1-4-dichloro-2-butene and Carcinoma

1-4-dichloro-2-butene has been researched along with Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for 1-4-dichloro-2-butene and Carcinoma

Article	Year
Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract. Drug and chemical toxicology, 2002, Volume: 25, Issue:2 Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes. Topics: Administration, Inhalation; Animals; Body Weight; Carcinogens; Carcinoma; Dose-Response Relationship, Drug; Female; Hydrocarbons, Chlorinated; Inhalation Exposure; Longevity; Male; Nose Neoplasms; Rats; Rats, Inbred Strains; Respiratory System	2002

Article

Year

Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract.

Drug and chemical toxicology, 2002, Volume: 25, Issue:2

Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes.

Topics: Administration, Inhalation; Animals; Body Weight; Carcinogens; Carcinoma; Dose-Response Relationship, Drug; Female; Hydrocarbons, Chlorinated; Inhalation Exposure; Longevity; Male; Nose Neoplasms; Rats; Rats, Inbred Strains; Respiratory System

2002