1,3-dipropyl-8-cyclopentylxanthine has been researched along with Nerve Pain in 9 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the involvement of the adenosinergic system in antiallodynia induced by exercise in an animal model of complex regional pain syndrome type I (CRPS-I)." | 3.79 | High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system. ( Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J, 2013) |
| "This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A(1) receptor, on thermal hyperalgesia and mechanical allodynia in a mouse model of neuropathic pain, the Spared Nerve Injury (SNI) of the sciatic nerve." | 3.78 | 5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions. ( Cappellacci, L; de Novellis, V; Franchetti, P; Gatta, L; Giordano, C; Grifantini, M; Guida, F; Luongo, L; Maione, S; Petrelli, R; Vita, P, 2012) |
| "It is associated with allodynia and hyperalgesia." | 1.48 | Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018) |
| "Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system." | 1.48 | Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain. ( Chen, S; Dai, Q; Han, K; Huang, L; Li, D; Liang, D; Wang, J; Zhang, M, 2018) |
| "Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems." | 1.36 | Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de ( Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K, 2010) |
| "(2) In rats with neuropathic pain induced by spinal nerve ligation (SNL), CPA reduced thermal hyperalgesia and mechanical allodynia, which could last 6h and 10h, respectively (n=6/group, P<0." | 1.36 | Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. ( Cui, Y; Gong, QJ; Li, YY; Liu, CC; Liu, XG; Liu, Y; Wang, J; Wei, XH; Xin, WJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, S | 1 |
| Nakata, E | 1 |
| Morita, A | 1 |
| Mizuno, K | 1 |
| Yamamura, K | 1 |
| Kato, A | 1 |
| Ohashi, K | 1 |
| Souza, A | 1 |
| Martins, DF | 3 |
| Medeiros, LF | 1 |
| Nucci-Martins, C | 1 |
| Martins, TC | 1 |
| Siteneski, A | 2 |
| Caumo, W | 1 |
| Dos Santos, ARS | 1 |
| Torres, ILS | 1 |
| Zhang, M | 1 |
| Dai, Q | 1 |
| Liang, D | 1 |
| Li, D | 1 |
| Chen, S | 2 |
| Han, K | 1 |
| Huang, L | 1 |
| Wang, J | 2 |
| Imlach, WL | 1 |
| Bhola, RF | 1 |
| May, LT | 1 |
| Christopoulos, A | 1 |
| Christie, MJ | 1 |
| Ludtke, DD | 1 |
| Dal-Secco, D | 1 |
| Santos, ARS | 1 |
| Gong, QJ | 1 |
| Li, YY | 2 |
| Xin, WJ | 1 |
| Wei, XH | 1 |
| Cui, Y | 1 |
| Liu, Y | 1 |
| Liu, CC | 1 |
| Liu, XG | 1 |
| Luongo, L | 1 |
| Petrelli, R | 1 |
| Gatta, L | 1 |
| Giordano, C | 1 |
| Guida, F | 1 |
| Vita, P | 1 |
| Franchetti, P | 1 |
| Grifantini, M | 1 |
| de Novellis, V | 1 |
| Cappellacci, L | 1 |
| Maione, S | 1 |
| Mazzardo-Martins, L | 1 |
| Soldi, F | 1 |
| Stramosk, J | 1 |
| Piovezan, AP | 1 |
| Santos, AR | 1 |
| Li, X | 1 |
| Conklin, D | 1 |
| Ma, W | 1 |
| Zhu, X | 1 |
| Eisenach, JC | 1 |
9 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Nerve Pain
| Article | Year |
|---|---|
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, | 2010 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod | 2018 |
Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain.
Topics: Animals; Astrocytes; Disease Models, Animal; Electroacupuncture; Injections, Spinal; Male; Neuralgia | 2018 |
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.
Topics: Adenosine A1 Receptor Agonists; Allosteric Regulation; Animals; Excitatory Postsynaptic Potentials; | 2015 |
High-Intensity Swimming Exercise Decreases Glutamate-Induced Nociception by Activation of G-Protein-Coupled Receptors Inhibiting Phosphorylated Protein Kinase A.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Glutamic Acid; Male; Mice; Naloxone; Neuralgia; Nocic | 2017 |
Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Drug Administ | 2010 |
5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiovascular System; Humans; Hyperalgesia; Mic | 2012 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine | 2013 |
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.
Topics: Adenosine; Adrenergic alpha-Antagonists; Allosteric Regulation; Animals; Dopamine beta-Hydroxylase; | 2002 |