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1,3-dipropyl-8-cyclopentylxanthine and Aura

1,3-dipropyl-8-cyclopentylxanthine has been researched along with Aura in 12 studies

DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Research Excerpts

ExcerptRelevanceReference
" A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration."7.83Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016)
" A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration."3.83Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016)
" This study also investigates the effects of a mild epileptic insult on neuronal death in rat hippocampus after a subsequent, lethal epileptic stress using kainic acid (KA) as a model of epilepsy."3.70Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. ( Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H, 1999)
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule."1.43Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's3 (25.00)18.2507
2000's5 (41.67)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Waszkielewicz, AM1
Gunia-Krzyżak, A1
Powroźnik, B1
Słoczyńska, K1
Pękala, E1
Walczak, M1
Bednarski, M1
Żesławska, E1
Nitek, W1
Marona, H1
Muzzi, M1
Coppi, E1
Pugliese, AM1
Chiarugi, A1
Amorim, BO1
Hamani, C1
Ferreira, E1
Miranda, MF1
Fernandes, MJS1
Rodrigues, AM1
de Almeida, AG1
Covolan, L1
Roseti, C1
Martinello, K1
Fucile, S1
Piccari, V1
Mascia, A1
Di Gennaro, G1
Quarato, PP1
Manfredi, M1
Esposito, V1
Cantore, G1
Arcella, A1
Simonato, M1
Fredholm, BB1
Limatola, C1
Miledi, R1
Eusebi, F1
Chwalczuk, K1
Rubaj, A1
Swiader, M1
Czuczwar, SJ1
Harrison, PK1
Tattersall, JE1
Clement, RA1
Uzbay, TI1
Kayir, H1
Ceyhan, M1
Alzheimer, C2
Sutor, B2
ten Bruggencate, G2
Chesi, AJ1
Stone, TW1
Plamondon, H1
Blondeau, N1
Heurteaux, C1
Lazdunski, M1
Tchekalarova, J1
Kambourova, T1
Georgiev, V1

Other Studies

12 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Aura

ArticleYear
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru

2016
Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor.
    Experimental neurology, 2013, Volume: 250

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals;

2013
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
    Epilepsy & behavior : E&B, 2016, Volume: 61

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec

2016
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-30, Volume: 105, Issue:39

    Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female;

2008
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
    Przeglad lekarski, 2008, Volume: 65, Issue:11

    Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal

2008
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice.
    Neuroscience letters, 2004, Mar-11, Volume: 357, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Atropine; Disease Models, Animal; Drug Interactions; El

2004
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:2

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep

2007
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: pre- and postsynaptic components.
    Neuroscience, 1993, Volume: 57, Issue:3

    Topics: Animals; Epilepsy; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Phosphoric Diester Hydrolas

1993
Alkylxanthine adenosine antagonists and epileptiform activity in rat hippocampal slices in vitro.
    Experimental brain research, 1997, Volume: 113, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; In Vitro Techniques; Male; Puriner

1997
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:12

    Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-E

1999
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
    Brain research bulletin, 2001, Sep-15, Volume: 56, Issue:2

    Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce

2001
Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs.
    Neuroscience letters, 1989, Apr-24, Volume: 99, Issue:1-2

    Topics: Action Potentials; Animals; Bicuculline; Convulsants; Epilepsy; Guinea Pigs; Hippocampus; In Vitro T

1989