1,5-dihydroxyisoquinoline has been researched along with Alloxan Diabetes in 12 studies
1,5-dihydroxyisoquinoline: structure in first source
isoquinoline-1,5-diol : An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Periodontitis was evaluated by gingival inflammatory cell infiltration, inflammatory gene expressions and micro-CT analyses." | 1.46 | Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes. ( Adachi, K; Kikuchi, T; Kobayashi, S; Kobayashi, Y; Matsubara, T; Mitani, A; Miyabe, M; Miyajima, SI; Mizutani, M; Nakamura, N; Naruse, K; Nishikawa, T; Noguchi, T; Ohno, N; Saiki, T; Suzuki, Y, 2017) |
| "Variables of diabetic nephropathy in urine and renal cortex were evaluated by ELISA, Western blot analysis, immunohistochemistry, and colorimetry." | 1.35 | Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy. ( Drel, VR; Obrosova, IG; Pavlov, IA; Shevalye, H; Slusher, B; Xu, W; Zhang, J, 2009) |
| "Diabetic rats developed thermal hyperalgesia (assessed by paw-withdrawal and tail-flick tests), mechanical hyperalgesia (von Frey anesthesiometer/rigid filaments and Randall-Sellito tests), tactile allodynia (flexible von Frey filaments), and increased flinching behavior in phases 1 and 2 of the 2% formalin pain test." | 1.33 | Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. ( Drel, VR; Ilnytska, O; Lyzogubov, VV; Mashtalir, N; Obrosova, IG; Pacher, P; Stevens, MJ; Yorek, MA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, K | 1 |
| Miyajima, SI | 1 |
| Nakamura, N | 1 |
| Miyabe, M | 1 |
| Kobayashi, Y | 1 |
| Nishikawa, T | 1 |
| Suzuki, Y | 1 |
| Kikuchi, T | 1 |
| Kobayashi, S | 1 |
| Saiki, T | 1 |
| Mizutani, M | 1 |
| Ohno, N | 1 |
| Noguchi, T | 1 |
| Mitani, A | 1 |
| Matsubara, T | 1 |
| Naruse, K | 1 |
| Mohammad, G | 1 |
| Siddiquei, MM | 1 |
| Abu El-Asrar, AM | 1 |
| Jangra, A | 1 |
| Datusalia, AK | 1 |
| Sharma, SS | 1 |
| Dhliwayo, N | 1 |
| Sarras, MP | 1 |
| Luczkowski, E | 1 |
| Mason, SM | 1 |
| Intine, RV | 1 |
| Byun, YS | 1 |
| Kang, B | 1 |
| Yoo, YS | 1 |
| Joo, CK | 1 |
| Drel, VR | 4 |
| Xu, W | 2 |
| Zhang, J | 2 |
| Kador, PF | 1 |
| Ali, TK | 1 |
| Shin, J | 1 |
| Julius, U | 1 |
| Slusher, B | 2 |
| El-Remessy, AB | 1 |
| Obrosova, IG | 6 |
| Pavlov, IA | 1 |
| Shevalye, H | 2 |
| Lupachyk, S | 1 |
| Maksimchyk, Y | 1 |
| Terashima, T | 1 |
| Kojima, H | 1 |
| Chan, L | 1 |
| Minchenko, AG | 2 |
| Stevens, MJ | 3 |
| White, L | 1 |
| Abatan, OI | 1 |
| Komjáti, K | 1 |
| Pacher, P | 3 |
| Szabó, C | 2 |
| Frank, RN | 1 |
| Seigel, GM | 1 |
| Zsengeller, Z | 1 |
| Ilnytska, O | 1 |
| Lyzogubov, VV | 1 |
| Mashtalir, N | 1 |
| Yorek, MA | 1 |
12 other studies available for 1,5-dihydroxyisoquinoline and Alloxan Diabetes
| Article | Year |
|---|---|
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Gene Expression; Isoquinolines; Male; Periodontitis; Poly( | 2017 |
Poly (ADP-ribose) polymerase mediates diabetes-induced retinal neuropathy.
Topics: Acetophenones; Animals; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Experimental; Diabetic | 2013 |
Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Blood Glucose; Body Weight; Diabetes Mellitus, Ex | 2014 |
Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation.
Topics: Animal Fins; Animals; Diabetes Mellitus, Experimental; Dioxygenases; Disease Models, Animal; DNA; DN | 2014 |
Poly(ADP-Ribose) Polymerase Inhibition Improves Corneal Epithelial Innervation and Wound Healing in Diabetic Rats.
Topics: Animals; Cornea; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Epitheliu | 2015 |
Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.
Topics: Animals; Blotting, Western; Cataract; Cattle; Cell Culture Techniques; Diabetes Mellitus, Experiment | 2009 |
Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy.
Topics: Albuminuria; Animals; Blood Glucose; Blotting, Western; Body Weight; Creatinine; Diabetes Mellitus, | 2009 |
PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function.
Topics: Aldehydes; Animals; Diabetes Mellitus, Experimental; Isoquinolines; Male; Nerve Tissue; Oxidative St | 2011 |
Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Fusion; Cells, Cultured; Diabetes Mell | 2012 |
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Endothelin-1; Enzyme Activation; Enzyme Inhibi | 2003 |
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
Topics: Animals; Benzamides; Cell Hypoxia; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inh | 2004 |
Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.
Topics: Animals; Apoptosis; Arthropathy, Neurogenic; Blood Glucose; Body Weight; Diabetes Mellitus, Experime | 2006 |