1,3-dipropyl-8-cyclopentylxanthine has been researched along with Brain Ischemia in 22 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 7.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 7.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown." | 7.69 | Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994) |
| "To observe whether adenosine Al receptor (Al R) mediated neuroprotection of Shenmai Injection (SI) on rat cerebral ischemia/reperfusion (I/R) injury." | 3.81 | [Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study]. ( Chen, SD; Dai, QX; Han, KY; Liu, HP; Lu, HR; Song, SW; Wang, JL, 2015) |
| "To investigate the role of the adenosine A1 receptor in the rapid tolerance to cerebral ischemia induced by isoflurane preconditioning." | 3.73 | Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. ( Chen, S; Liu, Y; Wang, Q; Xiong, L, 2006) |
| "The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown." | 3.69 | Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. ( Carter, MF; Jacobson, KA; Ji, XD; Lin, RC; Melman, N; Von Lubitz, DK, 1994) |
| "Our data provide evidence that during cerebral ischemia endogenous activation of A(1) receptors accelerates the electrical "shut-down" of the whole brain." | 1.33 | Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity. ( Ciocan, D; Ilie, A; Moldovan, M; Nita, DA; Zagrean, AM; Zagrean, L, 2006) |
| "In the present study, focal cerebral ischemia was induced in spontaneously hypertensive rats by filament insertion through the carotid artery." | 1.33 | Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. ( Akaiwa, K; Akashi, H; Aoyagi, S; Harada, H; Hiromatsu, S; Kano, T; Sakashita, H, 2006) |
| " The selective A1 receptor antagonist DPCPX also had no effect on release when administered at a low dosage (0." | 1.28 | Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. ( O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 12 (54.55) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colotta, V | 3 |
| Catarzi, D | 3 |
| Varano, F | 3 |
| Capelli, F | 1 |
| Lenzi, O | 3 |
| Filacchioni, G | 3 |
| Martini, C | 3 |
| Trincavelli, L | 3 |
| Ciampi, O | 3 |
| Pugliese, AM | 4 |
| Pedata, F | 5 |
| Schiesaro, A | 1 |
| Morizzo, E | 3 |
| Moro, S | 3 |
| Traini, C | 2 |
| Yuan, Q | 1 |
| Jia, HX | 1 |
| Li, SQ | 1 |
| Wu, YJ | 1 |
| Feng, L | 1 |
| Liu, XL | 1 |
| Sun, XC | 1 |
| Li, WB | 1 |
| Lu, HR | 1 |
| Song, SW | 1 |
| Han, KY | 1 |
| Liu, HP | 1 |
| Chen, SD | 1 |
| Wang, JL | 1 |
| Dai, QX | 1 |
| Saransaari, P | 1 |
| Oja, SS | 1 |
| Chauhan, NK | 1 |
| Young, AM | 1 |
| Gibson, CL | 1 |
| Davidson, C | 1 |
| Latini, S | 2 |
| Corradetti, R | 2 |
| Liu, Y | 1 |
| Xiong, L | 1 |
| Chen, S | 1 |
| Wang, Q | 1 |
| Ilie, A | 1 |
| Ciocan, D | 1 |
| Zagrean, AM | 1 |
| Nita, DA | 1 |
| Zagrean, L | 1 |
| Moldovan, M | 1 |
| Akaiwa, K | 1 |
| Akashi, H | 1 |
| Harada, H | 1 |
| Sakashita, H | 1 |
| Hiromatsu, S | 1 |
| Kano, T | 1 |
| Aoyagi, S | 1 |
| Von Lubitz, DK | 1 |
| Lin, RC | 1 |
| Melman, N | 1 |
| Ji, XD | 1 |
| Carter, MF | 1 |
| Jacobson, KA | 1 |
| Barth, A | 1 |
| Newell, DW | 1 |
| Nguyen, LB | 1 |
| Winn, HR | 1 |
| Wender, R | 1 |
| Meno, JR | 1 |
| Janigro, D | 1 |
| Bona, E | 1 |
| Adén, U | 2 |
| Gilland, E | 1 |
| Fredholm, BB | 2 |
| Hagberg, H | 2 |
| Cassar, M | 1 |
| Jones, MG | 1 |
| Szatkowski, M | 1 |
| Bordoni, F | 1 |
| Sperlágh, B | 1 |
| Zsilla, G | 1 |
| Vizi, ES | 1 |
| Hiraide, T | 1 |
| Katsura, K | 1 |
| Muramatsu, H | 1 |
| Asano, G | 1 |
| Katayama, Y | 1 |
| Centonze, D | 1 |
| Saulle, E | 1 |
| Pisani, A | 1 |
| Bernardi, G | 1 |
| Calabresi, P | 1 |
| Leverin, AL | 1 |
| Nakamura, M | 1 |
| Nakakimura, K | 1 |
| Matsumoto, M | 1 |
| Sakabe, T | 1 |
| Simpson, RE | 1 |
| O'Regan, MH | 1 |
| Perkins, LM | 1 |
| Phillis, JW | 1 |
22 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Brain Ischemia
| Article | Year |
|---|---|
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells; | 2007 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr | 2008 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corp | 2009 |
The role of adenosine in up-regulation of p38 MAPK and ERK during limb ischemic preconditioning-induced brain ischemic tolerance.
Topics: Adenosine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Extremities; Ischemic Preconditioning; | 2019 |
[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study].
Topics: Adenosine; Animals; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Infarction, Middle Cer | 2015 |
Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia.
Topics: Adenosine; Animals; Brain Ischemia; Brain Stem; Female; Male; Mice; Phenethylamines; Purinergic P1 R | 2010 |
Inhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Caudate Nucleus; Dizocilpine Maleate; Do | 2013 |
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagoni | 2003 |
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Precon | 2006 |
Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Cerebral Cortex; Electrocardiography; El | 2006 |
Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Brain; Brain Ischemia; Cerebral Ve | 2006 |
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
Topics: Adenosine; Animals; Body Temperature; Brain Ischemia; Down-Regulation; Female; Gerbillinae; Hippocam | 1994 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; | 1997 |
Reduced adenosine uptake accelerates ischaemic block of population spikes in hippocampal slices from streptozotocin-treated diabetic rats.
Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Brain Ischemia; Diabetes Mellitus, Experimen | 1998 |
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics; | 1999 |
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine; Animals; ATP-Binding Cassette Transporters; Binding, Comp | 2001 |
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch | 2001 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid | 2001 |
Adenosine A(1) receptor agonism in the immature rat brain and heart.
Topics: Adenosine; Animals; Animals, Newborn; Binding, Competitive; Body Temperature; Brain; Brain Ischemia; | 2001 |
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist.
Topics: Adaptation, Physiological; Animals; Brain Ischemia; Cerebral Infarction; Cryoprotective Agents; Dime | 2002 |
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Corte | 1992 |