1,4-bis(2-(3,5-dichloropyridyloxy))benzene has been researched along with Disease Models, Animal in 16 studies
1,4-bis(2-(3,5-dichloropyridyloxy))benzene: potent phenobarbital-like inducer of microsomal monooxygenase activity; structure given in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present experiments we investigated the efficiency of a primary hepatocyte mitogen 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOB) on two different liver cirrhosis/fibrosis models in mice induced by chronic administration of CCl(4) and thioacetamide respectively." | 3.78 | 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver. ( Bugyik, E; Dezso, K; Nagy, P; Paku, S; Szurián, K; Turányi, E, 2012) |
| "Obesity and type 2 diabetes are related metabolic disorders of high prevalence." | 1.35 | The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity. ( Gao, J; He, J; Wada, T; Xie, W; Zhai, Y, 2009) |
| "Lithocholic acid (LCA) was used to induce intrahepatic cholestasis." | 1.35 | Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. ( Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wang, X | 1 |
| Zheng, L | 1 |
| Wu, J | 1 |
| Tang, B | 1 |
| Zhang, M | 1 |
| Zhu, D | 1 |
| Lin, X | 1 |
| Uehara, D | 1 |
| Tojima, H | 2 |
| Kakizaki, S | 2 |
| Yamazaki, Y | 2 |
| Horiguchi, N | 2 |
| Takizawa, D | 2 |
| Sato, K | 1 |
| Yamada, M | 1 |
| Uraoka, T | 1 |
| Orsini, V | 1 |
| Zurbruegg, S | 1 |
| Pikiolek, M | 1 |
| Tchorz, JS | 1 |
| Beckmann, N | 1 |
| Blanco-Bose, WE | 1 |
| Murphy, MJ | 1 |
| Ehninger, A | 1 |
| Offner, S | 1 |
| Dubey, C | 1 |
| Huang, W | 2 |
| Moore, DD | 3 |
| Trumpp, A | 1 |
| Beilke, LD | 2 |
| Aleksunes, LM | 1 |
| Olson, ER | 1 |
| Besselsen, DG | 2 |
| Klaassen, CD | 1 |
| Dvorak, K | 1 |
| Cherrington, NJ | 2 |
| Gao, J | 1 |
| He, J | 1 |
| Zhai, Y | 1 |
| Wada, T | 1 |
| Xie, W | 1 |
| Tatsumi, K | 1 |
| Ohashi, K | 1 |
| Taminishi, S | 1 |
| Takagi, S | 1 |
| Utoh, R | 1 |
| Yoshioka, A | 1 |
| Shima, M | 1 |
| Okano, T | 1 |
| Mori, M | 1 |
| Donthamsetty, S | 1 |
| Bhave, VS | 1 |
| Kliment, CS | 1 |
| Bowen, WC | 1 |
| Mars, WM | 1 |
| Bell, AW | 1 |
| Stewart, RE | 1 |
| Orr, A | 1 |
| Wu, C | 1 |
| Michalopoulos, GK | 1 |
| Kowalik, MA | 1 |
| Saliba, C | 1 |
| Pibiri, M | 1 |
| Perra, A | 1 |
| Ledda-Columbano, GM | 1 |
| Sarotto, I | 1 |
| Ghiso, E | 1 |
| Giordano, S | 1 |
| Columbano, A | 1 |
| Sberna, AL | 1 |
| Assem, M | 1 |
| Xiao, R | 1 |
| Ayers, S | 1 |
| Gautier, T | 1 |
| Guiu, B | 1 |
| Deckert, V | 1 |
| Chevriaux, A | 1 |
| Grober, J | 1 |
| Le Guern, N | 1 |
| Pais de Barros, JP | 1 |
| Lagrost, L | 1 |
| Masson, D | 1 |
| Bugyik, E | 1 |
| Dezso, K | 1 |
| Turányi, E | 1 |
| Szurián, K | 1 |
| Paku, S | 1 |
| Nagy, P | 1 |
| Chen, WD | 1 |
| Fu, X | 1 |
| Dong, B | 1 |
| Wang, YD | 1 |
| Shiah, S | 1 |
| Cheng, Q | 1 |
| Kulkarni, S | 1 |
| Slitt, AL | 1 |
16 other studies available for 1,4-bis(2-(3,5-dichloropyridyloxy))benzene and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease.
Topics: Animals; Bilirubin; Biomarkers; Constitutive Androstane Receptor; Disease Models, Animal; Gene Expre | 2017 |
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.
Topics: Animals; Antigens, Differentiation; Apoptosis; Colitis; Constitutive Androstane Receptor; Dextran Su | 2019 |
MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Contrast Media; Disease Models, Anima | 2016 |
C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Disease Models, Animal; Forkhead Box | 2008 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Rec | 2009 |
The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.
Topics: Adipose Tissue; Animals; Constitutive Androstane Receptor; Diabetes Mellitus, Type 2; Diet; Dietary | 2009 |
Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia.
Topics: Animals; Blood Coagulation Factors; Blood Coagulation Tests; Disease Models, Animal; Female; Gene Ex | 2009 |
Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Cell Proliferation; Choline Deficiency; Constitutive Androstane Receptor; Disease Models, A | 2011 |
Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.
Topics: Animals; Body Weight; Cell Cycle; Cell Proliferation; Disease Models, Animal; Extracellular Matrix; | 2011 |
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell | 2011 |
Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
Topics: Amino Acid Sequence; Animals; Apolipoprotein B-100; Apolipoproteins B; Apolipoproteins E; Atheroscle | 2011 |
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Bromodeoxyuridine; Carbon Tetrachloride; Cell Pr | 2012 |
Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver.
Topics: Age Factors; Animals; Animals, Newborn; Cells, Cultured; Constitutive Androstane Receptor; Disease M | 2012 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytopro | 2008 |