1,3-dipropyl-8-cyclopentylxanthine has been researched along with Seizures in 25 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 7.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 7.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 7.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| "The effect of chronic administration of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and the adenosine A1 antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) on N-methyl-D-aspartate (NMDA)-evoked seizures was studied in C57BL/6 mice (20/group)." | 7.69 | Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. ( Carter, M; Jacobson, KA; Ji, XD; Paul, IA; Von Lubitz, DK, 1994) |
| " The effects of adenosine, the adenosine analogue, 2-chloroadenosine (2-CADO), the specific adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA) and A2 receptor agonist 5'-(N-cyclopropyl) carboxamidoadenosine (CPCA), were examined against seizures induced by acute administration of pentylenetetrazole (PTZ), 60 mg kg-1, and PTZ kindled seizures, in rats." | 7.69 | Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "The effect of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) on N-methyl-D-aspartate (NMDA)-evoked seizures was studied in C57BL/6 mice (20/group)." | 7.68 | Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice. ( Carter, M; Jacobson, KA; Paul, IA; Von Lubitz, DK, 1993) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 5.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 5.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| "Adenosine is an inhibitor of neuronal activity in the brain." | 5.31 | Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 3.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 3.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| "Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures." | 3.79 | The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice. ( Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H, 2013) |
| "The novel putative anticonvulsant drug 1-[2,6-difluorophenyl)-methyl]-1H-1,2,3-triazolo[4,5-c]) pyridine-4-amine monohydrochloride (BW534U87) effectively reduced seizures induced in rodents by threshold maximal and supramaximal electroshock, electrical kindling, pentylenetetrazole (PTZ) infusion and by vestibular stimulation in the genetically seizure-prone epilepsy-like (EL) mouse." | 3.71 | Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism. ( Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC, 2002) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 3.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| " The present study was conducted to determine if the adenosinergic system and adenosine A1 receptors are involved in the anticonvulsant action of the antiepileptic drugs phenobarbitone and carbamazepine, in pentylenetetrazole (PTZ)-induced seizures in rats." | 3.70 | Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine. ( Gupta, YK; Malhotra, J, 1999) |
| "The effect of chronic administration of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and the adenosine A1 antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) on N-methyl-D-aspartate (NMDA)-evoked seizures was studied in C57BL/6 mice (20/group)." | 3.69 | Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. ( Carter, M; Jacobson, KA; Ji, XD; Paul, IA; Von Lubitz, DK, 1994) |
| "Focal injection of the adenosine A2A receptor agonist CGS21680 (2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyl-carboxamidoaden osine) in the rat prepiriform cortex produced a reduction in the severity of bicuculline methiodide-induced motor seizures." | 3.69 | Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680. ( Franklin, PH; Murray, TF; Zhang, G, 1994) |
| " The effects of adenosine, the adenosine analogue, 2-chloroadenosine (2-CADO), the specific adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA) and A2 receptor agonist 5'-(N-cyclopropyl) carboxamidoadenosine (CPCA), were examined against seizures induced by acute administration of pentylenetetrazole (PTZ), 60 mg kg-1, and PTZ kindled seizures, in rats." | 3.69 | Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "The effect of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) on N-methyl-D-aspartate (NMDA)-evoked seizures was studied in C57BL/6 mice (20/group)." | 3.68 | Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice. ( Carter, M; Jacobson, KA; Paul, IA; Von Lubitz, DK, 1993) |
| "The role of adenosine systems in the initiation and termination of seizures was examined using a unique marker for limbic seizures--maximal dentate activation (MDA)." | 3.68 | A1 adenosinergic modulation alters the duration of maximal dentate activation. ( Lothman, EW; Stringer, JL, 1990) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 1.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "The enhanced anti-seizure and neuroprotective effect achieved by disruption of the A1R/neurabin/RGS4 complex is elicited by the on-site and on-demand release of endogenous adenosine, and does not require administration of A1R ligands." | 1.38 | Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine. ( Chen, Y; Cottingham, C; Greengard, P; Jiao, K; Liu, Y; McMahon, L; Wang, Q, 2012) |
| "Pentylenetetrazol (PTZ)-induced seizure model was used." | 1.37 | [Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501]. ( Li, W; Zhang, JJ, 2011) |
| "Stage 4-5 convulsions (Racine's scale) were induced in adult Wistar rats either through amygdala stimulation (kindling) or by intraperitoneal injection of kainate (10 mg/ml)." | 1.33 | Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. ( Cunha, RA; Lopes, LV; Oliveira, CR; Porciúncula, LO; Rebola, N; Soares-da-Silva, P, 2005) |
| "Organophosphate poisoning can result in seizures and subsequent neuropathology." | 1.32 | Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice. ( Bueters, TJ; Harrison, PK; Ijzerman, AP; Tattersall, JE; van Helden, HP, 2003) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 1.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| "Adenosine is an inhibitor of neuronal activity in the brain." | 1.31 | Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Moezi, L | 1 |
| Akbarian, R | 1 |
| Niknahad, H | 1 |
| Shafaroodi, H | 1 |
| Mallok, A | 1 |
| Vaillant, JD | 1 |
| Soto, MT | 1 |
| Viebahn-Hänsler, R | 1 |
| Viart, Mde L | 1 |
| Pérez, AF | 1 |
| Cedeño, RI | 1 |
| Fernández, OS | 1 |
| Socała, K | 1 |
| Nieoczym, D | 1 |
| Pieróg, M | 1 |
| Wlaź, P | 1 |
| Siebel, AM | 1 |
| Menezes, FP | 1 |
| Capiotti, KM | 1 |
| Kist, LW | 1 |
| da Costa Schaefer, I | 1 |
| Frantz, JZ | 1 |
| Bogo, MR | 1 |
| Da Silva, RS | 1 |
| Bonan, CD | 1 |
| Faingold, CL | 1 |
| Randall, M | 1 |
| Kommajosyula, SP | 1 |
| Amorim, BO | 1 |
| Hamani, C | 1 |
| Ferreira, E | 1 |
| Miranda, MF | 1 |
| Fernandes, MJS | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Covolan, L | 1 |
| Cognato, GP | 1 |
| Agostinho, PM | 1 |
| Hockemeyer, J | 1 |
| Müller, CE | 1 |
| Souza, DO | 1 |
| Cunha, RA | 2 |
| Li, W | 1 |
| Zhang, JJ | 1 |
| Chen, Y | 1 |
| Liu, Y | 1 |
| Cottingham, C | 1 |
| McMahon, L | 1 |
| Jiao, K | 1 |
| Greengard, P | 1 |
| Wang, Q | 1 |
| Southam, E | 1 |
| Stratton, SC | 1 |
| Sargent, RS | 1 |
| Brackenborough, KT | 1 |
| Duffy, C | 1 |
| Hagan, RM | 1 |
| Pratt, GD | 1 |
| Jones, SA | 1 |
| Morgan, PF | 1 |
| Harrison, PK | 1 |
| Bueters, TJ | 1 |
| Ijzerman, AP | 1 |
| van Helden, HP | 1 |
| Tattersall, JE | 1 |
| Adén, U | 1 |
| O'Connor, WT | 1 |
| Berman, RF | 1 |
| Rebola, N | 1 |
| Porciúncula, LO | 1 |
| Lopes, LV | 1 |
| Oliveira, CR | 1 |
| Soares-da-Silva, P | 1 |
| Von Lubitz, DK | 2 |
| Paul, IA | 2 |
| Ji, XD | 1 |
| Carter, M | 2 |
| Jacobson, KA | 2 |
| Zhang, G | 1 |
| Franklin, PH | 1 |
| Murray, TF | 1 |
| Concas, A | 2 |
| Santoro, G | 1 |
| Mascia, MP | 2 |
| Maciocco, E | 1 |
| Dazzi, L | 1 |
| Ongini, E | 1 |
| Biggio, G | 2 |
| Cuccheddu, T | 1 |
| Floris, S | 1 |
| Mostallino, MC | 1 |
| Perra, C | 1 |
| Satta, S | 1 |
| Malhotra, J | 2 |
| Gupta, YK | 2 |
| Khan, GM | 1 |
| Smolders, I | 1 |
| Ebinger, G | 1 |
| Michotte, Y | 1 |
| Huber, A | 1 |
| Padrun, V | 1 |
| Déglon, N | 1 |
| Aebischer, P | 1 |
| Möhler, H | 1 |
| Boison, D | 1 |
| Tchekalarova, J | 1 |
| Kambourova, T | 1 |
| Georgiev, V | 1 |
| Stringer, JL | 1 |
| Lothman, EW | 1 |
25 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2013 |
Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, An | 2015 |
Role of the adenosine system and glucose restriction in the acute anticonvulsant effect of caprylic acid in the 6 Hz psychomotor seizure test in mice.
Topics: 3-Hydroxybutyric Acid; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonis | 2015 |
Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Diphosphate; Animals; Benzyl Compou | 2015 |
Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine.
Topics: Adenosine; Animals; Caffeine; Death, Sudden; Disease Models, Animal; Disease Susceptibility; Dose-Re | 2016 |
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec | 2016 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Diseas | 2010 |
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvul | 2011 |
Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Cell Death; Cells, Cultured | 2012 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonv | 2002 |
Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Ani | 2003 |
Changes in purine levels and adenosine receptors in kindled seizures in the rat.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Carrier Proteins; Corpus Striatum; Disease | 2004 |
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.
Topics: Amygdala; Animals; Blotting, Western; Cerebral Cortex; Down-Regulation; Electric Stimulation; Kainic | 2005 |
Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice.
Topics: Adenosine; Animals; Binding Sites; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Motor A | 1994 |
Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680.
Topics: Adenosine; Animals; Anticonvulsants; Antihypertensive Agents; Behavior, Animal; Bicuculline; Cerebra | 1994 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice.
Topics: Adenosine; Animals; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; | 1993 |
Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellum.
Topics: Adenosine; Alcoholism; Animals; Cerebellar Cortex; Cerebellum; Dose-Response Relationship, Drug; Eth | 1996 |
Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats.
Topics: Adenosine; Animals; Blood Pressure; Body Temperature; Heart Rate; Male; Pentylenetetrazole; Rats; Ra | 1997 |
Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine.
Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Combinations; Male; Pentylenet | 1999 |
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Electroencephalography; Electrophysiology; gamma-Ami | 2001 |
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aggression; Animals; Brain; Cell Line; Cell Transp | 2001 |
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce | 2001 |
A1 adenosinergic modulation alters the duration of maximal dentate activation.
Topics: 2-Chloroadenosine; Adenosine; Animals; Electric Stimulation; Hippocampus; Limbic System; Male; Rats; | 1990 |