
    Dalton transactions (Cambridge, England : 2003), 2015, Jan-07, Volume: 44, Issue:1

    Topics: HeLa Cells; Humans; Lanthanoid Series Elements; Luminescent Measurements; Nanospheres; Neoplasms; Optical Imaging; Phenanthrolines; Silicon Dioxide

2015
New water-soluble copper (II) complexes including 4,7-dimethyl-1,10-phenanthroline and L-tyrosine: synthesis, characterization, DNA interactions and cytotoxicities.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, Feb-05, Volume: 136 Pt B

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Coordination Complexes; Copper; Crystallography, X-Ray; DNA; DNA Cleavage; Humans; Intercalating Agents; Models, Molecular; Neoplasms; Phenanthrolines; Tyrosine

2015
New Oxidovanadium Complexes Incorporating Thiosemicarbazones and 1, 10-Phenanthroline Derivatives as DNA Cleavage, Potential Anticancer Agents, and Hydroxyl Radical Scavenger.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Cleavage; Free Radical Scavengers; Humans; Hydroxyl Radical; Neoplasms; Phenanthrolines; Thiosemicarbazones; Vanadates

2015
Magnetic property, DFT calculation, and biological activity of bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] complex.
    Chemico-biological interactions, 2015, Apr-25, Volume: 231

    Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Copper; Crystallography, X-Ray; Halogenation; Humans; Magnetic Phenomena; Models, Molecular; Neoplasms; Phenanthrolines

2015
Reusable and dual-potential responses electrogenerated chemiluminescence biosensor for synchronously cytosensing and dynamic cell surface N-glycan evaluation.
    Analytical chemistry, 2015, Oct-06, Volume: 87, Issue:19

    Topics: Aptamers, Nucleotide; Biosensing Techniques; Cell Line, Tumor; Cell Membrane; Disulfides; Equipment Design; Humans; Luminescence; Luminescent Agents; Luminescent Measurements; Molybdenum; Nanostructures; Neoplasms; Organometallic Compounds; Phenanthrolines; Polysaccharides

2015
Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(ii) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives.
    Dalton transactions (Cambridge, England : 2003), 2016, Jun-28, Volume: 45, Issue:26

    Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; Humans; Molecular Docking Simulation; Neoplasms; Phenanthrolines; Ruthenium; Topoisomerase II Inhibitors

2016
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.
    European journal of medicinal chemistry, 2017, Mar-10, Volume: 128

    Topics: Antineoplastic Agents; Cell Cycle; Cell Survival; DNA; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Flow Cytometry; G-Quadruplexes; Humans; Imides; Jurkat Cells; Models, Molecular; Naphthalenes; Neoplasms; Phenanthrolines; Polyamines; Taq Polymerase

2017
Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species.
    Free radical biology & medicine, 2009, May-15, Volume: 46, Issue:10

    Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Copper; DNA; DNA Adducts; Hydroquinones; Hydroxylation; In Vitro Techniques; Mixed Function Oxygenases; Neoplasms; Oxidative Stress; Phenanthrolines; Phosphorus Radioisotopes; Polychlorinated Biphenyls; Reactive Oxygen Species; Salmon

2009
Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells.
    Mutagenesis, 2009, Volume: 24, Issue:5

    Topics: Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Shape; Comet Assay; Copper; Cytoprotection; Free Radical Scavengers; Humans; Naphthoquinones; Neoplasms; Oxidation-Reduction; Phenanthrolines; Skin Neoplasms

2009
Molecular study on copper-mediated tumor proteasome inhibition and cell death.
    International journal of oncology, 2010, Volume: 37, Issue:1

    Topics: Breast Neoplasms; Cell Death; Chelating Agents; Copper; Dose-Response Relationship, Drug; Humans; Jurkat Cells; Leukemia; Neoplasms; Phenanthrolines; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured

2010
Synthesis, structure, DNA-binding properties, and cytotoxicity of ruthenium(II) polypyridyl complexes.
    Chemistry & biodiversity, 2010, Volume: 7, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; DNA; Humans; Models, Molecular; Molecular Structure; Neoplasms; Nucleic Acid Denaturation; Phenanthrolines; Photochemical Processes; Ruthenium Compounds; Viscosity

2010
Mo(II) complexes: a new family of cytotoxic agents?
    Journal of inorganic biochemistry, 2010, Volume: 104, Issue:11

    Topics: 1-Octanol; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Molybdenum; Neoplasms; Neuroblastoma; Nucleic Acid Conformation; Phenanthrolines; Tetrazolium Salts; Thiazoles; Water

2010
Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indolizidines; Indolizines; Neoplasms; Phenanthrolines; Structure-Activity Relationship

2011
2D luminescence imaging of pH in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Feb-08, Volume: 108, Issue:6

    Topics: Biosensing Techniques; Cell Line; Fluorescein-5-isothiocyanate; Humans; Hydrogen-Ion Concentration; Keratinocytes; Luminescence; Neoplasms; Organometallic Compounds; Phenanthrolines; Wound Healing

2011
Interaction with DNA and different effect on the nucleus of cancer cells for copper(II) complexes of N-benzyl di(pyridylmethyl)amine.
    Dalton transactions (Cambridge, England : 2003), 2011, May-07, Volume: 40, Issue:17

    Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Nucleus; Coordination Complexes; Copper; Crystallography, X-Ray; DNA, Neoplasm; Humans; Ligands; Molecular Conformation; Neoplasms; Oxygen Consumption; Phenanthrolines; Spectrometry, Fluorescence

2011
Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone.
    Dalton transactions (Cambridge, England : 2003), 2011, Oct-07, Volume: 40, Issue:37

    Topics: 2,2'-Dipyridyl; 4-Quinolones; Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Copper; Crystallography, X-Ray; DNA; DNA Cleavage; Humans; Models, Molecular; Neoplasms; Organometallic Compounds; Phenanthrolines

2011
Photoinduced DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline.
    Inorganic chemistry, 2011, Nov-07, Volume: 50, Issue:21

    Topics: Animals; Copper; DNA; DNA Cleavage; Humans; Intercalating Agents; Neoplasms; Organometallic Compounds; Phenanthrolines; Photochemical Processes; Photochemotherapy; Photosensitizing Agents; Plasmids; Tetracyclines; Ultraviolet Rays

2011
Novel palladium(II) complexes containing a sulfur ligand: structure and biological activity on HeLa cells.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2012, Volume: 17, Issue:2

    Topics: 2,2'-Dipyridyl; Antineoplastic Agents; Apoptosis; DNA; HeLa Cells; Humans; Intercalating Agents; Ligands; Neoplasms; Palladium; Phenanthrolines; Salicylates; Sulfhydryl Compounds; Sulfur

2012
Spectral characteristics, DNA-binding and cytotoxicity of two functional Ru(II) mixed-ligand complexes.
    Dalton transactions (Cambridge, England : 2003), 2012, Apr-21, Volume: 41, Issue:15

    Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Cattle; Cell Survival; Coordination Complexes; DNA; HeLa Cells; Hep G2 Cells; Humans; Ligands; Models, Molecular; Neoplasms; Phenanthrolines; Ruthenium; Spectrum Analysis

2012
Heterodinuclear ruthenium(II)-cobalt(III) complexes as models for a new approach to selective cancer treatment.
    Dalton transactions (Cambridge, England : 2003), 2012, Dec-21, Volume: 41, Issue:47

    Topics: Antineoplastic Agents; Cobalt; Coordination Complexes; Crystallography, X-Ray; Drug Delivery Systems; Electron Transport; Humans; Light; Models, Molecular; Neoplasms; Oxidation-Reduction; Phenanthrolines; Pyridines; Ruthenium

2012
1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2012, Volume: 17, Issue:8

    Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Copper; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Neoplasms; Phenanthrolines; Proteasome Inhibitors

2012
INHIBITION OF LANDSCHUETZ ASCITES TUMOUR GROWTH BY METAL CHELATES DERIVED FROM 3,4,7,8-TETRAMETHYL-1,10-PHENANTHROLINE.
    British journal of cancer, 1965, Volume: 19

    Topics: Animals; Antineoplastic Agents; Ascites; Copper; Metals; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Phenanthrolines; Research; Ruthenium

1965
Iron down-regulates macrophage anti-tumour activity by blocking nitric oxide production.
    Clinical and experimental immunology, 2004, Volume: 137, Issue:1

    Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Cytotoxicity, Immunologic; Down-Regulation; Enzyme Inhibitors; Guanidines; Interferon-gamma; Iron; Iron Chelating Agents; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasms; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Phenanthrolines; Rats; Rats, Inbred Strains

2004
Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties.
    The international journal of biochemistry & cell biology, 2006, Volume: 38, Issue:12

    Topics: Antineoplastic Agents; Antioxidants; Ascorbic Acid; Comet Assay; Copper; DNA Damage; Drug Screening Assays, Antitumor; Free Radical Scavengers; Humans; Hydrogen Peroxide; Lymphocytes; Neoplasms; Oxidants; Oxidation-Reduction; Phenanthrolines; Tannins

2006
An in vitro investigation of the induction of apoptosis and modulation of cell cycle events in human cancer cells by bisphenanthroline-coumarin-6,7-dioxacetatocopper(II) complex.
    Chemico-biological interactions, 2007, Jun-30, Volume: 168, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; CHO Cells; Copper; Coumarins; Cricetinae; Cricetulus; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Neoplasms; Organometallic Compounds; Phenanthrolines

2007
Human chorionic gonadotropin beta-subunit nicking enzymes in pregnancy and cancer patient serum.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:3

    Topics: Amino Acid Sequence; Blotting, Western; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Chromatography, Gel; Disulfides; Endopeptidases; Female; Humans; Leupeptins; Macromolecular Substances; Male; Metalloendopeptidases; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phenanthrolines; Pregnancy

1994
The role of chelators in the catalysis of glutathione-gamma-glutamyl transpeptidase-dependent lipid peroxidation by transition metals.
    Biochemistry and molecular biology international, 1996, Volume: 40, Issue:6

    Topics: Animals; Catalysis; Chelating Agents; Citric Acid; Copper; Ferrous Compounds; gamma-Glutamyltransferase; Glutathione; Kidney; Lead; Ligands; Lipid Peroxidation; Microsomes; Microsomes, Liver; Neoplasms; Oxidation-Reduction; Phenanthrolines; Rats; Rats, Wistar; Sulfhydryl Compounds

1996
DNA breakage by resveratrol and Cu(II): reaction mechanism and bacteriophage inactivation.
    Cancer letters, 2000, Jun-01, Volume: 154, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Bacteriophage lambda; Cattle; Copper; DNA; DNA Damage; Dose-Response Relationship, Drug; Endoribonucleases; Formazans; Free Radical Scavengers; Ions; Neoplasms; Phenanthrolines; Reactive Oxygen Species; Resveratrol; Spectrophotometry; Stilbenes; Thymus Gland; Time Factors; Ultraviolet Rays

2000
Inhibition of collagen peptidase in HeLa cells and human tumours by compounds including drugs used in cancer therapy.
    British journal of cancer, 1978, Volume: 38, Issue:2

    Topics: Antineoplastic Agents; Aprotinin; Collagen; Cyclophosphamide; Edetic Acid; Fluorouracil; HeLa Cells; Humans; Microbial Collagenase; Neoplasms; Phenanthrolines; Razoxane; Thiotepa

1978
A sensitive and specific assay for dipeptidyl-aminopeptidase II in serum and tissues by liquid chromatography-fluorometry.
    Analytical biochemistry, 1985, May-15, Volume: 147, Issue:1

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Coumarins; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Humans; Kidney; Kinetics; Neoplasms; Phenanthrolines; Rats; Spectrometry, Fluorescence

1985
[The development and treatment of radiogenic diarrhea].
    Strahlentherapie, 1966, Volume: 130, Issue:3

    Topics: Adult; Aged; Clioquinol; Diarrhea; Enterocolitis, Pseudomembranous; Female; Humans; Male; Middle Aged; Neoplasms; Phenanthrolines; Quinones; Radiotherapy

1966