1,3-dipropyl-8-cyclopentylxanthine and Arthritis, Rheumatoid studies

DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Research Excerpts

Excerpt	Relevance	Reference
"To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation."	7.69	Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. ( Coffey, D; Cronstein, BN; Fisher, R; Lahita, RG; Merrill, JT; Salmon, J; Schreibman, D; Shen, C; Zakharenko, O, 1997)
"To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation."	3.69	Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. ( Coffey, D; Cronstein, BN; Fisher, R; Lahita, RG; Merrill, JT; Salmon, J; Schreibman, D; Shen, C; Zakharenko, O, 1997)

Research

Studies (1)

Authors

Other Studies

1 other study available for 1,3-dipropyl-8-cyclopentylxanthine and Arthritis, Rheumatoid

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Merrill, JT	1
Shen, C	1
Schreibman, D	1
Coffey, D	1
Zakharenko, O	1
Fisher, R	1
Lahita, RG	1
Salmon, J	1
Cronstein, BN	1