1,3-dipropyl-8-cyclopentylxanthine has been researched along with Reperfusion Injury in 23 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 7.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| "The cardioprotective effects of the selective adenosine A1-receptor agonist, GR79236 (N-[(1S, trans)-2-hydroxycyclopentyl]adenosine), were examined in a porcine model of myocardial ischaemia-reperfusion injury." | 7.70 | The time course of cardioprotection induced by GR79236, a selective adenosine A1-receptor agonist, in myocardial ischaemia-reperfusion injury in the pig. ( Drew, GM; Hunt, AA; Louttit, JB; Maxwell, MP, 1999) |
| "Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning." | 5.34 | Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007) |
| "The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle injury." | 5.34 | Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. ( Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J, 2007) |
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 3.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| " Seven minutes before hypoxia reoxygenation, muscles were exposed to 4 min of hypoxia and 7 min of reoxygenation or 15 min of sevoflurane at concentrations of 1, 2, and 3%." | 3.72 | Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro. ( Babatasi, G; Bricard, H; Ducouret, P; Gérard, JL; Haelewyn, B; Hanouz, JL; Khayat, A; Massetti, M; Terrien, X; Yvon, A, 2003) |
| "The cardioprotective effects of the selective adenosine A1-receptor agonist, GR79236 (N-[(1S, trans)-2-hydroxycyclopentyl]adenosine), were examined in a porcine model of myocardial ischaemia-reperfusion injury." | 3.70 | The time course of cardioprotection induced by GR79236, a selective adenosine A1-receptor agonist, in myocardial ischaemia-reperfusion injury in the pig. ( Drew, GM; Hunt, AA; Louttit, JB; Maxwell, MP, 1999) |
| "Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning." | 1.34 | Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007) |
| "The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle injury." | 1.34 | Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. ( Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J, 2007) |
| "Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning." | 1.32 | Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. ( Ishii, K; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Yonoki, Y, 2004) |
| "Adenosine treatment after ischemia protected renal function and improved tubular histology." | 1.31 | Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation. ( Emala, CW; Lee, HT, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 15 (65.22) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zamani, M | 1 |
| Soleimani, M | 1 |
| Golab, F | 1 |
| Mohamadzadeh, F | 1 |
| Mehdizadeh, M | 1 |
| Katebi, M | 1 |
| Lu, HR | 1 |
| Song, SW | 1 |
| Han, KY | 1 |
| Liu, HP | 1 |
| Chen, SD | 1 |
| Wang, JL | 1 |
| Dai, QX | 1 |
| Moosavi, SM | 1 |
| Bayat, G | 1 |
| Owji, SM | 1 |
| Panjehshahin, MR | 1 |
| Park, SW | 1 |
| Kim, JY | 1 |
| Ham, A | 1 |
| Brown, KM | 1 |
| Kim, M | 1 |
| D'Agati, VD | 1 |
| Lee, HT | 3 |
| Yvon, A | 1 |
| Hanouz, JL | 1 |
| Haelewyn, B | 1 |
| Terrien, X | 1 |
| Massetti, M | 1 |
| Babatasi, G | 1 |
| Khayat, A | 1 |
| Ducouret, P | 1 |
| Bricard, H | 1 |
| Gérard, JL | 1 |
| Xu, H | 1 |
| Nasr, SH | 1 |
| Schnermann, J | 1 |
| Emala, CW | 2 |
| Sakamoto, K | 1 |
| Yonoki, Y | 1 |
| Kuwagata, M | 1 |
| Saito, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Reid, EA | 1 |
| Kristo, G | 1 |
| Yoshimura, Y | 1 |
| Ballard-Croft, C | 1 |
| Keith, BJ | 1 |
| Mentzer, RM | 1 |
| Lasley, RD | 1 |
| Yildiz, G | 1 |
| Demiryürek, AT | 1 |
| Gümüşel, B | 1 |
| Lippton, H | 1 |
| Ozacmak, VH | 1 |
| Sayan, H | 1 |
| Zheng, J | 1 |
| Wang, R | 1 |
| Zambraski, E | 1 |
| Wu, D | 1 |
| Jacobson, KA | 1 |
| Liang, BT | 1 |
| León Fernández, OS | 1 |
| Ajamieh, HH | 2 |
| Berlanga, J | 1 |
| Menéndez, S | 1 |
| Viebahn-Hánsler, R | 1 |
| Re, L | 1 |
| Carmona, AM | 1 |
| Candelario-Jalil, E | 1 |
| Fernández, OS | 1 |
| Gerbes, AL | 1 |
| Neely, CF | 1 |
| Keith, IM | 1 |
| Phillis, JW | 1 |
| Li, B | 1 |
| Rosenbaum, PS | 1 |
| Jennings, NM | 1 |
| Maxwell, KM | 1 |
| Roth, S | 1 |
| Louttit, JB | 1 |
| Hunt, AA | 1 |
| Maxwell, MP | 1 |
| Drew, GM | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Kadowaki, M | 1 |
| Tokita, K | 1 |
| Nagakura, Y | 1 |
| Takeda, M | 1 |
| Hanaoka, K | 1 |
| Tomoi, M | 1 |
| Nonaka, A | 1 |
| Kiryu, J | 1 |
| Tsujikawa, A | 1 |
| Yamashiro, K | 1 |
| Nishijima, K | 1 |
| Miyamoto, K | 1 |
| Nishiwaki, H | 1 |
| Honda, Y | 1 |
| Ogura, Y | 1 |
| Sugino, H | 1 |
| Shimada, H | 1 |
| Tsuchimoto, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02276170] | 9 participants (Actual) | Observational | 2014-10-31 | Terminated (stopped due to insufficient rate of accrual) | |||
| The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335] | Phase 3 | 80 participants (Anticipated) | Interventional | 2019-02-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Reperfusion Injury
| Article | Year |
|---|---|
NeuroProtective effects of adenosine receptor agonist coadministration with ascorbic acid on CA1 hippocampus in a mouse model of ischemia reperfusion injury.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Antioxidants; | 2013 |
[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study].
Topics: Adenosine; Animals; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Infarction, Middle Cer | 2015 |
Early renal post-ischaemic tissue damage and dysfunction with contribution of A1-adenosine receptor activation in rat.
Topics: Acute Kidney Injury; Adenosine A1 Receptor Antagonists; Animals; Ischemia; Kidney; Male; Microscopy, | 2009 |
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Humans; Kidney; Kidney Tubules, Proximal; | 2012 |
Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro.
Topics: Aged; Anesthetics, Inhalation; ATP-Binding Cassette Transporters; Benzamides; Decanoic Acids; Heart | 2003 |
A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.
Topics: Acute Kidney Injury; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Apoptosis; Biomarkers; G | 2004 |
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina.
Topics: Adrenergic alpha-Antagonists; Animals; Enzyme Inhibitors; Intraocular Pressure; Ischemia; Ischemic P | 2004 |
In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling.
Topics: Animals; Butadienes; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; MAP Kinase | 2005 |
Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Ischemic Preconditioning; Lung; Male; Malondi | 2007 |
Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Glutathione; Ileum; Intestines; Male; Muscle Con | 2007 |
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Topics: Adenosine; Animals; Dihydropyridines; Disease Models, Animal; Hindlimb; Mice; Mice, Inbred C57BL; Mi | 2007 |
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Biomarkers; Disease Models, Animal; HSP72 Hea | 2008 |
Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Antioxidants; | 2008 |
A1 adenosine receptor antagonists block ischemia-reperfusion injury of the lung.
Topics: Animals; Cats; Erythrocytes; Infusions, Intra-Arterial; Ischemia; Lung; Lung Transplantation; Macrop | 1995 |
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; D | 1995 |
Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat.
Topics: Animals; Caffeine; Electroretinography; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawl | 1999 |
The time course of cardioprotection induced by GR79236, a selective adenosine A1-receptor agonist, in myocardial ischaemia-reperfusion injury in the pig.
Topics: Adenosine; Anesthesia; Animals; Blood Pressure; Coronary Disease; Female; Heart Rate; Male; Molecula | 1999 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra | 1999 |
Intrinsic A(1) adenosine receptor activation during ischemia or reperfusion improves recovery in mouse hearts.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Creatine; Extracellular Space; He | 2000 |
Adenosine A1 receptor blockade reverses dysmotility induced by ischemia-reperfusion in rat colon.
Topics: Animals; Colon; Gastrointestinal Motility; Male; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyri | 2000 |
Inhibitory effect of ischemic preconditioning on leukocyte participation in retinal ischemia-reperfusion injury.
Topics: Acridine Orange; Adenosine; Animals; Fluorescein Angiography; Fluorescent Dyes; Injections, Intramus | 2001 |
Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation.
Topics: Adenosine; Analysis of Variance; Animals; Bucladesine; Caffeine; Kidney; Male; Purinergic P1 Recepto | 2001 |
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco | 2001 |