1,3-dipropyl-8-cyclopentylxanthine has been researched along with Epilepsy in 12 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 7.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 3.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " This study also investigates the effects of a mild epileptic insult on neuronal death in rat hippocampus after a subsequent, lethal epileptic stress using kainic acid (KA) as a model of epilepsy." | 3.70 | Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. ( Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H, 1999) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Muzzi, M | 1 |
| Coppi, E | 1 |
| Pugliese, AM | 1 |
| Chiarugi, A | 1 |
| Amorim, BO | 1 |
| Hamani, C | 1 |
| Ferreira, E | 1 |
| Miranda, MF | 1 |
| Fernandes, MJS | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Covolan, L | 1 |
| Roseti, C | 1 |
| Martinello, K | 1 |
| Fucile, S | 1 |
| Piccari, V | 1 |
| Mascia, A | 1 |
| Di Gennaro, G | 1 |
| Quarato, PP | 1 |
| Manfredi, M | 1 |
| Esposito, V | 1 |
| Cantore, G | 1 |
| Arcella, A | 1 |
| Simonato, M | 1 |
| Fredholm, BB | 1 |
| Limatola, C | 1 |
| Miledi, R | 1 |
| Eusebi, F | 1 |
| Chwalczuk, K | 1 |
| Rubaj, A | 1 |
| Swiader, M | 1 |
| Czuczwar, SJ | 1 |
| Harrison, PK | 1 |
| Tattersall, JE | 1 |
| Clement, RA | 1 |
| Uzbay, TI | 1 |
| Kayir, H | 1 |
| Ceyhan, M | 1 |
| Alzheimer, C | 2 |
| Sutor, B | 2 |
| ten Bruggencate, G | 2 |
| Chesi, AJ | 1 |
| Stone, TW | 1 |
| Plamondon, H | 1 |
| Blondeau, N | 1 |
| Heurteaux, C | 1 |
| Lazdunski, M | 1 |
| Tchekalarova, J | 1 |
| Kambourova, T | 1 |
| Georgiev, V | 1 |
12 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; | 2013 |
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec | 2016 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; | 2008 |
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal | 2008 |
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atropine; Disease Models, Animal; Drug Interactions; El | 2004 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep | 2007 |
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: pre- and postsynaptic components.
Topics: Animals; Epilepsy; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Phosphoric Diester Hydrolas | 1993 |
Alkylxanthine adenosine antagonists and epileptiform activity in rat hippocampal slices in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; In Vitro Techniques; Male; Puriner | 1997 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-E | 1999 |
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce | 2001 |
Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Epilepsy; Guinea Pigs; Hippocampus; In Vitro T | 1989 |