1,3-dipropyl-8-cyclopentylxanthine has been researched along with Heart Failure in 4 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " β2-adrenergic, M2-muscarinic and A1-adenosine receptors) that are responsible for these abnormalities in heart failure by chronically administrating mice a selective antagonist of each receptor (ICI118,551, atropine and 8-cyclopentyl-1,3-dipropilxanthine (DPCPX), respectively) with isoproterenol." | 3.80 | β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure. ( Gomi, S; Hirose, M; Hongo, M; Kashihara, T; Nakada, T; Shimojo, H; Yamada, M, 2014) |
| "Cl and milrinone at A1 adenosine receptors and m-cholinoceptors were evaluated in human myocardium from patients with heart failure." | 3.68 | Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium. ( Böhm, M; Erdmann, E; Schwinger, RH; Ungerer, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Long, VP | 1 |
| Bonilla, IM | 1 |
| Baine, S | 1 |
| Glynn, P | 1 |
| Kumar, S | 1 |
| Schober, K | 1 |
| Mowrey, K | 1 |
| Weiss, R | 2 |
| Lee, NY | 1 |
| Mohler, PJ | 2 |
| Györke, S | 2 |
| Hund, TJ | 1 |
| Fedorov, VV | 2 |
| Carnes, CA | 2 |
| Kashihara, T | 1 |
| Hirose, M | 1 |
| Shimojo, H | 1 |
| Nakada, T | 1 |
| Gomi, S | 1 |
| Hongo, M | 1 |
| Yamada, M | 1 |
| Lou, Q | 1 |
| Hansen, BJ | 1 |
| Fedorenko, O | 1 |
| Csepe, TA | 1 |
| Kalyanasundaram, A | 1 |
| Li, N | 1 |
| Hage, LT | 1 |
| Glukhov, AV | 1 |
| Billman, GE | 1 |
| Biesiadecki, BJ | 1 |
| Ungerer, M | 1 |
| Böhm, M | 1 |
| Schwinger, RH | 1 |
| Erdmann, E | 1 |
4 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Heart Failure
| Article | Year |
|---|---|
Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated I
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Ani | 2020 |
β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.
Topics: Adenosine A1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Calcium Channels, | 2014 |
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Atrial Fibrillation; Brady | 2014 |
Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium.
Topics: Adult; Binding, Competitive; Cardiotonic Agents; Electric Stimulation; Guanylyl Imidodiphosphate; He | 1990 |