Page last updated: 2024-10-21

1,3-dipropyl-8-cyclopentylxanthine and Huntington Disease

1,3-dipropyl-8-cyclopentylxanthine has been researched along with Huntington Disease in 2 studies

DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ferrante, A1
Martire, A1
Pepponi, R1
Varani, K1
Vincenzi, F1
Ferraro, L1
Beggiato, S1
Tebano, MT1
Popoli, P1
Alfinito, PD1
Wang, SP1
Manzino, L1
Rijhsinghani, S1
Zeevalk, GD1
Sonsalla, PK1

Other Studies

2 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Huntington Disease

ArticleYear
Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease.
    Neurobiology of disease, 2014, Volume: 71

    Topics: Action Potentials; Adenine; Adenosine A1 Receptor Antagonists; Animals; Cerebral Cortex; Corpus Stri

2014
Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-26, Volume: 23, Issue:34

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Str

2003