1,3-dipropyl-8-cyclopentylxanthine has been researched along with Cerebral Ischemia in 22 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 7.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 7.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown." | 7.69 | Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994) |
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 3.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 3.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown." | 3.69 | Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994) |
| "Our data provide evidence that during cerebral ischemia endogenous activation of A(1) receptors accelerates the electrical "shut-down" of the whole brain." | 1.33 | Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity. ( Ciocan, D; Ilie, A; Moldovan, M; Nita, DA; Zagrean, AM; Zagrean, L, 2006) |
| "In the present study, focal cerebral ischemia was induced in spontaneously hypertensive rats by filament insertion through the carotid artery." | 1.33 | Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. ( Akaiwa, K; Akashi, H; Aoyagi, S; Harada, H; Hiromatsu, S; Kano, T; Sakashita, H, 2006) |
| " The selective A1 receptor antagonist DPCPX also had no effect on release when administered at a low dosage (0." | 1.28 | Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. ( O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 12 (54.55) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colotta, V | 3 |
| Catarzi, D | 3 |
| Varano, F | 3 |
| Capelli, F | 1 |
| Lenzi, O | 3 |
| Filacchioni, G | 3 |
| Martini, C | 3 |
| Trincavelli, L | 3 |
| Ciampi, O | 3 |
| Pugliese, AM | 4 |
| Pedata, F | 5 |
| Schiesaro, A | 1 |
| Morizzo, E | 3 |
| Moro, S | 3 |
| Traini, C | 2 |
| Yuan, Q | 1 |
| Jia, HX | 1 |
| Li, SQ | 1 |
| Wu, YJ | 1 |
| Feng, L | 1 |
| Liu, XL | 1 |
| Sun, XC | 1 |
| Li, WB | 1 |
| Lu, HR | 1 |
| Song, SW | 1 |
| Han, KY | 1 |
| Liu, HP | 1 |
| Chen, SD | 1 |
| Wang, JL | 1 |
| Dai, QX | 1 |
| Saransaari, P | 1 |
| Oja, SS | 1 |
| Chauhan, NK | 1 |
| Young, AM | 1 |
| Gibson, CL | 1 |
| Davidson, C | 1 |
| Latini, S | 2 |
| Corradetti, R | 2 |
| Liu, Y | 1 |
| Xiong, L | 1 |
| Chen, S | 1 |
| Wang, Q | 1 |
| Ilie, A | 1 |
| Ciocan, D | 1 |
| Zagrean, AM | 1 |
| Nita, DA | 1 |
| Zagrean, L | 1 |
| Moldovan, M | 1 |
| Akaiwa, K | 1 |
| Akashi, H | 1 |
| Harada, H | 1 |
| Sakashita, H | 1 |
| Hiromatsu, S | 1 |
| Kano, T | 1 |
| Aoyagi, S | 1 |
| Von Lubitz, DK | 1 |
| Lin, RC | 1 |
| Melman, N | 1 |
| Ji, XD | 1 |
| Carter, MF | 1 |
| Jacobson, KA | 1 |
| Barth, A | 1 |
| Newell, DW | 1 |
| Nguyen, LB | 1 |
| Winn, HR | 1 |
| Wender, R | 1 |
| Meno, JR | 1 |
| Janigro, D | 1 |
| Bona, E | 1 |
| Adén, U | 2 |
| Gilland, E | 1 |
| Fredholm, BB | 2 |
| Hagberg, H | 2 |
| Cassar, M | 1 |
| Jones, MG | 1 |
| Szatkowski, M | 1 |
| Bordoni, F | 1 |
| Sperlágh, B | 1 |
| Zsilla, G | 1 |
| Vizi, ES | 1 |
| Hiraide, T | 1 |
| Katsura, K | 1 |
| Muramatsu, H | 1 |
| Asano, G | 1 |
| Katayama, Y | 1 |
| Centonze, D | 1 |
| Saulle, E | 1 |
| Pisani, A | 1 |
| Bernardi, G | 1 |
| Calabresi, P | 1 |
| Leverin, AL | 1 |
| Nakamura, M | 1 |
| Nakakimura, K | 1 |
| Matsumoto, M | 1 |
| Sakabe, T | 1 |
| Simpson, RE | 1 |
| O'Regan, MH | 1 |
| Perkins, LM | 1 |
| Phillis, JW | 1 |
22 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Cerebral Ischemia
| Article | Year |
|---|---|
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells; | 2007 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr | 2008 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corp | 2009 |
The role of adenosine in up-regulation of p38 MAPK and ERK during limb ischemic preconditioning-induced brain ischemic tolerance.
Topics: Adenosine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Extremities; Ischemic Preconditioning; | 2019 |
[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study].
Topics: Adenosine; Animals; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Infarction, Middle Cer | 2015 |
Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia.
Topics: Adenosine; Animals; Brain Ischemia; Brain Stem; Female; Male; Mice; Phenethylamines; Purinergic P1 R | 2010 |
Inhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Caudate Nucleus; Dizocilpine Maleate; Do | 2013 |
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagoni | 2003 |
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Precon | 2006 |
Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Cerebral Cortex; Electrocardiography; El | 2006 |
Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Brain; Brain Ischemia; Cerebral Ve | 2006 |
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
Topics: Adenosine; Animals; Body Temperature; Brain Ischemia; Down-Regulation; Female; Gerbillinae; Hippocam | 1994 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; | 1997 |
Reduced adenosine uptake accelerates ischaemic block of population spikes in hippocampal slices from streptozotocin-treated diabetic rats.
Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Brain Ischemia; Diabetes Mellitus, Experimen | 1998 |
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics; | 1999 |
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine; Animals; ATP-Binding Cassette Transporters; Binding, Comp | 2001 |
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch | 2001 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid | 2001 |
Adenosine A(1) receptor agonism in the immature rat brain and heart.
Topics: Adenosine; Animals; Animals, Newborn; Binding, Competitive; Body Temperature; Brain; Brain Ischemia; | 2001 |
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist.
Topics: Adaptation, Physiological; Animals; Brain Ischemia; Cerebral Infarction; Cryoprotective Agents; Dime | 2002 |
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Corte | 1992 |