1,7-dimethylxanthine has been researched along with Pregnancy in 29 studies
1,7-dimethylxanthine : A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy." | 9.22 | Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites. ( Campbell, SC; Clark, EA; Schoen, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Tak, C; Varner, MW; Yu, T, 2016) |
| "Although caffeine is commonly consumed during pregnancy, there are few reports on the association of in utero caffeine exposure with offspring cognition or behavior during childhood." | 7.81 | Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age. ( Keim, SA; Klebanoff, MA, 2015) |
| "Outside pregnancy, acute caffeine consumption is associated with insulin resistance." | 7.77 | Caffeine and insulin resistance in pregnancy. ( Catov, J; Laughon, SK; Parana, S; Powers, RW; Roberts, JM, 2011) |
| "Previous studies of maternal caffeine use and pregnancy outcome have relied on self-reported use." | 7.70 | Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy. ( Clemens, JD; Dersimonian, R; Klebanoff, MA; Levine, RJ; Wilkins, DG, 1998) |
| "This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy." | 5.22 | Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites. ( Campbell, SC; Clark, EA; Schoen, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Tak, C; Varner, MW; Yu, T, 2016) |
| "We examined preconception and pregnancy caffeine exposure with DNAm alterations in neonate cord blood (n = 378)." | 4.12 | Maternal caffeine intake and DNA methylation in newborn cord blood. ( Guan, W; Mumford, SL; Polinski, KJ; Purdue-Smithe, A; Robinson, SL; Schisterman, EF; Schliep, KC; Silver, RM; Yeung, EH; Zhao, SK, 2022) |
| "Higher caffeine consumption during pregnancy has been associated with lower birth weight." | 4.02 | Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons. ( Amyx, M; Bever, AM; Buck Louis, GM; Gerlanc, N; Gleason, JL; Grantz, KL; Hinkle, SN; Kannan, K; Robinson, M; Smarr, MM; Sundaram, R; Tekola-Ayele, F; Vafai, Y, 2021) |
| "This study does not support an increased risk of childhood obesity with increasing maternal caffeine consumption during pregnancy." | 3.81 | Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years. ( Keim, SA; Klebanoff, MA, 2015) |
| "Although caffeine is commonly consumed during pregnancy, there are few reports on the association of in utero caffeine exposure with offspring cognition or behavior during childhood." | 3.81 | Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age. ( Keim, SA; Klebanoff, MA, 2015) |
| "Outside pregnancy, acute caffeine consumption is associated with insulin resistance." | 3.77 | Caffeine and insulin resistance in pregnancy. ( Catov, J; Laughon, SK; Parana, S; Powers, RW; Roberts, JM, 2011) |
| "Previous studies of maternal caffeine use and pregnancy outcome have relied on self-reported use." | 3.70 | Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy. ( Clemens, JD; Dersimonian, R; Klebanoff, MA; Levine, RJ; Wilkins, DG, 1998) |
| "Whether the consumption of caffeine during pregnancy increases the risk of spontaneous abortion is controversial." | 3.70 | Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. ( Clemens, JD; DerSimonian, R; Klebanoff, MA; Levine, RJ; Wilkins, DG, 1999) |
| "Caffeine disposition was studied over 24 h in rats on the 12th day of pregnancy given 80 mg/kg of drug as a single oral dose or in four divided doses every three hours." | 3.67 | Caffeine disposition after oral administration to pregnant rats. ( Bonati, M; Bortolotti, A; Gaspari, F; Jiritano, L, 1985) |
| "The outcome of interest was severe preeclampsia, and exposures were serum paraxanthine (1,7-dimethylxanthine), measured through high-performance liquid chromatography, and CYP1A2 activity, assessed by paraxanthine/caffeine ratios." | 1.42 | Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia. ( Baker, AM; Eichelberger, KY; Haeri, S; Strauss, RA; Stuebe, AM; Woodham, PC, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Polinski, KJ | 1 |
| Purdue-Smithe, A | 1 |
| Robinson, SL | 1 |
| Zhao, SK | 1 |
| Schliep, KC | 1 |
| Silver, RM | 1 |
| Guan, W | 1 |
| Schisterman, EF | 1 |
| Mumford, SL | 1 |
| Yeung, EH | 1 |
| Gleason, JL | 1 |
| Tekola-Ayele, F | 1 |
| Sundaram, R | 1 |
| Hinkle, SN | 1 |
| Vafai, Y | 1 |
| Buck Louis, GM | 1 |
| Gerlanc, N | 1 |
| Amyx, M | 1 |
| Bever, AM | 1 |
| Smarr, MM | 1 |
| Robinson, M | 1 |
| Kannan, K | 1 |
| Grantz, KL | 1 |
| Wierzejska, R | 1 |
| Jarosz, M | 1 |
| Siuba, M | 1 |
| Sawicki, W | 1 |
| Klebanoff, MA | 5 |
| Keim, SA | 2 |
| Eichelberger, KY | 1 |
| Baker, AM | 1 |
| Woodham, PC | 1 |
| Haeri, S | 1 |
| Strauss, RA | 1 |
| Stuebe, AM | 1 |
| Yu, T | 1 |
| Campbell, SC | 1 |
| Stockmann, C | 1 |
| Tak, C | 1 |
| Schoen, K | 1 |
| Clark, EA | 1 |
| Varner, MW | 1 |
| Spigarelli, MG | 1 |
| Sherwin, CM | 1 |
| Laughon, SK | 1 |
| Powers, RW | 1 |
| Roberts, JM | 1 |
| Parana, S | 1 |
| Catov, J | 1 |
| Grosso, L | 1 |
| Triche, E | 1 |
| Bracken, MB | 2 |
| Grosso, LM | 1 |
| Triche, EW | 1 |
| Belanger, K | 1 |
| Benowitz, NL | 1 |
| Holford, TR | 1 |
| ten Tusscher, GW | 1 |
| Guchelaar, HJ | 1 |
| Koch, J | 1 |
| Ilsen, A | 1 |
| Vulsma, T | 1 |
| Westra, M | 1 |
| van der Slikke, JW | 1 |
| Olie, K | 1 |
| Koppe, JG | 1 |
| Boylan, SM | 1 |
| Cade, JE | 1 |
| Kirk, SF | 1 |
| Greenwood, DC | 1 |
| White, KL | 1 |
| Shires, S | 1 |
| Simpson, NA | 1 |
| Wild, CP | 1 |
| Hay, AW | 1 |
| Nakatsuka, T | 1 |
| Hanada, S | 1 |
| Fujii, T | 1 |
| Tanaka, H | 3 |
| Nakazawa, K | 3 |
| Arima, M | 2 |
| Iwasaki, S | 1 |
| Brazier, JL | 1 |
| Ribon, B | 1 |
| Desage, M | 1 |
| Comet, F | 1 |
| Lièvre, M | 1 |
| Berland, M | 1 |
| Salle, B | 1 |
| Dorrbecker, BR | 3 |
| Mercik, SH | 1 |
| Kramer, PA | 3 |
| Wilkinson, JM | 1 |
| Pollard, I | 1 |
| Levine, RJ | 3 |
| Dersimonian, R | 2 |
| Clemens, JD | 3 |
| Wilkins, DG | 3 |
| Eskenazi, B | 1 |
| Jester, DM | 1 |
| Grant, MM | 1 |
| Dorrbecker, SH | 2 |
| Raye, JR | 2 |
| Scott, NR | 1 |
| Chakraborty, J | 1 |
| Marks, V | 1 |
| York, RG | 1 |
| Randall, JL | 1 |
| Scott, WJ | 1 |
| Jiritano, L | 1 |
| Bortolotti, A | 1 |
| Gaspari, F | 1 |
| Bonati, M | 1 |
1 trial available for 1,7-dimethylxanthine and Pregnancy
| Article | Year |
|---|---|
Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Pregnancy; Pregnancy Trimesters; Theobromi | 2016 |
28 other studies available for 1,7-dimethylxanthine and Pregnancy
| Article | Year |
|---|---|
Maternal caffeine intake and DNA methylation in newborn cord blood.
Topics: Adult; Caffeine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Blood; Gestational Age; Humans; | 2022 |
Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.
Topics: Adult; Anthropometry; Biomarkers; Birth Weight; Caffeine; Female; Fetal Development; Follow-Up Studi | 2021 |
Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study.
Topics: Adult; Caffeine; Female; Fetal Blood; Humans; Infant, Newborn; Logistic Models; Male; Pilot Projects | 2014 |
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female; | 2015 |
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
Topics: Adult; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Humans; Pre-Eclampsia; Pregn | 2015 |
Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age.
Topics: Adult; Caffeine; Child; Child Behavior; Child, Preschool; Coffee; Cognition; Female; Follow-Up Studi | 2015 |
Caffeine and insulin resistance in pregnancy.
Topics: Birth Weight; Caffeine; Female; Homeostasis; Humans; Infant, Newborn; Insulin Resistance; Male; Preg | 2011 |
Regarding "An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years".
Topics: Abortion, Spontaneous; Adult; Bias; Caffeine; Female; Humans; Pregnancy; Risk Factors; Sodium; Speci | 2004 |
Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.
Topics: Adult; Biomarkers; Caffeine; Chi-Square Distribution; Connecticut; Cytochrome P-450 Enzyme System; F | 2006 |
Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Caffeine; Child; Cytochrome P-450 CYP1A2; Dioxins | 2008 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Ou | 2008 |
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female; | 1983 |
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregn | 1984 |
Placental transfer model in the pregnant ewe: use of stable isotopes.
Topics: Animals; Female; Fetus; Kinetics; Maternal-Fetal Exchange; Models, Biological; Placenta; Pregnancy; | 1984 |
Improved micro-method for the high-performance liquid chromatographic determination of caffeine and paraxanthine in biological fluids.
Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Pregnancy | 1984 |
Accumulation of theophylline, theobromine and paraxanthine in the fetal rat brain following a single oral dose of caffeine.
Topics: Animals; Biotransformation; Brain; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy | 1993 |
Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
Topics: Biomarkers; Blood Specimen Collection; Caffeine; Cohort Studies; Diet; Female; Humans; Mental Recall | 1998 |
Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion.
Topics: Abortion, Spontaneous; Adult; Caffeine; Case-Control Studies; Female; Humans; Odds Ratio; Pregnancy; | 1999 |
Caffeine--filtering the facts.
Topics: Abortion, Spontaneous; Breast Feeding; Caffeine; Child Development; Female; Fetus; Humans; Infant; P | 1999 |
Caffeine consumption and the risk of spontaneous abortions.
Topics: Abortion, Spontaneous; Caffeine; Case-Control Studies; Female; Humans; Pregnancy; Reproducibility of | 2000 |
Maternal serum caffeine metabolites and small-for-gestational age birth.
Topics: Adult; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Humans; Infant, Newborn; Inf | 2002 |
[Pharmacokinetics of caffeine and dimethylxanthines in plasma and saliva].
Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Models, Biological; Pregnancy; Saliva; Theophyll | 1988 |
Caffeine disposition in the pregnant rabbit. I. Pharmacokinetics following administration by intravenous bolus and continuous zero-order infusion.
Topics: Animals; Caffeine; Female; Infusion Pumps; Infusions, Intravenous; Kinetics; Male; Pregnancy; Pregna | 1988 |
Caffeine disposition in the pregnant rabbit. II. Fetal distribution of caffeine and paraxanthine during chronic maternal caffeine administration.
Topics: Albumins; Amniotic Fluid; Animals; Caffeine; Female; Fetal Proteins; Fetus; Infusions, Intravenous; | 1988 |
Urinary metabolites of caffeine in pregnant women.
Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines | 1986 |
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Fema | 1986 |
The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats.
Topics: Administration, Oral; Animals; Caffeine; Female; Injections, Intravenous; Kinetics; Pregnancy; Rats; | 1985 |
Caffeine disposition after oral administration to pregnant rats.
Topics: Administration, Oral; Amniotic Fluid; Animals; Caffeine; Female; Fetus; Pregnancy; Rats; Theobromine | 1985 |