1-4-dichloro-2-butene and Body-Weight

1-4-dichloro-2-butene has been researched along with Body-Weight* in 2 studies

Other Studies

2 other study(ies) available for 1-4-dichloro-2-butene and Body-Weight

Article	Year
Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract. Drug and chemical toxicology, 2002, Volume: 25, Issue:2 Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes. Topics: Administration, Inhalation; Animals; Body Weight; Carcinogens; Carcinoma; Dose-Response Relationship, Drug; Female; Hydrocarbons, Chlorinated; Inhalation Exposure; Longevity; Male; Nose Neoplasms; Rats; Rats, Inbred Strains; Respiratory System	2002
Nasal tumors in rats following long-term inhalation exposure to 1,4-dichlorobutene-2 (DCB). Drug and chemical toxicology, 2000, Volume: 23, Issue:3 This study was conducted to elucidate the time- and dose-response relationships of long-term, low-level 1,4-dichlorobutene-2 (DCB) inhalation exposure to nasal tumor induction in rats. Male Crl:CD BR rats were exposed 6 hours per day, 5 days week to 0, 0.1, 0.3, or 1.0 ppm DCB for up to 19 months; some rats were sacrificed at various time intervals during the study. After 19 months of exposure, surviving rats were held without treatment for an additional 5 months. Tissues from the respiratory tract, lymph nodes, and brain were evaluated microscopically. Compound-related non-neoplastic lesions were observed in the nasal cavities of rats in the 1.0 ppm group after three months of exposure and in the other two groups after twelve months of exposure. The lesions were progressive in severity and frequency. A statistically significant increase in benign nasal tumors (adenomas) occurred in rats from all three DCB-exposed groups. The adenomas occurred in the respiratory region of the nasal cavity and were first observed in the 1.0 ppm group at study month 10. Malignant nasal tumors occurred in the olfactory region of the nasal cavity and were statistically increased at 1.0 ppm. Topics: Adenocarcinoma; Adenoma; Administration, Inhalation; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carcinosarcoma; Corynebacterium Infections; Dose-Response Relationship, Drug; Hydrocarbons, Chlorinated; Inhalation Exposure; Lung Diseases; Male; Nasal Cavity; Nose Neoplasms; Organ Size; Precancerous Conditions; Rats; Rhabdomyosarcoma; Time Factors	2000

Article

Year

Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract.

Drug and chemical toxicology, 2002, Volume: 25, Issue:2

Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes.

Topics: Administration, Inhalation; Animals; Body Weight; Carcinogens; Carcinoma; Dose-Response Relationship, Drug; Female; Hydrocarbons, Chlorinated; Inhalation Exposure; Longevity; Male; Nose Neoplasms; Rats; Rats, Inbred Strains; Respiratory System

2002

Nasal tumors in rats following long-term inhalation exposure to 1,4-dichlorobutene-2 (DCB).

Drug and chemical toxicology, 2000, Volume: 23, Issue:3

This study was conducted to elucidate the time- and dose-response relationships of long-term, low-level 1,4-dichlorobutene-2 (DCB) inhalation exposure to nasal tumor induction in rats. Male Crl:CD BR rats were exposed 6 hours per day, 5 days week to 0, 0.1, 0.3, or 1.0 ppm DCB for up to 19 months; some rats were sacrificed at various time intervals during the study. After 19 months of exposure, surviving rats were held without treatment for an additional 5 months. Tissues from the respiratory tract, lymph nodes, and brain were evaluated microscopically. Compound-related non-neoplastic lesions were observed in the nasal cavities of rats in the 1.0 ppm group after three months of exposure and in the other two groups after twelve months of exposure. The lesions were progressive in severity and frequency. A statistically significant increase in benign nasal tumors (adenomas) occurred in rats from all three DCB-exposed groups. The adenomas occurred in the respiratory region of the nasal cavity and were first observed in the 1.0 ppm group at study month 10. Malignant nasal tumors occurred in the olfactory region of the nasal cavity and were statistically increased at 1.0 ppm.

Topics: Adenocarcinoma; Adenoma; Administration, Inhalation; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carcinosarcoma; Corynebacterium Infections; Dose-Response Relationship, Drug; Hydrocarbons, Chlorinated; Inhalation Exposure; Lung Diseases; Male; Nasal Cavity; Nose Neoplasms; Organ Size; Precancerous Conditions; Rats; Rhabdomyosarcoma; Time Factors

2000