1,6-hexamethylene diisocyanate and Asthma

1,6-hexamethylene diisocyanate has been researched along with Asthma in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (28.21)	18.7374
1990's	6 (15.38)	18.2507
2000's	17 (43.59)	29.6817
2010's	5 (12.82)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Doekes, G; Heederik, D; Jonaid, BS; Pronk, A	1
Cassidy, LD; Cummings, BJ; Feeley, TM; Hathaway, JA; Li, SH; Molenaar, DM; Simpson, P	1
Bernstein, DI; Boulet, LP; Cartier, A; Gautrin, D; Johnson, VJ; Khurana Hershey, G; Kissling, GE; Langmeyer, S; Lummus, ZL; Luster, MI; Malo, JL; Quirce, S; Sastre, J; Tarlo, SM; Yucesoy, B	1
Decamp, D; Kleinsmith, CR; Nerlinger, A; Opare-Addo, P; Redlich, CA; Stowe, MH; Wisnewski, AV	1
Bernstein, DI; Boulet, LP; Cartier, A; Cruz, MJ; Fluharty, K; Gautrin, D; Germolec, DR; Johnson, VJ; Kissling, GE; Lummus, ZL; Luster, MI; Malo, JL; Munoz, X; Quirce, S; Sastre, J; Tarlo, SM; Yucesoy, B	1
Gordon, T; Redlich, CA; Wisnewski, AV	1
Coren, BA; Cullen, MR; Holm, CT; Redlich, CA; Stowe, MH; Wisnewski, AV	1
Cuesta, J; De Las Heras, M; Fernández-Nieto, M; Novalbos, A; Quirce, S; Sastre, J	1
Liu, Q; Wisnewski, AV	1
Bottomly, K; Chen, L; Herrick, CA; Liu, Q; Redlich, CA; Wisnewski, AV	1
Malo, JL	1
Johnson, VJ; Luster, MI; Matheson, JM	1
Cartier, A; Chen, L; Liu, J; Liu, Q; Redlich, CA; Stowe, MH; Wisnewski, AV	1
Liu, J; Liu, Q; Redlich, CA; Wisnewski, AV	1
Bernstein, DI; Boulet, LP; Campo, P; Cartier, A; Lummus, Z; Malo, JL; Wisnewski, AV	1
Doekes, G; Heederik, D; Jonkers, IC; Lammers, JW; Preller, L; Pronk, A; Raulf-Heimsoth, M; Wisnewski, AV; Wouters, IM	1
Baur, X; Fruhmann, G	1
Bernstein, IL; Chen, SE	1
Bernstein, IL; Chen, SE; Splansky, GL; Vinegar, A	1
Baur, X	1
Butcher, BT	1
Cartier, A; Levitz, D; Malo, JL; Ouimet, G; Zeiss, CR	1
Laitinen, J; Muittari, A; Sovijärvi, A	1
Cockcroft, DW	1
Huynh, CK; Savolainen, H; Vu-Duc, T	1
Cartier, A; Cloutier, Y; Grammer, LC; Lesage, J; Malo, JL; Perreault, G; Shaughnessy, MA; Vandenplas, O	1
Karol, MH; Kramarik, JA	1
Cullen, MR; Graham, C; Holm, CT; Homer, RJ; Karol, MH; Redlich, CA; Wirth, JA	1
Alam, R; Bernstein, DI; Bernstein, JA; Lummus, ZL	1
Karol, MH; Lemus, R; Redlich, CA; Wisnewski, AV	1
Ducatman, AM; Franklin, E; Franklin, PJ; Goldenberg, WS	1
Keskinen, HM; Luukkonen, R; Nordman, H; Piirilä, PL; Salo, SP; Tuomi, TO; Tuppurainen, M	1
Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, S	1
Appiah-Pippim, J; Chung, JS; Cullen, MR; Eisen, EA; Gore, R; Holm, CT; Karol, MH; Lemus, R; Liu, Y; Redlich, CA; Sparer, J; Stowe, MH; Wisnewski, AV; Woskie, SR	1
Redlich, CA; Wisnewski, AV	1
Bottomly, K; Das, J; Herrick, CA; Redlich, CA; Wisnewski, AV; Xu, L	1
Belin, L; Wass, U	1
Cartier, A; Ghezzo, H; Grammer, L; Harris, K; Lagier, F; Malo, JL; Patterson, R	1
Keskinen, H; Nordman, H; Tiikkainen, U; Tupasela, O	1

Reviews

4 review(s) available for 1,6-hexamethylene diisocyanate and Asthma

Article	Year
Mouse models of diisocyanate asthma. American journal of respiratory cell and molecular biology, 2002, Volume: 27, Issue:4 Topics: Allergens; Animals; Asthma; Cyanates; Disease Models, Animal; Isocyanates; Mice; Models, Biological; Models, Chemical; Toluene 2,4-Diisocyanate	2002
Recent developments in diisocyanate asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5 Suppl 2 Topics: Asthma; Cyanates; Epithelial Cells; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Isocyanates; Lung; Occupational Diseases; Occupational Exposure; Skin; Toluene 2,4-Diisocyanate	2003
Animal models for diisocyanate asthma: answers for lingering questions. Current opinion in allergy and clinical immunology, 2004, Volume: 4, Issue:2 Topics: Air Pollutants, Occupational; Allergens; Animals; Asthma; Cyanates; Humans; Isocyanates; Occupational Diseases	2004
Recent developments in diisocyanate asthma. Current opinion in allergy and clinical immunology, 2001, Volume: 1, Issue:2 Topics: Asthma; Cyanates; Genes, MHC Class II; Genetic Predisposition to Disease; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Skin; T-Lymphocytes, Helper-Inducer; Toluene 2,4-Diisocyanate	2001

Other Studies

35 other study(ies) available for 1,6-hexamethylene diisocyanate and Asthma

Article	Year
Exhaled nitric oxide in spray painters exposed to isocyanates: effect modification by atopy and smoking. Occupational and environmental medicine, 2014, Volume: 71, Issue:6 Topics: Adult; Asthma; Biomarkers; Conjunctivitis; Cross-Sectional Studies; Exhalation; Female; Humans; Hypersensitivity, Immediate; Immunoglobulins; Inflammation; Isocyanates; Male; Middle Aged; Nitric Oxide; Occupational Diseases; Occupational Exposure; Paint; Rhinitis; Smoking	2014
Trends in pulmonary function and prevalence of asthma in hexamethylene diisocyanate workers during a 19-year period. Journal of occupational and environmental medicine, 2010, Volume: 52, Issue:10 Topics: Adult; Air Pollutants, Occupational; Asthma; Cohort Studies; Cyanates; Female; Humans; Isocyanates; Male; Medical Audit; Middle Aged; Occupational Exposure; Respiration; Retrospective Studies; Young Adult	2010
Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor α. The Journal of allergy and clinical immunology, 2011, Volume: 128, Issue:2 Topics: Asthma; Case-Control Studies; Cyanates; Female; Humans; Interleukin-13; Interleukin-4 Receptor alpha Subunit; Isocyanates; Lipopolysaccharide Receptors; Male; Occupational Diseases; Occupational Exposure; Polymorphism, Single Nucleotide; Time Factors	2011
Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG. The Annals of occupational hygiene, 2012, Volume: 56, Issue:8 Topics: Adult; Aged; Asthma; Biomarkers; Cyanates; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Isocyanates; Male; Middle Aged; Occupational Exposure; Paint; Polyurethanes; Young Adult	2012
Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 129, Issue:1 Topics: Adult; Antioxidants; Asthma; Canada; Cyanates; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Isocyanates; Male; Toluene 2,4-Diisocyanate	2012
Diisocyanate-exposed auto body shop workers: a one-year follow-up. American journal of industrial medicine, 2002, Volume: 42, Issue:6 Topics: Adult; Aged; Air Pollutants, Occupational; Analysis of Variance; Asthma; Automobiles; Chi-Square Distribution; Cross-Sectional Studies; Cyanates; Female; Follow-Up Studies; Humans; Isocyanates; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Paint; Prevalence	2002
Need for monitoring nonspecific bronchial hyperresponsiveness before and after isocyanate inhalation challenge. Chest, 2003, Volume: 123, Issue:4 Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cyanates; False Negative Reactions; Female; Forced Expiratory Volume; Humans; Isocyanates; Male; Middle Aged; Monitoring, Physiologic; Occupational Diseases; Prospective Studies; Toluene 2,4-Diisocyanate	2003
Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate. The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:3 Topics: Allergens; Amino Acid Sequence; Asthma; Cell Division; Cell Line; Cyanates; Genes, T-Cell Receptor delta; Genetic Variation; Humans; Interferon-gamma; Isocyanates; Molecular Sequence Data; Occupational Diseases; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets	2003
'Daily pattern' of an asthmatic reaction due to isocyanates. Allergy, 2004, Volume: 59, Issue:2 Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Cyanates; Forced Expiratory Volume; Humans; Isocyanates; Male; Occupational Diseases	2004
Isocyanate vapor-induced antigenicity of human albumin. The Journal of allergy and clinical immunology, 2004, Volume: 113, Issue:6 Topics: Albumins; Asthma; Cyanates; Gels; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Occupational Exposure; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Volatilization	2004
Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:3 Topics: Air Pollutants, Occupational; Asthma; Cell Line; Cyanates; Epithelial Cells; Glutathione; Humans; Hypersensitivity; Isocyanates; Occupational Diseases; Respiratory Mucosa	2005
Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI-exposed workers. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Volume: 37, Issue:7 Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Cyanates; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoassay; Immunoglobulin E; Immunoglobulin G; Inhalation Exposure; Isocyanates; Male; Middle Aged; Molecular Structure; Observer Variation; Occupational Diseases; Predictive Value of Tests; Quality Control; Quebec; Radioallergosorbent Test; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Serum Albumin; Skin Tests	2007
Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates. American journal of respiratory and critical care medicine, 2007, Dec-01, Volume: 176, Issue:11 Topics: Adult; Aerosols; Air Pollutants, Occupational; Asthma; Chest Pain; Cyanates; Female; Humans; Immunoglobulin E; Immunoglobulin G; Inhalation Exposure; Isocyanates; Male; Middle Aged; Occupational Diseases; Paint; Prevalence; Pulmonary Disease, Chronic Obstructive; Respiration Disorders; Respiratory Hypersensitivity	2007
Specific IgE antibodies in patients with isocyanate asthma. Chest, 1981, Volume: 80, Issue:1 Suppl Topics: Antibodies; Asthma; Benzhydryl Compounds; Cyanates; Humans; Immunoglobulin E; Isocyanates; Toluene 2,4-Diisocyanate	1981
The guinea pig model of diisocyanate sensitization. I. Immunologic studies. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:5 Topics: Animals; Asthma; Cross Reactions; Cyanates; Disease Models, Animal; Female; Guinea Pigs; Humans; Immunization; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin E; Immunoglobulin G; Isocyanates; Occupational Diseases; Passive Cutaneous Anaphylaxis; Serum Albumin; Toluene 2,4-Diisocyanate; Transferrin	1982
The guinea pig model of diisocyanate sensitization. II. Physiologic studies. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:5 Topics: Animals; Asthma; Cyanates; Disease Models, Animal; Female; Guinea Pigs; Immune Sera; Immunoglobulin E; Isocyanates; Occupational Diseases; Respiratory Function Tests; Toluene 2,4-Diisocyanate; Transferrin	1982
Immunologic cross-reactivity between different albumin-bound isocyanates. The Journal of allergy and clinical immunology, 1983, Volume: 71, Issue:2 Topics: Adult; Aerosols; Asthma; Cyanates; Drug Hypersensitivity; Humans; Isocyanates; Middle Aged; Occupational Diseases; Radioallergosorbent Test; Serum Albumin; Skin Tests; Toluene 2,4-Diisocyanate	1983
Isocyanate induced asthma. European journal of respiratory diseases. Supplement, 1982, Volume: 123 Topics: Asthma; Bronchial Provocation Tests; Cyanates; Forced Expiratory Volume; Humans; Isocyanates; Occupational Diseases; Toluene 2,4-Diisocyanate	1982
Combined alveolitis and asthma due to hexamethylene diisocyanate (HDI), with demonstration of crossed respiratory and immunologic reactivities to diphenylmethane diisocyanate (MDI). The Journal of allergy and clinical immunology, 1983, Volume: 72, Issue:4 Topics: Alveolitis, Extrinsic Allergic; Asthma; Binding Sites, Antibody; Bronchial Provocation Tests; Cross Reactions; Cyanates; Humans; Isocyanates; Male; Middle Aged; Occupational Diseases; Paint; Respiratory Function Tests	1983
[Diisocyanate-induced asthma and alveolitis]. Duodecim; laaketieteellinen aikakauskirja, 1984, Volume: 100, Issue:4 Topics: Adult; Alveolitis, Extrinsic Allergic; Asthma; Construction Materials; Cyanates; Humans; Isocyanates; Male; Occupational Diseases; Paint; Respiratory Function Tests	1984
Acquired persistent increase in nonspecific bronchial, reactivity associated with isocyanate exposure. Annals of allergy, 1982, Volume: 48, Issue:2 Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Cyanates; Forced Expiratory Volume; Histamine; Humans; Isocyanates; Male; Occupational Diseases	1982
[Occupational asthma due to isocyanates: current research orientation in occupational hygiene]. Sozial- und Praventivmedizin, 1993, Volume: 38 Suppl 2 Topics: Air Pollutants, Occupational; Asthma; Cyanates; Humans; Isocyanates; Maximum Allowable Concentration; Pneumoconiosis; Switzerland	1993
Prepolymers of hexamethylene diisocyanate as a cause of occupational asthma. The Journal of allergy and clinical immunology, 1993, Volume: 91, Issue:4 Topics: Adult; Asthma; Bronchial Provocation Tests; Cyanates; Female; Humans; Immunoglobulin E; Isocyanates; Male; Middle Aged; Occupational Diseases; Polymers	1993
Phenyl isocyanate is a potent chemical sensitizer. Toxicology letters, 1996, Dec-16, Volume: 89, Issue:2 Topics: Animals; Antibody Formation; Asthma; Cyanates; Dermatitis, Contact; Ear, External; Immunity, Cellular; Immunoglobulin E; Isocyanates; Mice; Mice, Inbred BALB C; Toluene 2,4-Diisocyanate	1996
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian journal of work, environment & health, 1997, Volume: 23, Issue:3 Topics: Adult; Air Pollutants, Occupational; Asthma; Biopsy; Bronchi; Cyanates; Epithelium; Humans; Immunoglobulin E; Isocyanates; Male; Occupational Diseases; Occupational Exposure	1997
Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. The Journal of allergy and clinical immunology, 1998, Volume: 102, Issue:2 Topics: Adult; Antigens; Asthma; Biomarkers, Tumor; Chemokine CCL2; Chemokines; Cyanates; Female; Humans; Interleukin-8; Isocyanates; Leukocytes, Mononuclear; Lymphokines; Male; Middle Aged; Occupational Diseases; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha; Tumor Protein, Translationally-Controlled 1	1998
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:2 Pt 1 Topics: Air Pollutants; Antibody Specificity; Asthma; Carrier Proteins; Cell Division; Cyanates; Environmental Exposure; Epithelial Cells; Humans; Immune Sera; Isocyanates; Leukocytes, Mononuclear; Lung	1999
Too hot to handle: an unusual exposure of HDI in specialty painters. American journal of industrial medicine, 2000, Volume: 37, Issue:4 Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cost of Illness; Cross-Linking Reagents; Cyanates; Dermatitis, Contact; Dyspnea; Exanthema; Follow-Up Studies; Hot Temperature; Humans; Isocyanates; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Paint; Spirometry; Volatilization	2000
Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:2 Pt 1 Topics: Adult; Air Pollutants; Allergens; Asthma; Cyanates; Female; Follow-Up Studies; Humans; Immunoglobulin E; Isocyanates; Male; Surveys and Questionnaires; Toluene 2,4-Diisocyanate	2000
Hexamethylene diisocyanate causes contraction of canine tracheal smooth muscles through activation of muscarinic receptors. International archives of allergy and immunology, 2000, Volume: 123, Issue:2 Topics: Acetylcholine; Air Pollutants; Animals; Asthma; Atropine; Cyanates; Dogs; Dose-Response Relationship, Drug; Isocyanates; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Occupational Diseases; Receptors, Muscarinic; Trachea	2000
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers. American journal of industrial medicine, 2001, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Air Pollutants, Occupational; Analysis of Variance; Asthma; Automobiles; Chi-Square Distribution; Cross-Sectional Studies; Cyanates; Epidemiologic Studies; Female; Humans; Isocyanates; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Paint; Statistics, Nonparametric; Surveys and Questionnaires	2001
A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. The Journal of allergy and clinical immunology, 2002, Volume: 109, Issue:5 Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cyanates; Cytokines; Dermatitis, Contact; Disease Models, Animal; Eosinophilia; Female; Immunization; Isocyanates; Mice; Mice, Inbred BALB C; Mice, Knockout; Pneumonia; Th2 Cells	2002
Immunologic specificity of isocyanate-induced IgE antibodies in serum from 10 sensitized workers. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:1 Topics: Antibody Specificity; Asthma; Carrier Proteins; Cyanates; Haptens; Humans; Immunoglobulin E; Isocyanates; Male; Occupational Diseases; Radioallergosorbent Test; Serum Albumin; Toluene 2,4-Diisocyanate	1989
Specific serum antibodies against isocyanates: association with occupational asthma. The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:4 Pt 1 Topics: Antibodies; Asthma; Cyanates; Female; Humans; Immunoglobulin E; Immunoglobulin G; Isocyanates; Male; Occupational Diseases; Skin Tests	1989
Experiences of specific IgE in asthma due to diisocyanates. Clinical allergy, 1988, Volume: 18, Issue:6 Topics: Antibody Formation; Antibody Specificity; Antigen-Antibody Complex; Asthma; Bronchial Provocation Tests; Cyanates; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Isocyanates; Radioallergosorbent Test; Skin Tests; Toluene 2,4-Diisocyanate	1988