1,5-dihydroxyisoquinoline has been researched along with Injury, Myocardial Reperfusion in 3 studies
1,5-dihydroxyisoquinoline: structure in first source
isoquinoline-1,5-diol : An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During myocardial reperfusion injury, oxidative stress induces DNA damage and activation of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1), resulting in cardiovascular dysfunction." | 1.33 | Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. ( Hake, PW; Kaplan, J; O'Connor, M; Zingarelli, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eltze, T | 1 |
| Boer, R | 1 |
| Wagner, T | 1 |
| Weinbrenner, S | 1 |
| McDonald, MC | 2 |
| Thiemermann, C | 2 |
| Bürkle, A | 1 |
| Klein, T | 1 |
| Kaplan, J | 1 |
| O'Connor, M | 1 |
| Hake, PW | 1 |
| Zingarelli, B | 1 |
| Bowes, J | 1 |
| Piper, J | 1 |
3 other studies available for 1,5-dihydroxyisoquinoline and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Topics: Animals; Cell Line; Cell Line, Tumor; Fibroblasts; Humans; Imidazoles; Isoquinolines; Kinetics; Male | 2008 |
Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
Topics: Animals; Benzamides; Caspase 3; Caspases; Cell Adhesion Molecules; Cells, Cultured; Endothelium, Vas | 2005 |
Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.
Topics: Aminobenzoates; Animals; Benzamides; Cell Death; Cell Line; Enzyme Inhibitors; Heart; Hydrogen Perox | 1999 |