1,3-dipropyl-8-cyclopentylxanthine has been researched along with Heart Disease, Ischemic in 35 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To address this concern, the present study was designed to compare the actions of the A(1)AR antagonists CPX (1,3-dipropyl-8-cyclopentylxanthine), BG 9719 (1,3-dipropyl-8-[2-(5,6-epoxynorbornyl)]xanthine), and BG 9928 (1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine) on acute myocardial ischemia/reperfusion injury and ischemic preconditioning (IPC) in an in vivo dog model of infarction." | 3.72 | Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. ( Auchampach, JA; Ge, ZD; Gross, GJ; Jin, X; Kiesman, W; Kreckler, LM; Moore, J; Narayanan, J; Smits, G; Ticho, B; Wan, TC; Whalley, E, 2004) |
| "Adenosine (100 microM) was administered to these neurons via their local arterial blood supply during or immediately after transient coronary artery occlusion." | 1.32 | Adenosine A1 receptor activation reduces myocardial reperfusion effects on intrinsic cardiac nervous system. ( Armour, JA; Arora, RC, 2003) |
| "Adenosine (ADO) is a well-known regulator of a variety of physiological functions in the heart." | 1.31 | Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. ( Balas, N; Jacobson, KA; Nawrath, H; Safran, N; Shainberg, A; Shneyvays, V, 2001) |
| "The adenosine A3 receptor is a novel cardiac receptor capable of mediating potentially important cardioprotective functions." | 1.30 | A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. ( Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K, 1997) |
| "The incidence of arrhythmias observed upon restoration of control flow was increased by ISO when the action of endogenous adenosine was blocked with DPCPX." | 1.29 | Endogenous adenosine reduces depression of cardiac function induced by beta-adrenergic stimulation during low flow perfusion. ( Dobson, JG; Fenton, RA; Galeckas, KJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 24 (68.57) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Urmaliya, VB | 1 |
| Church, JE | 1 |
| Coupar, IM | 1 |
| Rose'Meyer, RB | 1 |
| Pouton, CW | 2 |
| White, PJ | 1 |
| Abd-Elfattah, AS | 1 |
| Ding, M | 1 |
| Jessen, ME | 1 |
| Wechsler, AS | 1 |
| Arora, RC | 1 |
| Armour, JA | 1 |
| Le, DE | 1 |
| Pelberg, RA | 1 |
| Leong-Poi, H | 1 |
| Bin, JP | 1 |
| Linden, J | 2 |
| Kaul, S | 1 |
| Auchampach, JA | 1 |
| Jin, X | 1 |
| Moore, J | 1 |
| Wan, TC | 1 |
| Kreckler, LM | 1 |
| Ge, ZD | 1 |
| Narayanan, J | 1 |
| Whalley, E | 1 |
| Kiesman, W | 1 |
| Ticho, B | 1 |
| Smits, G | 1 |
| Gross, GJ | 2 |
| Tikh, EI | 1 |
| Fenton, RA | 2 |
| Dobson, JG | 2 |
| Gregg, A | 1 |
| Bottle, SE | 1 |
| Devine, SM | 1 |
| Figler, H | 1 |
| White, P | 1 |
| Urmaliya, V | 1 |
| Scammells, PJ | 1 |
| Armstrong, S | 2 |
| Ganote, CE | 3 |
| Raschke, P | 2 |
| Becker, BF | 2 |
| Monopoli, A | 1 |
| Conti, A | 1 |
| Dionisotti, S | 1 |
| Casati, C | 1 |
| Camaioni, E | 1 |
| Cristalli, G | 1 |
| Ongini, E | 1 |
| Khandoudi, N | 1 |
| Moffat, MP | 1 |
| Karmazyn, M | 1 |
| Liu, GS | 2 |
| Richards, SC | 1 |
| Olsson, RA | 1 |
| Mullane, K | 1 |
| Walsh, RS | 1 |
| Downey, JM | 2 |
| Schwartz, LM | 1 |
| Gerlach, E | 1 |
| Lasley, RD | 3 |
| Anderson, GM | 1 |
| Mentzer, RM | 3 |
| Armstrong, SC | 1 |
| Galeckas, KJ | 1 |
| Grover, GJ | 2 |
| Baird, AJ | 1 |
| Sleph, PG | 2 |
| Finegan, BA | 1 |
| Lopaschuk, GD | 1 |
| Gandhi, M | 1 |
| Clanachan, AS | 1 |
| Neely, CF | 1 |
| DiPierro, FV | 1 |
| Kong, M | 1 |
| Greelish, JP | 1 |
| Gardner, TJ | 1 |
| Mei, DA | 1 |
| Stambaugh, K | 1 |
| Jacobson, KA | 3 |
| Jiang, JL | 1 |
| Liang, BT | 2 |
| Felix, SB | 3 |
| Stangl, V | 3 |
| Frank, TM | 2 |
| Harms, C | 2 |
| Berndt, T | 1 |
| Kästner, R | 1 |
| Baumann, G | 3 |
| Carr, CS | 1 |
| Hill, RJ | 1 |
| Masamune, H | 1 |
| Kennedy, SP | 1 |
| Knight, DR | 1 |
| Tracey, WR | 1 |
| Yellon, DM | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
| Frank, T | 1 |
| Stangl, K | 2 |
| Muss, J | 1 |
| Buttke, K | 1 |
| Gattullo, D | 1 |
| Linden, RJ | 1 |
| Losano, G | 1 |
| Pagliaro, P | 1 |
| Westerhof, N | 1 |
| Schrör, K | 1 |
| Sheldrick, A | 1 |
| Gray, KM | 1 |
| Drew, GM | 1 |
| Louttit, JB | 1 |
| Morrison, RR | 1 |
| Jones, R | 1 |
| Byford, AM | 1 |
| Stell, AR | 1 |
| Peart, J | 2 |
| Headrick, JP | 2 |
| Matherne, GP | 1 |
| Safran, N | 1 |
| Shneyvays, V | 1 |
| Balas, N | 1 |
| Nawrath, H | 1 |
| Shainberg, A | 1 |
| Kilpatrick, EL | 1 |
| Narayan, P | 1 |
35 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 | 2009 |
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Chromatography, High Pressure Liquid; Constriction | 2012 |
Adenosine A1 receptor activation reduces myocardial reperfusion effects on intrinsic cardiac nervous system.
Topics: Adenosine; Animals; Female; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Recepto | 2003 |
A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy.
Topics: Aminophylline; Animals; Coronary Stenosis; Dogs; Microspheres; Myocardial Ischemia; Purinergic P1 Re | 2003 |
Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs.
Topics: Adenosine A1 Receptor Antagonists; Anesthesia; Animals; Disease Models, Animal; Dogs; Ischemic Preco | 2004 |
Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.
Topics: Adenosine; Animals; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial | 2006 |
Dual acting antioxidant A1 adenosine receptor agonists.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Antioxidants; Binding Sites; Cardiotonic Agents; | 2007 |
Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement.
Topics: Adenosine; Animals; Antihypertensive Agents; Cells, Cultured; Glucose; Myocardial Infarction; Myocar | 1994 |
In vitro ischaemic preconditioning of isolated rabbit cardiomyocytes: effects of selective adenosine receptor blockade and calphostin C.
Topics: Animals; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Naphth | 1995 |
Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia.
Topics: Adenosine; Animals; Azepines; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion | 1995 |
Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
Topics: Adenosine; Anesthesia; Animals; Behavior, Animal; Cattle; Coronary Circulation; Heart Rate; Hemodyna | 1994 |
Adenosine-sensitive alpha 1-adrenoceptor effects on reperfused ischaemic hearts: comparison with phorbol ester.
Topics: Adenosine; Animals; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Prote | 1994 |
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart.
Topics: Adenosine; Animals; Antihypertensive Agents; Female; In Vitro Techniques; Male; Myocardial Infarctio | 1994 |
Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts.
Topics: Adenosine; Adenosine Deaminase; Animals; Blood Flow Velocity; Cardiac Output; Coronary Circulation; | 1993 |
Ischaemic and hypoxic preconditioning enhance postischaemic recovery of function in the rat heart.
Topics: Animals; Hypoxia; Male; Myocardial Ischemia; Myocardial Reperfusion; Organ Culture Techniques; Purin | 1993 |
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Topics: Analysis of Variance; Animals; Cells, Cultured; Glyburide; Guanidines; Heart; Hypoglycemic Agents; K | 1995 |
Endogenous adenosine reduces depression of cardiac function induced by beta-adrenergic stimulation during low flow perfusion.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Coronary Circulation; Epinephrin | 1995 |
Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburid | 1996 |
Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia.
Topics: Adenosine; Animals; Energy Metabolism; Glycolysis; Heart; Male; Myocardial Ischemia; Myocardial Repe | 1996 |
A1 adenosine receptor antagonists block ischemia-reperfusion injury of the heart.
Topics: Animals; Arrhythmias, Cardiac; Cats; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myoca | 1996 |
Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Dogs; Heart Rate; | 1997 |
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridine | 1997 |
Release of a stable cardiodepressant mediator after myocardial ischaemia during reperfusion.
Topics: Adenosine Deaminase; Adrenergic beta-Antagonists; Animals; Autacoids; Catalase; Depression, Chemical | 1997 |
Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia.
Topics: Adenosine; Dinucleoside Phosphates; Heart Atria; Humans; In Vitro Techniques; Ischemic Preconditioni | 1997 |
A physiological role of the adenosine A3 receptor: sustained cardioprotection.
Topics: Adenosine; Animals; Chick Embryo; Dihydropyridines; Gene Transfer Techniques; Humans; Myocardial Isc | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra | 1999 |
Cardiodepressant mediators are released after myocardial ischaemia: modulation by catecholamines and adenosine.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Catecholamines; Chromatography, High Pressure Liqui | 1999 |
Ischaemic preconditioning changes the pattern of coronary reactive hyperaemia in the goat: role of adenosine and nitric oxide.
Topics: Adenosine; Analysis of Variance; Animals; Coronary Circulation; Endothelium, Vascular; Goats; Hypere | 1999 |
Interaction of adenosine and prostacyclin in coronary flow regulation after myocardial ischemia.
Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Drug Interactions; Epoprostenol; Guinea Pigs; Heart; | 1999 |
The effect of body temperature on myocardial protection conferred by ischaemic preconditioning or the selective adenosine A1 receptor agonist GR79236, in an anaesthetized rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine; Anesthesia; Animals; Blood Pressure; Body Temperature; Heart Rate; Ischemic Preconditioni | 1999 |
Transgenic overexpression of cardiac A(1) adenosine receptors mimics ischemic preconditioning.
Topics: Animals; Blood Flow Velocity; Cell Survival; Coloring Agents; Coronary Circulation; In Vitro Techniq | 2000 |
Intrinsic A(1) adenosine receptor activation during ischemia or reperfusion improves recovery in mouse hearts.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Creatine; Extracellular Space; He | 2000 |
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.
Topics: Adenosine; Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; L-Lactate Dehydrogenase; Micros | 2001 |
Adenosine A3 agonist cardioprotection in isolated rat and rabbit hearts is blocked by the A1 antagonist DPCPX.
Topics: Animals; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; R | 2001 |
Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism.
Topics: Adenine Nucleotides; Adenosine; Animals; Hemodynamics; In Vitro Techniques; Male; Myocardial Ischemi | 1992 |