1,3-dipropyl-8-cyclopentylxanthine has been researched along with Asthma in 4 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesize that asthmatic inflammation translates into systemic inflammation and alters vascular responses where adenosine (AD) plays an important role." | 7.74 | Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. ( Mustafa, SJ; Nadeem, A; Ponnoth, DS, 2008) |
| "Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics." | 7.73 | A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. ( Batra, VK; Borron, P; Mustafa, SJ; Nadeem, A; Obiefuna, PC; Wilson, CN, 2005) |
| " We hypothesize that asthmatic inflammation translates into systemic inflammation and alters vascular responses where adenosine (AD) plays an important role." | 3.74 | Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. ( Mustafa, SJ; Nadeem, A; Ponnoth, DS, 2008) |
| "Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics." | 3.73 | A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. ( Batra, VK; Borron, P; Mustafa, SJ; Nadeem, A; Obiefuna, PC; Wilson, CN, 2005) |
| "Recently, there has been an increasing interest in adenosine as a potential mediator of allergic asthma." | 3.69 | Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor. ( Ali, S; Metzger, WJ; Mustafa, SJ, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Obiefuna, PC | 1 |
| Batra, VK | 1 |
| Nadeem, A | 2 |
| Borron, P | 1 |
| Wilson, CN | 1 |
| Mustafa, SJ | 3 |
| Smith, N | 1 |
| Broadley, KJ | 1 |
| Ponnoth, DS | 1 |
| Ali, S | 1 |
| Metzger, WJ | 1 |
4 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Asthma
| Article | Year |
|---|---|
A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hype | 2005 |
Adenosine receptor subtypes in the airways responses to 5'-adenosine monophosphate inhalation of sensitized guinea-pigs.
Topics: Adenosine Monophosphate; Administration, Inhalation; Animals; Anti-Inflammatory Agents; Asthma; Bron | 2008 |
Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma.
Topics: Acetylcholine; Adenosine; Administration, Inhalation; Allergens; Ambrosia; Animals; Aorta; Asthma; D | 2008 |
Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor.
Topics: Adenosine; Animals; Asthma; Binding, Competitive; Bronchoconstriction; Disease Models, Animal; In Vi | 1994 |