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1,3-dipropyl-8-cyclopentylxanthine and Brain Ischemia

1,3-dipropyl-8-cyclopentylxanthine has been researched along with Brain Ischemia in 22 studies

DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury."7.81[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015)
"To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning."7.73Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006)
"The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown."7.69Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994)
"To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury."3.81[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015)
"To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning."3.73Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006)
"The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown."3.69Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994)
"Our data provide evidence that during cerebral ischemia endogenous activation of A(1) receptors accelerates the electrical "shut-down" of the whole brain."1.33Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity. ( Ciocan, D; Ilie, A; Moldovan, M; Nita, DA; Zagrean, AM; Zagrean, L, 2006)
"In the present study, focal cerebral ischemia was induced in spontaneously hypertensive rats by filament insertion through the carotid artery."1.33Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. ( Akaiwa, K; Akashi, H; Aoyagi, S; Harada, H; Hiromatsu, S; Kano, T; Sakashita, H, 2006)
" The selective A1 receptor antagonist DPCPX also had no effect on release when administered at a low dosage (0."1.28Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. ( O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE, 1992)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (27.27)18.2507
2000's12 (54.55)29.6817
2010's4 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Colotta, V3
Catarzi, D3
Varano, F3
Capelli, F1
Lenzi, O3
Filacchioni, G3
Martini, C3
Trincavelli, L3
Ciampi, O3
Pugliese, AM4
Pedata, F5
Schiesaro, A1
Morizzo, E3
Moro, S3
Traini, C2
Yuan, Q1
Jia, HX1
Li, SQ1
Wu, YJ1
Feng, L1
Liu, XL1
Sun, XC1
Li, WB1
Lu, HR1
Song, SW1
Han, KY1
Liu, HP1
Chen, SD1
Wang, JL1
Dai, QX1
Saransaari, P1
Oja, SS1
Chauhan, NK1
Young, AM1
Gibson, CL1
Davidson, C1
Latini, S2
Corradetti, R2
Liu, Y1
Xiong, L1
Chen, S1
Wang, Q1
Ilie, A1
Ciocan, D1
Zagrean, AM1
Nita, DA1
Zagrean, L1
Moldovan, M1
Akaiwa, K1
Akashi, H1
Harada, H1
Sakashita, H1
Hiromatsu, S1
Kano, T1
Aoyagi, S1
Von Lubitz, DK1
Lin, RC1
Melman, N1
Ji, XD1
Carter, MF1
Jacobson, KA1
Barth, A1
Newell, DW1
Nguyen, LB1
Winn, HR1
Wender, R1
Meno, JR1
Janigro, D1
Bona, E1
Adén, U2
Gilland, E1
Fredholm, BB2
Hagberg, H2
Cassar, M1
Jones, MG1
Szatkowski, M1
Bordoni, F1
Sperlágh, B1
Zsilla, G1
Vizi, ES1
Hiraide, T1
Katsura, K1
Muramatsu, H1
Asano, G1
Katayama, Y1
Centonze, D1
Saulle, E1
Pisani, A1
Bernardi, G1
Calabresi, P1
Leverin, AL1
Nakamura, M1
Nakakimura, K1
Matsumoto, M1
Sakabe, T1
Simpson, RE1
O'Regan, MH1
Perkins, LM1
Phillis, JW1

Other Studies

22 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Brain Ischemia

ArticleYear
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells;

2007
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr

2008
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
    Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8

    Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corp

2009
The role of adenosine in up-regulation of p38 MAPK and ERK during limb ischemic preconditioning-induced brain ischemic tolerance.
    Brain research, 2019, 03-15, Volume: 1707

    Topics: Adenosine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Extremities; Ischemic Preconditioning;

2019
[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015, Volume: 35, Issue:9

    Topics: Adenosine; Animals; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Infarction, Middle Cer

2015
Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia.
    Amino acids, 2010, Volume: 38, Issue:5

    Topics: Adenosine; Animals; Brain Ischemia; Brain Stem; Female; Male; Mice; Phenethylamines; Purinergic P1 R

2010
Inhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Caudate Nucleus; Dizocilpine Maleate; Do

2013
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagoni

2003
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2006, Volume: 53, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Precon

2006
Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity.
    Journal of neurophysiology, 2006, Volume: 96, Issue:5

    Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Cerebral Cortex; Electrocardiography; El

2006
Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation.
    Brain research, 2006, Nov-29, Volume: 1122, Issue:1

    Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Brain; Brain Ischemia; Cerebral Ve

2006
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
    European journal of pharmacology, 1994, Apr-21, Volume: 256, Issue:2

    Topics: Adenosine; Animals; Body Temperature; Brain Ischemia; Down-Regulation; Female; Gerbillinae; Hippocam

1994
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br

1997
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
    Neuropharmacology, 1997, Volume: 36, Issue:9

    Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain;

1997
Reduced adenosine uptake accelerates ischaemic block of population spikes in hippocampal slices from streptozotocin-treated diabetic rats.
    The European journal of neuroscience, 1998, Volume: 10, Issue:1

    Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Brain Ischemia; Diabetes Mellitus, Experimen

1998
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices.
    British journal of pharmacology, 1999, Volume: 127, Issue:3

    Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics;

1999
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
    Brain research, 2001, Jan-19, Volume: 889, Issue:1-2

    Topics: 4-Aminopyridine; Acetylcholine; Adenosine; Animals; ATP-Binding Cassette Transporters; Binding, Comp

2001
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
    Brain research, 2001, Aug-10, Volume: 910, Issue:1-2

    Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch

2001
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
    Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 9

    Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid

2001
Adenosine A(1) receptor agonism in the immature rat brain and heart.
    European journal of pharmacology, 2001, Aug-31, Volume: 426, Issue:3

    Topics: Adenosine; Animals; Animals, Newborn; Binding, Competitive; Body Temperature; Brain; Brain Ischemia;

2001
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:2

    Topics: Adaptation, Physiological; Animals; Brain Ischemia; Cerebral Infarction; Cryoprotective Agents; Dime

2002
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
    Journal of neurochemistry, 1992, Volume: 58, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Corte

1992