1-5-diphenyl-2-penten-1-one has been researched along with Acquired-Immunodeficiency-Syndrome* in 1 studies
1 other study(ies) available for 1-5-diphenyl-2-penten-1-one and Acquired-Immunodeficiency-Syndrome
| Article | Year |
|---|---|
Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.
Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates. Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Survival; Diterpenes; Flavanones; Molecular Structure; Nepal; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Thymelaeaceae | 2013 |