1,3-dipropyl-8-cyclopentylxanthine has been researched along with Aura in 12 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 7.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 3.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " This study also investigates the effects of a mild epileptic insult on neuronal death in rat hippocampus after a subsequent, lethal epileptic stress using kainic acid (KA) as a model of epilepsy." | 3.70 | Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. ( Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H, 1999) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Muzzi, M | 1 |
| Coppi, E | 1 |
| Pugliese, AM | 1 |
| Chiarugi, A | 1 |
| Amorim, BO | 1 |
| Hamani, C | 1 |
| Ferreira, E | 1 |
| Miranda, MF | 1 |
| Fernandes, MJS | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Covolan, L | 1 |
| Roseti, C | 1 |
| Martinello, K | 1 |
| Fucile, S | 1 |
| Piccari, V | 1 |
| Mascia, A | 1 |
| Di Gennaro, G | 1 |
| Quarato, PP | 1 |
| Manfredi, M | 1 |
| Esposito, V | 1 |
| Cantore, G | 1 |
| Arcella, A | 1 |
| Simonato, M | 1 |
| Fredholm, BB | 1 |
| Limatola, C | 1 |
| Miledi, R | 1 |
| Eusebi, F | 1 |
| Chwalczuk, K | 1 |
| Rubaj, A | 1 |
| Swiader, M | 1 |
| Czuczwar, SJ | 1 |
| Harrison, PK | 1 |
| Tattersall, JE | 1 |
| Clement, RA | 1 |
| Uzbay, TI | 1 |
| Kayir, H | 1 |
| Ceyhan, M | 1 |
| Alzheimer, C | 2 |
| Sutor, B | 2 |
| ten Bruggencate, G | 2 |
| Chesi, AJ | 1 |
| Stone, TW | 1 |
| Plamondon, H | 1 |
| Blondeau, N | 1 |
| Heurteaux, C | 1 |
| Lazdunski, M | 1 |
| Tchekalarova, J | 1 |
| Kambourova, T | 1 |
| Georgiev, V | 1 |
12 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Aura
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; | 2013 |
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec | 2016 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; | 2008 |
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal | 2008 |
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atropine; Disease Models, Animal; Drug Interactions; El | 2004 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep | 2007 |
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: pre- and postsynaptic components.
Topics: Animals; Epilepsy; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Phosphoric Diester Hydrolas | 1993 |
Alkylxanthine adenosine antagonists and epileptiform activity in rat hippocampal slices in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; In Vitro Techniques; Male; Puriner | 1997 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-E | 1999 |
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce | 2001 |
Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Epilepsy; Guinea Pigs; Hippocampus; In Vitro T | 1989 |