1,3-dipropyl-8-cyclopentylxanthine has been researched along with Disease Models, Animal in 72 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 7.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| " Colitis was induced by 2,4-dinitrobenzenesulfonic acid." | 7.77 | Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis. ( Antonioli, L; Awwad, O; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2011) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 7.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| " We hypothesize that asthmatic inflammation translates into systemic inflammation and alters vascular responses where adenosine (AD) plays an important role." | 7.74 | Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. ( Mustafa, SJ; Nadeem, A; Ponnoth, DS, 2008) |
| "Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics." | 7.73 | A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. ( Batra, VK; Borron, P; Mustafa, SJ; Nadeem, A; Obiefuna, PC; Wilson, CN, 2005) |
| " Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects." | 7.73 | Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. ( Chaimovitz, C; Douvdevani, A; Mazar, J; Nakav, S; Rogachev, B; Ziv, NY; Zlotnik, M, 2006) |
| " Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks." | 7.71 | Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001) |
| "The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle injury." | 5.34 | Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. ( Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J, 2007) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 5.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| "Adenosine has powerful inhibitory effects in the central nervous system." | 5.32 | Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy. ( Avsar, E; Empson, RM, 2004) |
| " Adenosine signaling is capable of inducing an antinociceptive action against somatic pain; however, the association between changes in the adenosinergic system and visceral pain perception has not been investigated." | 3.83 | Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats. ( Kumei, S; Miyagishi, S; Nozu, T; Ohhira, M; Okumura, T; Takakusaki, K, 2016) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 3.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| " Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected." | 3.81 | Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. ( Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY, 2015) |
| "Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures." | 3.79 | The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice. ( Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H, 2013) |
| "We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine." | 3.78 | Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats. ( Li, T; Liu, L; Xu, J; Yang, G, 2012) |
| " Colitis was induced by 2,4-dinitrobenzenesulfonic acid." | 3.77 | Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis. ( Antonioli, L; Awwad, O; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2011) |
| "Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for studies of tremor." | 3.76 | Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. ( Brennum, LT; Chrobak, JJ; Collins, LE; Galtieri, DJ; Hinman, JR; Hockemeyer, J; Müller, CE; Sager, TN; Salamone, JD, 2010) |
| " We hypothesize that asthmatic inflammation translates into systemic inflammation and alters vascular responses where adenosine (AD) plays an important role." | 3.74 | Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. ( Mustafa, SJ; Nadeem, A; Ponnoth, DS, 2008) |
| " Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects." | 3.73 | Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. ( Chaimovitz, C; Douvdevani, A; Mazar, J; Nakav, S; Rogachev, B; Ziv, NY; Zlotnik, M, 2006) |
| "Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics." | 3.73 | A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. ( Batra, VK; Borron, P; Mustafa, SJ; Nadeem, A; Obiefuna, PC; Wilson, CN, 2005) |
| " The purposes of this study were to characterize the role of adenosine receptors in modulating status epilepticus (SE) induced by pilocarpine and evaluate its neuroprotective action." | 3.73 | Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. ( Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP, 2005) |
| " To address this concern, the present study was designed to compare the actions of the A(1)AR antagonists CPX (1,3-dipropyl-8-cyclopentylxanthine), BG 9719 (1,3-dipropyl-8-[2-(5,6-epoxynorbornyl)]xanthine), and BG 9928 (1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine) on acute myocardial ischemia/reperfusion injury and ischemic preconditioning (IPC) in an in vivo dog model of infarction." | 3.72 | Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. ( Auchampach, JA; Ge, ZD; Gross, GJ; Jin, X; Kiesman, W; Kreckler, LM; Moore, J; Narayanan, J; Smits, G; Ticho, B; Wan, TC; Whalley, E, 2004) |
| " Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks." | 3.71 | Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001) |
| " This study also investigates the effects of a mild epileptic insult on neuronal death in rat hippocampus after a subsequent, lethal epileptic stress using kainic acid (KA) as a model of epilepsy." | 3.70 | Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. ( Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H, 1999) |
| "Recently, there has been an increasing interest in adenosine as a potential mediator of allergic asthma." | 3.69 | Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor. ( Ali, S; Metzger, WJ; Mustafa, SJ, 1994) |
| "KEKS-supplemented food-generated ketosis may increase adenosine levels, and may thus modulate both neuroinflammatory processes and epileptic activity through adenosine receptors (such as A1Rs and A2ARs)." | 1.62 | Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats. ( Ari, C; Brunner, B; D'Agostino, DP; Kovács, Z, 2021) |
| "Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system." | 1.48 | Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain. ( Chen, S; Dai, Q; Han, K; Huang, L; Li, D; Liang, D; Wang, J; Zhang, M, 2018) |
| "It is associated with allodynia and hyperalgesia." | 1.48 | Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018) |
| "In the primed paw AMP hyperalgesia was dependent on conversion to adenosine, being prevented by ecto-5'nucleotidase inhibitor α,β-methyleneadenosine 5'-diphosphate sodium salt and A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine." | 1.46 | Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat. ( Araldi, D; Ferrari, LF; Levine, JD, 2017) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "The enhanced anti-seizure and neuroprotective effect achieved by disruption of the A1R/neurabin/RGS4 complex is elicited by the on-site and on-demand release of endogenous adenosine, and does not require administration of A1R ligands." | 1.38 | Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine. ( Chen, Y; Cottingham, C; Greengard, P; Jiao, K; Liu, Y; McMahon, L; Wang, Q, 2012) |
| "In addition, demyelination and axonal damage in brainstem were exacerbated, levels of Th1 cytokines increased, and Th2 cytokines decreased." | 1.38 | Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis. ( Augusto, E; Chen, JF; He, JC; Huang, QY; Li, F; Li, ZZ; Wang, XT; Wang, ZW; Yao, SQ; Zheng, RY, 2012) |
| "All animals underwent right middle cerebral artery occlusion (MCAO) for 2 h." | 1.38 | Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats. ( Chen, S; Dong, H; Hou, L; Hu, S; Wang, S; Xiong, L; Zhang, H; Zhang, J, 2012) |
| " Chronic administration did not cause any effect on memory, but decreased adenosine A(1) receptors immunocontent in the frontal cortex." | 1.37 | Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice. ( Ardais, AP; Botton, PH; Costa, MS; Espinosa, J; Matte, VL; Mioranzza, S; Porciúncula, LO; Souza, DO, 2011) |
| "SCI-induced thermal hyperalgesia was mimicked by the intrathecal application of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist." | 1.36 | Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats. ( Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H, 2010) |
| " Since theophylline has two modes of action, in the present study we tested whether chronic administration of pentoxifylline, a non-selective phosphodiesterase inhibitor, rolipram, a phosphodiesterase-4 specific inhibitor, and 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), an adenosine A1 receptor antagonist, would induce recovery similar to that induced by theophylline in male Sprague-Dawley rats following a left C2 spinal cord lesion." | 1.35 | Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. ( Goshgarian, HG; Kajana, S, 2008) |
| "The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle injury." | 1.34 | Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. ( Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J, 2007) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 1.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| "Adenosine has powerful inhibitory effects in the central nervous system." | 1.32 | Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy. ( Avsar, E; Empson, RM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (9.72) | 18.2507 |
| 2000's | 33 (45.83) | 29.6817 |
| 2010's | 29 (40.28) | 24.3611 |
| 2020's | 3 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Obiefuna, PC | 1 |
| Batra, VK | 1 |
| Nadeem, A | 2 |
| Borron, P | 1 |
| Wilson, CN | 1 |
| Mustafa, SJ | 3 |
| Colotta, V | 1 |
| Catarzi, D | 1 |
| Varano, F | 1 |
| Lenzi, O | 1 |
| Filacchioni, G | 1 |
| Martini, C | 1 |
| Trincavelli, L | 1 |
| Ciampi, O | 1 |
| Traini, C | 1 |
| Pugliese, AM | 2 |
| Pedata, F | 1 |
| Morizzo, E | 1 |
| Moro, S | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Brunner, B | 1 |
| Ari, C | 1 |
| D'Agostino, DP | 1 |
| Kovács, Z | 1 |
| Alves, CB | 1 |
| Almeida, AS | 1 |
| Marques, DM | 1 |
| Faé, AHL | 1 |
| Machado, ACL | 1 |
| Oliveira, DL | 1 |
| Portela, LVC | 1 |
| Porciúncula, LO | 2 |
| Souza, A | 1 |
| Martins, DF | 2 |
| Medeiros, LF | 1 |
| Nucci-Martins, C | 1 |
| Martins, TC | 1 |
| Siteneski, A | 1 |
| Caumo, W | 1 |
| Dos Santos, ARS | 1 |
| Torres, ILS | 1 |
| Zhang, M | 1 |
| Dai, Q | 1 |
| Liang, D | 1 |
| Li, D | 1 |
| Chen, S | 3 |
| Han, K | 1 |
| Huang, L | 1 |
| Wang, J | 1 |
| Moezi, L | 1 |
| Akbarian, R | 1 |
| Niknahad, H | 1 |
| Shafaroodi, H | 1 |
| Muzzi, M | 1 |
| Coppi, E | 1 |
| Chiarugi, A | 1 |
| Chen, Z | 1 |
| Xiong, C | 1 |
| Pancyr, C | 1 |
| Stockwell, J | 1 |
| Walz, W | 1 |
| Cayabyab, FS | 1 |
| Ferrante, A | 1 |
| Martire, A | 1 |
| Pepponi, R | 1 |
| Varani, K | 1 |
| Vincenzi, F | 1 |
| Ferraro, L | 1 |
| Beggiato, S | 1 |
| Tebano, MT | 1 |
| Popoli, P | 1 |
| Mango, D | 1 |
| Bonito-Oliva, A | 1 |
| Ledonne, A | 1 |
| Cappellacci, L | 1 |
| Petrelli, R | 1 |
| Nisticò, R | 1 |
| Berretta, N | 1 |
| Fisone, G | 1 |
| Mercuri, NB | 1 |
| Mallok, A | 1 |
| Vaillant, JD | 1 |
| Soto, MT | 1 |
| Viebahn-Hänsler, R | 2 |
| Viart, Mde L | 1 |
| Pérez, AF | 1 |
| Cedeño, RI | 1 |
| Fernández, OS | 1 |
| Wang, ML | 1 |
| Yu, G | 1 |
| Yi, SP | 1 |
| Zhang, FY | 1 |
| Wang, ZT | 1 |
| Huang, B | 1 |
| Su, RB | 1 |
| Jia, YX | 1 |
| Gong, ZH | 1 |
| Okumura, T | 1 |
| Nozu, T | 1 |
| Kumei, S | 1 |
| Takakusaki, K | 1 |
| Miyagishi, S | 1 |
| Ohhira, M | 1 |
| Faingold, CL | 1 |
| Randall, M | 1 |
| Kommajosyula, SP | 1 |
| Ferrari, LF | 1 |
| Araldi, D | 1 |
| Levine, JD | 1 |
| Varty, GB | 1 |
| Hodgson, RA | 1 |
| Pond, AJ | 1 |
| Grzelak, ME | 1 |
| Parker, EM | 1 |
| Hunter, JC | 1 |
| Carrettiero, DC | 1 |
| Almeida, RS | 1 |
| Fior-Chadi, DR | 1 |
| Pires, VA | 1 |
| Pamplona, FA | 1 |
| Pandolfo, P | 1 |
| Fernandes, D | 1 |
| Prediger, RD | 1 |
| Takahashi, RN | 1 |
| Cognato, GP | 1 |
| Agostinho, PM | 1 |
| Hockemeyer, J | 2 |
| Müller, CE | 2 |
| Souza, DO | 2 |
| Cunha, RA | 2 |
| Collins, LE | 1 |
| Galtieri, DJ | 1 |
| Brennum, LT | 1 |
| Sager, TN | 1 |
| Hinman, JR | 1 |
| Chrobak, JJ | 1 |
| Salamone, JD | 1 |
| Horiuchi, H | 1 |
| Ogata, T | 1 |
| Morino, T | 1 |
| Yamamoto, H | 1 |
| Constantinescu, AO | 1 |
| Ilie, A | 1 |
| Ciocan, D | 1 |
| Zagrean, AM | 1 |
| Zagrean, L | 1 |
| Moldovan, M | 1 |
| Antonioli, L | 1 |
| Fornai, M | 1 |
| Colucci, R | 1 |
| Awwad, O | 1 |
| Ghisu, N | 1 |
| Tuccori, M | 1 |
| Del Tacca, M | 1 |
| Blandizzi, C | 1 |
| Mioranzza, S | 1 |
| Costa, MS | 1 |
| Botton, PH | 1 |
| Ardais, AP | 1 |
| Matte, VL | 1 |
| Espinosa, J | 1 |
| Cipriani, R | 1 |
| Villa, P | 1 |
| Chece, G | 1 |
| Lauro, C | 1 |
| Paladini, A | 1 |
| Micotti, E | 1 |
| Perego, C | 1 |
| De Simoni, MG | 1 |
| Fredholm, BB | 2 |
| Eusebi, F | 1 |
| Limatola, C | 1 |
| Abd-Elfattah, AS | 1 |
| Ding, M | 1 |
| Jessen, ME | 1 |
| Wechsler, AS | 1 |
| Xu, J | 1 |
| Li, T | 1 |
| Yang, G | 1 |
| Liu, L | 1 |
| Chen, Y | 1 |
| Liu, Y | 1 |
| Cottingham, C | 1 |
| McMahon, L | 1 |
| Jiao, K | 1 |
| Greengard, P | 1 |
| Wang, Q | 1 |
| Hu, S | 1 |
| Dong, H | 1 |
| Zhang, H | 1 |
| Wang, S | 1 |
| Hou, L | 1 |
| Zhang, J | 1 |
| Xiong, L | 1 |
| Yao, SQ | 1 |
| Li, ZZ | 1 |
| Huang, QY | 1 |
| Li, F | 1 |
| Wang, ZW | 1 |
| Augusto, E | 1 |
| He, JC | 1 |
| Wang, XT | 1 |
| Chen, JF | 2 |
| Zheng, RY | 1 |
| Takenaka, T | 1 |
| Inoue, T | 1 |
| Ohno, Y | 1 |
| Miyazaki, T | 1 |
| Nishiyama, A | 1 |
| Ishii, N | 1 |
| Suzuki, H | 1 |
| Mazzardo-Martins, L | 1 |
| Cidral-Filho, FJ | 1 |
| Stramosk, J | 1 |
| Santos, AR | 2 |
| Crema, LM | 1 |
| Pettenuzzo, LF | 1 |
| Schlabitz, M | 1 |
| Diehl, L | 1 |
| Hoppe, J | 1 |
| Mestriner, R | 1 |
| Laureano, D | 1 |
| Salbego, C | 1 |
| Dalmaz, C | 1 |
| Vendite, D | 1 |
| Kehl, F | 1 |
| Krolikowski, JG | 1 |
| LaDisa, JF | 1 |
| Kersten, JR | 1 |
| Warltier, DC | 1 |
| Pagel, PS | 1 |
| Hunter, CJ | 1 |
| Bennet, L | 1 |
| Power, GG | 1 |
| Roelfsema, V | 1 |
| Blood, AB | 1 |
| Quaedackers, JS | 1 |
| George, S | 1 |
| Guan, J | 1 |
| Gunn, AJ | 1 |
| Auchampach, JA | 1 |
| Jin, X | 1 |
| Moore, J | 1 |
| Wan, TC | 1 |
| Kreckler, LM | 1 |
| Ge, ZD | 1 |
| Narayanan, J | 1 |
| Whalley, E | 1 |
| Kiesman, W | 1 |
| Ticho, B | 1 |
| Smits, G | 1 |
| Gross, GJ | 1 |
| Kaster, MP | 1 |
| Rosa, AO | 1 |
| Rosso, MM | 1 |
| Goulart, EC | 1 |
| Rodrigues, AL | 1 |
| Gouder, N | 1 |
| Scheurer, L | 1 |
| Fritschy, JM | 1 |
| Boison, D | 1 |
| Harrison, PK | 1 |
| Tattersall, JE | 1 |
| Clement, RA | 1 |
| Adén, U | 1 |
| O'Connor, WT | 1 |
| Berman, RF | 1 |
| Avsar, E | 1 |
| Empson, RM | 1 |
| Nobrega, JN | 1 |
| Barlow, KL | 1 |
| Raymond, R | 1 |
| Richter, A | 2 |
| Vianna, EP | 1 |
| Ferreira, AT | 1 |
| Doná, F | 1 |
| Cavalheiro, EA | 1 |
| da Silva Fernandes, MJ | 1 |
| Liu, DZ | 1 |
| Xie, KQ | 1 |
| Ji, XQ | 1 |
| Ye, Y | 1 |
| Jiang, CL | 1 |
| Zhu, XZ | 1 |
| Coelho, JE | 1 |
| Rebola, N | 1 |
| Fragata, I | 1 |
| Ribeiro, JA | 1 |
| de Mendonça, A | 1 |
| Vuckovic, S | 1 |
| Tomic, M | 1 |
| Stepanovic-Petrovic, R | 1 |
| Ugresic, N | 1 |
| Prostran, M | 1 |
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72 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Disease Models, Animal
| Article | Year |
|---|---|
A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hype | 2005 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Dietary Supplements; Disease Models, Ani | 2021 |
Caffeine and adenosine A
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Animals; Attention Deficit Disord | 2020 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod | 2018 |
Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain.
Topics: Animals; Astrocytes; Disease Models, Animal; Electroacupuncture; Injections, Spinal; Male; Neuralgia | 2018 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2013 |
Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; | 2013 |
Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
Topics: Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Clathrin; Disease Models, Animal; Endo | 2014 |
Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease.
Topics: Action Potentials; Adenine; Adenosine A1 Receptor Antagonists; Animals; Cerebral Cortex; Corpus Stri | 2014 |
Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice.
Topics: Action Potentials; Age Factors; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Anim | 2014 |
Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, An | 2015 |
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease | 2015 |
Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Analgesics; Animals; Colon; Consciousness; Disease Mod | 2016 |
Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine.
Topics: Adenosine; Animals; Caffeine; Death, Sudden; Disease Models, Animal; Disease Susceptibility; Dose-Re | 2016 |
Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; Chr | 2017 |
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus | 2008 |
Adenosine modulates alpha2-adrenergic receptors within specific subnuclei of the nucleus tractus solitarius in normotensive and spontaneously hypertensive rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relatio | 2008 |
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Dis | 2009 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Diseas | 2010 |
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Anima | 2010 |
Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor | 2010 |
Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Delta Rhythm; Disease Models, Animal; Electro | 2011 |
Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adeno | 2011 |
Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Central Nervous System Stimulants; | 2011 |
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Animals, Genetically Modified; Ani | 2011 |
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Chromatography, High Pressure Liquid; Constriction | 2012 |
Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.
Topics: Adenosine; Animals; Calcium; Disease Models, Animal; Female; Fluid Therapy; Male; Mesenteric Artery, | 2012 |
Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Cell Death; Cells, Cultured | 2012 |
Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.
Topics: Adenosine; Analysis of Variance; Animals; Brain Infarction; Diffusion Magnetic Resonance Imaging; Di | 2012 |
Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis.
Topics: Adenosine A1 Receptor Antagonists; Animals; Astrocytes; Axons; Brain Injuries; Cell Proliferation; C | 2012 |
Elucidating mechanisms underlying altered renal autoregulation in diabetes.
Topics: Animals; Connexins; Diabetes Mellitus, Experimental; Disease Models, Animal; Glomerular Filtration R | 2012 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Corpus Striatum; Depression; Disease Models, Ani | 2013 |
Adenosine type 1 (A1) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs.
Topics: Administration, Oral; Animals; Collateral Circulation; Coronary Circulation; Disease Models, Animal; | 2003 |
Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep.
Topics: Animals; Asphyxia; Blood Gas Analysis; Body Temperature; Brain; Calorimetry; Cell Count; Cerebrovasc | 2003 |
Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs.
Topics: Adenosine A1 Receptor Antagonists; Anesthesia; Animals; Disease Models, Animal; Dogs; Ischemic Preco | 2004 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Fe | 2004 |
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Anticonvulsants; As | 2004 |
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atropine; Disease Models, Animal; Drug Interactions; El | 2004 |
Changes in purine levels and adenosine receptors in kindled seizures in the rat.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Carrier Proteins; Corpus Striatum; Disease | 2004 |
Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Analysis of Variance; Animals; | 2004 |
Decreased adenosine receptor binding in dystonic brains of the dt(sz) mutant.
Topics: Animals; Animals, Genetically Modified; Autoradiography; Cricetinae; Disease Models, Animal; Dystoni | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2005 |
Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists.
Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Benzoates; Binding, Competitive; Bridged-Ring Compounds; | 2005 |
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus.
Topics: 2-Chloroadenosine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; En | 2006 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response | 2006 |
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Ant | 2006 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep | 2007 |
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Chemical and Drug Ind | 2006 |
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems.
Topics: Acute Disease; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Alcohol | 2006 |
Ischemic postconditioning reduces infarct size by activation of A1 receptors and K+(ATP) channels in both normal and hypercholesterolemic rabbits.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary C | 2007 |
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Topics: Adenosine; Animals; Dihydropyridines; Disease Models, Animal; Hindlimb; Mice; Mice, Inbred C57BL; Mi | 2007 |
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Biomarkers; Disease Models, Animal; HSP72 Hea | 2008 |
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats.
Topics: Action Potentials; Animals; Cervical Vertebrae; Diaphragm; Disease Models, Animal; Electromyography; | 2008 |
Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma.
Topics: Acetylcholine; Adenosine; Administration, Inhalation; Allergens; Ambrosia; Animals; Aorta; Asthma; D | 2008 |
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; | 2008 |
Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor.
Topics: Adenosine; Animals; Asthma; Binding, Competitive; Bronchoconstriction; Disease Models, Animal; In Vi | 1994 |
Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts.
Topics: Adenosine; Adenosine Deaminase; Animals; Blood Flow Velocity; Cardiac Output; Coronary Circulation; | 1993 |
Renal haemodynamic responses to adenosine in acute renal failure.
Topics: Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Glycerol; Hemodynamics; Male; Mercu | 1995 |
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; D | 1995 |
Prevention of radiocontrast-induced nephropathy by adenosine antagonists in rats with chronic nitric oxide deficiency.
Topics: Acute Kidney Injury; Adenosine; Animals; Blood Pressure; Contrast Media; Disease Models, Animal; Enz | 1997 |
Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum: lack of changes after a neonatal bilateral lesion of the ventral hippocampus.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Benzazepines; Corpus Striatum; Disease Models, Anim | 1999 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-E | 1999 |
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caffeine; Cat | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; | 2001 |
Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats.
Topics: Adenosine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dipyridamole; Disea | 2000 |
A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Guinea Pigs; Hyperalgesia; Imm | 2001 |