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1,3-dipropyl-8-cyclopentylxanthine and Cystic Fibrosis

1,3-dipropyl-8-cyclopentylxanthine has been researched along with Cystic Fibrosis in 13 studies

DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research Excerpts

ExcerptRelevanceReference
" Efficacy was determined using nasal transepithelial potential difference and sweat chloride measurements prior to dosing and at 1, 2, and 4 hr postdose."2.70A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis. ( Ahrens, RC; Aitken, ML; Hilliard, KA; Kelley, TJ; Konstan, MW; Launspach, J; McCarty, NA; Milgram, LJ; Regelmann, WE; Standaert, TA; Teresi, M; Tuthill, C; Weatherly, MR, 2002)
"Cystic fibrosis is an autosomal recessive disorder affecting chloride transport in pancreas, lung, and other tissues, which is caused by mutations in the cystic fibrosis transmembrane regulator (CFTR)."1.29A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation. ( Barnoy, S; Cabantchik, ZI; Eidelman, O; Guay-Broder, C; Guggino, WB; Jacobson, KA; Pollard, HB; Turner, RJ; Vergara, L; Zeitlin, PL, 1995)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (61.54)18.2507
2000's4 (30.77)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chung, WJ1
Goeckeler-Fried, JL1
Havasi, V1
Chiang, A1
Rowe, SM1
Plyler, ZE1
Hong, JS1
Mazur, M1
Piazza, GA1
Keeton, AB1
White, EL1
Rasmussen, L1
Weissman, AM1
Denny, RA1
Brodsky, JL1
Sorscher, EJ1
Guay-Broder, C3
Jacobson, KA4
Barnoy, S1
Cabantchik, ZI2
Guggino, WB1
Zeitlin, PL1
Turner, RJ3
Vergara, L1
Eidelman, O5
Pollard, HB6
Casavola, V1
Rugolo, M1
Mastrocola, T1
Whörle, C1
Rasola, A1
Gruenert, DC1
Romeo, G1
Galietta, LJ1
Arispe, N1
Ma, J1
Kunzelmann, K1
Briel, M1
Schreiber, R1
Ricken, S1
Nitschke, R1
Greger, R1
Al-Nakkash, L1
Hwang, TC1
Srivastava, M2
Andersson, C1
Roomans, GM1
Zhang, J1
Leighton, X1
Murtie, J1
Jozwik, C1
Jacobson, K1
Weinstein, DL1
Metcalf, EL1
McCarty, NA2
Standaert, TA2
Teresi, M1
Tuthill, C1
Launspach, J2
Kelley, TJ2
Milgram, LJ2
Hilliard, KA2
Regelmann, WE1
Weatherly, MR2
Aitken, ML2
Konstan, MW2
Ahrens, RC2
Han, SH1
Teresi, ME1
van Galen, PJ1
Fox, C1

Trials

1 trial available for 1,3-dipropyl-8-cyclopentylxanthine and Cystic Fibrosis

ArticleYear
A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis.
    Pediatric pulmonology, 2002, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator;

2002

Other Studies

12 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Cystic Fibrosis

ArticleYear
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu

2016
A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation.
    Biochemistry, 1995, Jul-18, Volume: 34, Issue:28

    Topics: Animals; Cell Line; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator;

1995
CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells.
    The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1

    Topics: Calcium; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Hy

1995
ATP and A1 adenosine receptor agonists mobilize intracellular calcium and activate K+ and Cl- currents in normal and cystic fibrosis airway epithelial cells.
    The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33

    Topics: 2-Chloroadenosine; Adenosine Triphosphate; Adult; Calcium; Cells, Cultured; Chloride Channels; Cysti

1993
Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX).
    The Journal of biological chemistry, 1998, Mar-06, Volume: 273, Issue:10

    Topics: Cell Line; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator;

1998
No evidence for direct activation of the cystic fibrosis transmembrane conductance regulator by 8-cyclopentyl-1,3-dipropylxanthine.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1998, Volume: 8, Issue:4

    Topics: Animals; Cell Line; Cells, Cultured; Chlorides; CHO Cells; Cricetinae; Cystic Fibrosis; Cystic Fibro

1998
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis;

1999
Pharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis.
    Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:11

    Topics: Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Complementary;

1999
Activation of deltaF508 CFTR in a cystic fibrosis respiratory epithelial cell line by 4-phenylbutyrate, genistein and CPX.
    The European respiratory journal, 2000, Volume: 15, Issue:5

    Topics: Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; G

2000
Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway.
    Molecular medicine (Cambridge, Mass.), 2001, Volume: 7, Issue:8

    Topics: Algorithms; Cell Line; Child; Cluster Analysis; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu

2001
Use of nasal potential difference and sweat chloride as outcome measures in multicenter clinical trials in subjects with cystic fibrosis.
    Pediatric pulmonology, 2002, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Chlorides; Clinical Trials, Phase I as Topic; Cystic Fibros

2002
A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Jun-15, Volume: 89, Issue:12

    Topics: 2-Chloroadenosine; Adenocarcinoma; Adenosine; Cell Line; Chlorides; Chromosome Deletion; Colonic Neo

1992