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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid and Neoplasms

1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid has been researched along with Neoplasms in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (2.60)18.2507
2000's27 (35.06)29.6817
2010's42 (54.55)24.3611
2020's6 (7.79)2.80

Authors

AuthorsStudies
Baradaran, S; Sadeghi, M; Saeedzadeh, E; Sahafi-Pour, SA; Shirmardi, SP1
Almasi, CE; Bentestuen, M; Gossili, F; Zacho, HD1
Ematsu, Y; Fuchigami, T; Hirose, K; Imai, S; Kinuya, S; Mishiro, K; Munekane, M; Ogawa, K1
Abedi, SM; Hosseinimehr, SJ; Khorramimoghaddam, A; Molavipordanjani, S; Mousavi, T; Talebpour Amiri, F1
Rustagi, V; Udugamasooriya, DG1
Costa, PF; Epple, M; Fendler, WP; Herrmann, K; Klose, J; Knuschke, T; Kollenda, SA; Schmitz, J; Sokolova, V; Staniszewska, M; Westendorf, AM1
Cao, Q; Huang, Q; Li, C; Wang, YA1
Copping, R; Johnson, FL; Kunkel, F; Lee, D; Li, M; Liu, D; McAlister, D; Menda, Y; Mirzadeh, S; Olewein, K; Quinn, TP; Schultz, MK; Zhang, X; Zimmerman, BE1
Andresen, TL; Eliasen, R; Fliedner, FP; Hansen, AE; Henriksen, JR; Jensen, AI; Kjær, A; Parhamifar, L; Severin, GW1
Aboagye, EO; Carroll, L; Cowell, S; Lavdas, I; Vilar, R1
Bu, W; Chen, X; Cui, Z; He, M; Liu, Y; Song, R; Tang, Z; Wu, H; Yao, Z; Zhang, H; Zhang, M1
Albertoni, C; Anastasi, AM; Battistuzzi, G; De Santis, R; Giannini, G; Leone, L; Milazzo, FM; Petronzelli, F; Rosi, A; Salvini, L; Tei, L1
Antoine, R; Besse, S; Chezal, JM; Dugourd, P; Janier, M; Kryza, D; Lux, F; Mignot, A; Miot-Noirault, E; Morlieras, J; Perriat, P; Redini, F; Sancey, L; Tillement, O; Truillet, C; Vidal, A1
Greguric, I; Howell, NR; Katsifis, AG; Lengkeek, NA; Oehlke, E; Pellegrini, PA; Shepherd, RK1
Bérubé-Lauzière, Y; Guérin, B; Klarskov, K; Lebel, R; Lecomte, R; Ranyuk, E; van Lier, JE1
Cescato, R; Gmeiner, P; Hübner, H; Kolesinska, B; Maschauer, S; Prante, O; Purkayastha, N; Reubi, JC; Seebach, D; Sparr, C; Waser, B; Yoshinari, T1
Cescato, R; Cordopatis, P; de Jong, M; Krenning, EP; Maina, T; Nock, BA; Reubi, JC; Tatsi, A; Waser, B1
Barnhart, TE; Cai, W; Chakravarty, R; Hernandez, R; Hong, H; Valdovinos, HF; Yang, Y1
Braun, F; Kolenc Peitl, P; Kroselj, M; Maecke, HR; Mansi, R; Reubi, JC; Sollner Dolenc, M; Tamma, M; Waser, B1
Arleth, L; Binderup, T; Elema, DR; Huda, P; Jensen, M; Kjær, A; Midtgaard, SR; Pedersen, MC1
Baker, JR; Bhattacharjee, S; Kotylar, A; Otis, JB; Wang, H; Wang, SH; Yin, A; Zong, H1
Ahn, H; Chung, YH; Han, EH; Kim, I; Lee, E; Min, JY; Ryu, J1
Cai, W; Chen, K; Chen, X; Li, ZB; Wang, H1
Beck-Sickinger, AG; Dinkelborg, L; Friebe, M; Khan, IU; Lehmann, L; Neundorf, I; Sieger, S; Zwanziger, D1
Czernin, J; Hildebrandt, IJ; McCoy, MR; Meares, C; Olafsen, T; Phelps, ME; Radu, C; Weber, WA; Wei, LH; Wu, AM1
de Jong, M; Mindt, TL; Müller, C; Schibli, R1
Heiskanen, T; Kairemo, K1
Chen, X; Kim, YS; Liu, S; Liu, Z; Shi, J; Zhai, S1
Cescato, R; Forrer, F; Kneifel, S; Maecke, HR; Mansi, R; Reubi, JC; Tamma, ML; Wang, X; Waser, B1
Hansson, M; Orlova, A; Rosik, D; Sandström, M; Sjöberg, A; Tolmachev, V; Wållberg, H; Wennborg, A1
Ellison, D; Finucane, C; Foster, JM; Mather, SJ; Matzow, T; Sosabowski, JK; Watson, SA1
Chen, K; Chen, X; Gao, J; Huang, J; Lee, S; Li, X; Wang, J; Xie, J1
Cheng, Z; Cochran, JR; Gambhir, SS; Jiang, L; Kimura, RH; Li, P; Liu, H; Miao, Z; Ren, G; Silverman, AP1
Cheng, Z; Cochran, JR; Gambhir, SS; Kimura, RH; Miao, Z1
Cheng, D; Dou, S; Hnatowich, DJ; Liang, M; Liu, G; Liu, X; Rusckowski, M; Wang, Y1
Accardo, A; Benedetti, E; Morelli, G; Morisco, A; Palumbo, R; Tesauro, D1
Ambrosini, V; Baum, RP; Bomanji, JB; Chiti, A; De Cristoforo, C; Fanti, S; Gabriel, M; Oyen, W; Papathanasiou, ND; Pepe, G; Virgolini, I1
Banerjee, S; Chakraborty, S; Das, T; Sarma, HD; Venakatesh, M1
Boturyn, D; Dumy, P; Fujibayashi, Y; Fukumura, T; Furukawa, T; Galibert, M; Jin, ZH; Saga, T1
Chung, JK; Jeong, JM; Ju, CH; Kim, YJ; Lee, DS; Lee, JY; Lee, MC; Lee, YS; Shetty, D1
Chen, X; Ma, Y; Niu, G; Ye, Y; Zhu, L1
De Silva, CR; Hruby, VJ; Josan, JS; Lynch, RM; Pagel, MD; Vagner, J; Yoo, B1
Boerman, OC; Dijkgraaf, I; Eek, A; Joosten, L; Liskamp, RM; Rijkers, DT; van der Wildt, B; Versluis, C; Yim, CB1
Brechbiel, MW; Yong, K1
Anderson, AL; Bading, JR; Carmichael, J; Colcher, D; Crow, D; Hudson, PJ; Leong, D; Li, L; Poku, E; Raubitschek, AA; Shively, JE; Turatti, F; Wheatcroft, D; Wheatcroft, MP; Yazaki, PJ1
Baum, RP; Rösch, F1
Cheng, Z; Fan, F; Kimura, R; Liu, H; Miao, Z; Zhang, X1
Alshoukr, F; Barbet, J; Brans, L; Gruaz-Guyon, A; Jallane, A; Mendes, S; Prignon, A; Talbot, JN; Tourwé, D1
Gandomkar, M; Maragheh, MG; Shamsaei, M; Shirmardi, SP1
Demmer, O; Gourni, E; Kessler, H; Schumacher, U; Wester, HJ1
Divilov, V; Hilderbrand, SA; Lewis, JS; Mohindra, P; Weissleder, R; Weissmann, GI; Zeglis, BM1
Cescato, R; Fani, M; Reubi, JC; Waser, B1
Hong, MK; Jeong, JM; Kim, SE; Kim, YJ; Lee, JJ; Lee, YS; Shetty, D; Son, JY1
Boswell, CA; Firestein, R; Fourie, A; Fuji, R; Gill, H; Khawli, LA; Kozak, KR; Lin, K; Ljumanovic, N; Mao, W; Mundo, EE; Polakis, P; Stainton, S; Ulufatu, S; Young, C; Zhang, C1
Chen, H; Li, Z; Luo, Q; Luo, Y; Wang, Q; Yan, X; Yang, L; Zhang, B; Zhang, Z1
Andersen, JT; Channappa, D; Chea, J; Cheung, CW; Colcher, D; Crow, D; Lee, B; Li, L; Orcutt, KD; Poku, E; Raubitschek, A; Sandlie, I; Shively, JE; Wittrup, KD; Yazaki, PJ1
Chelli, M; Chinol, M; De Luca, A; Ginanneschi, M; Leone, G; Paganelli, G; Papi, S; Papini, AM; Sabatino, G1
Areces, L; Bussolati, G; Cassoni, P; Chini, B; Chinol, M; Manning, M; Marrocco, T; Paganelli, G; Papi, S; Reversi, A1
Barrett, J; Bartis, J; Bozarth, J; Edwards, S; Ellars, C; Harris, TD; Kalogeropoulos, S; Lazewatsky, J; Liu, S; Nguyen, T; Onthank, D; Robinson, S; Silva, P; Yalamanchili, P1
Afroze, F; Akhurst, T; Larson, SM; Rosen, N; Smith-Jones, PM; Solit, DB1
Cavanaugh, SX; Hammond, LA; Thomas, CR1
Adamson, GN; DeNardo, GL; DeNardo, SJ; Foreman, AR; Gruettner, C; Ivkov, R; Miers, LA; Natarajan, A1
Amirkhanov, NV; Wickstrom, E1
Albert, R; Bruns, C; Hoyer, D; Kerrad, S; Kneuer, R; Lewis, I; Pless, J; Simeon, C1
Chu, DZ; Leong, L; Liu, A; Raubitschek, AA; Shively, JE; Wilczynski, S; Williams, LE; Wong, JY; Wu, AM; Yamauchi, DM; Yazaki, PJ; Zhan, J1
Mårtensson, L; Nilsson, R; Ohlsson, T; Sjögren, HO; Strand, SE; Tennvall, J1
Boerman, OC; Brouwer, AJ; Corstens, FH; Dechesne, AC; Dijkgraaf, I; Liskamp, RM; Rijkers, DT; Rijnders, AY; Soede, A; van Esse, GW1
Kessler, H; Knör, S; Modlinger, A; Poethko, T; Schottelius, M; Wester, HJ1
Reilly, RM1
Bartlett, DW; Davis, ME; Hildebrandt, IJ; Su, H; Weber, WA1
Fukase, K; Tanaka, K1
Anderson, CJ; Capretto, DA; Meyer, LA; Ping Li, W; Sherman, CD1
Chinol, M; Cremonesi, M; Ferrari, M; Grana, C; Paganelli, G; Prisco, G; Robertson, C; Stabin, MG; Tosi, G1
Cutler, CS; Deutsch, E; Ehrhardt, GJ; Jurisson, SS; Smith, CJ; Tyler, TT1
Bander, NH; Borchardt, P; Curcio, MJ; Frank, RK; Lai, LT; Ma, D; McDevitt, MR; Miederer, M; Pellegrini, V; Scheinberg, DA; Simon, J; Wu, K1
DeNardo, DG; DeNardo, GL; DeNardo, SJ; Shi, XB; Xiong, CY1
Courtenay-Luck, NS; Epenetos, AA; Gooden, CS; Kosmas, C; McCall, MJ; Meares, CF; Snook, D1

Reviews

3 review(s) available for 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid and Neoplasms

ArticleYear
Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.
    Cancer imaging : the official publication of the International Cancer Imaging Society, 2022, Sep-03, Volume: 22, Issue:1

    Topics: Heterocyclic Compounds, 1-Ring; Humans; Incidental Findings; Neoplasms; Peptides; Positron Emission Tomography Computed Tomography; Prevalence; Receptors, Somatostatin; Retrospective Studies

2022
PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.
    Organic & biomolecular chemistry, 2008, Mar-07, Volume: 6, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antigens; Glycoproteins; Heterocyclic Compounds, 1-Ring; Humans; Ligands; Metals; Neoplasms; Oligonucleotides; Organometallic Compounds; Peptides; Positron-Emission Tomography

2008
Current and potential therapeutic uses of lanthanide radioisotopes.
    Cancer biotherapy & radiopharmaceuticals, 2000, Volume: 15, Issue:6

    Topics: Alpha Particles; Beta Particles; Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Metals, Rare Earth; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Peptide Fragments; Radioisotopes; Radionuclide Imaging; Receptors, Somatostatin; Technetium

2000

Trials

3 trial(s) available for 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid and Neoplasms

ArticleYear
A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies.
    Cancer biotherapy & radiopharmaceuticals, 2006, Volume: 21, Issue:2

    Topics: Adult; Aged; Antibodies, Monoclonal; Carcinoembryonic Antigen; Female; Heterocyclic Compounds, 1-Ring; Humans; Immunoglobulin G; Immunotoxins; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Radioimmunotherapy; Yttrium Radioisotopes

2006
Three-step radioimmunotherapy with yttrium-90 biotin: dosimetry and pharmacokinetics in cancer patients.
    European journal of nuclear medicine, 1999, Volume: 26, Issue:2

    Topics: Antibodies, Monoclonal; Avidin; Biotinylation; Bone Marrow; Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Kidney; Liver; Models, Biological; Neoplasms; Pentetic Acid; Radioimmunotherapy; Radiopharmaceuticals; Radiotherapy Dosage; Streptavidin; Tomography, Emission-Computed; Urinary Bladder; Whole-Body Counting; Yttrium Radioisotopes

1999
Development of humoral immune responses against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy.
    Cancer research, 1992, Feb-15, Volume: 52, Issue:4

    Topics: Aged; Antibodies; Antibodies, Monoclonal; Antibody Formation; Breast; Breast Neoplasms; Chelating Agents; Drug Evaluation; Female; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Male; Middle Aged; Neoplasm Staging; Neoplasms; Ovarian Neoplasms; Radioimmunotherapy; Radionuclide Imaging; Stomach Neoplasms; Testicular Neoplasms; Yttrium Radioisotopes

1992

Other Studies

71 other study(ies) available for 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid and Neoplasms

ArticleYear
Internal dosimetry studies of
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2022, Volume: 186

    Topics: Animals; gamma-Aminobutyric Acid; Heterocyclic Compounds, 1-Ring; Humans; Male; Monte Carlo Method; Neoplasms; Radiometry; Radiopharmaceuticals

2022
RGD Peptide-Conjugated Dodecaborate with the Ga-DOTA Complex: A Preliminary Study for the Development of Theranostic Agents for Boron Neutron Capture Therapy and Its Companion Diagnostics.
    Journal of medicinal chemistry, 2022, 12-22, Volume: 65, Issue:24

    Topics: Albumins; Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Iodine Radioisotopes; Mice; Neoplasms; Precision Medicine; Tissue Distribution

2022
The preclinical study of
    Annals of nuclear medicine, 2023, Volume: 37, Issue:7

    Topics: Animals; Cell Line, Tumor; Humans; Lutetium; Mice; Mice, Nude; Neoplasms; Radiopharmaceuticals; Tissue Distribution

2023
Identification of side arm-modified DOTA scaffolds as multi-site binding ligands for cancer cells over normal cells.
    Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19

    Topics: Bronchi; Cells, Cultured; Chelating Agents; Epithelial Cells; Heterocyclic Compounds, 1-Ring; Humans; Magnetic Resonance Imaging; Molecular Structure; Neoplasms; Positron-Emission Tomography; Small Molecule Libraries

2019
In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT.
    Acta biomaterialia, 2020, Volume: 109

    Topics: Animals; Calcium Phosphates; Cell Line, Tumor; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Injections, Intramuscular; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Positron Emission Tomography Computed Tomography

2020
Abraxane-induced bone marrow CD11b
    Theranostics, 2021, Volume: 11, Issue:7

    Topics: Albumin-Bound Paclitaxel; Animals; Antibodies; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; CD11b Antigen; Cell Line, Tumor; Copper Radioisotopes; Female; Gene Expression; Heterocyclic Compounds, 1-Ring; Heterografts; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Nude; Myeloid Cells; Neoplasms; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Spleen; Tumor Microenvironment

2021
Automated cassette-based production of high specific activity [
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2017, Volume: 127

    Topics: Animals; Chromatography, High Pressure Liquid; Heterocyclic Compounds, 1-Ring; Humans; Lead Radioisotopes; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasms; Peptides; Radiopharmaceuticals; Radiotherapy, Image-Guided; Theranostic Nanomedicine; Tissue Distribution

2017
Remote-loading of liposomes with manganese-52 and in vivo evaluation of the stabilities of
    Journal of controlled release : official journal of the Controlled Release Society, 2018, 01-10, Volume: 269

    Topics: Animals; Cell Line, Tumor; Chelating Agents; Copper Radioisotopes; Heterocyclic Compounds, 1-Ring; Liposomes; Manganese; Mice, Inbred BALB C; Neoplasms; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals; Tissue Distribution

2018
Towards an MMP-2-activated molecular agent for cancer imaging.
    Dalton transactions (Cambridge, England : 2003), 2018, Jan-30, Volume: 47, Issue:5

    Topics: Amino Acid Sequence; Enzyme Activation; Gadolinium; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Magnetic Resonance Imaging; Matrix Metalloproteinase 2; Neoplasms; Organometallic Compounds; Peptides

2018
A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.
    Biomaterials, 2018, Volume: 175

    Topics: Animals; Antineoplastic Agents; Cell Survival; Contrast Media; Doxorubicin; Drug Carriers; Female; HeLa Cells; Heterocyclic Compounds, 1-Ring; Humans; Magnetic Resonance Imaging; Manganese Compounds; Mice; Mice, Nude; Nanoparticles; Neoplasms; Oxides; Porosity; Silicon Dioxide; Theranostic Nanomedicine; Tumor Hypoxia

2018
Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors.
    Bioorganic & medicinal chemistry, 2019, 08-01, Volume: 27, Issue:15

    Topics: Dose-Response Relationship, Drug; Heterocyclic Compounds, 1-Ring; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Tenascin; Theranostic Nanomedicine

2019
In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles.
    Chemical communications (Cambridge, England), 2013, Apr-14, Volume: 49, Issue:29

    Topics: Animals; Contrast Media; Gadolinium; Heterocyclic Compounds, 1-Ring; Indium Radioisotopes; Isotope Labeling; Knee Joint; Nanoparticles; Neoplasms; Proteoglycans; Pyridinium Compounds; Quantum Dots; Quaternary Ammonium Compounds; Radionuclide Imaging; Rats

2013
Synthesis and radiolabelling of DOTA-linked glutamine analogues with ⁶⁷,⁶⁸Ga as markers for increased glutamine metabolism in tumour cells.
    Molecules (Basel, Switzerland), 2013, Jun-19, Volume: 18, Issue:6

    Topics: Biomarkers; Cell Line, Tumor; Gallium Radioisotopes; Glutamine; Heterocyclic Compounds, 1-Ring; Humans; Isotope Labeling; Neoplasms; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals

2013
(68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes.
    Bioconjugate chemistry, 2013, Sep-18, Volume: 24, Issue:9

    Topics: Animals; Copper Radioisotopes; Fluorescent Dyes; Gallium Radioisotopes; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Indoles; Isoindoles; Mice; Mice, Nude; Neoplasms; Optical Imaging; Positron-Emission Tomography

2013
Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments.
    Chemistry & biodiversity, 2013, Volume: 10, Issue:12

    Topics: Animals; Binding Sites; Contrast Media; Coordination Complexes; Crystallography, X-Ray; Gadolinium; Heterocyclic Compounds, 1-Ring; HT29 Cells; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Neoplasms; Neurotensin; Positron-Emission Tomography; Protein Structure, Tertiary; Receptors, Neurotensin; Tissue Distribution; Transplantation, Heterologous

2013
[DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.
    European journal of medicinal chemistry, 2014, Feb-12, Volume: 73

    Topics: Animals; Autoradiography; Cell Line, Tumor; Drug Stability; HEK293 Cells; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Ligands; Mice; Mice, SCID; Microscopy, Fluorescence; Molecular Structure; Neoplasms; Protein Binding; Radiopharmaceuticals; Rats; Receptors, Somatostatin; Somatostatin; Structure-Activity Relationship; Tissue Distribution

2014
(44)Sc: an attractive isotope for peptide-based PET imaging.
    Molecular pharmaceutics, 2014, Aug-04, Volume: 11, Issue:8

    Topics: Amino Acid Motifs; Animals; Binding, Competitive; Calcium; Cell Line, Tumor; Disease Models, Animal; Heterocyclic Compounds, 1-Ring; Humans; Image Processing, Computer-Assisted; Inhibitory Concentration 50; Integrin alphaVbeta3; Mice; Molecular Imaging; Neoplasm Transplantation; Neoplasms; Oligopeptides; Peptides; Positron-Emission Tomography; Radioisotopes; Scandium; Tissue Distribution

2014
Stereochemistry of amino acid spacers determines the pharmacokinetics of (111)In-DOTA-minigastrin analogues for targeting the CCK2/gastrin receptor.
    Bioconjugate chemistry, 2015, Jun-17, Volume: 26, Issue:6

    Topics: Amino Acid Sequence; Animals; Gastrins; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Male; Neoplasms; Positron-Emission Tomography; Rats, Inbred Lew; Receptor, Cholecystokinin B

2015
PET/CT Based In Vivo Evaluation of 64Cu Labelled Nanodiscs in Tumor Bearing Mice.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Animals; Cell Line, Tumor; Copper Radioisotopes; Disease Models, Animal; Heterocyclic Compounds, 1-Ring; Heterografts; Humans; Mice; Nanostructures; Neoplasms; Particle Size; Phosphatidylcholines; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed

2015
Dendrimer antibody conjugate to target and image HER-2 overexpressing cancer cells.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: A549 Cells; Cell Line, Tumor; Cell Tracking; Dendrimers; Heterocyclic Compounds, 1-Ring; Humans; Metal Nanoparticles; Microscopy, Confocal; Neoplasms; Receptor, ErbB-2; Trastuzumab

2016
One-Dimensional Supramolecular Nanoplatforms for Theranostics Based on Co-Assembly of Peptide Amphiphiles.
    Biomacromolecules, 2016, 10-10, Volume: 17, Issue:10

    Topics: Doxorubicin; Gene Transfer Techniques; Heterocyclic Compounds, 1-Ring; Humans; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Imaging; MCF-7 Cells; Nanoparticles; Neoplasms; Peptides; Solutions; Surface-Active Agents; Theranostic Nanomedicine; Water

2016
Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:12

    Topics: Amines; Animals; Chelating Agents; Copper Radioisotopes; Fluorescence; Fluorescent Antibody Technique; Fluorescent Dyes; Frozen Sections; Heterocyclic Compounds, 1-Ring; Humans; Infrared Rays; Mice; Neoplasms; Positron-Emission Tomography; Quantum Dots; Rats; Receptors, Vascular Endothelial Growth Factor; Staining and Labeling; Tomography, Optical; Vascular Endothelial Growth Factor A

2008
Novel chemically modified analogues of neuropeptide Y for tumor targeting.
    Bioconjugate chemistry, 2008, Volume: 19, Issue:7

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Cattle; Cell Line; Cell Line, Tumor; Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Ligands; Mice; Neoplasms; Neuropeptide Y; Receptors, Neuropeptide Y; Staining and Labeling; Tissue Distribution

2008
Engineered antibody fragments with infinite affinity as reporter genes for PET imaging.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Antibody Affinity; Base Sequence; Cell Line, Tumor; Feasibility Studies; Gene Expression Regulation, Neoplastic; Genes, Reporter; Heterocyclic Compounds, 1-Ring; Humans; Immunoglobulin Fragments; Mice; Neoplasms; Positron-Emission Tomography; Protein Engineering; Substrate Specificity; Tissue Distribution; Yttrium

2008
Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy.
    European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:6

    Topics: Animals; Carrier Proteins; Cell Line, Tumor; Female; Folate Receptors, GPI-Anchored; Folic Acid; Heterocyclic Compounds, 1-Ring; Humans; Mice; Neoplasms; Radiopharmaceuticals; Receptors, Cell Surface; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

2009
Development of a PBPK model for monoclonal antibodies and simulation of human and mice PBPK of a radiolabelled monoclonal antibody.
    Current pharmaceutical design, 2009, Volume: 15, Issue:9

    Topics: alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Computer Simulation; Drug Delivery Systems; Female; Heterocyclic Compounds, 1-Ring; Humans; Immunoglobulin G; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Models, Biological; Neoplasms; Permeability; Species Specificity; Tissue Distribution

2009
Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.
    Bioconjugate chemistry, 2009, Volume: 20, Issue:4

    Topics: Animals; Copper Radioisotopes; Dimerization; Gene Expression Regulation, Neoplastic; Glioma; Heterocyclic Compounds, 1-Ring; Humans; Integrin alphaVbeta3; Mice; Neoplasms; Oligopeptides; Peptides, Cyclic; Polyethylene Glycols; Positron-Emission Tomography; Radiochemistry; Staining and Labeling; Tissue Distribution; Transplantation, Heterologous

2009
Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Aug-15, Volume: 15, Issue:16

    Topics: Animals; Bombesin; Cells, Cultured; Drug Delivery Systems; Female; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Mice; Mice, Nude; Models, Biological; Neoplasms; Oligopeptides; Positron-Emission Tomography; Radioisotopes; Receptors, Bombesin; Receptors, G-Protein-Coupled; Tomography, Emission-Computed, Single-Photon; Transplantation, Heterologous

2009
Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-Z EGFR:2377 Affibody molecule: aspect of the injected tracer amount.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:3

    Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Injections; Mice; Molecular Imaging; Neoplasms; Radioactive Tracers; Radionuclide Imaging; Recombinant Fusion Proteins; Substrate Specificity; Tissue Distribution

2010
Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:12

    Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Female; Gastrins; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 1-Ring; Isotope Labeling; Mice; Neoplasms; Protein Stability; Protein Transport; Rats; Receptor, Cholecystokinin B; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

2009
PET/NIRF/MRI triple functional iron oxide nanoparticles.
    Biomaterials, 2010, Volume: 31, Issue:11

    Topics: Animals; Biocompatible Materials; Carbocyanines; Cell Line, Tumor; Chelating Agents; Copper Radioisotopes; Drug Carriers; Ferric Compounds; Heterocyclic Compounds, 1-Ring; Humans; Magnetic Resonance Imaging; Materials Testing; Metal Nanoparticles; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Neoplasms; Positron-Emission Tomography; Spectroscopy, Near-Infrared; Transplantation, Heterologous

2010
Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:2

    Topics: Agouti-Related Protein; Amino Acid Sequence; Animals; Cell Line, Tumor; Copper Radioisotopes; Drug Stability; Heterocyclic Compounds, 1-Ring; Humans; Integrin alphaVbeta3; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Neoplasms; Peptides; Positron-Emission Tomography; Protein Engineering; Radiopharmaceuticals; Recombinant Proteins; Tissue Distribution; Transplantation, Heterologous

2010
A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects.
    Bioconjugate chemistry, 2010, Mar-17, Volume: 21, Issue:3

    Topics: Animals; Carbocyanines; Cell Line, Tumor; Copper Radioisotopes; Cystine-Knot Miniproteins; Female; Heterocyclic Compounds, 1-Ring; Humans; Mice; Mice, Nude; Molecular Imaging; Molecular Structure; Neoplasms; Positron-Emission Tomography; Spectroscopy, Near-Infrared; Tissue Distribution

2010
Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle.
    Bioconjugate chemistry, 2010, Jul-21, Volume: 21, Issue:7

    Topics: Animals; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Female; Fluorescence; Heterocyclic Compounds, 1-Ring; Humans; Mice; Mice, Nude; Nanoparticles; Neoplasms; Organometallic Compounds; Streptavidin; Xenograft Model Antitumor Assays

2010
Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells.
    Biopolymers, 2011, Volume: 96, Issue:1

    Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Carriers; Drug Delivery Systems; Flow Cytometry; Heterocyclic Compounds, 1-Ring; Humans; Liposomes; Neoplasms; Peptides; Receptors, Cholecystokinin; Sincalide

2011
Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:10

    Topics: Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Image Interpretation, Computer-Assisted; Injections; Neoplasms; Octreotide; Positron-Emission Tomography; Quality Control; Research Design; Tomography, X-Ray Computed

2010
A novel 177Lu-labeled porphyrin for possible use in targeted tumor therapy.
    Nuclear medicine and biology, 2010, Volume: 37, Issue:5

    Topics: Animals; Chelating Agents; Cross-Linking Reagents; Female; Heterocyclic Compounds, 1-Ring; Lutetium; Mice; Neoplasms; Porphyrins; Radioisotopes; Radionuclide Imaging; Treatment Outcome

2010
RGD-cyclam conjugate: synthesis and potential application for positron emission tomography.
    Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18

    Topics: Animals; Copper Radioisotopes; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Mice; Mice, Nude; Neoplasms; Oligopeptides; Positron-Emission Tomography

2010
Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography.
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Animals; Blood Proteins; Cell Line, Tumor; Chelating Agents; Gallium Radioisotopes; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Humans; Mice; Neoplasms; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals

2010
Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging.
    Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4

    Topics: Amino Acid Sequence; Animals; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Integrin alphaVbeta3; Mice; Mice, Nude; Neoplasms; Oligopeptides; Peptides, Cyclic; Positron-Emission Tomography; Transplantation, Heterologous

2011
Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 716

    Topics: Animals; Binding Sites; Cell Line; Chelating Agents; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Humans; Lanthanoid Series Elements; Ligands; Magnetic Resonance Imaging; Mice; Microscopy, Fluorescence; Molecular Imaging; Neoplasms; Pentetic Acid

2011
Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides synthesized by a "Cu(I)-click" and "sulfo-click" ligation method.
    Chembiochem : a European journal of chemical biology, 2011, Mar-21, Volume: 12, Issue:5

    Topics: Animals; Cell Line, Tumor; Click Chemistry; Heterocyclic Compounds, 1-Ring; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Peptides, Cyclic; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Receptors, Somatostatin

2011
Towards translation of 212Pb as a clinical therapeutic; getting the lead in!
    Dalton transactions (Cambridge, England : 2003), 2011, Jun-21, Volume: 40, Issue:23

    Topics: Alpha Particles; Coordination Complexes; Drug Evaluation, Preclinical; Heterocyclic Compounds, 1-Ring; Humans; Lead; Lead Radioisotopes; Linear Energy Transfer; Neoplasms; Radioimmunotherapy; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon

2011
Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging.
    Bioconjugate chemistry, 2011, Apr-20, Volume: 22, Issue:4

    Topics: Animals; Binding Sites; Copper Radioisotopes; Female; Heterocyclic Compounds, 1-Ring; Kidney; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Neoplasms; Polyethylene Glycols; Positron-Emission Tomography; Radiopharmaceuticals; Sulfhydryl Compounds; Tissue Distribution

2011
Generator-based PET radiopharmaceuticals for molecular imaging of tumours: on the way to THERANOSTICS.
    Dalton transactions (Cambridge, England : 2003), 2011, Jun-21, Volume: 40, Issue:23

    Topics: Coordination Complexes; Heterocyclic Compounds, 1-Ring; Humans; Metals; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals

2011
Macrocyclic chelator assembled RGD multimers for tumor targeting.
    Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11

    Topics: Animals; Chelating Agents; Diagnostic Imaging; Drug Delivery Systems; Heterocyclic Compounds, 1-Ring; Macrocyclic Compounds; Mice; Molecular Structure; Neoplasms; Oligopeptides

2011
Novel DOTA-neurotensin analogues for 111In scintigraphy and 68Ga PET imaging of neurotensin receptor-positive tumors.
    Bioconjugate chemistry, 2011, Jul-20, Volume: 22, Issue:7

    Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Female; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Mice; Mice, Inbred BALB C; Neoplasms; Positron-Emission Tomography; Receptors, Neurotensin

2011
Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing peptide receptors.
    Cancer biotherapy & radiopharmaceuticals, 2011, Volume: 26, Issue:3

    Topics: Animals; Bombesin; Cell Line, Tumor; Chelating Agents; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 1-Ring; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasms; Peptides; Receptors, Bombesin; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

2011
PET imaging of CXCR4 receptors in cancer by a new optimized ligand.
    ChemMedChem, 2011, Oct-04, Volume: 6, Issue:10

    Topics: Animals; Cell Line, Tumor; Contrast Media; Coordination Complexes; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Ligands; Mice; Mice, Nude; Neoplasms; Positron-Emission Tomography; Receptors, CXCR4; Structure-Activity Relationship; Tissue Distribution; Transplantation, Heterologous

2011
Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry.
    Bioconjugate chemistry, 2011, Oct-19, Volume: 22, Issue:10

    Topics: Animals; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Click Chemistry; Female; Heterocyclic Compounds, 1-Ring; Humans; Mice; Mice, Nude; Neoplasms; Norbornanes; Positron-Emission Tomography; Radiopharmaceuticals; Receptor, ErbB-2; Trastuzumab

2011
Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:12

    Topics: Amino Acid Sequence; Autoradiography; Heterocyclic Compounds, 1-Ring; Humans; Ligands; Lutetium; Neoplasms; Oligopeptides; Protein Binding; Radioisotopes; Receptors, Somatostatin

2011
Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging.
    Nuclear medicine and biology, 2012, Volume: 39, Issue:3

    Topics: Amino Acids; Aminobutyrates; Animals; Cell Line, Tumor; Chelating Agents; Glioma; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Mice; Mice, Nude; Neoplasms; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Transplantation, Heterologous

2012
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.
    British journal of pharmacology, 2013, Volume: 168, Issue:2

    Topics: Animals; Antigens; Cell Line, Tumor; Cytotoxins; Heterocyclic Compounds, 1-Ring; Immunoconjugates; Male; Membrane Proteins; Mice; Mice, SCID; Neoplasm Proteins; Neoplasms; Oligopeptides; Pharmaceutical Preparations; Tissue Distribution

2013
Integrin-targeted trifunctional probe for cancer cells: a "seeing and counting" approach.
    Analytical chemistry, 2012, Nov-06, Volume: 84, Issue:21

    Topics: Amides; Cell Count; Cell Line, Tumor; Drug Design; Europium; Fluorescein; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Humans; Integrin alphaVbeta3; Molecular Probes; Neoplasms; Oligopeptides

2012
A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance.
    Protein engineering, design & selection : PEDS, 2013, Volume: 26, Issue:3

    Topics: Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Carcinoembryonic Antigen; Female; Heterocyclic Compounds, 1-Ring; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Neoplasms; Protein Engineering; Protein Stability; Radioimmunotherapy; Single-Chain Antibodies; Tissue Distribution

2013
A new biotin derivative-DOTA conjugate as a candidate for pretargeted diagnosis and therapy of tumors.
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Antineoplastic Agents; Avidin; Biotin; Chelating Agents; Drug Stability; Heterocyclic Compounds, 1-Ring; Humans; Isotope Labeling; Neoplasms; Protein Binding; Radiopharmaceuticals; Yttrium

2003
Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue.
    British journal of cancer, 2003, Sep-01, Volume: 89, Issue:5

    Topics: Animals; Breast Neoplasms; Carcinoma; Chelating Agents; COS Cells; Glioblastoma; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Isotope Labeling; Mice; Neoplasms; Oxytocin; Protein Binding; Radioactive Tracers; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Oxytocin; Sensitivity and Specificity; Stomach Neoplasms; Tissue Distribution; Transfection; Tumor Cells, Cultured; Vasotocin

2003
Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy.
    Cancer biotherapy & radiopharmaceuticals, 2003, Volume: 18, Issue:4

    Topics: Adenocarcinoma; Animals; beta-Alanine; Binding, Competitive; Cell-Matrix Junctions; Dose-Response Relationship, Radiation; Drug Design; Female; Fibrinogen; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Integrin alpha5beta1; Integrin alphaVbeta3; Integrins; Jurkat Cells; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Neoplasms; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Radioisotopes; Radionuclide Imaging; Receptors, Vitronectin; Sulfonamides; Tissue Distribution; Vitronectin; Yttrium Radioisotopes

2003
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors.
    Nature biotechnology, 2004, Volume: 22, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzoquinones; Blotting, Western; Cell Line, Tumor; Copper Radioisotopes; Female; Heterocyclic Compounds, 1-Ring; HSP90 Heat-Shock Proteins; Humans; Immunoblotting; Immunoglobulin Fab Fragments; Indium Radioisotopes; Isotope Labeling; Lactams, Macrocyclic; Mice; Mice, Nude; Molecular Probe Techniques; Neoplasms; Phosphatidylinositol 3-Kinases; Positron-Emission Tomography; Protein Serine-Threonine Kinases; Receptor, ErbB-2; Rifabutin; Tissue Distribution; Trastuzumab; Xenograft Model Antitumor Assays

2004
An image worth a thousand lives?
    Nature biotechnology, 2004, Volume: 22, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzoquinones; Bibenzyls; Diagnostic Imaging; Down-Regulation; ErbB Receptors; Gefitinib; Heterocyclic Compounds, 1-Ring; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Magnetic Resonance Imaging; Molecular Probe Techniques; Mutation; Neoplasms; Phthalazines; Physiological Phenomena; Positron-Emission Tomography; Protein Binding; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Rifabutin; Stilbenes; Tissue Distribution; Trastuzumab

2004
Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 2

    Topics: Animals; Antibodies, Monoclonal; Biosensing Techniques; Chelating Agents; Cohort Studies; Electromagnetic Fields; Heterocyclic Compounds, 1-Ring; Immunoconjugates; Indium Radioisotopes; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms; Polyethylene Glycols; Radioimmunotherapy; Time Factors; Tissue Distribution

2005
Synthesis of novel polydiamidopropanoate dendrimer PNA-peptide chimeras for non-invasive magnetic resonance imaging of cancer.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7

    Topics: Base Sequence; Chelating Agents; Chromatography, High Pressure Liquid; Genes, ras; Heterocyclic Compounds, 1-Ring; Humans; Magnetic Resonance Imaging; Models, Chemical; Molecular Sequence Data; Neoplasms; Peptide Nucleic Acids; Peptides; Polymers; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors

2005
Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.
    Journal of endocrinological investigation, 2005, Volume: 28, Issue:11 Suppl I

    Topics: Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Hydroxyproline; Isotope Labeling; Neoplasms; Pentetic Acid; Receptors, Somatostatin; Somatostatin; Technology, Pharmaceutical; Urethane

2005
Reduced myelotoxicity with sustained tumor concentration of radioimmunoconjugates in rats after extracorporeal depletion.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:2

    Topics: Adsorption; Animals; Antibodies, Monoclonal; Bone Marrow Diseases; Extracorporeal Circulation; Heterocyclic Compounds, 1-Ring; Immunoconjugates; Immunotoxins; Indium Radioisotopes; Neoplasm Transplantation; Neoplasms; Radiation Injuries; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred BN; Transplantation, Isogeneic

2007
Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes.
    Organic & biomolecular chemistry, 2007, Mar-21, Volume: 5, Issue:6

    Topics: Alkynes; Animals; Binding, Competitive; Dendrimers; Drug Delivery Systems; Female; Heterocyclic Compounds, 1-Ring; Humans; Imaging, Three-Dimensional; Integrin alphaVbeta3; Mice; Mice, Nude; Neoplasms; Peptides, Cyclic; Protein Binding; Tissue Distribution; Xenograft Model Antitumor Assays

2007
Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:21

    Topics: Alkynes; Amination; Animals; Azides; Carbonic Acid; Catalysis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Copper; Cyclization; Female; Heterocyclic Compounds, 1-Ring; Ketones; Mice; Mice, Nude; Molecular Structure; Neoplasms; Oximes; Oxygen; Peptides; Rats; Tyrosine; Xenograft Model Antitumor Assays

2007
Carbon nanotubes: potential benefits and risks of nanotechnology in nuclear medicine.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:7

    Topics: Antibodies; Cell Membrane Permeability; Chelating Agents; Drug Delivery Systems; Heterocyclic Compounds, 1-Ring; Humans; Indium Radioisotopes; Lymphoma, B-Cell; Nanotubes, Carbon; Neoplasms; Radioimmunotherapy; Radiopharmaceuticals

2007
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Sep-25, Volume: 104, Issue:39

    Topics: Animals; Chemistry, Pharmaceutical; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Heterocyclic Compounds, 1-Ring; Humans; Mice; Mice, SCID; Nanoparticles; Neoplasm Transplantation; Neoplasms; Positron-Emission Tomography; RNA, Small Interfering; Technology, Pharmaceutical

2007
Receptor-binding, biodistribution, and metabolism studies of 64Cu-DOTA-cetuximab, a PET-imaging agent for epidermal growth-factor receptor-positive tumors.
    Cancer biotherapy & radiopharmaceuticals, 2008, Volume: 23, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Cetuximab; Copper Radioisotopes; ErbB Receptors; Heterocyclic Compounds, 1-Ring; Humans; Immunotherapy; Mice; Mice, Nude; Neoplasms; Positron-Emission Tomography; Radiochemistry; Tissue Distribution; Xenograft Model Antitumor Assays

2008
Tumor therapy with targeted atomic nanogenerators.
    Science (New York, N.Y.), 2001, Nov-16, Volume: 294, Issue:5546

    Topics: Actinium; Alpha Particles; Animals; Antibodies, Monoclonal; Female; Half-Life; Heterocyclic Compounds, 1-Ring; Humans; Immunoconjugates; Linear Energy Transfer; Lymphoma; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Prostate-Specific Antigen; Prostatic Neoplasms; Radioimmunotherapy; Survival Rate; Tumor Cells, Cultured

2001
Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy.
    Cancer biotherapy & radiopharmaceuticals, 2001, Volume: 16, Issue:6

    Topics: Antibodies, Bispecific; Antibodies, Monoclonal; Antibody Affinity; Bacteriophages; Blotting, Western; Chelating Agents; DNA Primers; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Gene Expression; Heterocyclic Compounds, 1-Ring; HLA-DR Antigens; Humans; Immunoglobulin Fc Fragments; Neoplasms; Peptide Library; Polymerase Chain Reaction; Radioimmunotherapy

2001