1,7-dimethylxanthine has been researched along with Sensitivity and Specificity in 11 studies
1,7-dimethylxanthine : A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Caffeine has been extensively used as a probe to measure CYP1A2 activity in humans with caffeine clearance or the paraxanthine (major metabolite of caffeine) to caffeine concentration ratio being regarded as the preferred metric." | 2.75 | Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma. ( Gross, AS; McLachlan, AJ; Perera, V, 2010) |
| " This method can be applied to the pharmacokinetic study of norfloxacin and enoxacin after repeated administration to assess changes in CYP1A2 activity in healthy subjects." | 1.37 | A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition. ( Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K, 2011) |
| "Theophylline was completely separated from paraxanthine, a major metabolite of caffeine which has been known to interfere with most isocratic reversed-phase HPLC methods, with a mixture of acetonitrile/tetrahydrofuran/acetate buffer (10 mM, pH 5." | 1.28 | Separation and determination of theophylline from paraxanthine in human serum by reversed-phase high-performance liquid chromatography. ( Chikuma, M; Kawai, M; Kawakatsu, K; Nishimura, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Jordan, NY | 1 |
| Mimpen, JY | 1 |
| van den Bogaard, WJ | 1 |
| Flesch, FM | 1 |
| van de Meent, MH | 1 |
| Torano, JS | 1 |
| De Kesel, PM | 1 |
| Lambert, WE | 1 |
| Stove, CP | 1 |
| Kobayashi, T | 1 |
| Homma, M | 1 |
| Momo, K | 1 |
| Kobayashi, D | 1 |
| Kohda, Y | 1 |
| Perera, V | 1 |
| Gross, AS | 1 |
| McLachlan, AJ | 1 |
| Pinhancos, R | 1 |
| Maass, S | 1 |
| Ramanathan, DM | 1 |
| Begas, E | 1 |
| Kouvaras, E | 1 |
| Tsakalof, A | 1 |
| Papakosta, S | 1 |
| Asprodini, EK | 1 |
| Boylan, SM | 1 |
| Cade, JE | 1 |
| Kirk, SF | 1 |
| Greenwood, DC | 1 |
| White, KL | 1 |
| Shires, S | 1 |
| Simpson, NA | 1 |
| Wild, CP | 1 |
| Hay, AW | 1 |
| Koch, JP | 1 |
| ten Tusscher, GW | 1 |
| Koppe, JG | 1 |
| Guchelaar, HJ | 1 |
| Scott, RJ | 1 |
| Palmer, J | 1 |
| Lewis, IA | 1 |
| Pleasance, S | 1 |
| Kawakatsu, K | 1 |
| Nishimura, K | 1 |
| Kawai, M | 1 |
| Chikuma, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 1,7-dimethylxanthine and Sensitivity and Specificity
| Article | Year |
|---|---|
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stab | 2010 |
10 other studies available for 1,7-dimethylxanthine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phen | 2015 |
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Voluntee | 2015 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-4 | 2011 |
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Prep | 2011 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High | 2007 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Ou | 2008 |
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproduc | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
Separation and determination of theophylline from paraxanthine in human serum by reversed-phase high-performance liquid chromatography.
Topics: Aged; Aged, 80 and over; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Reproduc | 1989 |